Circulating Liver mRNA as a DILI Biomarker - AASLD

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Circulating Liver mRNA as a DILI Biomarker - AASLD

Circulating mRNA Levels are Elevated in PatientsAdmitted for Drug-induced Liver InjuryCopies / mL Plasma100010010Day 1Day 2Day 3Alb• mRNA values track with ALT/ASTelevations• Fold increases over controls arecomparable or greater than (Hp) ALT/ASTfold increases1Cont 1 2 3 4 5Patient IDCopies / mL Plasma10000100010010Day 1Day 2Day 3FgbCopies / mL Plasma1000100101Day 1Day 2Day 3Hp1Cont 1 2 3 4 5Patient ID0.1Cont 1 2 3 4 5Patient IDThe Hamner Institutes for Health Sciences | DILI Conference | March 25, 201028

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