"-1r-180 I'\112007(J)Jr' '- jwry¥Iyears,Ir-- age 75senile diabetes,~. )Udietetic confrril• •eased pain'20bmJHfrJjt f- dJillN coHte incr1~rsomesweds /rsemifiv. dy/tJW-II I~A / \t' "" "~--~.to,"",)"/' .......-,,' ogt'25"tJG 8, ~' " '...~\80".''-.-" .....l1ea60 ~-- __"EfX'OX ~wesf_ confrollabl!..JlluCQs.! --- ------ --- -,4020increasil!:i!TJ1./2!11!16 8 10 12 14 16 18 20 22 24 2 4 6timtddoy ..Fig. 121 Correlation between pain and blood glucose concentration. Typical course of blood glucose concentrationin the 24-hour cycle of a senile diabetic (AI and a healthy person (Blin Fig. 119 occurs when the BNB is breached.The overacidification of the nerve fibres thenleads to the strong sensation of pain. In this itis, in principle, of little importance whether thedamage to the myelin sheath occurs by injuries,by mechanical pressure, by the unrestrainedgrowth of a tumor, or by some other means.Depending on the momentary blood glucoselevel and the extent of the injury, the damageleads to an increased traversing of glucose tothe nerve fiber (this increase is sometimes more,sometimes less, but always great), and therebyto the pH reduction and triggering of pain.When the damage is very extensive (e.g. cancerin its advanced stage, burns etc.), very great pHreductions are to be expected, and particularlysevere pain does indeed occur.It is well known that the blood glucose concentrationfluctuates considerably in the 24-hcycle. The typical courses of these fluctuationswhen the food intake is spread over 4 meals areshown in Fig. 121. Particularly strong fluctuationsoccur in diabetics (solid line). Accordingto the discussed ideas about generation of painevery type should exhibit a corresponding circadianprofile with highs and lows. We questionednumerous patients with chronic pain. The re ult(Fig. 121, above) confirms in accordance withour hypothesis, that pain sensation is al 0 ubjectto very great fluctuation in the cir adiancycle and that, in good approximation the painmaxima and minima corre pond to the bloodglucose profile. Because of the drop in glu 0concentration in the nerve ti ue a a re ult ofthe occurring fermentation, a not in on iderabledrop in concentration to th bl od ir ulationmust be assumed for the pain-free ondition,in the case of damage of th B B tWe estimate that, for moderat B B injuri .a blood glucose concentration ofapproximat I40-60.10- 5 gil for freedom of pain mu t ballowed for. Further re earch hould b und Ttaken for th accurate quantitativ d t rminationof thi blood gluco thr h Id I 1freedom from pain and it ariati n, d p nd nton th t nt of th .B B damag, 1 1 hi h
61w:o.seII6W tissutconantmltOn-i1:blood1O-/gI-117016015011,()RemarKS1~glv.r:: ' .... '20~IlYma/ /_K!.{j.,..!}% ~nlalianpH-ii!}(napain)1~:: ]'00 normo/90 increasing poin80 IUGluslight fJ!J1il70 I60 ..pain thresholdI!nopaintfangerofsliJcIr!painIPlief by opproochirytl7eb/oaiglucose leve/topaifl tl1resholdcnrpnic polyarlhnfis/Kl/fl !KJj tfisopfll'aredFig. 122 Relief of physical pain by approachingthe blood glucose level to theobserved "pain threshold"i of uch importance for pain theory. To supportour estimation we include a finding ofCa per (Deutsches Zentrum flir SauerstoffMehr chritt-Therapie, Bad Fussing, FRG), onthe complete disappearance ofvery severe polyarthriticpains when the blood glucose level wasreduced to 60· ]0 -5 gil.The above considerations lead to a basic recognitionof the combat of physical pain byreducing the blood glucose: the pain does notdi 'appear only when a zero blood glucose leveli reached, which could never be attained dueto the known reasons of hypoglycemic shock,but much sooner, by reduction to levels ofaround 40-60·] 0- 5 gil. Thus there exists apain threshold of blood glucose concentration.The finding of the pain thre hold means thatwe must try to come as close as pas ible to thisthre hold in the combat of pain, by mean ofthe manipulated (and monitored!) reductionan the blood gluco e. Since this threshold existsand, furthermore at glucose levels which aretill more or Ie. tolerable, it seems that ourpath to the combat of pain can be practicallytrodden. The overview in Fig. 122the above findings.ummanzeThe further guidelines which follow re uIt fromour ideas on the combat of chronic pain: onprinciple, the aim of all measures mu t be toreduce the blood glucose to a level which is aslow and as undeviating as possible. The eatingof sweets must be cut to a minimum. In orderto reduce the deviation (Fig. 121) we recommendthat the normal rule for diabeti bestrictly observed, such a adherence to the dietregulations to keep the blood gluco e at a lowlevel, and the distributions of food intake overa larger number ofmeals.It is to be expected from the nergeti nsideration at the beginning of thi paragraphthat a longer ]a. ting O2 utilizati n defi it in tharea of BBB and B B ha parti ularl . rpathological can qu nee and that. in r Ithe measure f th 02MT an al h lp ignificantlyin the. fi Id . H w v r, m r thanp ctation and motivat d hop hould n ten in th word, as m di al r . aT h h rtill in it arl infan .
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