Circulating Liver mRNA as a DILI Biomarker - AASLD

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Circulating Liver mRNA as a DILI Biomarker - AASLD

Circulating RNA as a Biomarker• Blood mRNA used in trauma patients to predict mortalityand detect complications (not clear the form of the RNA)(Clin Chem, 2004)debrismicroRNAsHomeostasis...Injury...Necrosis...microvesicles• Fetal corticotrophin-releasing hormone mRNA inmaternal plasma associated with factor VII activity in preeclampsia.(J Thromb Haemost, 2008)• Blood miRNA profile altered following acetaminophenoverdose (PNAS, 2009)• Circulating mRNAs and miRNAs used for diagnosis andpredicting prognosis in multiple cancers:• Ovarian cancer (Gynecol Oncol, 2008)• Prostate cancer (PNAS, 2008)• Lung cancer (Clin Lung Cancer, 2009)• Melanoma (Clin Cancer Res, 1999)• Colorectal (Lab Invest, 2001)• And many more...The Hamner Institutes for Health Sciences | DILI Conference | March 25, 20102

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