Type 1 Diabetes - Dcpa.us

Patient Education• How should I use insulin levemir?• Insulin detemir is for injection under the skin and choosing differentferentinjection sites each time is advised• How should I store insulin detemir?• Unused insulin levemir should be refrigerated• Insulin levemir that is being used can be kept at room temperature re forup to 6 weeks• What are the possible side effects?• Hypoglycemia• Injection site reactions• Lipodystrophy• Allergic reactions• Urticaria, rash• Temporary worsening of diabetic retinopathyLevemir [package insert]. Bagsvaerd, Denmark. Novo Nordisk.2005.New Agents Awaiting FDAApproval…• Inhaled insulin• Alternative for patients with type 2 diabetes who do not achieveglycemic control with oral agent therapy alone• Pooled data from two Phase III studies involving 304 adults withtype II diabetes• Maintained glycemic control for two years• Experienced no clinically important effects on pulmonary functioncompared to patients treated with oral agents alone• Vidagliptin• Oral dipeptidyl peptidase-IV inhibitor for type 2 diabetes• Randomized, double-blind, blind, placebo-controlled controlled trial• Increased levels of glucagon-like like peptide-1 1 (GLP-1)• Increased insulin secretory rate• Decreased mean prandial glucose and glucagonRosenstock J, Zinman B, Murphy, LJ, et.al. Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy intype 2 diabetes. Ann Intern Med. 143:549-558, 2005.Mari A, Sallas Y, He L, et.al. Vidagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-associated ß-cell function in patients with type 2 diabetes.J Clin Endocrinol Metab. 90:4888-4894, 2005.Conclusion• Prevalence of diabetes is growing at epidemicproportions• Current treatment options provide similarglucose lowering and efficacy• Despite the availability of several medication classesoptimal glycemic control is not achieved in themajority of patients• New classes of medications can offer furtherimprovements in glycemic control and additionalclinical benefits in the management of patientswith type 1 and type 2 diabetes