Prof. Dr. Thomas Höfer
25 March 1967, Dresden Professor
German Cancer Research Center (DKFZ)
69120 Heidelberg, Germany
Phone: 06221-54 51380
Fax: 06221-54 51487
2011 Head of division Theoretical Systems Biology at DKFZ and Full
professorship (W3) at University of Heidelberg
2007–present Group leader, German Cancer Research Center Heidelberg (DKFZ)
2006 Offered full professorship, Humboldt University Berlin (declined)
2005 Offered Chair in Systems Biology at University of Warwick (declined)
2002–2006 Junior Professor, Mathematical modeling of complex biological systems
Humboldt University Berlin
2001–2002 Extended research visits to Collège de France, Paris
2000–2002 Junior group leader, Humboldt University Berlin, Institute of Biology
1997–1999 Postdoctoral researcher, Humboldt University Berlin, Institute of Biology
1996–1997 Postdoctoral fellow, Max-Planck Institute for Physics of Complex Systems
1994–1996 Jowett Senior Scholar at Balliol College, Oxford
1993–1996 University of Oxford, Doctoral thesis in mathematics PhD fellow, Boehringer
1992–1993 University of Oxford, visiting student in applied mathematics
1991–1993 Studienstiftung des deutschen Volkes (German National Merit Foundation)
1988–1993 Humboldt University Berlin, studies of biophysics
COORDINATING FUNCTIONS & HONORS
2009–2012 Coordinator BMBF-SYSTEC consortium: dissecting the dynamics of
epigenetic gene silencing
2011–present Academic editor, PLoS ONE
2002–2006 Governing body, DFG Collaborative Research Center Theoretical Biology
1994–1996 Jowett Senior Scholar, Balliol College Oxford
1993–1996 PhD fellowship, Boehringer Ingelheim Fonds
Landahl Award, Society of Mathematical Biology
1991–1993 Studienstiftung des deutschen Volkes
FIELDS OF INTEREST
Systems biology and mathematical modeling of regulatory networks:
• Regulatory networks in the innate and adaptive immune systems
• Cell-cycle regulation and DNA repair
• Spatio-temporal dynamics of signaling networks
CURRENTLY FUNDED PROJECTS
EU-FP7 large IP: ASSET: Assessing and striking sensitivities of embryonal tumors; SYBILLA:
Systems biology of T-cell activation in health and disease
BMBF systems biology consortium on: project: Dissecting the dynamics of epigenetic gene
silencing; project: Transcriptional control of T lymphocyte differentiation; project: A systems
approach to Candida infections
DFG-SFB 618, project: Integration of signal transduction and gene regulation of T cell
Helmholtz Alliance on Systems Biology /SB Cancer
Currently supervising 8 doctoral theses, 2 MSc dissertations
Luijsterburg MS, von Bornstaedt G, Gourdin AM, Politi AZ, Moné MJ, Warmerdam DO,
Goedhart J, Vermeulen W, van Driel R and Höfer T, Stochastic and reversible assembly of a
multiprotein DNA repair complex ensures accurate target site recognition and efficient repair. J.
Cell Biol. 2010; 189: 445-463.
Salazar C, Brümmer A, Alberghina L and Höfer T, Timing control in regulatory networks by
multisite protein modifications. Trends Cell Biol. 2010; 20: 634-641.
Brümmer A, Salazar C, Zinzalla V, Alberghina L and Höfer T, Mathematical modeling of DNA
replication reveals a trade-off between coherence of origin activation and robustness against
rereplication. PLoS Comput. Biol.2010; 6:e1000783.
Mariani L, Schulz E, Lexberg M, Helmstetter C, Radbruch A, Löhning M and Höfer T, Shortterm
memory in gene induction reveals the regulatory principle behind stochastic interleukin-4
expression. Mol. Syst. Biol. 2010; 6:359.
Busse D, de la Rosa M, Hobiger K, Thurley K, Floßdorf M, Scheffold A and Höfer T, Competing
feedback loops shape IL-2 signaling between helper and regulatory T cells in cellular
microenvironments. Proc. Natl. Acad. Sci. USA 2010; 107: 3058–3063.
Nika K, Soldani S, Salek M, Gray A, Etzensperger R, Fugger L, Polzella P, Cerundolo V,
Dushek O, Höfer T, Viola A and Acuto O, Constitutive high levels of activated Lck drive T cell
antigen receptor signal transduction. Immunity 2010; 32: 766-777.
Schulz E, Mariani L, Radbruch A and Höfer T, Sequential polarization and imprinting of T-helper
type 1 differentiation by interferon-γ and interleukin-12. Immunity 2009; 30: 678-688.
Diernfellner ACR, Querfurth C, Salazar C, Höfer T and Brunner M, Phosphorylation modulates
rapid nucleo-cytoplasmic shuttling and cytoplasmic accumulation of Neurospora clock protein
FRQ on a circadian time scale. Genes Dev. 2009; 23: 2192-2200.
Salazar C, Politi A and Höfer T, Decoding of Ca2+ oscillations by phosphorylation cycles:
analytic results. Biophys. J. 2008; 94: 1203-1215.
Scheffold A, Murphy KM and Höfer T, Competition for cytokines: Treg cells take all. Nat.
Immunol. 2007; 8: 1285-1287.