Abstracts Poster Abstracts - Dr Falk

84The study of risk groups for cholangiocarcinomaMitrut Paul, M.D., Ph.D., Genunche Amelia, M.D., Ph.D.UMF Craiova, Emergency District Hospital of Craiova - The IInd Medical Clinic -RomaniaIntroduction: Cholangiocarcinoma is a neoplasic disease arising from the intrahepaticand extrahepatic bile ducts. The disease is associated with known risk factors: bile ductinflammation accompanying Caroli's disease, choledochol cysts, Clonorchis sinensisinfections, hepatolithiasis and primary sclerosing cholangitis (PSC); however, mostpatients have no known indentifiable predisposing conditions.Aim of study: Recognized etiological factors in the development of cholangiocarcinoma.Material and methods: This prospective study involving a group of 96 patients withcholangiocarcinoma developed during a 10 years, period January 1995-January 2005.Statistically the majority were male patients (60.41% men comparative with 26.5%women); and the mean ages is 59.05 ± 8.56 years. The clinical, biochemical (serum CA19-9) and imagistic evaluation has been complete (PET scans, magnetic resonance orERCP).Results and discussions: We recognized etiological factors in the development ofcholangiocarcinoma in 39 cases (40.62%). Primary sclerosing cholangitis (PSC) wasrecognized in 11 cases (11.45%), Caroli's disease in 5 cases (5.20%), choledochol cystin 8 cases (8.33%), hepatolithiasis in 10 cases (9.6%) and liver fluke infestation in 1case (1.04%). In 57 cases have no know indentifiable predisposing condition.Conclusions: Primary sclerosing cholangitis (PSC) is the major risk factor associatedwith the development of cholangiocarcinoma. Another risk factors were hepatolithiasisand choledochol cyst. This information suggest screening strategies for cholangiocarcinomain PSC.