40TH ANNUAL ESDR MEETING - ESDR 2010

40TH ANNUAL 

ESDR MEETING 

8-11 September 2010 Helsinki, Finland 

PROGRAM BOOK 

1 

1 

In partnership with: 

European Epidermal Barrier Research Network 

European Dermato-Epidemiology Network 

European Immunodermatology Society 

European Society of Dermatopathology 

Fondation René Touraine 

Society for Cutaneous Ultrastructure Research 

www.esdr.org

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TABLE OF CONTENTS 

TaonTenTs 

Acknowledgment of Sponsors of the 40th Annual ESDR Meeting 2010 4 

Meeting Organisers 4 

Welcome to Helsinki 5 

Social Program 6 

Scientific Program Highlights 

Major Lectures 7 

Postgraduate Course 7 

Clinical saturday 7 

Plenary Sessions 9 

Concurrent Sessions 13 

Educational Tracks 23 

Day-by-Day Program 

Wednesday 8 september 24 

Thursday 9 september 25 

Friday 10 september 26 

saturday 11 september 27 

Special Workshops 

CTCL-Challenges in Cutaneous Lymphoma 28 

Psoriasis: an autoinflammatory or autoimmune Disease? 28 

Satellite Meetings 

society for Cutaneous Ultrastructure Research (sCUR) 29 

european epidermal Barrier Research network (e2BRn) 30 

european Immuno-Dermatology society (eIs) 31 

european society for Dermatopathology (esDP) 32 

european Dermato-epidemiology network (eDen) 33 

neurobiology of the skin 34 

Drug Development in Dermatology - Principles and Practice 35 

acta Dermato-Venerologica 36 

Sponsored Symposia 

Biotest, 9 september 38 

Galderma, 10 september 39 

Intendis, Bausch & Lomb, 11 september 40 

Tourist Information 41 

General Information 42 

Exhibitor Information 

List of exhibitors and map 44 

Poster Information/Slide Preview Room 45 

About the ESDR 

Current officers of the esDR Board 46 

Past officers of the esDR Board 46 

esDR Committees 47 

Patron Members of the esDR 47 

abstract Reviewers in 2010 47 

List of esDR awards and Honourary Memberships 48 

Future esDR Meetings 48 

TABLE OF CONTENTS

SPONSORS 

ORGANISATION 

PLATINUM SPONSORS OF THE 2010 ESDR MEETING 

SPONSORS OF THE 2010 ESDR MEETING 

Chanel R&T 

ESDR PROGRAM COMMITTEE 

eugene Healy (Chair) 

Tilo Biedermann 

antonio Costanzo 

alexander enk 

ESDR Carien SCIENTIFIC niessen PROGRAM COMMITTEE 

Vincent Piguet 

nick Reynolds 

Peter steijlen 

ESDR OFFICE 

european society for Dermatological Research 

7 Rue Cingria 

CH-1205 Geneva 

switzerland 

Tel: +41 22 321 48 90 

Fax: +41 22 321 48 92 

email: office@esdr.org 

Web: www.esdr.org 

4 

LOCAL ORGANISING COMMITTEE 

Veli-Matti Kähäri (Chair) 

antti Lauerma 

sirkku Peltonen 

annamari Ranki 

sari suomela 

Kaisa Tasanen 

MEETING SECRETARIAT (PCO) 

CongCreator CC Ltd 

albertinkatu 27 B 5th. floor 

FI-00180 Helsinki 

Finland 

Tel: +358 9 4542 190 

Fax: +358 9 4542 1930 

email: info[at]congcreator.com

Welcome to ESDR 2010 

on behalf of the Local organising Committee and the 

Finnish association of Dermatologists I wish to welcome 

you all to the 40th annual Meeting of the esDR in Helsinki. 

We have chosen Marina Congress Center in the harbor of 

Helsinki as the venue for this event and hope that you will 

enjoy the seaside charm of the city. 

The esDR scientific Program Committee has worked hard 

to generate an exciting scientific program for the meeting 

and the Local organising Committee has made every 

effort to make the social program including Welcome 

Reception and Gala evening attractive and enjoyable to 

all participants. 

The esDR 2010 meeting will give an excellent opportunity 

to meet old friends, make new acquaintances, generate 

novel ideas and develop scientific collaborations. 

Welcome from the ESDR President 

The esDR is 40 years old this year; congratulations to 

the esDR on the birthday at which people frequently 

say that “life is just beginning”. In reality, life is just 

getting better and better for the esDR. as a result of 

the hard work undertaken by many of the current and 

former Board members, including many of its former 

presidents, the esDR continues to grow in strength 

and in numbers and has established itself as hosting 

“THe MeeTInG” to attend for top quality science 

during the day and good socialising each evening. 

The esDR recognises that major advances in clinical care 

for patients with skin disorders result from a combination of 

advances in the understanding of genetic, epidemiological 

and molecular processes in normal and diseased skin, 

with a continuing drive towards the development of novel 

biomarkers and therapeutic agents through high-quality 

interactions between clinicians, scientists and members 

of the pharmaceutical/biotechnological industries. 

In addition, there is widespread recognition within our 

society that the optimal clinical care for future patients 

with skin diseases rests not only on the shoulders 

of its current members, and on the members of its 

sister societies (sID and JsID), but is dependent 

5 

I wish you all a very pleasant and exciting 40th annual 

Meeting of the esDR. 

Prof Veli-Matti Kähäri 

Chair, Local organising Committee 

on first-rate education and mentoring of junior 

clinicians and scientists-in-training across the world. 

This means that the program for the annual meeting has 

been developed in a manner which provides something 

for everyone, via a mixture of invited lectures, original 

research presentations, symposia and workshops. 

But it is not just about passive listening during these 

sessions, it is about active participation through asking 

questions, chatting to other delegates during the coffee 

breaks and discussing the latest science which has just 

been presented by familiar and not-so-familiar faces. 

Looking forward to seeing you in Helsinki! 

Prof Eugene Healy 

President, european society for Dermatological Research 

WELCOME

SOCIAL 

PROGRAM 

ESDR WELCOME RECEPTION 

Thursday 9 September 2010, 19.00-21.00 

all delegates are invited to attend the esDR Welcome Reception at the Helsinki City Hall on Thursday 9 september 

2010. a warm buffet and drinks will be provided free of charge to all registered delegates. 

Address 

Pohjoisesplanadi 11-13 

The City Hall is a short walk from the esDR 2010 meeting venue and is located opposite the Market square and 

Helsinki Port. Guides will be situated outside the Marina Congress Center and along the route to show you the way. 

ESDR 2010 GALA EVENING 

Friday 10 September 2010, 19.30-24.00 

Wanha Satama 

all delegates, exhibitors and sponsors are invited to the esDR 2010 Gala evening. The Gala evening will be held a 

short walk from the meeting venue at Wanha satama. The name "Wanha satama" means "old Harbour" and the 

brick building dates from the 19th century. 

a hot buffet and drinks will be provided free of charge to all registered delegates.There will also be musical 

entertainment throughout the evening and dancing after dinner. Rooms with seating will be available away from 

the music. 

Address 

Pikku satamakatu 3 

6

SCIENTIFIC AND EDUCATIONAL HIGHLIGHTS 

MAJOR LECTURES 

■ ESDR Guest Lecture: Angiogenesis 

Kari Alitalo (Finland) 

Lymphangiogenesis in Development and Disease 

■ Merck Serono Lecture 

Hidde Ploegh (USA) 

a Biochemist's Take on Innate and adaptive 

Immunity: new Models for allergy? 

supported by 

■ Rudi Cormane Lecture 

Thomas Schwarz (Germany) 

Understanding the sun's Language 

■ René Touraine Lecture 

Alain Hovnanian (France) 

epidermal serine Proteases and their Inhibitors 

in skin Barrier and Diseases 

POSTGRADUATE COURSE 

our knowledge in basic science is rapidly increasing. 

Dermatology has numerous interfaces with basic 

science fields. Thus, a constant update in these areas is 

crucial for the further development of dermatological 

research. The purpose of the Postgraduate Course is 

to provide overviews about primarily non-dermatologic 

topics that are relevant for experimental and clinical 

dermatology. These talks are principally intended as 

essential updates for “non-experts”. 

The 2010 esDR Postgraduate Course is dedicated to 

the memory of Prof Ulpu saarialho-Kere. 

Program 

9 september 2010, 11.00-12.30 

Chairs: Veli-Matti Kähäri, Philippe Musette 

■ Jonathan Barker (London) 

Clinical Implications of Gene Discovery in 

Common Complex Disease: example of Psoriasis 

■ Irma Thesleff (Helsinki) 

The Pathogenesis of ectodermal Dysplasia 

syndromes 

■ William C Parks (USA) 

Metalloproteinases in Repair and Immunity 

■ Juha Kere (Stockholm) 

From Genes to skin Biology 

7 

CLINICAL SATURDAy 

The main mission of the esDR is to foster basic 

research in dermatology and skin biology. To increase 

the exchange between basic scientists and clinicians 

at the annual meeting, the esDR has included a 

“Clinical saturday” as part of the regular program. 

By offering Clinical saturday and industry sponsored 

symposia, the esDR hopes to make the meeting as 

attractive for clinicians as it always has been for basic 

scientists. The esDR feels committed to satisfying the 

needs and interests of both scientists and clinicians. 

The dialogue and cross fertilization between these 

two groups is essential for the future prosperous 

development of dermatology. 

Clinical saturday 2010 is held in association with the 

european academy for Dermatology and Venereology 

Program 

Clinical saturday 1: 11 september 2010, 09.00-10.30 

Chairs: Luca Borradori, Jonathan Rees 

■ Daniel Hohl (Switzerland) 

Genetic Tumor syndromes 

■ Luigi Naldi (Italy) 

evidence-based Dermatology: Importance and 

Lessons for the Practice 

■ Michael Hertl (Germany) 

Targeted Therapies in Inflammatory skin 

Disorders 

Clinical saturday 2: 11 september 2010, 14.30-16.00 

Chairs: stefan Beissert, Thomas Luger 

■ Leena Bruckner-Tuderman (Germany) 

skin Fragility: Will Biological Therapies Become 

Possible? 

■ Reinhard Dummer (Switzerland) 

Cutaneous Lymphoma: From Clinics to Lab and 

Back 

■ Jens M Schröder (Germany) 

Keratinocyte-derived antimicrobial Peptides: 

effector Molecules in Healthy and Inflamed skin 

SCIENTIFIC 

HIGHLIGHTS

PLENARy SESSION 1: THURSDAy 9 SEPTEMBER 2010, 14.15-16.15 

EUROPAEA ROOM 

Chairs: Leena Bruckner-Tuderman, Eugene Healy 

Talk duration is 12 minutes plus 3 minutes questions 

Oral 001 [Poster 022] 

Halting angiogenesis by non-viral somatic gene therapy alleviates psoriasis and murine 

psoriasiform skin lesions 

Katrin Wallbrecht 1 , John R. Zibert 2 , Lluis M. Mir 3 , Grete K. Jacobsen 4 , Veronique Trochon-Joseph 5 , 

Louise s. Villadsen 2 , Ruggero Cadossi 6 , Lone skov 2 , Michael P. schön 1 

1 Dept Derm, Georg august Univ, Göttingen, Germany, 2 Dept Derm-allergol, Univ Copenhagen, 

Denmark, 3 CnRs, Inst Gustave-Roussy, Villejuif, France, 4 Bartholin Inst, Copenhagen, Denmark, 

5 Bioalliance Pharma sa, Paris, France, 6 IGea s.r.l., Carpi, Italy 


The survival of DNA damaged cancer cells is ensured by mTOR-dependent phosphorylation of 

Sirtuin 1 

arianna Kim, Jung Ho Back, Yucui Zhu, Desiree Ratner, David Bickers Columbia University, new York, 

nY, United states 


The antimicrobial peptide murine beta defensin-14 induces immunosuppression via switching 

CD4+CD25- cells into regulatory T cells 

Fatemeh navid, Kerstin ahrens, Thomas schwarz, agatha schwarz 

University Clinics schleswig-Holstein, Kiel, schleswig-Holstein, Germany 


Genetic Dissection of a New Biochemical Pathway in Epidermal Differentiation 

Patrick Zeeuwen 1 , Ivonne van Vlijmen-Willems 1 , Tsing Cheng 1 , Diana Rodijk-olthuis 1 , Kiyotaka 

Hitomi 2 , susan John 3 , Ikuko Hara-nishimura 4 , Thomas Reinheckel 5 , Wiljan Hendriks 1 , Joost 

schalkwijk 1 1 Radboud University nijmegen Medical Centre, nijmegen, netherlands, 2 nagoya 

University, nagoya, Japan, 3 University of Cologne, Cologne, Germany, 4 Kyoto University, Kyoto, Japan, 

5 albert-Ludwigs-University, Freiburg, Germany 


The role of basophils in skin Th2 response using newly generated basophil specific conditional 

depletion model 

atsushi otsuka 1 , Yusuke Minegaki 1 , Chisa nakashima 1 , Masato Kubo 2 , Yoshiki Miyachi 1 , Kenji 

Kabashima 1 1 Department of Dermatology, Kyoto University, Kyoto, Japan, 2 Laboratory for signal 

network, Research Center for allergy and Immunology, RIKen, Kanagawa, Japan 


Role of Caveolin-1 in Desmosomal Homeostasis and Desmoglein-Mediated Signaling 

Donna Brennan 1 , sirkku Peltonen 2 , alicia Dowling 1 , Walid Medhat 1 , Kathleen Green 3 , Francesco Del 

Galdo 4 , My Mahoney 1 1 Thomas Jefferson University, Philadelphia, Pa, United states, 2 University of 

Turku, Turku, Finland, 3 northwestern University, Chicago, IL, United states, 4 st James’s University 

Hospital, Leeds, United Kingdom 


Concerted activation of TLR2 and IL-4R mediates Staphylococcus aureus dependent exaggeration 

of atopic dermatitis inflammation 

susanne Kaesler, Thomas Volz, Yuliya Böttcher, Ko-Ming Chen, emmanuella Guenova, Ulrike Hein, 

Tilo Biedermann University of Tübingen, Tübingen, Germany 


The role of human microRNA-125b in psoriasis 

ning Xu, Petter Brodin, Tianling Wei, Florian Meisgen, Liv eidsmo, Mona ståhle, enikö sonkoly, andor 

Pivarcsi Karolinska Institute, stockholm, sweden 

9 

PLENARy 

SESSIONS

PLENARy 

SESSIONS 

PLENARy SESSION 2: FRIDAy 10 SEPTEMBER 2010, 09.00-11.00 

EUROPAEA ROOM 

Chairs: Masa Amagai, Vincent Piguet 



Ex-vivo gene therapy restores LEKTI activity and corrects the architecture of Netherton syndrome derived 

skin grafts 

Wei-Li Di 1 , Fernando Larcher 2 , ekaterina semenova 1 , Gill e Talbot 1 , John I Harper 1 , Marcela Del Rio 2 , adrian 

J Thrasher 1 , Waseem Qasim 1 1 UCL Institute of Child Health, London, UK, 2 Cutaneous Diseases Modelling 

Unit, epithelial Biomedicine Division Centro de Investigaciones energeticas Medioambientales y Tecnologicas- 

CIBeReR, Madrid, spain 


Macrophages as sentinels directing the quality of skin repair 

Tina Lucas 1 , ari Waisman 2 , Thomas Krieg 1,3 , sabine eming 1 1 Department of Dermatology, University of 

Cologne, Cologne, Germany, 2 First Medical Department, University of Mainz, Mainz, Germany, 3 Cologne 

excellence Cluster on Cellular stress Responses in aging-associated Diseases (CeCaD), University of Cologne, 

Germany 


Loss of corneodesmosin due to early truncating autosomal recessive nonsense mutations leads to peeling 

skin disease 

Heiko Traupe 1 , Katja eckl 2,3 , Karin aufenvenne 1 , Marc nätebus 2 , Tatjana Walker 1 , natalia seller 1 , Regina 

Fölster-Holst 4 , ozan angün 5 , Patrick Terheyden 5 , Dieter Metze 1 , Ingrid Hausser 6 , Vinzenz oji 1 , Hans Christian 

Hennies 1,7 1 Dept of Derm, Univ Hosp Münster, Germany, 2 Cologne Ctr for Genomics, Germany, 3 Ctr for Physiol 

& Pathophys, Univ Cologne, Germany, 4 Univ Clinic of Derm, Kiel, Germany, 5 Dept of Derm, Lübeck, Germany, 

6 Dept of Derm, Heidelberg, Germany, 7 Ctr Molec Med Cologne, Germany 


The Hedgehog response gene Gli1 marks multipotent stem cells in the telogen bulge 

Isaac Brownell 1 , Cynthia a. Loomis 2 , alexandra L. Joyner 1 1 Memorial sloan-Kettering Cancer Center, new 

York, nY, United states, 2 new York University school of Medicine, new York, nY, United states 


SIRT1 counteracts STAT3 activity and STAT3-dependent gene expression induced by IL-22 in human 

keratinocytes 

Rosanna sestito 1 , Claudia scarponi 1 , stefania Madonna 1 , andrea Cavani 1 , Giampiero Girolomoni 2 , Cristina 

albanesi 11 IDI-IRCCs, Rome, Italy, 2 University of Verona, Italy 


Skin grafts recruit bone marrow-derived mesenchymal stem cells through SDF-1a/CXCR4 interaction to 

enhance tissue regeneration 

shin Iinuma 1,5 , Katsuto Tamai 1 , Takenao Chino 1 , John a. McGrath 2 , Jouni Uitto 4 , noriko Umegaki 3 , Ichiro 

Katayama 3 , Hajime Iizuka 5 , Yasufumi Kaneda 1 1 Division of Gene Therapy science, osaka Univ Graduate school 

of Medicine, suita, osaka, Japan, 2 st John’s Institute of Dermatology, King’s College London, London, UK, 

3 Dept of Dermatology, osaka Univ Graduate school of Medicine, suita, osaka, Japan, 4 Dept of Dermatology and 

Cutaneous Biology, Jefferson Medical College, Philadelphia, Pa, Usa, 5 Dept of Dermatology, asahikawa Medical 

College, Hokkaido, Japan 


Identification of novel psoriasis susceptibility loci and genetic interaction between HLA-C and ERAP1 provides 

evidence for an integrated pathogenic pathway 

Richard Trembath for the Genetic analysis of Psoriasis Consortium and Wellcome Trust Case Control 

Consortium II Division of Genetics and Molecular Medicine, King‘s College London, London, United Kingdom 


XPC silencing in normal human keratinocytes increases reactive oxygen species and triggers metabolic 

alterations that drive the formation of squamous cell carcinomas 

Hamid Reza Rezvani 1,2 , Frédéric Mazurier 1 , arianna Kim 2 , nsrein ali 1 , Meaghan Daly 2 , Hubert de Verneuil 1 , 

David R Bickers 2 , alain Taieb 1,3 1 Inserm U876, Bordeaux, France, 2 Columbia University, new York, nY, United 

states, 3 national Reference Centre for Rare skin Disorders, Bordeaux, France 

10

PLENARy SESSION 3: FRIDAy 10 SEPTEMBER 2010, 15.00-16.30 

EUROPAEA ROOM 

Chairs: Alexander Enk, Irene Leigh 



The Toll-like Receptor 4 Ligands Mrp8 and Mrp14 are Crucial in the Development of Autoreactive CD8+ T 

Cells 

Karin Loser 1 , Thomas Vogl 2 , Thomas a. Luger 1 , Johannes Roth 2 , stefan Beissert 1 1 Univeristy of Münster, 

Department of Dermatology, Münster, Germany, 2 University of Münster, Department of Immunology, Germany 


Long Term Genetic Correction of Xeroderma Pigmentosum Epidermal Stem Cells: A Preclinical Model of ex 

vivo and in vivo of Cutaneous Gene Therapy 

emilie Warrick 1 , Marta Garcia 2 , Del Rio Marcela 2 , Fernando Larcher 2 , Francoise Bernerd 3 , Thierry Magnaldo 1 

1 CnRs, nice, France, 2 Ciemat, Madrid, spain, 3 L‘oreal advanced Res., Clichy, France 


TGF-b and IL-10 are Critical Regulators of Langerhans and Dendritic Cell Function in vivo 

Mathilde Girard-Madoux 1 , Junda Kel 1 , Boris Reizis 2 , Björn Clausen 1 1 Dept of Immunology, erasmus MC, Univ 

Medical Center, Rotterdam, netherlands, 2 Dept of Microbiology & Immunology, Columbia Univ Medical Center, 

new York, Usa 


MicroRNA-21 Mediates the Effects of the BMP Signalling Pathway in Keratinocytes 

Mohammed ahmed 1 , andrei Mardaryev 1 , andrey sharov 2 , natalia Botchkareva 1 1 University of Bradford, 

Bradford, United Kingdom, 2 Boston University, Boston, Ma, United states 


HIV-1 Activates Cdc42 and Induces Filopodia in Immature Dendritic Cells to Facilitate Cell-to-Cell Virus 

Propagation 

Damjan nikolic 1 , 2 , Martin Lehmann 1 , 2 , Richard Felts 3 , eduardo Garcia 1 , 2 , Fabien Blanchet 1 , 2 , sriram 

subramaniam 3 , Vincent Pigeut 1 , 2 1 University of Geneva, Faculty of Medicine, Department of Microbiology and 

Molecular Medicine, Geneva, switzerland, 2 University Hospitals of Geneva, Department of Dermatology and 

Venereology, Geneva, switzerland, 3 nIH, Bethesda MD, United states 


Filaggrin Loss-of-Function Mutations are Associated with Early Onset Eczema, Eczema Severity, and 

Transepidermal Water Loss at Three Months of Age 

Carsten Flohr 1 , 2 , Kirsty england 1 , suzana Radulovic 1 , W.H. Irwin McLean 3 , Linda e. Campbell 3 , Jonathan 

Barker 2 , Michael Perkin 1 , Gideon Lack 1 1 Dept of Children‘s allergies, MRC/asthma UK Centre in allergic 

Mechanisms of asthma, King‘s College London, UK, 2 st John‘s Inst of Dermatology, Guy‘s & st Thomas‘ 

Hospital nHs Foundation Trust, London, UK, 3 Div of Molecular Medicine, Univ of Dundee, UK 

11 

PLENARy 

SESSIONS

PLENARy 

SESSIONS 

PLENARy SESSION 4: SATURDAy 11 SEPTEMBER 2010, 12.00-13.00 

EUROPAEA ROOM 

Chairs: Tilo Biedermann, Annamari Ranki 

Talk duration is 12 minutes plus 3 minutes questions. 


Identification of slan (6-sulfo LacNAc+) dendritic cells as a novel proinflammatory DC population in atopic 

dermatitis driving strong Th17 and Th1 responses 

anja Hänsel 1 , Wojchiech Baran 2 , Jens Ingwersen 3 , ernst Peter Rieber 3 , Michael Meurer 2 , Knut schäkel 1 

1 Department of Dermatology, University Hospital Heidelberg, Heidelberg, Germany, 2 Department of 

Dermatology, Faculty of Medicine of the Technical University Dresden, Dresden, Germany, 3 Institute of 

Immunology, Faculty of Medicine of the Technical University Dresden, Dresden, Germany 


Dysregulated tropomyosin receptor kinase (Trk) signalling in CyLD mutant tumours 

neil Rajan 1 , Richard elliott 2 , Christopher Lord 2 , oliver Clewes 1 , John Burn 1 , Maya sieber-Blum 1 , alan 

ashworth 2 1 Inst of Human Genetics, newcastle upon Tyne, UK, 2 Breakthrough Breast Cancer Research Centre, 

Inst of Cancer Research, London, UK 


Synthetic Peptide K5 Efficiently Detects in situ Transglutaminase1 Activity; Its Application for Diagnosis of 

Lamellar Ichthyosis 

Masashi akiyama 1 , Kaori sakai 1 , Teruki Yanagi 1 , satoshi Fukushima 2 , Hironobu Ihn 2 , Kiyotaka Hitomi 3 , Hiroshi 

shimizu 1 1 Dept of Dermatology, Hokkaido University Graduate school of Medicine, sapporo, Japan, 2 Dept 

of Dermatology & Plastic surgery, Faculty of Life sciences, Kumamoto University, Japan, 3 Dept of applied 

Molecular Biosciences, Graduate school of Bioagricultural sciences, nagoya University, Japan 


First double-blind randomized clinical trial of intradermal allogeneic fibroblast therapy for severe 

generalized recessive dystrophic epidermolysis bullosa randomized against placebo injections resulted in 

similar wound healing that is independent of collagen VII expression 

s.s. Venugopal 1 , 2 , W.F. Yan 1 , 2 , J.W. Frew 1 , 2 , H.I. Cohn 2 , 3 , M. sturm 4 , J. Fogarty 4 , P. Marinkovich 5 , s. Igawa 6 , a. 

Ishida-Yamamoto 6 , D.F. Murrell 1 , 2 1 st George Hospital, sydney, australia, 2 Univ of new south Wales, sydney, 

australia, 3 Jefferson Medical College, Philadelphia, Usa, 4 Cell & Tissue Therapies, Royal Perth Hospital, 

australia, 5 stanford University, stanford, Usa, 6 asahikawa Medical College, Japan 

12

CONCURRENT SESSION 1: Immunology 


EUROPAEA ROOM 

Chairs: Antonio Costanzo, yoshiki Tokura 



Lipid Signaling Through Liver X Receptor Alters Functions of Dendritic Cells 

Daniel Torocsik, Laszlo nagy University of Debrecen, Medical and Health science Center, Debrecen, Hungary 


Interferon y represses cancer cell proliferation through Tumor Necrosis Factor Receptor 1-mediated cell 

cycle arrest 

sonja Fischer, Heidi Braumüller, Thomas Wieder, Martin Röcken eberhard-Karls-University, Dept of 

Dermatology, Tübingen, Germany 


Cross-talk of novel phenotypes of MDSC and regulatory T cells (Tregs) during the melanoma growth 

Taku Fujimura 1 , 3 , Karsten Mahnke 1 , sabine Ring 1 , Viktor Umansky 2 , setsuya aiba 3 , alexander enk 1 1 Dept of 

Dermatology, Univ Hospital Heidelberg, Germany, 2 German Cancer Research Center, Heidelberg, Germany, 

3 Dept of Dermatology, Tohoku Univ, Graduate school of Medicine, sendai, Japan 


Treg deficient in IL-10 do not suppress the CHS reaction due to a lack of adenosine production 

sabine Ring, alexander enk, Karsten Mahnke University Hospital Heidelberg, Heidelberg, Germany 


Over-expression of epidermal protease-activated receptor-2 leads to spontaneous pruritic skin lesions in 

mice 

akihiko Ikoma 1 , Ferda Cevikbas 1 , Victoria Fong 1 , eric Camerer 2 , shaun Coughlin 3 , Martin steinhoff 1 1 UCsF 

Depts Dermatology and surgery, san Francisco, United states, 2 InseRM Cardiovascular Research Center, 

Paris, France, 3 UCsF Cardiovascular Research Institute, san Francisco, United states 


Optical Imaging (OI)- and Positron Emission Tomography (PET)-investigations reveal different migration and 

activation patterns of T cells after either intra-venous or intra-peritoneal administration 

Christoph M. Griessinger 1 , Daniel Bukala 1 , Kerstin Fuchs 2 , Ivana Glocova 2 , Walter ehrlichmann 3 , Martin 

Röcken 2 , Bernd J. Pichler 1 , Manfred Kneilling 2 1 Laboratory for Preclinical Imaging & Imaging Technology 

of the Werner siemens-Foundation, Dept of Radiology, eberhard Karls Univ, Tübingen, Germany, 2 Dept of 

Dermatology, eberhard Karls Univ, Tübingen, Germany, 3 Radiopharmacy, Dept of Radiology, eberhard Karls 

Univ, Tübingen, Germany 


Reciprocal regulation of IL-10 and IL-17 in human Th17 cells 

Christina Zielinski, antonio Lanzavecchia, Federica sallusto Institute for Research in Biomedicine, Bellinzona, 

switzerland 


CD8+ T cell migration to hapten exposed skin sites requires CD4+ help in a murine model 

nanna Fyhrquist 1 , Henrik Wolff 1 , 3 , antti Lauerma 1 , 2 , Harri alenius 1 1 Finnish Institute of occupational Health, 

Helsinki, Finland, 2 University of Helsinki, Helsinki, Finland, 3 Helsinki University Central Hospital, Helsinki, 

Finland 


Effect of IL-10-modulated tolerogenic DC in a humanized mouse model of lethal GvHD 

Henric adler 1 , Fanny Kryczanowsky 1 , Fabian Hermann 1 , Helen Martin 2 , stephan sudowe 1 , Christian Taube 2 , 

Kerstin steinbrink 1 1 Department of Dermatology, University Medical Center Mainz, Mainz, Germany, 2 III. 

Medical Clinic, University Medical Center Mainz, Mainz, Germany 

13 

CONCURRENT 

SESSIONS

CONCURRENT 

SESSIONS 

CONCURRENT SESSION 2: Vascular Biology, Signal Transduction & Cell Adhesion 


FENNIA I ROOM 

Chairs: Sabine Eming, Nick Reynolds 



Calpain activity is essential for cell recruitment, myofibroblast differentiation and angiogenesis in early 

stages of skin wounding 

Dany nassar 1 , emmanuel Letavernier 2 , Laurent Baud 2 , selim aractingi 1 , Kiarash Khosrotehrani 3 , 1 1 InseRM_ 

U938, saint antoine Research Center, Paris, France, 2 nephrology, Univ Paris 6 , France, 3 Centre for Clinical 

Research, University of Queensland, Brisbane, australia 


Topical Simvastatin Accelerates Wound Healing in Diabetes by Enhancing Lymphangiogenesis 

Jun asai 1 , Hideya Takenaka 1 , Kentaro Kajiya 2 , saburo Kishimoto 1 , norito Katoh 1 1 Dept of Dermatology, 

Graduate school of Med science, Kyoto Prefectural Univ of Medicine, Kyoto, Japan, 2 shiseido Innovative science 

Research Ctr, Yokohama, Japan 


How do Peroxisome-Proliferator-Activated-Receptors regulate the expression of Cathepsin in endothelial 

cells? 

Gabi Reichenbach, Igor Hrgovic, Monika Doll, Jens Gille, Roland Kaufmann, Markus Meissner Institute of 

Dermatology, University-Hospital Frankfurt a.M., Germany 


Integration of innate immune signalling pathways in epidermal barrier dysfunction and hyperkeratosis 

Ryan o‘shaughnessy 1 , Gehad Youssef 1 , Ishaan Choudhary 1 , John Harper 2 , 1 1 UCL Institute of Child Health, 

London, United Kingdom, 2 Great ormond street Hospital for sick Children, London, United Kingdom 


ARNT controls the expression of epidermal differentiation genes through EGFR- and HDAC-dependent 

pathways 

Douglas Robertson, Lynda Weir, Irene Leigh, andrey Panteleyev University of Dundee, Dundee, United Kingdom 


Activation of wnt5a in epidermis triggers massive hypersensitivity to double-stranded RNA 

Louise Reilly, Malgorzata Romanowska, John Foerster University of Dundee, UK 


The role of the receptor tyrosine kinase Axl in intercellular adhesion and signalling in cutaneous squamous 

cell carcinoma 

Monika Cichon, Ian Mackenzie, edel o‘Toole Centre for Cutaneous Research, BICMs, Barts and the London 

sMD, Queen Mary University of London, London, United Kingdom 


Defective granulation tissue formation in mice with specific ablation of integrin-linked kinase in fibroblasts - 

role of RhoA/ROCK signaling and TGF?1 levels 

Katrin Blumbach 1 , Manon C. Zweers 1 , Georg Brunner 2 , andreas s. Peters 1 , Markus schmitz 1 , Jan-niklas 

schulz 1 , Christopher P. Denton 3 , Reinhard Fässler 4 , Thomas Krieg 1 , Beate eckes 1 1 Dermatology, University 

of Cologne, Cologne, Germany, 2 Cancer Research, Fachklinik Hornheide, Münster, Germany, 3 Rheumatology, 

UCL, London, United Kingdom, 4 Max-Planck Institute, Martinsried, Germany 


Transmembrane Collagen XVII Is Involved In The Glomerular Filtration Barrier Failure In Knock Out Mice 

Jyri Moilanen 1 , Raija sormunen 3 , 4 , Claus-Werner Franzke 2 , stefanie Loeffek 2 , Raija soininen 3 , 4 , Leena 

Bruckner-Tuderman 2 , Kaisa Tasanen 1 , Helena autio-Harmainen 4 , Tiina Hurskainen 1 1 Dept of Derm, Univ of 

oulu & Clin Res Center, oulu Univ Hosp Finland, 2 Dept of Derm, Univ Med Ctr Freiburg, Germany, 3 Bioctr oulu, 

Univ of oulu, Finland, 4 Dept of Path, Univ of oulu, Finland, 5 Dept of Paed, oulu Univ Hosp, Finland 

14

CONCURRENT SESSION 3: Clinical, Translational Research & Therapeutics 


FENNIA II ROOM 

Chairs: Marcus Maurer, Mauro Picardo 



Ustekinumab prevents development of psoriatic alterations in a humanized mouse model of psoriasis 

Graham elliott Derphartox, Leiden, netherlands 


Efficacy of PUVA therapy compared with biologics in moderate to severe chronic plaque psoriasis 

Martin Inzinger, Bettina Heschl, Wolfgang Weger, angelika Hofer, Franz Josef Legat, alexandra Gruber 

- Wackernagel, Wolfgang salmhofer, Peter Wolf Research Unit for Photodermatology, Department of 

Dermatology, Medical University of Graz, austria 


Aprepitant as an antipruritic agent: results of a first case series 

sonja ständer, ngoc Quan Phan, Dorothee siepmann, Ilka Herrgott, Cord sunderkötter, Thomas a. Luger 

Competence Center Pruritus, Department of Dermatology, University of Münster, Münster, Germany 


Cognitive performance and neuroimaging in patients with chronic plaque psoriasis 

Paolo Gisondi 1 , Francesca sala 2 , Franco alessandrini 3 , V. avesani 2 , Giada Zoccatelli 2 , alberto Beltramello 3 , 

Giuseppe Moretto 2 , Giuseppe Gambina 2 , Giampiero Girolomoni 1 1 section of Dermatology, Department of 

Medicine, University of Verona, Italy, 2 Division of neurology, azienda ospedaliera Integrata, Verona, Italy, 

3 neuroradiology, azienda ospedaliera Integrata, Verona, Italy 


Etanercept in the treatment of toxic epidermal necrolysis 

Biagio Didona, Fabio Bergamo, annarita Giampetruzzi, Massimo Papi Istituto Dermopatico dell‘Immacolata, 

Rome, Italy 


Notch 1 as a potential therapeutic target in cutaneous T-cell lymphoma 

Maria Kamstrup 1 , edyta Biskup 1 , Lise Mette Gjerdrum 4 , Britt Lauenborg 3 , 1 , elisabeth Ralfkiær 4 , 2 , 

niels Ødum 3 , 2 , Robert Gniadecki 1 , 2 1 Department of Dermatology, Bispebjerg Hospital, Copenhagen, 

Denmark, 2 University of Copenhagen, Faculty of Health sciences, Copenhagen, Denmark, 3 Institute of 

Medical Microbiology and Immunology, Rigshospitalet, Copenhagen, Denmark, 4 Department of Pathology, 

Rigshospitalet, Copenhagen, Denmark 


MiR-122 regulates apoptosis in malignant T-cells derived from mycosis fungoides 

Valentina Manfé1 , edyta Biskup1 , anne Rosbjerg1 , Line Marie Holst1 , Britt Lauenborg1 , 2 , Robert Gniadecki1 , 2 

1Bispebjerg Hospital, Copenhagen, Denmark, 2University of Copenhagen, Faculty of Health sciences, 

Copenhagen, Denmark 


Th2 cytokines enhance tissue kallikrein 7 expression and the serine protease activity of keratinocytes in 

atopic dermatitis 

shin Morizane 1 , Kenshi Yamasaki 2 , ai Kazita 1 , Maosheng Zhan 1 , Richard Gallo 3 , Keiji Iwatsuki 1 1 Department 

of Dermatology, okayama University Graduate school of Medicine, Dentistry, and Pharmaceutical sciences, 

okayama, Japan, 2 Department of Dermatology, Tohoku University Graduate school of Medicine, Tohoku, 

Japan, 3 Division of Dermatology, Department of Medicine, University of California, san Diego and Va san Diego 

Healthcare system, san Diego, Ca, United states 


Improvement of epidermal barrier function and erythema by cis-urocanic acid emulsion cream in adult 

patients with mild to moderate atopic dermatitis 

Christer T. Jansén 1 , Liisa Pylkkänen 2 , Jarmo K. Laihia 2 , Juha Peltonen 3 , Iina Volanen 3 , Lasse Leino 2 

1 Mehiläinen Medical Center, Turku, Finland, 2 BioCis Pharma Ltd., Turku, Finland, 3 Clinical Research services 

Turku, University of Turku, Turku, Finland 

15 

CONCURRENT 

SESSIONS

CONCURRENT 

SESSIONS 

CONCURRENT SESSION 4: Epidermal Structure & Function 


NORDIA ROOM 

Chairs: Carien Niessen, Anders Vahlquist 



Thyrotropin-releasing hormone (TRH) controls mitochondrial function and biogenesis in human keratinocytes 

in situ 

Jana Knuever1, Burkhard Poeggeler1, erzsébet Gáspár1, Tamás Bíró2, Balázs Toth2, Thomas Hellwig-Buergel3, 

Matthias Klinger4, Ralf Paus1 1Dept of Dermatology, Univ of Luebeck, Germany, 2Dept of Phys, Univ of 

Debrecen, Hungary, 3Dept of Physiology, Univ of Luebeck, Germany, 4Department of anatomy, Univ of Luebeck, 

Germany 


p63 and p53 transcription factors co-regulate RUNX1 to control proliferation to differentiation transition in 

human interfollicular epidermis 

Ingrid Masse1, Laetitia Barbollat-Boutrand1, Claude Caron de Fromentel2, Jérôme Lamartine1 1Université de 

Lyon; Université Lyon 1; CnRs UMR5534 Centre de Génétique Moléculaire et Cellulaire, Lyon, Villeurbanne, 

France, 2InseRM UMR590 Unité d‘oncogenèse et de Progression Tumorale, Centre Léon Bérard, Lyon, France 


Hornerin is a component of cornified cell envelopes which may contribute to atopic dermatitis epidermal 

barrier defect 

Julie Henry1, Chiung-Yueh Hsu1, Marek Haftek2, Isabelle Gardinal-Galera1, Kiyotaka Hitomi3, Catherine 

Jean-Descoster4, anne-Marie schmitt4, Carle Paul1, Guy serre1, Michel simon1 1UMR5165, CnRs-Toulouse 

III University, Toulouse, France, 2e4169a, Lyon I University, Lyon, France, 3nagoya University, nagoya, Japan, 

4Pierre Fabre Dermo-Cosmétique, Toulouse, France 


Involvement of Proteinase Activated Receptor -2 on Mite-induced Atopic Dermatitis Model in Filaggrin 

Deficiency Mouse 

Catharina Moniaga1, se Kyoo Jeong2, Yoshiki Miyachi1, Kenji Kabashima1 1Department of Dermatology, Kyoto 

University Graduate school of Medicine, Kyoto, Japan, 2neoPharm Co., Ltd., Daejeon, Republic of Korea 


IGFBP7 plays a critical role in the pathogenesis of psoriasis 

Janna nousbeck1,2, Miri Bidder1, Dana Fuchs2, andrea Gat2, Meri Gini2, Hagit Matz2, Ilan Goldberg2, D. enk 

Claes3, ofer sarig2, amos Gilhar1, eli sprecher2 1Technion – Israel Institute of Technology, Haifa, Israel, 2Tel 

aviv sourasky Medical Center, Tel aviv, Israel, 3Hadassah Hebrew Univ Medical school, Jerusalem, Israel 


Deimination of filaggrin-2 increases its proteolysis by calpain I 

Chiung-Yueh Hsu 1 , Julie Henry 1 , anne-aurelie Raymond 2 , stefana Balica 3 , Catherine Jean-Decoster 4 , Hidenari 

Takahara 5 , anne-Marie schmitt 4 , Carle Paul 1 , 3 , Guy serre 1 , Michel simon 1 1 UMR5165, CnRs-University 

of Toulouse, Toulouse, France, 2 UMR5089, CnRs-University of Toulouse, Toulouse, France, 3 Department of 

Dermatology, Toulouse University Hospital, Toulouse, France, 4 CeRPeR, Pierre Fabr, Toulouse, France, 5 school 

of agriculture, university of Ibaraki, Ibaraki, Japan 


The Ubiquitous Dermokine Delta Directly Interacts With Rab5 And Modulates Its Activity In The Early 

Endocytic Pathway 

emilie a. Leclerc, Leila Gazeilles, Guy serre, Marina Guerrin, nathalie Jonca UMR 5165 “epidermis 

Differentiation and Rheumatoid autoimmunity Unit”, CnRs – University Toulouse III (IFR 150, InseRM – CnRs – 

University Toulouse III – CHU), CHU Purpan, Toulouse, France 


Insulin/IGF-1 signaling controls epidermal morphogenesis by regulating G2/M cell cycle progression 

Heike stachelscheid 1 , 4 , Bjorn schumacher 2 , 3 , Jens Bruning 2 , 3 , Carien niessen 1 , 2 1 Department of 

Dermatology, University of Cologne, Cologne, Germany, 2 Cologne excellence Cluster on Cellular stress 

Responses in aging-associated Diseases (CeCaD), University of Cologne, Germany, 3 Institute for Genetics, 

University of Cologne, Germany, 4 Center for Molecular Medicine Cologne, Germany 


Hair follicle stem cell derived progeny drives sebaceous gland regeneration 

Monika Petersson, Heike Brylka, andreas Kraus, Catherin niemann Centre for Molecular Medicine Cologne 

(CMMC), Cologne, Germany 

16

CONCURRENT SESSION 5: Auto-Immunity & Inflammation 

Saturday 11 September 2010, 09.00-10.30 

FENNIA I ROOM 

Chairs: Robert Gniadecki, Marcel Jonkman 



Human IL-10 producing regulatory B cells control CD4+ T cell proliferation 

Jean-David Bouaziz 1 , sébastien Calbo 2 , 3 , Maud Maho-Vaillant 2 , anne saussine 1 , Martine Bagot 1 , armand 

Bensussan 1 , Philippe Musette 2 1 InseRM U976, saint Louis Hospital, Paris, France, 2 InseRM U905, Charles 

nicolle Hospital, Rouen, France, 3 singapore Immunology network, agency for science, Technology and 

Research, Biopolis, singapore 


The genetics of murine epidermolysis bullosa acquisita 

Ralf Ludwig, andreia de Castro Marques, Hengameh sadeghi, susen Mueller, steffen Moeller, Detlef Zillikens, 

saleh Ibrahim Department of Dermatology, University of Lübeck, Germany 


Novel cleavage sites and specific neoepitopes on shed ectodomain of collagen XVII/BP180: role in 

autoimmune blistering diseases 

Wataru nishie 1 , stephanie Lamer 2 , andreas schlosser 2 , emilia Licarete 1 , Claus-Werner Franzke 1 , silke C. 

Hofmann 1 , Joanna Jackow 1 , Cassian sitaru 1 , Leena Bruckner-Tuderman 1 1 Dept of Dermatology, University 

Medical Center Freiburg, Germany, 2 Core Facility Proteomics, Center for systems Biology (ZBsa), Freiburg, 

Germany 


Mast cell committed progenitors travel through peripheral tissues and lymph - implication for the 

accumulation of mature mast cells due to inflammatory signals 

Frank siebenhaar 1 , 2 , Ulrich H. von andrian 2 , Marcus Maurer 1 1 Dept of Dermatology and allergy, Charité - 

Universitätsmedizin Berlin, Berlin, Germany, 2 Dept of Pathology, Harvard Medical school, Boston, Ma, United 

states 


Epidermal EGFR signaling controls leukocyte infiltration in the skin and prevents systemic disease 

Francesca Mascia 1 , Gary Lam 1 , David Threadgill 2 , stuart Yuspa 1 1 nCI-nIH, Bethesda, United states, 2 UnC, 

north Carolina, United states 


Desmoglein 3-specific T cells induce Experimental Autoimmune Dermatitis (EAD), a novel model for interface 

dermatitis 

Michiyoshi Kouno 1 , Hayato Takahashi 1 , Taketo Yamada 2 , Keisuke nagao 1 , Masayuki amagai 1 1 Department of 

Dermatology Keio University school of Medicine, Tokyo, Japan, 2 Department of Pathology Keio University school 

of Medicine, Tokyo, Japan 


Platelet-activating factor blockade inhibits Th17 pathway and suppresses psoriatic-like skin disease in 

K5.hTGF-beta1 transgenic mice 

Tej Pratap singh 1 , 2 , Barbara Huettner 2 , Harald Koefeler 2 , Gerlinde Mayer 1 , Katrin Wallbrecht 3 , Michael P 

schön 3 , Peter Wolf 1 1 Research Unit for Photodermatology, Department of Dermatology, Medical University of 

Graz, austria, 2 Center for Medical Research, Medical University of Graz, austria, 3 Department of Dermatology, 

Venereology and allergology, Georg august University, Göttingen, Germany 


MiR-155 is overexpressed in atopic dermatitis and modulates T cell proliferative responses by targeting 

CTLA-4 

eniko sonkoly 1 , Peter Janson 1 , Marja-Leena Majuri 2 , Terhi savinko 2 , nanna Fyhrquist 2 , Liv eidsmo 1 , ning 

Xu 1 , Florian Meisgen 1 , Tianling Wei 1 , Maria Bradley 1 , Jan stenvang 3 , sakari Kauppinen 3 , Harri alenius 2 , 

antti Lauerma 2 , 5 , Bernhard Homey 6 , ola Winqvist 1 , Mona ståhle 1 , andor Pivarcsi 1 1 Karolinska Institutet, 

stockholm, sweden, 2 Finnish Institute of occupational Health, Helsinki, Finland, 3 santaris Pharma, Hoersholm, 

Denmark, 4 Copenhagen Institute of Technology, aalborg University, Denmark, 5 University of Helsinki, Finland, 

6 Heinrich-Heine-University, Dusseldorf, Germany 


A peptide within HSP70i driving vitiligo development 

John D. nieland 1 , Jeffrey Mosenson 2 , andrew Zloza 3 , Jared Klarquist 2 , Thor Las Holtet 4 , anke Kretz-Rommel 4 , 

Jose a. Guevara-Patino 3 , I. Caroline Le Poole 2 1 aarhus school of engineering, aarhus, Denmark, 2 Loyola 

University Medical Center, Maywood, IL, United states, 3 University of Chicago, Chicago, IL, United states, 

4 anaphore, Inc, La Jolla, Ca, United states 

17 

CONCURRENT 

SESSIONS

CONCURRENT 

SESSIONS 

CONCURRENT SESSION 6: Photobiology & Carcinogenesis 



Chairs: Alain Mauviel, Peter Steijlen 



Matrix Metalloproteinase (MMP)-7 Activates Heparin-binding EGF-like Growth Factor in Squamous Cell 

Carcinomas Complicating Recessive Dystrophic Epidermolysis Bullosa 

atte Kivisaari 1 , Markku Kallajoki 1 , Risto ala-aho 1 , John McGrath 2 , Johann Bauer 3 , Radana Königova 6 , Marta 

Medvecz 4 , Wolfgang Beckert 5 , Reidar Grenman 1 , Veli-Matti Kähäri 1 1 Univ of Turku, Finland, 2 King’s College 

London, London, UK, 3 General Hospital, salzburg, austria, 4 semmelweis Univ Budapest, Hungary, 5 Lab for 

Histology and Cytology, nürtingen, Germany, 6 Charles Univ, Prague, Czech Republic 


Tumor suppressor activity of the developmental factor IRF6 in squamocellular carcinomas 

Giulia spallone 1 , elisabetta Botti 1 , Francesca Moretti 1 , Valentina Pinetti 1 , Barbara Marinari 1 , sergio Chimenti 1 , 

Luisa Guerrini 2 , antonio Costanzo 1 1 University of Rome Tor vergata, Rome, Italy, 2 Department of Biomolecular 

sciences, Milan, Italy 


Identification and characterization of SerpinA 1 as a Novel Biomarker for Progression of Cutaneous 

Squamous Cell Carcinoma 

Mehdi Farshchian 1 , atte Kivisaari 1 , Risto ala-aho 1 , Markku Kallajoki 2 , Reidar Grenman 3 , Juha Peltonen 4 , 

Veli-Matti Kähäri 1 1 Dept of Dermatology, and Medicity Research Laboratory, Univ of Turku, Finland, 2 Dept of 

Pathology, Turku Univ Hospital, Finland, 3 Dept of otorhinolaryngology, Head and neck surgery, Turku Univ 

Hospital, Finland, 4 Dept of anatomy & Cell Biology, Univ of Turku, Finland 


Endothelial cell-specific RAGE signaling sustains inflammation and promotes tumor-angiogenesis 

Christoffer Gebhardt 1 , 2 , Fabian Kiessling 3 , stefan Delorme 1 , Peter Paul nawroth 1 , angelika Bierhaus 1 , Bernd 

arnold 2 , alexander enk 1 , Peter angel 2 1 University Hospital Heidelberg, Heidelberg, Germany, 2 German Cancer 

Research Center (DKFZ), Heidelberg, Germany, 3 University Hospital aachen, aachen, Germany 


Tumor derived CCL20 production critically contributes to angiogenesis and tumor progression 

andreas Hippe1 , anne schorr1 , anja Mueller-Homey2 , stefan seeliger3 , Katharina Jannasch4 , Bettina 

alexandra Buhren1 , Jonathan sleeman5 , 6 , nikolas stoecklein7 , Frauke alves4 , Thomas Hoffmann8 , Bernhard 

Homey1 1Dept of Dermatology, Univ Hospital, Duesseldorf, 2Radiation oncology, Univ Hospital, Duesseldorf, 

3Pediatric Cardiol & Intens Care, Georg-august-Univ, Goettingen, 4Hematology & oncology, Georg-august- 

Univ, Goettingen, 5Dept of Genetics, Univ of Karlsruhe, Germany, 6Centre for Biomed & Med Tech, Mannheim, 

7Gen-, Visceral- & Pediatric surgery, Univ Hospital, Duesseldorf, 8otorhinolaryngology, Univ Hospital essen (all 

Germany) 


Polo-like kinase 1 inhibitors hold potential as targeted therapies for squamous cell carcinoma 

stephen Watt 1 , Celine Pourreyron 1 , John Foerster 1 , Carol Hogan 1 , Karin Purdie 2 , Leena Bruckner-Tuderman 3 , 

Charlotte Proby 1 , John McGrath 4 , Irene Leigh 1 , andrew south 1 1 University of Dundee, United Kingdom, 2 Queen 

Mary University of London, UK, 3 University of Freiburg, Germany, 4 Kings College, London, UK 


In vivo education of UVR-induced regulatory T cells to inhibit the elicitation of contact hypersensitivity 

agatha schwarz 1 , Björn Clausen 2 , Thomas schwarz 1 1 Department of Dermatology, University Kiel, Kiel, 

Germany, 2 Department of Immunology, erasmus University, Rotterdam, netherlands 


Calcioptriol cream as a prophylactic treatment for polymorphic light eruption 

alexandra Gruber-Wackernagel 1 , Isabella Bambach 1 , Franz J. Legat 1 , angelika Hofer 1 , scott n. Byrne 2 , Franz 

Quehenberger 3 , Peter Wolf 1 1 Research Unit for Photodermatology, Department of Dermatology, Medical 

University of Graz, Graz, austria, 2 Department of Infectious Diseases and Immunology, sydney Medical school, 

The University of sydney, sydney, australia, 3 Institute for Medical Informatics, statistics, and Documentation, 

Medical University of Graz, Graz, austria 


UVB-induced CD1a+ Langerhans‘ cell trafficking occurs in histidinaemic human skin lacking urocanic acid 

Joanne Tye 1 , John Walter 2 , Christopher e.M. Griffiths 1 , neil K. Gibbs 1 1 Dermatological sciences, University of 

Manchester, Manchester academic Health science Centre, United Kingdom, 2 Willink Biochemical Genetics Unit, 

University of Manchester, Manchester academic Health science Centre, United Kingdom 

18

CONCURRENT SESSION 7: Clinical Research & Epidemiology 


NORDIA ROOM 

Chairs: Tamar Nijsten, Luis Santamaria 



Diabetes impairs adipose-derived stem cell pro-healing function 

Francesca Cianfarani 1 , Gabriele Toietta 1 , Giuliana Di Rocco 2 , eleonora Cesareo 1 , Maurizio C Capogrossi 1 , 

Giovanna Zambruno 1 , Teresa odorisio 1 1 Isituto Dermopatico dell‘Immacolata, IDI-IRCCs, Rome, Italy, 2 Istituto 

Cardiologico Monzino, ICM-IRCCs, Milan, Italy 


Acrosyringium is a target of vesicle/pustule formation in palmoplantar pustulosis (pustulosis Palmaris et 

plantaris) 

Masamoto Murakami 1 , akemi Ishida-Yamamoto 1 , Vera Morhen 2 , Richard Gallo 2 , Hajime Iizuka 1 1 asahikawa 

Medical College, asahikawa, Hokkaido, Japan, 2 University of California, san Diego, san Diego, Ca, United states 


Increased serum levels of secreted protein acidic and rich in cysteine in patients with localized scleroderma 

satoshi Fukushima, satoshi Hayano, Masatoshi Jinnin, Hironobu Ihn Kumamoto University, Kumamoto, Japan 


Cytotoxic T lymphocyte stimulation with artificial antigen-presenting cells activates anti-melanoma natural 

responding cells 

Jean-François Chatillon 1 , Florence Bayeux 1 , Jean-Baptiste Latouche 2 , Philippe Musette 1 1 InseRM U905, 

Rouen, France, 2 InseRM U614, Rouen, France 


Isotretinoin and Inflammatory Bowel Disease: Population-Based Study 

Raed alhusayen 1 , David n. Juurlink 1 , Muhammad M. Mamdani 1 , Richard Morrow 2 , neil H. shear 1 , Colin R. 

Dormuth 2 1 University of Toronto, Toronto, ontario, Canada, 2 University of British Columbia, Vancouver, BC, 

Canada 


Obesity and atopic diseases: evidence from a population-based cross-sectional study in Germany 

Christian apfelbacher 1 , Jochen schmitt 2 , adrian Loerbroks 3 , 4 1 Department of Clinical social Medicine, 

University of Heidelberg, Heidelberg, Germany, 2 Department of Dermatology, University Hospital Carl Gustav 

Carus, Dresden, Germany, 3 Mannheim Institute of Public Health, social and Preventive Medicine, Mannheim, 

Germany, 4 Competence Center for social Medicine and occupational Health Promotion, Heidelberg University, 

Mannheim, Germany 


Determinants of atopic and non-atopic eczema: results from a population-based cross-sectional study in 

Germany 

Thomas Diepgen 1 , Jochen schmitt 2 , Christian apfelbacher 1 1 Department of Clinical social Medicine, University 

of Heidelberg, Heidelberg, Germany, 2 University Hospital Carl Gustav Carus, Technical University Dresden, 

Dresden, Germany 


Suicidal Ideation, Mental Health Problems and Social Impairment are increased in Acne: A Population-Based 

Study in Adolescents 

Jon anders Halvorsen 1 , 2 , Robert s. stern 3 , Florence Dalgard 2 , Magne Thoresen 4 , espen Bjertness 2 , 5 , Lars 

Lien 6 1 Dept of Dermatology, oslo Univ Hosp Rikshospitalet, Fac of Medicine, Univ of oslo, norway, 2 Inst of 

General Practice and Community Medicine, Univ of oslo, norway, 3 Beth Israel Deaconess Medical Center, 

Harvard Med school, Boston, Usa, 4 Dept of Biostatistics, Inst of Basic Medical sciences, Univ of oslo, norway, 

5 Tibet Univ Med College, Lhasa, China, 6 Inst of Psych, Univ of oslo, norway 


Low winter levels of 25-hydroxyvitamin D, not summer levels, are associated with increased risk of internal 

cancer in organ transplant recipients 

Jan nico Bouwes Bavinck, Frank de Gruijl Leiden University Medical Center, Leiden, netherlands 

19 

CONCURRENT 

SESSIONS

CONCURRENT 

SESSIONS 

CONCURRENT SESSION 8: Genetics & Stem Cells 


FENNIA I ROOM 

Chairs: Johann Bauer, Giovanna Zambruno 



Targeting of human interleukin-12B by small hairpin RNAs in xenografted psoriatic skin 

Karin stenderup 1 , Rasmus otkjær Bak 2 , Cecilia Rosada 1 , Line Barrett Petersen 2 , Brian Moldt 2 , Frederik 

Dagnæs-Hansen 3 , Maria Jakobsen 2 , søren Kamp 4 , Thomas G Jensen 2 , Tomas norman Dam 4 , Jacob Giehm 

Mikkelsen 2 1 Dept of Dermatology, aarhus, Denmark, 2 Dept of Human Genetics, aarhus, Denmark, 3 Dept of 

Medical Microbiol & Immunol, aarhus, Denmark, 4 Dept of Dermatology, Roskilde, Denmark 


Zebrafish Type XVII Collagen: Gene Structures, Expression Profiles, and Morpholino “Knock-Down“ 

Phenotypes 

Qiaoli Li 1 , Michael Frank 1 , seong-Hyun Kim 2 , Hae Young Choi 3 , Ju-Hoon so 4 , Cheol-Hee Kim 4 , shiu-Ying Ho 5 , 

Jouni Uitto 1 1 Jefferson Medical College, Philadelphia, Pa, United states, 2 Inje University, Ilsna Paik Hospital, 

Koyang, Korea, Democratic People‘s Republic of, 3 ewha Womans University, seoul, Korea, Democratic People‘s 

Republic of, 4 Chungnam national University, Daejeon, Korea, Democratic People‘s Republic of, 5 Thomas 

Jefferson University, Philadelphia, Pa, United states 


Transcriptional profiling after lipid raft disruption in keratinocytes identifies new actors in atopic dermatitis 

Conny Mathay 1 , Michael Pierre 2 , Mark R. Pittelkow 3 , eric Depiereux 2 , arjen F. nikkels 4 , alain Colige 5 , Yves 

Poumay 1 1 Cell & Tissue Lab, URPYHM, Univ of namur, Belgium, 2 Lab of Biostats & Bioinformatics, URBM, 

Univ of namur, Belgium, 3 Depts of Derm & Biochem & Molec Biol, Mayo Clinic, Rochester, Usa, 4 Dept of Derm, 

Univ of Liège, Belgium, 5 Lab of Connective Tissues Biol, Univ of Liège, Belgium 


COL17A1 splicing mutations: lessons for design of molecular therapies 

Dimitra Kiritsi 1 , Johannes-steffen Kern 1 , Hauke schumann 1 , Claus-Werner Franzke 1 , Jürgen Kohlhase 2 , 

Cristina Has 1 , Leena Bruckner-Tuderman 1 , 3 1 Dept of Dermatology, University Medical Center Freiburg, 

Germany, 2 Center for Human Genetics Freiburg, Germany, 3 Freiburg Institute for advanced studies, University 

of Freiburg, Germany 


Germline melanocortin-1-receptor variants are associated with severity of phenotype in individuals with 

congenital melanocytic naevi 

Veronica Kinsler 1 , Raoul Hennekam 4 , neil sebire 1 , sayeda abu-amero 1 , Philip stanier 1 , Peter Budd 3 , Ian 

Jackson 3 , Gudrun Moore 1 , eugene Healy 2 1 Great ormond street Hospital/Institute of Child Health, London, UK, 

2 University of southampton, UK, 3 MRC Human Genetics Unit, edinburgh, UK, 4 Univ of amsterdam, netherlands 


3‘ trans-splicing repair of COL7A1 mutations in recessive dystrophic epidermolysis bullosa patients 

eva M Murauer 1 , Yannick Gache 3 , 2 , Fernando Larcher 5 , Marcela Del Rio 5 , Wolfgang Muss 4 , Guerrino 

Meneguzzi 3 , Helmut Hintner 1 , Johann W Bauer 1 1 eB House austria, Dept of Dermatology, Paracelsus Med 

Univ, salzburg, austria, 2 InseRM U998 - CnRs UM6267, Univ of nice-sophia antipolis, France, 3 InseRM 

U634, Univ of nice-sophia antipolis, France, 4 Inst of Pathology, Paracelsus Medical Univ of salzburg, salzburg, 

austria, 5 Cutaneous Disease Modeling Unit, CIeMaT-CIBeReR, Madrid, spain 


Progressive Decrease in Number and Change in Niche Preference of the ABCB5+ Mesenchymal Stem Cell 

Subset in the Skin during Aging 

Barbara Meier 1 , Yvonne Ziouta 2 , abhijit Basu 1 , anca sindrilaru 1 , adelheid Hainzl 1 , Pallab Maity 1 , Meinhard 

Wlaschek 1 , Christoph Ganss 2 , Markus F. Frank 3 , natasha Y. Frank 3 , 4 , Karin scharffetter-Kochanek 1 

1 Department of Dermatology and allergic Diseases, University of Ulm, Ulm, Germany, 2 TICeBa GmbH, 

Heidelberg, Germany, 3 Transplantation Research Center, Children’s Hospital Boston, Harvard Medical school, 

Boston Ma, United states, 4 Division of Genetics, Brigham and Women’s Hospital, Harvard Medical school, 

Boston Ma, United states 


Functional importance and hormonal regulation of nestin expression in multipotent adult human skin 

progenitor cells in situ and in vitro 

stephan Tiede 1 , Peter Keckeis 1 , anna Petschnik 3 , Mohd Hilmi abu Bakar 4 , Charli Kruse 3 , Ralf Paus 1 , 2 1 Dept. 

of Dermatology, University of Lübeck, Lübeck, Germany, 2 school of Translational Medicine, University of 

Manchester, Manchester, United Kingdom, 3 Fraunhofer Institute of Marine Biotechnology, Lübeck, Germany, 

4 Unit of sciences Reconstructive, University sains Malaysia, Kubang Kerian, Malaysia 

20

CONCURRENT SESSION 9: Pigmentation & Melanoma 



Chairs: Günther Hofbauer, Lionel Larue 



SLC24A5/NCKX5 influences melanocyte cholesterol homeostasis and MC1R expression: a novel mechanism 

for natural human skin colour variation? 

Martin R. Green, Tony Dadd, David Gunn, Fei-Ling Lim, Magda sawicka, Rebecca Ginger, steve Wilson Unilever 

Research, sharnbrook, Bedford, United Kingdom 


Shot gun proteome analysis identified the PPARg ligand 15d-PGJ2 (15-deoxy-D12,14-prostaglandin J2) as a 

novel drug interfering with melanoma-stroma interaction 

Verena Paulitschke 1 , silke Gruber 1 , Christopher Gerner 2 , Hubert Pehamberger 1 , Rainer Kunstfeld 1 

1 Department for Dermatology, Vienna, austria, 2 Clinic for Internal Medicine I, Vienna, austria 


Beta-catenin is activated by cAMP in normal human melanocytes and melanoma cells: implication in 

melanogenesis regulation 

Barbara Bellei 1 , angela Pitisci 1 , Lionel Larue 2 , Mauro Picardo 1 1 Laboratory of Cutaneous Physiopathology, 

san Gallicano Dermatologic Institute, IRCCs, Rome, Italy, 2 Developmental Genetics of Melanocytes, UMR 3347 

CnRs, U1021 InseRM, Institut Curie, orsay Cedex, France 


Astaxanthin attenuates the stem cell factor-stimulated pigmentation of human epidermal equivalents 

through interruption of Raf-1 activity within melanocytes 

Genji Imokawa 1 , Katsunori Fukazawa 1 , Hiroaki nakajima 1 , Kazumasa Wakamatsu 2 , Yashuhiro senda 3 1 Tokyo 

University of Technology, Tokyo, Japan, 2 Fujita Health University, nagya, Japan, 3 Revanche Co. Ltd., Kanazawa, 

Japan 


Loss of E-cadherin increases metastasic potential of melanoma 

Lionel Larue 1 , Flavie Luciani 1 , Friedrich Beermann 2 , Rolf Kemler 3 , Véronique Delmas 1 1 Institut Curie, 

U1021 InseRM, UMR 146 CnRs, orsay, France, 2 ePFL, Lausanne, switzerland, 3 Max-Planck Institut für 

Immunbiologie, Freiburg, Germany 


a-MSH-mediated melanocyte differentiation involves PPAR-g activation through a Phospholipase-C mediated 

pathway 

Vittoria Maresca, enrica Flori, Barbara Bellei, nicaela aspite, emanuela Camera, Giorgia Cardinali, Mauro 

Picardo san Gallicano Dermatologic Institute, Rome, Italy 


Inhibition of protein deacetylase SIRT1 suppresses in vitro and in vivo invasion of melanoma cells 

Risa Kunimoto 1 , 2 , Kowichi Jimbow 2 , Toshiharu Yamashita 2 , Masae okura 2 , Tomohisa Hirobe 3 , Masahiro 

sato 1 , shin Hisahara 4 , Yoshiyuki Horio 1 1 Departments of Pharmacology, sapporo Medical University, sapporo, 

Hokkaido, Japan, 2 Departments of Dermatology, sapporo Medical University, sapporo, Hokkaido, Japan, 

3 Division of Biology, national Institute of Radiological sciences, anagawa,Chiba, Japan, 4 Departments of 

neurology, sapporo Medical University, sapporo, Hokkaido, Japan 


Polo-like kinase 1 expression is indirectly regulated through MAPK signaling pathway and is a potential 

therapeutic target in human melanoma 

ahmad Jalili 1 , anna Moser 1 , Mikhail Pashenkov 1 , Christine Wagner 1 , Gaurav Pathria 1 , Viola Borgdorff 1 , 

Melanie Gschaider 1 , Georg stingl 1 , sridhar Ramaswamy 2 , Jean-Philippe Brunet 2 , Todd R. Golub 2 , stephan 

n. Wagner 1 1 DIaID, Department of Dermatology, Medical University of Vienna, Vienna, austria, 2 The Broad 

Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, Usa 

21 

CONCURRENT 

SESSIONS

CONCURRENT 

SESSIONS 

CONCURRENT SESSION 10: Innate Immunity & Infection 


NORDIA ROOM 

Chairs: Karin Scharffetter-Kochanek, Mark Udey 



E-cadherin on epidermal gamma delta T cells is an inhibitory receptor 

Youhei Uchida, Kazuhiro Kawai, Takuro Kanekura Kagoshima University Graduate school of Medical and Dental 

sciences, Kagoshima, Japan 


The Malassezia metabolites indirubin and malassezin are potent activators of the aryl hydrocarbon receptor 

in HaCaT cells 

Georgios Gaitanis 1 , Maria Galanou 2 , Prokopios Magiatis 3 , nikitia Mexia 3 , Konstantina stathopoulou 3 , 

alexios-Leandros skaltsounis 3 , Marios Marselos 2 , aristea Velegraki 4 , Ioannis Bassukas 1 , Periklis Pappas 2 

1 Department for skin and Venereal Diseases, Univ of Ioannina, Greece, 2 Department of Pharmacology, Univ of 

Ioannina, Greece, 3 Department of Pharmacognocy and natural Products Chemistry, Univ of athens, Greece, 

4 Mycology Laboratory, Department of Microbiology, Univ of athens, Greece 


Mast cells play a key role in host defense against lethal herpes simplex virus infection 

Rui aoki 1 , Tatsuyoshi Kawamura 1 , Youichi ogawa 1 , Fumi Goshima 2 , Yukihiro nishiyama 2 , shinji shimada 1 

1 University of Yamanashi, Yamanashi, Japan, 2 nagoya University Graduate school of Medicine, nagoya, Japan 


A unique population of inflammatory macrophages induced by iron impairs cutaneous wound healing 

anca sindrilaru 1 , Thorsten Peters 1 , Corina Baican 2 , Johannes Weiss 1 , Meinhard Wlaschek 1 , Cord 

sunderkötter 3 , Karin scharffetter-Kochanek 1 1 University of Ulm, Dept of Dermatology & allergic Diseases, 

Germany, 2 University of Cluj-napoca, Dept of Dermatology & Venerology, Cluj-napoca, Romania, 3 University of 

Münster, Dept of Dermatology, Germany 


Toll-like receptor signaling in dendritic cells is sufficient to mediate Imiquimod-induced psoriasis-like skin 

inflammation in mice 

Christian Wohn 1 , errol Prens 2 , sabina onderwater 1 , edwin Florencia 2 , Heike Weighardt 3 , Björn Clausen 1 

1 Dept of Immunology, erasmusMC, University Medical Center, Rotterdam, netherlands, 2 Dept of Dermatology, 

erasmusMC, University Medical Center, Rotterdam, netherlands, 3 Institut für Umweltmedizinische Forschung, 

Heinrich-Heine-Universität Düsseldorf, Germany 


Dietary vitamin D3 protects against bacterial skin infection 

Beda Muehleisen 1 , Tara Jaleel 2 , Katherine Radek 3 , Richard Gallo 1 1 Division of Dermatology, UCsD, san Diego, 

United states, 2 school of Medicine, University of alabama, Birmingham, United states, 3 Dept. of surgery, 

Loyola University, Maywood, United states 


Induction of Broadly Cross-neutralizing Antisera against Mucosal and Cutaneous Human Papillomaviruses 

(HPV) by HPV16L1-16L2 Virus-like Particles (RG1-VLP) 

Christina schellenbacher 1 , saeed shafti-Keramat 1 , Helena Faust 2 , Joakim Dillner 2 , Richard Roden 3 , Reinhard 

Kirnbauer 1 1 Lab of Viral oncology, Medical Univ Vienna, austria, 2 Malmö Univ Hosp, Malmö, sweden, 3 Johns 

Hopkins Univ, Baltimore, Usa 


Innate signals of non-pathogenic bacteria induce IL-10 producing dendritic cells, regulatory Th cells and 

clear atopic dermatitis 

Thomas Volz 1 , audrey Gueniche 2 , Björn Knaudt 1 , eva schuck 1 , emmanuella Guenova 1 , susanne Kaesler 1 , 

Martin Röcken 1 , Tilo Biedermann 1 1 eberhard Karls University, Dept. of Dermatology, Tübingen, Germany, 

2 L’oReaL Recherche, Clichy, France 

22

EDUCATIONAL TRACKS 

The scientific Program Committee of the esDR has identified two educational tracks within 

the 2010 esDR Meeting. The tracks are intended as a optional guide to help you get the most 

out of the meeting. You are welcome to participate in all sessions at the esDR meeting. The 

full program can be found on the four following pages. 

EDUCATIONAL TRACKS PHARMA RESIDENT 

Thursday 9 September 2010 

08.30-10.30 Drug Development in Dermatology - Principles and Practice 

11.00-12.30 esDR Postgraduate Course 

12.30-14.00 Biotest sponsored symposium 

14.15-16.15 Plenary session 1 

16.15-16.45 esDR Guest Lecture - angiogenesis 

17.20-18.50 Concurrent session 1: Immunology 

17.20-18.50 Concurrent session 2: Vascular Biology, signal Transduction & Cell adhesion 

17.20-18.50 Concurrent session 3: Clinical, Translational Research & Therapeutics 

17.20-18.50 Concurrent session 4: epidermal structure & Function 

19.00-21.00 Welcome Reception at City Hall 

Friday 10 September 2010 

08.00-08.50 Janssen Cilag Workshop Choose 1 

08.00-08.50 Cephalon Workshop 


11.00-11.30 Merck serono Lecture 

11.30-13.00 Coffee Break & Poster Viewing & Poster Walks 

13.00-14.30 Galderma symposium 

14.30-15.00 René Touraine Lecture 


17.30-18.00 Rudi Cormane Lecture 

19.30- esDR 2010 Gala evening 

Saturday 11 September 2010 

09.00-10.30 Concurrent session 5: auto-Immunity & Inflammation 

09.00-10.30 Concurrent session 6: Photobiology & Carcinogenesis 

09.00-10.30 Concurrent session 7: Clinical Research & epidemiology 

09.00-10.30 Clinical saturday I 

10.30-12.00 Poster Viewing II (with Poster Walks and coffee break) 

12.00-13.00 Plenary session IV 

13.05-14.30 Intendis/Bausch & Lomb symposium 

13.05-14.30 Concurrent session 8: Genetics & stem Cells 

13.05-14.30 Concurrent session 9: Pigmentation & Melanoma 

13.05-14.30 Concurrent session 10: Innate Immunity & Infection 

14.35-16.00 Clinical saturday II 

23 

Choose 1 

Choose 1 

Choose 1 

EDUCATIONAL 

TRACKS

WEDNESDAy 8 SEPTEMBER 2010 

DAy-By-DAy PROGRAM 

Time Session Room Program 

10.00-19.00 Registration 

08.30-13.00 sCUR Meeting (Part II) nordia p 29 

13.30-18.00 european epidermal Barrier Research 

network (e2BRn) Meeting (Part I) 

14.00-17.30 european Immunodermatology society 

(eIs) Meeting 

14.00-17.30 european society of Dermatopathology 

(esDP) symposium 

24 

nautica p 30 

Fennia II p 31 

Fennia I p 32



07.00-19.00 Registration 

08.00-14.00 Poster Mounting (for Posters 001-296) 

08.00-10.30 neurobiology of the skin nordia p 34 

08.30-10.30 european Dermato-epidemiology 

network (eDen) Meeting 

08.30-10.30 Drug Development in Dermatology - 

Principles and Practice 

09.00-10.30 acta Dermato Venerologica 

symposium 

09.00-10.30 european epidermal Barrier Research 

network (e2BRn) Meeting (Part II) 

10.30-11.00 Coffee Break 

25 

Press Room p 33 

europaea p 35 


nautica p 30 

11.00-12.30 esDR Postgraduate Course europaea p 7 

12.30-14.00 Biotest sponsored symposium Fennia II p 38 

14.00-14.15 esDR 2010 Welcome Ceremony europaea 

14.15-16.15 Plenary session 1 europaea p 9 

16.15-16.45 ESDR Guest Lecture - Angiogenesis 

Kari alitalo 


europaea p 7 

17.20-18.50 Concurrent session 1: Immunology europaea p 13 

17.20-18.50 Concurrent session 2: Vascular 

Biology, signal Transduction & Cell 

adhesion 

17.20-18.50 Concurrent session 3: Clinical, 

Translational Research & 

Therapeutics 

17.20-18.50 Concurrent session 4: epidermal 

structure & Function 

Fennia I p 14 


nordia p 16 

19.00-21.00 Welcome Reception City Hall p 6 

THURSDAy 9 SEPTEMBER 2010

FRIDAy 10 SEPTEMBER 2010 



08.00-08.50 Cephalon sponsored Workshop Fennia I p 28 

08.00-08.50 Janssen-Cilag sponsored Workshop Fennia II p 28 


11.00-11.30 Merck Serono Lecture 

Hidde Ploegh 

11.30-13.00 Coffee Break/Poster Viewing I/ 

Poster Walks 

26 

europaea p 7 

13.00 PosTeRs 001-296 removed and stored by meeting staff (can be 

collected from 15.00) 

PosTeRs 297-600 attached by meeting staff 

13.00-14.30 Galderma sponsored symposium Fennia II p 39 

14.30-15.00 René Touraine Lecture 

alain Hovnanian 

europaea p 7 



17.00-17.10 Presentation of esDR Honorary 

Memberships 

17.10-17.15 sID/esDR Collegiality awards europaea 

17.15-17.25 JsID/esDR Collegiality awards europaea 

17.25-17.30 Celgene award europaea 

17.30-18.00 Rudi Cormane Lecture 

Thomas schwarz 

18.00-19.00 esDR annual General Meeting of 

Members 

europaea p 48 

europaea p 7 

europaea 

19.30- esDR 2010 Gala evening Wanha satama p 6



09.00-10.30 Concurrent session 5: auto-Immunity 

& Inflammation 

09.00-10.30 Concurrent session 6: Photobiology & 

Carcinogenesis 

09.00-10.30 Concurrent session 7: Clinical 

Research & epidemiology 

27 

Fennia I p 17 


nordia p 19 

09.00-10.30 Clinical saturday I europaea p 7 

10.30-12.00 Coffee Break/Poster Viewing II/ 

Poster Walks 


13.05-14.30 Intendis/Bausch & Lomb symposium europaea p 40 

14.35-16.00 Concurrent session 8: Genetics & 

stem Cells 

14.35-16.00 Concurrent session 9: Pigmentation & 

Melanoma 

14.35-16.00 Concurrent session 10: Innate 

Immunity & Infection 

Fennia I p 20 


nordia p 22 

14.35-16.00 Clinical saturday II europaea p 7 

16.00-16.20 Closing Ceremony and Poster Prizes europaea 

SATURDAy 11 SEPTEMBER 2010

SPECIAL 

WORKSHOP 

SPECIAL 

WORKSHOP 

CHALLENGES IN CUTANEOUS LyMPHOMAS 


FENNIA I ROOM 

Chairs: Martine Bagot (Paris), Reinhard Dummer (Zurich), Annamari Ranki (Helsinki) 

Program 

08.00-08.15 Search for Molecular Pathway Targets in Subcutaneous Panniculitis like 

T-cell Lymphoma 

annamari Ranki (Helsinki) 

08.15-08.30 Specific Markers in CTCL – Are There Any? 

Martine Bagot (Paris, France) 

08.30-08.45 Targeted Therapy in CTCL – Does it Hit the Target? 

Reinhard Dummer (Zurich, switzerland) 

08.45-08.50 Round Table Discussion 

This Workshop is open to all esDR meeting participants. 

PSORIASIS: AN AUTOINFLAMMATORy OR AUTOIMMUNE DISEASE? 



Chair: Tilo Biedermann (Tübingen) 

Program 

08.00-08.20 Mechanisms of the Disease 

Frank nestle (London) 

08.20-08.50 Interactive Panel Discussion 

Tilo Biedermann (Tübingen), Frank nestle (London), annamari Ranki 

(Helsinki), Martin Röcken (Tübingen), Georg stingl (Vienna) 

This Workshop is open to all esDR meeting participants. 

28

SOCIETy FOR CUTANEOUS ULTRASTRUCTURE RESEARCH MEETING 

Wednesday 8 September 2010, 08.30-13.00 

NORDIA ROOM 

Program 

08.30-10.00 Dermatopathology Club Presentations Session 5 

10.00-10.45 Special Invited Lecture 

New Inherited Diseases of Hemidesmosomes and Desmosomes 

John a. McGrath (London) 


Formal poster viewing and poster walk. 

11.30-12.30 Final Plenary Session 6 

12.30-13.00 End of SCUR final session close and meeting close. 

Presentation of sCUR awards and official Closure of the sCUR 2010 

Meeting 

The Wednesday 8 september 2010 sessions are open to all registered esDR meeting delegates. 

The Tuesday 7 september 2010 sessions at the Grand Marina Hotel require separate registration. 

For more information please visit the sCUR website: 

http://orgs.dermis.net/content/e04scur/e03meetings/e770/e771/index_ger.html 

29 

SPECIAL 

SCUR MEETING 

WORKSHOPS

E2BRN 

MEETING 

EUROPEAN EPIDERMAL BARRIER RESEARCH NETWORK MEETING 

Wednesday 8 September 2010-Thursday 9 September 2010 

NAUTICA ROOM 

european epidermal Barrier Research network (e2BRn) and CosT action on skin barrier and atopic 

diseases (sKInBaD). 

Program 

Wednesday 8 September 2010 

13.30-16.00 Session 1: Chair: Marek Haftek (Lyon) 

13.30-14.00 Involvement of Tight Junctions in Barrier Function in Mouse and Man 

Johanna Brandner (Hamburg) 

14.00-14.15 Inner surface of the stratum corneum and the barrier ultrastructure in atopic 

dermatitis investigated by electron microscopy using the non invasive sampling 

technique Lipbarvis® 

stephan Dähnhardt-Pfeiffer (Kiel) 

14.15-14.30 The role the lipid organisation plays in the skin barrier in healthy and diseased skin 

Joke Bouwstra (Leiden) 

14.30-14.45 Caspase-14 is required for filaggrin degradation to natural moisturizing factors in 

the skin 

Wim Declercq (Ghent) 


15.00-15.30 Cellular response to cholesterol depletion in human epidermal keratinocytes 

Yves Poumay (namur) 

15.30-15.45 Deimination of filaggrin-2 increases its proteolysis by calpain I 

Chiung-Yueh Hsu (Toulouse) 

15.45-16.00 A mouse strain with a filaggrin mutation: a model for human atopic dermatitis 

sean saunders (Dublin) 

16.00-16.30 Coffee Break/Poster Viewing 

16.30-18.00 Workshop on the epidermal barrier in atopic eczema 

Joint session with the CosT action on skin barrier and atopic diseases (sKInBaD) 

Chair: ehrhardt Proksch (Kiel) 

16.30-17.00 Skin Barrier in Atopic Eczema 

sanja Kezic (amsterdam) 

17.00-17.30 Correlation Between Genotype and Skin Barrier Function in Ichthyosis Vulgaris 

Matthias schmuth (Innsbruck) 

17.30-18.00 Skin Barrier Defect and Allergy by Dysregulation of Epidermal Proteases: From 

Mouse Models to Netherton Syndrome 

alain Hovnanian (Paris) 

Thursday 9 September 2010 

09.00-10.30 Session 2: Chair: Patrick Zeeuwen (Nijmegen) 

09.00-09.30 Testing Intradermal Macromolecule and Vaccine Delivery in 'Live' Human Skin 

James Birchall (Cardiff) 

09.30-09.45 Expression of pattern recognition receptors in normal and inflamed human 

epidermis: upregulation of dectin-1 in psoriasis 

Heleen D. De Koning (nijmegen) 

09.45-10.00 Delivery of flagellin by Pseudomonas aeruginosa rhamnolipids throughout the 

skin barrier induces an innate immune response 

Ulf Meyer Hoffert (Kiel) 

10.00-10.30 Human Epidermal Tight Junctions in Health and Disease 

sirkku Peltonen (Turku) 

10.30-11.00 General Assembly of E2BRN 

This satellite meeting is free to all registered esDR delegates. 

30

EUROPEAN IMMUNODERMATOLOGy SOCIETy MEETING 



Chair: Richard Groves (London) 

Program 

14.00-14.05 Introduction and welcome 

Richard Groves (London) 

14.05-14.17 IL-20, IL-21 and p40: Potential Biomarkers of Treatment Response for Ustekinumab 

anne Gedebjerg (aarhus) 

14.17-14.29 Expression of pattern recognition receptors in normal and inflamed human epidermis: 

upregulation of dectin-1 in psoriasis 

Heleende Koning (nijmegen) 

14.29-14.41 Fumarates improve Psoriasis and Multiple Sclerosis by inducing type II dendritic cells 

Jürgen Brück (Tübingen) 

14.41-14.53 Increase in IL-17A and IL-22 producing CD8 T cells in lesional psoriatic skin 

Pieter Res (amsterdam) 

14.53-15.05 Differential capacity of human skin dendritic cell populations to polarize naïve T cells 

into IL-17, IL-21 and IL-22 producing cells 

Karine Penel-sotirakis (Lyon) 

15.05-15.17 Formation of DC-Treg aggregates depends on adenosine 

sabine Ring (Heidelberg) 

15.17-15.29 Lesional skin of patients with chronic atopic dermatitis shows increased proportions of 

IL-31 positive T cells and a Th2/Th22 dominance 

Krisztina szegedi (amsterdam) 

15.29-15.41 Decreased TNF-alpha synthesis by macrophages restricts cutaneous 

immunosurveillance by memory CD4+ T cells during ageing 

elaine agius (London) 


16.05-16.17 Tissue derived ATP activates CD4+CD25+FoxP3+ regulatory T cells and stimulates its 

own degradation to immunosuppressive adenosine during contact hypersensitivity 

reactions 

Karsten Mahnke (Heidelberg) 

16.17-16.29 The contact allergen 2,4-dinitrochlorobenzene does not affect microRNAs’ -155, -125b 

and -146a expression in skin explants, keratinocytes and monocyte derived dendritic cells 

eirini Vavatsikou (southampton) 

16.29-16.41 FcgammaRIV Promotes, while FcgammaRIIB Protects from Autoantibody-induced 

Tissue Damage in Autoimmunity to Type VII Collagen 

Michael Kasperkiewicz (Lübeck) 

16.41-16.53 Anti-desmocollin autoantibodies in pemphigus herpetiformis and pemphigus vegetans. 

IgG antibodies to desmocollins 1-3 are the key factor for their characteristic phenotypes 

norito Ishii (Kurume, Japan) 

16.53-17.05 Towards a better understanding of paraneoplastic pemphigus pathogenesis: 

identification of the p170 antigen recognized by PNP autoantibodies 

Isabelle schepens (Bern) 

17.05-17.17 Human monoclonal antibodies bind desmoglein 3 epitopes shared by pemphigus 

vulgaris patient autoantibodies and synergistically induce loss of adhesion between 

keratinocytes 

Valentina Calabresi (Rome) 

17.17-17.29 The vast majority of pemphigus vulgaris patients possess circulating autoantibodies 

reacting with an immunodominant epitope on desmoglein 3 

Giovanni Di Zenzo (Rome) 

This satellite meeting is free to all registered esDR delegates. 

31 

EIS MEETING

ESDP 

SyMPOSIUM 

EUROPEAN SOCIETy OF DERMATOPATHOLOGy SyMPOSIUM 


FENNIA I ROOM 

7th Joint Satellite Symposium of the European Society of Dermatopathology 

The Importance of Dermatopathology in Experimental Dermatology 

Chair: Gürkan Kaya (switzerland) 

Program 

14.00-14.05 Welcome 

14.05-14.35 Epidermal insulin/IGF signaling: Coordination morphogenesis with skin 

barrier function 

Carrien niessen (Germany) 

14.35-15.05 Sentinel node biopsy in Merkel cell carcinoma 

susanna Virolainen (Finland) 

15.05-15.35 Mechanisms of hyperkeratosis in lamellar ichthyosis, the role of 

Interleukin-1 alpha 

Ryan o'shaughnessy (UK) 

15.35-16.05 Correlate epidermodysplasia verruciformis lesions with specific single 

nucleotide polymorphisms in TMC6 and TMC8? 

Bettina Burger (switzerland) 

16.05-16.35 Zebrafish: Model system to study heritable skin diseases 

Jouni Uitto (Usa) 

16.35-17.05 UV modulation of the skin’s microfibrillar network 

Rachel Watson (UK) 

17.05-17.25 Panel Discussion 

17.25-17.30 Closing remarks 

32

EUROPEAN DERMATO-EPIDEMIOLOGy NETWORK MEETING 


PRESS ROOM 

Chair: Pieter-Jan Coenraads (netherlands) 

Program 

08.30-08.35 Welcome and introduction. 

Pieter-Jan Coenraads (netherlands) 

08.35-08.55 Critical perspective on comorbidities in psoriasis 

Tamar nijsten (netherlands) 

08.55-09.10 Chromosome 11q13.5 variant: No association with atopic eczema in 

Japanese population 

Yukiko nomura (Japan) 

09.10-09.25 Evidence that adequate vitamin D levels can be maintained in healthy 

adults in the absence of environmental ultraviolet radiation exposure 

shantini Rice (UK) 

09.25-09.40 Children and adolescents’ health related quality of life in relation to 

eczema, asthma and hay fever: results from a population-based crosssectional 

study 

Uwe Matterne (Germany) 

09.40-09.55 Assessment tools to measure pruritus intensity: study on validity of visual 

analogue scale (VAS), numeric rating scale (NRS) and verbal rating scale 

(VRS) 

ngoc Quan Phan (Germany) 

09.55-10.10 Epidemiology of chronic pruritus: Population-based cross-sectional study 

on prevalence, correlates and characteristics 

Uwe Matterne (Germany) 

10.10-10.25 Discrepancy in patient and physician global assessments of dermatologic 

diseases 

stefano Tabolli (Italy) 

10.25-10.30 Closing remarks 

33 

EDEN MEETING

NEUROBIOLOGy OF THE SKIN 

SyMPOSIUM 

NEUROBIOLOGy OF THE SKIN 


NORDIA ROOM 

Chairs: anna Zalewska (Lodz, Poland), Marcus Maurer (Berlin, Germany) 

Program 

1 Merkel Cells 

Laurent Misery (Brest) 

2 The Effect of Neuropeptides On CLA+ T Cells in Atopic Dermatitis 

Luis F santamaria-Babi (Barcelona) 

3 Neutrophin Receptors in Psoriasis 

Carlo Pincelli (Modena) 

4 Sebaceous Gland: The Brain Of The Skin 

Christos C Zouboulis (Dessau) 

5 Molecular Mechanisms Of Itch And Pain 

Martin steinhoff (Münster) 

6 Pruritus in Mast Cell-Mediated Diseases 

Marcus Maurer (Berlin, Germany) 

7 fMRI Brain Scan Studies In Dermatology 

Christopher Griffiths (Manchester) 

8 Back To Clinic – Coping Strategies In Chronic Skin Diseases 

anna Zalewska (Lodz) 

34

DRUG DEVELOPMENT IN DERMATOLOGy - PRINCIPLES AND PRACTICE 


EUROPAEA ROOM 

Chairs: nick Reynolds, Philippe Musette 

Introduction 

This session is open to all participants registered for the main meeting. as you will see from 

the program below, this session has been designed to include 4 educational overview talks, 2 

from an academic setting and 2 from a pharma setting. one of the aims is to increase interaction 

between academia and Pharma and we hope this will an interesting and interactive session. 

This program emphasises a stronger educational track within the Helsinki meeting and may 

be usefully linked to translational medicine and therapeutics poster walks that will facilitate 

discussion of new data and abstracts submitted by both academia and Pharma. 

Program 

The Skin - A Unique Opportunity for Translating Science into Practice 

Thomas Jung 

novartis exploratory Clinical Development 

Translational Medicine Dermatology 

Vienna, austria 

Partnering with Biotech and Big Pharma: Opportunity Benefits for Translational Medicine 

anthony Quinn 

senior Vice President 

Chief Medical officer and Head of Research & Development synageva BioPharma Corp. 

Boston, Usa 

Antibody Based Therapeutics in Dermatology 

Frank nestle 

Mary Dunhill Chair of Cutaneous Medicine and Immunotherapy 

st. John's Institute of Dermatology 

London, UK 

Development of a Broad-Spectrum Human Papillomavirus (HPV) Vaccine 

Reinhard Kirnbauer 

Medical University of Vienna, austria 

35 

DRUG 

DEVELOPMENT

ACTA 

MEETING 

ACTA DERMATO-VENEROLOGICA SyMPOSIUM 



Chairs: anders Vahlquist, Kristian Thestrup-Pedersen, annamari Ranki 

The Nordic Light in Dermatological Research 

Program 

09.00-09.05 Introduction 

anders Vahlquist (sweden) 

09.05-09.20 Large Scale Protein Analysis of Human Primary Keratinocytes by Antibody 

Arrays 

Daniel de la Rosa Carrillo (norway) 

09.20-09.40 Antimicrobial Peptides 

artur schmidtchen (sweden) 

09.40-09.55 Psoriasis Inflammation 

Lone skov (Denmark) 

09.55-10.10 MAPK Dependent Signal Transduction in Inflammatory Skin Diseases 

Lars Iversen (Denmark) 

10.10-10.30 Mast Cell Biology 

Illka Harvima (Finland) 

36

37 

Immunoglobulin 

as designed by nature 

For full prescribing information please refer to the Summary of Product Characteristics: 

Intratect® - Human Normal Immunoglobulin for Intravenous Administration, Ph. Eur. Composition: 1ml of solution contains: human plasma protein 50mg, thereof at least 96% is IgG, excipients: Glycine and water for 

injection. Indications: Replacement therapy in: Primary immunodefi ciency syndromes such as: - congenital agammaglobulinaemia and hypogammaglobulinaemia, - common variable immunodefi ciency, - severe combined 

immunodefi ciency, - Wiskott-Aldrich syndrome; Myeloma or chronic lymphocytic leukaemia with severe secondary hypogammaglobulinaemia and recurrent infections; Children with congenital AIDS and recurrent 

infections. Immunomodulation: Idiopathic thrombocytopenia purpura (ITP), in children or adults with a high risk of bleeding or prior to surgery to correct the platelet count; Guillain-Barré syndrome, Kawasaki disease. 

Allogeneic bone marrow transplantation. Contraindication: Hypersensitivity to any of the components. Hypersensitivity to homologous immunoglobulins especially in very rare cases of IgA defi ciency when the patient 

has antibodies against IgA. Special warnings and special precautions for use: Certain adverse may occur more frequently: in cases of high rate of infusion, in patients with hypo- or agammaglobulinaemia with or without 

IgA defi ciency, in patients who receive human normal immunoglobulin for the fi rst time or, in rare cases, when the product is switched or there is a long interval since the previous infusion. Rarely, human normal immunoglobulin 

can induce a fall in blood pressure with anaphylactic reaction, even in patients who had previously tolerated treatment with human normal immunoglobulin. Cases of acute renal failure have been reported 

in patients receiving IVIg therapy. Standard measures to prevent infections resulting from the use of medicinal products prepared from human blood or plasma include the selection of donors, screening of individual 

donations and plasma pools for specifi c markers of infection and the inclusion of effective manufacturing steps for the the inactivation/removal of viruses. Despite this, when medicinal products prepared from human 

blood or plasma are administered the possibility of transmitting infective agents cannot be totally excluded. This also applies to unknown or emerging viruses and other pathogens. Undesirable effects: Adverse reactions 

such as chills, headache, fever, vomiting, allergic reactions, nausea, arthralgia, low blood pressure and moderate back pain may occur occasionally. Rarely IVIg may cause a sudden fall in blood pressure and, in isolated 

cases, anaphylactic shock, even when the patient has shown no hypersensitivity to previous administration. Cases of reversible aseptic meningitis, isolated cases of reversible haemolytic anaemia/haemolysis, rare cases 

of transient cutaneous reactions, and increase in serum creatinine level and/or acute renal failure have been observed with IVIg. Very rarely thromboembolic reactions such as myocardial infarction, stroke, pulmonary 

embolism, deep vein thrombosis may occur. 

Biotest Pharma GmbH · Landsteinerstr. 5 · D-63303 Dreieich, Germany · www.biotest.de

BIOTEST 

SyMPOSIUM 

Intravenous Immunoglobulin in Dermatology - The Only True Biological Response Modifier? 



Note: Lunch boxes will be provided to symposium participants. 

Chair: Alexander Enk (Heidelberg) 

Program 

12.30-13.00 IVIg – The Renaissance of an Old "Biological" for 

Dermatological Autoimmune Diseases 

alexander enk (Heidelberg) 

13.00-13.30 Factors Associated with Malignancy in Dermatomyositis 

Martine Bagot (Paris) 

13.30-14.00 Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: 

Pathogenesis, Diagnosis and Management 

Lars French (Zurich) 

NOTES 

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38

WHAT’S NEW IN ROSACEA IN 2010? 



Note: Lunch boxes will be provided to symposium participants. 

Chair: Martin steinhoff (Usa) 

Program 

From Bedside to Bench - Rosacea: A Complex Inflammatory Skin Disease 

Martin steinhoff, MD, Ph.D, M. sc. (Usa) 

Neurovascular Regulation in Chronic Inflammation 

susan Brain, B.sc., Ph.D (United Kingdom) 

Neuroimmune Mechanisms in Chronic Inflammation and Rosacea 

Martin steinhoff, MD, Ph.D, M. sc. (Usa) 

Innate Immunity in Rosacea and Chronic Inflammation 

Jens-M schroeder, Ph.D (Germany) 

Leukocytes Recruitment in Rosacea and Chronic Inflammation 

Bernhard Homey, MD (Germany) 

Insights into the Etiology of Rosacea: Large Scale Gene Expression Profiling of Three 

Subtypes of Rosacea Reveals a Strong Inflammatory Component 

Jérôme aubert, Ph.D (France) 

NOTES 

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39 

GALDERMA 

SyMPOSIUM

INTENDIS BAUSCH & LOMB 

SyMPOSIUM 

NEW FRONTIERS IN THE TREATMENT OF INFLAMMATORy DISEASES 


EUROPAEA ROOM 

Chair: Thomas Bieber (Bonn) 

Program 

1 Atopic Dermatitis: Modern Immune Concept of Cutaneous 

Inflammation Treatment Options: What Do We Have, What Do We 

Need? 

Prof T. Bieber (Bonn) 

2 Discovery and Development of Selective Glucocorticoid Receptor 

Agonists (SEGRAs) for the Treatment of Inflammatory Diseases 

Dr H. Rehwinkel (Berlin) 

3 Selective Glucocorticoid Receptor Agonists: On the Way from the 

Bench to the Clinic 

Dr H. schaecke (Berlin) 

4 The Eyes Have It - Ocular Safety and Efficacy of a Novel SEGRA 

Dr K. Ward (Rochester, Usa) 

5 Novel Glucocorticoid Receptor Agonists: Improving Upon 

Established Drugs by Selectivity? 

Prof T. Bieber (Bonn) 

6 Closing Remarks and Discussion 

NOTES 

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40

TOURIST INFORMATION 

Helsinki tourist Information 

Phone: +358 (0)9 3101 3300 

Fax: +358 (0)9 3101 3301 

email: tourist.info@hel.fi 

Finnish Tourist Board/Visit Finland 

Phone: +358 (0)10 60 58000 

Fax: +358 (0)10 60 58333 

email: mek@visitfinland.com 

Transport 

Helsinki is mostly accessible on foot. a well-integrated, safe local transport system consists of trams, buses, 

an underground line and commuter train services. Tickets (2,50 eUR per ticket valid through one hour in trams, 

trains, buses and metro) are purchased from the driver (buses and trams) or at newspaper stands (R-kioski). 

When visiting and travelling in the Helsinki area from one day up to seven days, the most valuable practical way 

to get around is the HKL Tourist Ticket. HKL Tourist Tickets are available from one to seven days for both children 

and adults. 

single-charge card, day tickets in Helsinki (eUR) 

adult Child 

1 day 6,80 3,40 

2 days 10,20 5,10 

3 days 13,60 6,80 

4 days 17,00 8,50 

5 days 20,40 10,20 

one-day tourist tickets can be purchased at ticket automats at tram stops, newspaper stands (R-kioski), and at 

the stockmann department store. Tourist tickets for several days are purchased at newspaper stands (R-kioski), 

and at the stockmann department store. 

The route of tram line 3T is ideal for a sightseeing tour. You can get on the tram at any stop and the tour takes 

about 60 minutes. 

41 

TOURIST 

INFORMATION

GENERAL 

INFORMATION 

GENERAL INFORMATION 

THE MEETING VENUE 

The meeting is held at the Marina Congress Centre, which is located by the sea near the centre of Helsinki. The 

address is Katajanokanlaituri 6. 

The Registration and information desk is located on the entrance floor. 

The desk will be at your service: 

Wednesday 10.00-19.00 

Thursday 07.00-19.00 

Friday-saturday 07.30-17.00 

Registration desk phone: +358 500 604 686 

scandic Grand Marina /Reception, phone: +358 9 1666 840 

Services for ESDR 2010 delegates 

Registered delegates are entitled to the following services and material: 

• admission to all meeting sessions and to the welcome and farewell ceremonies 

• abstract book 

• meeting bag 

• coffee/tea 

• welcome reception at the Helsinki City Hall on Thursday 9 september 

• Gala dinner at Wanha satama on Friday 10 september 

Before and After the Meeting 

esDR 

Rue Cingria 7 

CH-1205 Geneva 

switzerland 

Tel: +41 22 321 48 90 

Fax: +41 22 321 48 92 

email: office@esdr.org 

Web: www.esdr.org 

Continuing Medical Education 

The european society for Dermatological Research is accredited by the european accreditation Council for 

Continuing Medical education (eaCCMe) to provide the following CMe activity for medical specialists. The 

eaCCMe is an institution of the european Union of Medical specialists (UeMs): 

The "40th annual esDR Meeting" is designated for a maximum of (or "for up to") 18 hours of european external 

CMe credits. each medical specialist should claim only those hours of credit that he/she actually spent in the 

educational activity. 

eaCCMe credits are recognized by the american Medical association towards the Physician's Recognition award 

(PRa). To convert eaCCMe credit to aMa PRa category 1 credit, contact the aMa. 

CMe certificates can be obtained from the esDR office after the meeting. 

Duplication, Recording, Photos 

Photography, audio-taping, video-recording, or any other form of duplication is strictly prohibited in the session 

rooms and poster areas. In the exhibition area, pictures or film are allowed only if permitted by the concerned 

exhibitor. Failure to comply with this rule could lead to your meeting credentials being removed. 

Membership 

If you wish to apply for membership of the esDR, forms are available at the Registration Desk. For membership 

enquiries after the meeting, please contact the esDR: office@esdr.org 

42

PRACTICAL INFORMATION 

Banks 

Banks are open 09.30-16.15 except during weekends. automatic cash dispensers (oTTo) are widely available. 

Major credit cards are accepted in shops, cafés, restaurants etc. 

Certificate of Attendance 

Included in your registration material. 

Copying and Printing 

0,35 eUR / copy. Please contact Marina Congress Center Information Desk 

Credit Cards 

all major credit cards are in general use in Finland. at the registration desk you can use Visa and Mastercard. 

Currency & Exchange 

The currency in Finland is the euro. You can change money at the Helsinki-Vantaa airport, at banks or at the 

Helsinki Railway station. There are also many specialised currency exchange locations in the city centre. 

Insurance 

Delegates are advised to take out their own comprehensive travel insurance as the organisers shall not be liable 

for personal accidents, illness, losses or damage to private property. 

Internet 

WLan is free of charge. Please go to the Marina Congress Center Information Desk for a password. 

Language 

The official congress language is english. 

Medical Assistance 

ambulance services emergency number: 112. 

Name Badge 

You will receive a name badge on registration. Please wear your badge at all times, as it will serve as your “ticket” 

to meeting events. 

Phones 

Most mobile phones are useable in Helsinki; provided your operator has a roaming agreement with a Finnish 

company. 

organisers recommend to buy a Prepaid and Refill Voucher sold at the at several dealers e.g. R-Kiosks. 

There are no public phones in Helsinki. Phoning at the hotel is expensive. 

Police 

Police services emergency number: 10022. 

Restaurants 

For a quick and tasty outdoor lunch, you may try the Harbour Market / Market square (Kauppatori-salutorget), 

where you will find delicacies like seasonal fruits and vegetables, pies and smoked fish. an even wider variety can 

be found in the adjacent Market Hall. There are several restaurants close to Marina Congress Centre; at almost 

all restaurants lunch is served between 11-14 and costs max 10 eUR. 

Sauna 

Most of the hotels in Helsinki have saunas. To experience a sauna bath contact your hotel reception. 

Shopping 

Most department stores and shopping centres are open Monday-Friday from 09.00-21.00, on saturday from 09.00- 

18.00, on sunday from 12.00-18.00. 

Smoking 

This is a non-smoking meeting. In Marina Congress Centre smoking is permitted on the balcony or at the main 

entrance. Please note that in Finland smoking is restricted in all public places, including restaurants. 

Taxi 

Dial 0100 0700 to call a taxi. Taxis are rather expensive but safe. There is a taxi stop in front of Marina hotel. 

Tipping 

Tipping is not customary in Finland. In restaurants service is included in the bill. You may however, want to tip 

for a good service. 

43 

GENERAL 

INFORMATION

2010 MAP OF EXHIBITORS - GROUND FLOOR LEVEL 

ESDR 40th Annual Meeting 

8 - 11 September 2010 

Marina Congress Centre 

Helsinki, Finland 

Ground floor 

EXHIBITORS 

POSTERS 

SESSIONS 

1 2 3 4 

1 astellas Pharma 

2 Basilea Phramaceuticals 

3 esDR 2011, Barcelona 

4 Leo Pharma 

5 esDR 

6 Janssen-Cilag 

17 

5 

16 

COFFEE 

6 

9 

7 

13 

8 

E POSTERS 

REGISTRATION 

7 Cellsystems Biotechnologie 

8 Intendis GmbH 

9 nature Publishing Group 

13 CeLLnTeC 

16 Dinona Inc 

17 Biotest aB

POSTER INFORMATION 

Installation and Removal 

FoR PosTeRs 001-296 

• Posters must be installed on: Thursday 9 september (poster areas open at 8.00). If you have used esDR's poster 

printing service, we will install your poster for you. 

• Posters will be removed by esDR staff on Friday 10 september at 13.00. You may collect your poster from the 

registration area from 15.00 on Friday 

FoR PosTeRs 297-600 

• Please leave your poster at the registration desk when you arrive at the esDR meeting. Do not leave your poster 

tube. We can only store flat posters. 

• Posters will be installed by esDR staff on Friday 10 september at 13.00. 

•Please remove your poster by 17.00 on saturday 11 september 

Poster Sessions 

Two Poster sessions are scheduled: 

• PosTeR sessIon I (Posters 001-296) Friday 10 september, 11.30-13.00 

all poster presenters to be in front of posters, except those joining poster walks (see below). Coffee will be 

available during this session. 

• PosTeR sessIon II (Posters 297-600) saturday 11 september, 10.30 to 12.00 

all poster presenters to be in front of posters, except those joining poster walks (see below). Coffee will be 

available during this session. 

• PosTeR sessIon III (one-hour session) saturday 12 september, 10.15-11.15 

ELECTRONIC POSTER AREA 

all 2010 esDR posters will be available for viewing throughout the meeting at the electronic Poster area. This 

area contains 20 computers and is only available for poster viewing (no Internet connection). The electronic Poster 

technology enables fast browsing/search and a facility to contact the author. a technician will be available to assist 

with any questions/problems. 

Poster Prizes 

several poster prizes will be awarded at the 2010 esDR Meeting. The awards will be made at a special ceremony 

on saturday 11 september from 16.00-16.20 in the europaea Room. 

Poster Walks 

The purpose of poster walks is to encourage interaction between junior and senior researchers and to promote 

discussion on work presented at the meeting as posters. Poster walks take place during both Poster sessions. 

PosTeR WaLK I: Meet at registration desk at 11.30 on Friday 10 september 

PosTeR WaLK II: Meet at registration desk at 10.30 on saturday 11 september 

If you wish to join a poster walk simply meet at the meeting registration desk at these times. a list of poster walk 

leaders and topics will be made known at the meeting. Confirmed walk leaders at the time of publication of this 

program are: 

Posters that have been selected for discussion will have a sticker placed on the poster board. If your poster is 

selected for a poster walk, please feel free to join the relevant walking tour group. 

SLIDE PREVIEW ROOM 

The slide preview room is located on the second floor. 

after completing meeting registration at the Registration Desk, each speaker should go to the slide preview room. 

The preview room will be open from 10.00 on Wednesday 8 september until the close of the Meeting. 

all presentations must be in english. each speaker should also verify in the final program that the name of the 

room and the time of the session have not changed. each meeting room is equipped with a single video-projector 

(LCD for computer assisted presentations, ie, Powerpoint). speakers are reminded that they may noT connect 

their own laptop to the LCD projector in the meeting rooms. 

45 

POSTER 

INFORMATION 

SLIDE 

PREVIEW

ABOUT 

THE ESDR 

CURRENT ESDR EXECUTIVE COMMITTEE AND BOARD 

Executive Committee 

President 

eugene Healy, southampton 

President Elect 

Vincent Piguet, Cardiff 

Immediate Past President 

Reinhard Dummer, Zurich 

Secretary-Treasurer 

Vincent Piguet, Cardiff 

Secretary-Treasurer Elect 

alexander enk, Heidelberg 

PAST OFFICERS OF THE ESDR BOARD 

46 

Board 

Johann Bauer, salzburg 

Tilo Biedermann, Tübingen 

antonio Costanzo, Rome 

Robert Gniadecki, Copenhagen 

Philippe Musette, Rouen 

Carien niessen, Cologne 

Mauro Picardo, Rome 

nick Reynolds, newcastle 

Luis santamaria, Barcelona 

Peter steijlen, Maastrict 

year President Secretary Treasurer 

1971 F. serri M. Prunieras R. Cormane 

1972 o. Braun-Falco M. Prunieras R. Cormane 

1973 s. shuster M. Prunieras R. Cormane 

1974 H. Rorsman M. Prunieras R. Cormane 

1975 R. Cormane C. Lapière e. Christophers 

1976 K. Wolff C. Lapière e. Christophers 

1977 e. Jung C. Lapière e. Christophers 

1978 e. Christophers M. Greaves T. van Joost 

1979 R. Marks M. Greaves W. van Vloten 

1980 H. schaefer M. Greaves W. van Vloten 

1981 e. Frenk M. Greaves W. van Vloten 

1982 M. Greaves H. Hönigsmann W. van Vloten 

1983 G. Plewig H. Hönigsmann W. van Vloten 

1984 W. van Vloten H. Hönigsmann B. Vermeer 

1985 a. Giannetti W.J. Cunliffe B. Vermeer 

1986 J.H. saurat W.J. Cunliffe B. Vermeer 

1987 P. Fritsch W.J. Cunliffe B. Vermeer 

1988 W.J. Cunliffe G.L. Vejlsgaard R. Willemze 

1989 B. Vermeer G.L. Vejlsgaard R. Willemze 

1990 J. Ring G.L. Vejlsgaard R. Willemze 

1991 G.L. Vejlsgaard P.s. Friedmann R. Willemze 

1992 D.M. MacDonald P.s. Friedmann R. Willemze 

1993 G. stingl P.s. Friedmann R. Willemze 

1994 P.s. Friedmann W. sterry P. van de Kerkhof 

1995 T. Krieg W. sterry P. van de Kerkhof 

year President Secretary-Treasurer 

1996 W. sterry P. van de Kerkhof 

1997 K. Thestrup-Pedersen P. van de Kerkhof 

1998 R. Camp P. van de Kerkhof 

1999 P. van de Kerkhof L. Bruckner-Tuderman 

2000 I. Leigh L. Bruckner-Tuderman 

2001 G. Zambruno L. Bruckner-Tuderman 

2002 L. Bruckner-Tuderman L. French 

2003 J. Rees L. French 

2004 M. Röcken L. French 

2005 L. French M. Röcken 

2006 T. schwarz M. Röcken 

2007 C. Pincelli M. Röcken 

2008 J. McGrath V. Piguet 

2009 R. Dummer V. Piguet

ESDR COMMITTEES 

easTeRn eURoPean CoMMITTee 

Johann Bauer (Chair) 

Cezary Kowalewski 

alla Kyagov 

norbert Wikonkál 

anna Zalewska 

eDUCaTIon CoMMITTee 

nick Reynolds (Chair) 

Johann Bauer 

Carien niessen 

Mauro Picardo 

MeMBeRsHIP CoMMITTee 

Peter steijlen (Chair) 

Johann Bauer 


Mauro Picardo 

Luis santamaria 

PATRON MEMBERS OF THE ESDR 

The esDR acknowledges the ongoing support from its Patron Members. Patron memberships help support 

esDR members from eastern europe, the development of the JID and annual meeting-related projects. 

Martine Bagot 

Luca Borradori 

Leena Bruckner-Tuderman 

anthony Chu 

Louis Dubertret 

Reinhard Dummer 

alexander enk 

Lars e French 

Peter s Friedmann 

alberto Giannetti 

Giammaria Giuliani 

Christopher e.M. Griffiths 

eugene Healy 

Marcel F Jonkman 

Roland Kaufmann 

Irene Leigh 

Cornelia Mauch 

Michael Meurer 

ABSTRACT REVIEWERS 2010 

Daniel aberdam 

François aubin 

Monique aumailley 

Hervé Bachelez 

Martine Bagot 

Jens-Malte Baron 

Johann Bauer 

stefan Beissert 

Mark Berneburg 


Markus Böhm 

Jan-nico Bouwes Bavinck 

andrea Cavani 

Pieter-Jan Coenraads 


Frank de Gruijl 

Robert Dellavalle 

Michael Detmar 

Thomas Diepgen 

Beate eckes 

alexander enk 

Marjan Garmyn 

neil Gibbs 

Robert Gniadecki 

Marek Haftek 

Christina Has 

eugene Healy 

Bernhard Homey 

Delphine Javelaud 

Marcel Jonkman 

Veli-Matti Kähäri 

David Kelsell 

Jorma Keski-oja 

Reinhard Kirnbauer 

Maranke Koster 

Cezary Kowalewski 

Peter Kurschat 

Charlie Lambert 

Bernhard Lange-asschenfeldt 

Lionel Larue 

Thierry Magnaldo 

alain Mauviel 

47 

PHaRMa ReLaTIons CoMMITTee 

Philippe Musette (Chair) 

nick Reynolds (Vice-Chair) 


alexander enk 

Robert Gniadecki 

Chris Griffiths 

eugene Healy 

eugene o'Keefe 

anthony Quinn 


Braham shroot 

sCIenTIFIC PRoGRaM CoMMITTee 

eugene Healy (Chair) 



alexander enk 



nick Reynolds 

Peter steijlen 

Colin s Munro 

Dedee F Murrell 

Filippa nyberg 


Gerd Plewig 

Jonathan L Rees 

Timo Reunala 

Johannes Ring 

Martin Röcken 

Jean-Hilaire saurat 


Guy Bruno serre 

Georg stingl 

Kristian Thestrup-Pedersen 

erwin Tschachler 

anders Vahlquist 

Peter CM van de Kerkhof 

The esDR acknowledges the contributions of the following 2010 esDR abstract reviewers: 

alain Mauviel 

John McGrath 

James McMillan 

Martin Mempel 

Laurence Michel 

Maya Mockenhaupt 

Jean-Pierre Moles 

Maria Morasso 

Colin Munro 

Philippe Musette 

Luigi naldi 


Teresa odorisio 

Mauro Picardo 


ehrhardt Proksch 

nick Reynolds 

Thomas Ruenger 

Rudolph Rupec 


Jens schröder 


eli sprecher 

Kerstin steinbrink 

Cord sunderkötter 

Rolf-Markus szeimies 

Minoru Takata 

Des Tobin 

Franz Trautinger 

erwin Tschachler 

Maurice van steensel 

Thomas Volz 

esther Von stebut 

stefan Weidinger 

norbert Wikonkal 

Hywell Williams 

Helen Young 

anna Zalewska 

Giovanna Zambruno 

Thomas Zollner 

ABOUT 

THE ESDR 

ABSTRACT 

REVIEWERS

AWARDS 

FUTURE 

ESDR MEETINGS 

ESDR AWARDS AND ESDR HONORARy MEMBERSHIPS 

year ESDR Awards ESDR Honorary Members 

2010 Alberto Giannetti (Italy) 

Shinji Shimada (Japan) 

2009 ervin epstein (Usa) 

Peter Friedmann (UK) 

2008 Kristian Thestrup-Pedersen (Denmark) 

William Cunliffe (UK) 

2007 Thomas Krieg (Germany) 

John stanley (Usa) 

2006 Rona MacKie (UK) 

Rein Willemze (netherlands) 

2003 Georg stingl (austria) 

Jouni Uitto (Usa) 

2000 J.P. ortonne (France) M. Greaves (UK) 

J-H. saurat (switzerland) e. Macher (Germany) 

1999 s. Jablonska (Poland) 

H. Ueki (Japan) 

1998 T. nishikawa (Japan) 

J. Voorhees (Usa) 

1997 L. Juhlin (sweden) 

1996 o. Braun-Falco (Germany) W. van Vloten (netherlands) 

J. Thivolet (France) e. Christophers (Germany) 

a. Giannetti (Italy) s. Katz (Usa) 

D. McDonald (UK) s. Imamura (Japan) 

Previously Awarded F. serri (Italy), M. Prunieras (France) 

o. Braun-Falco (Germany), R. Cormane (netherlands) 

R. Brun (switzerland), a. Kint (Belgium) 

Ch. Lapière (Belgium), K. Mustakallio (Finland) 

H. Rorsman (sweden), s. shuster (UK) 

K. Wolff (austria) 

FUTURE ESDR MEETINGS 

2011 41st Annual ESDR Meeting 

Barcelona, spain 

7-10 september 2011 

2012 42nd Annual ESDR Meeting 

Venice, Italy 

19-22 september 2012 

2013 International Investigative Dermatology (IID) 

edinburgh, scotland 

8-11 May 2013 

48

ESDR MEMBERSHIP FORM 

Application for Membership of the ESDR 

For further information regarding membership of the ESDR please visit our website (www.esdr.org) 

Name of applicant ___________________________________________________________________________________ 

Department _________________________________________________________________________________________ 

Institution ___________________________________________________________________________________________ 

Full postal address ____________________________________________________________________________________ 

Phone __________________________ Fax ___________________________ Email ___________________________ 

AREAS OF RESEARCH ACTIVITY ____________________________________________________________________________ 

Signature ________________________________________ Date ________________________________________________ 

THIS APPLICATION IS SUPPORTED BY TWO CURRENT MEMBERS OF THE ESDR 

Supporter 1 Supporter 2 

Name ___________________________________________ Name ____________________________________________ 

Email ___________________________________________ Email ____________________________________________ 

PLEASE INDICATE IF YOU ARE A MEMBER OF 

The Society for Investigative Dermatology (SID)* 

The Japanese Society for Investigative Dermatology (JSID) * 

MEMBERSHIP FEES 

Standard Membership EUR 135 

Patron Membership EUR 250 

Joint Membership for SID/JSID Members EUR 60* 

Membership fee Eastern European Members EUR 60 

Resident/Student Membership EUR 60 

* Fully paid-up members of the SID/JSID are eligible for a reduced ESDR (Joint) Membership fee of EUR 60. 

This only applies to those SID/JSID members who reside OUTSIDE Europe. 

RETURN THE COMPLETED FORM TO THE ESDR OFFICE OR MEETING REGISTRATION DESK 

European Society for Dermatological Research 

Rue Cingria 7, 1205 Geneva, Switzerland 

Telephone: +41 22 321 48 90, Fax: +41 22 321 48 92 

Email: office@esdr.org 

After verifying your application, you will receive an invoice for your membership fee. 

49

HELP 

CREATE 

THE 

FUTURE 

The Celgene Award 

for Innovation in 

Inflammation & 

Immunology Research 

into Dermatological 

Diseases 

Full details will be announced 

on Friday 10 September 2010 

from 17.25-17.30 at the 40th Annual 

ESDR meeting in the Europaea 

auditorium (main lecture theatre)

CE.R.I.E.S. 

RESEARCH AWARD 

The Epidermal and Sensory Research and Investigation Center, the CE.R.I.E.S., is the healthy skin 

research center of Chanel Research and Technology based in Paris, France. It aims to better 

understand the structure and function of healthy skin through clinical studies carried out at its 

laboratories and fundamental research projects performed in collaboration with leading researchers 

worldwide. 

The CE.R.I.E.S. Research Award of 40,000 € is intended to honour a scientific researcher with a 

proven track record in fundamental or clinical research work, for a one year period, on the subject of: 

PHYSIOLOGY OR BIOLOGY OF HEALTHY 

SKIN AND/OR ITS REACTIONS 

TO ENVIRONMENTAL FACTORS 

The awardee is selected by an international jury consisting of the members of the Scientific 

Advisory Board of the CE.R.I.E.S. 

In 2010, Howard Y. Chang, M.D., Ph.D., Stanford, USA 

for “Aging and Rejuvenation: Genome Regulation over Time”. 

Previous CE.R.I.E.S. Research Award Winners: 

2009 Sabine Werner, Ph.D., Zurich, Switzerland 

2008 Paul A. Khavari, M.D., Ph.D., Stanford, USA 

2007 Richard L. Gallo, M.D., Ph.D., San Diego, USA 

2006 Irwin Mc Lean, Ph.D., DSc, FRSE, Dundee, Scotland, UK 

2005 Masayuki Amagaï, M.D., Ph.D. Tokyo, Japan 

2004 Thomas Schwarz, M.D. Kiel, Germany 

2003 Angela M. Christiano, Ph.D., New York, USA 

2002 Dennis R. Roop, Ph.D., Houston, USA 

2001 Fiona M. Watt, D. Phil., London, UK 

2000 Michael Karin, Ph.D., San Diego, USA 

1999 Jonathan Rees, M.D., Edinburgh, UK 

1998 Jean Krutmann, M.D., Düsseldorf, Germany 

1997 Jens-Michael Schröder, Ph.D., Kiel, Germany 

1996 Akira Takashima, M.D., Ph.D., Dallas, USA 

CE.R.I.E.S. Research Award 

www.ceries.com 

The Award will be granted without regard to sex, sexual orientation, age, race, religion, 

national origin, creed, disability, marital or veterans status.

41st annual esDR Meeting, Barcelona: 7-10 september 2011 

SAVE THE DATES: FUTURE ESDR MEETINGS 

42nd annual esDR Meeting, Venice: 19-22 september 2012 

52

40TH ANNUAL ESDR MEETING - ESDR 2010

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