Prof. Dr. Thomas Höfer BioQuant and German ... - CellNetworks

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Prof. Dr. Thomas Höfer BioQuant and German ... - CellNetworks

Prof. Dr. Thomas Höfer

BioQuant and

25 March 1967, Dresden Professor

German Cancer Research Center (DKFZ)

69120 Heidelberg, Germany

Phone: 06221-54 51380

Fax: 06221-54 51487

Email: t.hoefer@dkfz.de

SCIENTIFIC VITA

2011 Head of division Theoretical Systems Biology at DKFZ and Full

professorship (W3) at University of Heidelberg

2007–present Group leader, German Cancer Research Center Heidelberg (DKFZ)

2006 Offered full professorship, Humboldt University Berlin (declined)

2005 Offered Chair in Systems Biology at University of Warwick (declined)

2002–2006 Junior Professor, Mathematical modeling of complex biological systems

Humboldt University Berlin

2001–2002 Extended research visits to Collège de France, Paris

2000–2002 Junior group leader, Humboldt University Berlin, Institute of Biology

1997–1999 Postdoctoral researcher, Humboldt University Berlin, Institute of Biology

1996–1997 Postdoctoral fellow, Max-Planck Institute for Physics of Complex Systems

Dresden

1994–1996 Jowett Senior Scholar at Balliol College, Oxford

1993–1996 University of Oxford, Doctoral thesis in mathematics PhD fellow, Boehringer

Ingelheim Fonds

1992–1993 University of Oxford, visiting student in applied mathematics

1991–1993 Studienstiftung des deutschen Volkes (German National Merit Foundation)

1988–1993 Humboldt University Berlin, studies of biophysics

COORDINATING FUNCTIONS & HONORS

2009–2012 Coordinator BMBF-SYSTEC consortium: dissecting the dynamics of

epigenetic gene silencing

2011–present Academic editor, PLoS ONE

2002–2006 Governing body, DFG Collaborative Research Center Theoretical Biology

1994–1996 Jowett Senior Scholar, Balliol College Oxford

1993–1996 PhD fellowship, Boehringer Ingelheim Fonds

1994

Landahl Award, Society of Mathematical Biology

1991–1993 Studienstiftung des deutschen Volkes

FIELDS OF INTEREST

Systems biology and mathematical modeling of regulatory networks:

• Regulatory networks in the innate and adaptive immune systems

• Cell-cycle regulation and DNA repair

• Spatio-temporal dynamics of signaling networks


CURRENTLY FUNDED PROJECTS

EU-FP7 large IP: ASSET: Assessing and striking sensitivities of embryonal tumors; SYBILLA:

Systems biology of T-cell activation in health and disease

BMBF systems biology consortium on: project: Dissecting the dynamics of epigenetic gene

silencing; project: Transcriptional control of T lymphocyte differentiation; project: A systems

approach to Candida infections

DFG-SFB 618, project: Integration of signal transduction and gene regulation of T cell

differentiation

Helmholtz Alliance on Systems Biology /SB Cancer

Currently supervising 8 doctoral theses, 2 MSc dissertations

PUBLICATIONS

Luijsterburg MS, von Bornstaedt G, Gourdin AM, Politi AZ, Moné MJ, Warmerdam DO,

Goedhart J, Vermeulen W, van Driel R and Höfer T, Stochastic and reversible assembly of a

multiprotein DNA repair complex ensures accurate target site recognition and efficient repair. J.

Cell Biol. 2010; 189: 445-463.

Salazar C, Brümmer A, Alberghina L and Höfer T, Timing control in regulatory networks by

multisite protein modifications. Trends Cell Biol. 2010; 20: 634-641.

Brümmer A, Salazar C, Zinzalla V, Alberghina L and Höfer T, Mathematical modeling of DNA

replication reveals a trade-off between coherence of origin activation and robustness against

rereplication. PLoS Comput. Biol.2010; 6:e1000783.

Mariani L, Schulz E, Lexberg M, Helmstetter C, Radbruch A, Löhning M and Höfer T, Shortterm

memory in gene induction reveals the regulatory principle behind stochastic interleukin-4

expression. Mol. Syst. Biol. 2010; 6:359.

Busse D, de la Rosa M, Hobiger K, Thurley K, Floßdorf M, Scheffold A and Höfer T, Competing

feedback loops shape IL-2 signaling between helper and regulatory T cells in cellular

microenvironments. Proc. Natl. Acad. Sci. USA 2010; 107: 3058–3063.

Nika K, Soldani S, Salek M, Gray A, Etzensperger R, Fugger L, Polzella P, Cerundolo V,

Dushek O, Höfer T, Viola A and Acuto O, Constitutive high levels of activated Lck drive T cell

antigen receptor signal transduction. Immunity 2010; 32: 766-777.

Schulz E, Mariani L, Radbruch A and Höfer T, Sequential polarization and imprinting of T-helper

type 1 differentiation by interferon-γ and interleukin-12. Immunity 2009; 30: 678-688.

Diernfellner ACR, Querfurth C, Salazar C, Höfer T and Brunner M, Phosphorylation modulates

rapid nucleo-cytoplasmic shuttling and cytoplasmic accumulation of Neurospora clock protein

FRQ on a circadian time scale. Genes Dev. 2009; 23: 2192-2200.

Salazar C, Politi A and Höfer T, Decoding of Ca2+ oscillations by phosphorylation cycles:

analytic results. Biophys. J. 2008; 94: 1203-1215.

Scheffold A, Murphy KM and Höfer T, Competition for cytokines: Treg cells take all. Nat.

Immunol. 2007; 8: 1285-1287.

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