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Neurochemical regulation of auditory information ... - Helda - Helsinki.fi

Table 3. Main information about patients from Studies I, II

Study I Study II

Diagnosis schizotypal disorder F21 (N = 2)

schizoaffective disorder, depressive type F25.1

(N = 7)

schizoaffective disorder, mixed type F25.2

(N = 1)

delusional disorder F22.0 (N = 1)

History of

antipsychotic

treatment

Medication

at 4 weeks of

follow-up

Additional

treatment

neuroleptic naive (N = 2)

neuroleptic free (N = 7; 1 for at least half a

year, and 6 for at least 1 month)

treated with other antipsychotics before

the switch to olanzapine (N = 2; 1 patient

with trifluoperazine 30 mg/d; 1 patient with

haloperidol decanoate 50 mg)

42

schizotypal

disorder F21.0

(N = 5)

paranoid

schizophrenia

F20.0 (N = 4)

neuroleptic naive

patients

5-10 mg/d of olanzapine 2.5±1 mg/day of

risperidone

benzodiazepines (5 received clonazepam

2-4 mg/d, 3 – lorazepam 2-4 mg/d)

citalopram (4 patients – 20 mg/d)

trihexyphenidyl (3 patients – 4 mg/d)

no additional

therapy

Before the EEG/MEG measurements, the subjective levels of anxiety, mood, and arousal

were measured with the visual analogue scales (VAS). The VAS allows the quantification

of small changes over time and there is a good subject/observer agreement for this method

(Hornblow and Kidson 1976; Hotopf et al. 1999; Lundberg 1980). The VAS was presented

in the form of a 10-cm line. The anchor statements were “not at all” and “very much so”.

Two experimental sessions were separated by one week.

Studies were performed at the Republican Vilnius Psychiatric Hospital (Vilnius, Lithuania)

(Studies I, II) and at the BioMag Laboratory, at the Helsinki University Central Hospital

(Helsinki, Finland) (Studies III, IV). The studies were approved by the Ethic Committees

of the Hospitals. Subjects gave their written informed consent to participate in the study.

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