Circulating Liver mRNA as a DILI Biomarker - AASLD

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Circulating Liver mRNA as a DILI Biomarker - AASLD

Rat Models of Drug-Induced Liver and MuscleInjuryStudy #1: Galactosamine Hepatotoxicity• D-(+)-Galactosamine ip exposure in Sprague Dawley rats• Single dose plus control (1000 mg/kg) at 24 h• n= 15 animals per doseStudy #2: Acetaminophen Hepatotoxicity• Acetaminophen gavage exposure in fasted Sprague Dawley rats• 3 Doses plus control (100, 700, and 1400 mg/kg)• 3 Time points 6, 24, 48 hr• n= 8 animals per dose per time pointStudy #3: Bupivacaine-induced Skeletal Muscle Toxicity• Bupivacaine HCL (BPVC) i.m. exposure in Sprague Dawley rats• Single dose plus control (0.5 ml, 0.5% in sterile saline) at 24 hr• n=10 animals (control); 20 animals (treated)The Hamner Institutes for Health Sciences | DILI Conference | March 25, 201014

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