Society of ToxicologyInhalation and Respiratory Specialty SectionINHALATION AND RESPIRATORY SPECIALTY SECTION (IRSS)NEWSLETTER — MARCH 2013Dear IRSS Members,As much as I had been looking forward to attending the 52nd Annual Meeting andToxExpo in San Antonio, I and my DoD colleagues will not be attending.Unfortunately DoD has made the decision that we will not be allowed to attendnon‐DoD sponsored conferences this year. However, the show must go on.The Technical Committee Meeting will be held in room 203A on the concourse level ofthe Convention Center on Wednesday morning at 7:30 am. Dr. Juergen Pauluhn of‐Bayer Healthcare will chair the meeting. In addition to his presentation, he will host adiscussion to define “poison”. This should be a stimulating and lively discussion.The 52nd Annual Meeting ofSociety of Toxicologywill be held in San Antonio,Texas on March 10‐14, 2013For additionalinformation please visit:http://www.toxicology.org/AI/MEET/AM2013/The Inhalation & Respiratory Specialty Section will hold its meeting and reception on Tuesday evening, March 12th from6:00 pm to 7:30 pm in the Lone Star Ballroom C of the Grand Hyatt. I trust that this year’s attendance will exceed lastyear’s where we actually filled the room. As is our custom, we reprint last years minutes as a reminder of what’s going on.I wish to thank the officers, especially our past President Jim Wagner, our current President Mike Kleinman andVice‐President Ian Gilmour for a great year and a wonderful conference.Cheers, Harry Salem
PAST PRESIDENT’S MESSAGEDear IRSS Members,In only a few days the 2013 annual meeting willbegin in San Antonio, where the Inhalation andRespiratory Specialty Section has helped contributeto an outstanding scientific program. Like NIHfunding, proposal selection for the annual meetingprogram has become extremely competitiveover the last decade, in part due to the addition ofnew specialty sections. However this year the IRSSis sponsoring four sessions, and has endorsedseven more that should be of interest to many ofour members. Topics include diesel and cancer,the effect of air pollution on the cardiovascularand nervous systems, pulmonomics, and nanotubetoxicity in the lung, to name a few. Specialthanks to our IRSS members who worked hard togenerate these proposals, and to VP Ian Gilmourwho shepherded them through the evaluationprocess. It is never too early to start thinking ofsession ideas for 2014! Please contact a counciloror officer if you have some potential proposals, aswe hope to leave this year’s meeting with someideas to polish over the next few weeks.This meeting will mark the last of my four yeartenure in the executive line of IRSS leadership. Iwould like to thank Mike Foster, who solicited mynomination five years ago, and the presidentswho preceded me from whom I learned so much,including Mary Jane Selgrade, Lung‐Chi Chen, JinkleSeagrave, and Vince Castranova. I was fortunateto be here for the 50 th anniversary of SOT,the 25 th anniversary of the IRSS newsletter, andplan the 30 th anniversary of our proud specialtysection. I would especially like to thank Dan Costafor his contribution to the 30 th anniversary, andHarry Salem, our newsletter editor and chair ofthe IRSS technical committee. Both have providedme with the historical perspective which I thinkwas essential for this job. Thank you and see youin San Antonio!Cheers!Jim WagnerIRSS Past‐President, 3/5/2013Of course the highlight for IRSS is the receptionand business meeting that will be held on Tuesdaynight. In addition to meeting up with old friendsand colleagues, please make an effort to attend tocongratulate our young, and not so young, awardwinners for 2013. Our VP‐elect Urmila Kodavantiand her awards committee had a difficult time selectingfrom a record number of student applicants.Because there were so many outstandingcandidates, we decided to award two IRSS StudentAwards, in addition to the Mary Amdur StudentAward. The IRSS is fortunate among SOT specialtysection to have the luxury of an endowedfund that allows us to recognize our excellenttrainees. We will also recognize an outstandingpostdoctoral student, an outstanding manuscript,and excellence in career achievement and thereception.
IRSS BUSINESS MEETING MINUTES – Last YearMarch 12, 2012; 6:30 AM - 8:00 AM; Room 256(Convention Center)Present: Jim Wagner (President), Ian Gilmour (VP-elect),Councilors Willie McKinney, Flemming Cassee, AimenFarraj, Student rep Chris Carosino, incoming 2012 officers:Urmila Kodavanti (VP- elect) and Councilors SteveGavett and Mitch Cohen.The meeting was called to order at 6:35 am. Jim Wagnerwelcomed the presence of newly elected officers (UrmilaKodavanti; VP- elect), Steve Gavett (Councilor) and MitchCohen (Councilor), who are getting an early start on theirduties.Jim Wagner handed out copies of the historical poster createdChris Carosino. All officers were impressed with thework and were very happy with the finished product. MitchCohen mentioned that the ImmunoTox poster from 2011was published in a journal. A similar option will be pursuedwith the journal Inhalation Toxicology to acknowledge the30 th anniversary of IRSS.Chris Carosino provided an update on student involvementin the Society and specialty sections. Chris showed theIRSS poster at the Sunday night mixer and discussed theSS activities with student colleagues. Approaches to expandrecruitment and student involvement were discussed,with a possible creation of a student newsletter. Chrisagreed to maintain communications with the incoming studentrep to maintain momentum on student initiatives.Jim Wagner presented details of the SS budget with a premeetingbalance of $6,733. and indicated that most will bespent on the Annual Meeting expenses, including costs forthe Officers meeting, the Technical Meeting and the eveningreception. These expenses include room rental andfood and drinks costs. Costs for awards and certificatesare also the responsibility of the SS.The agenda items for the evening reception were discussed.Harry Salem will make a brief announcement atthe evening reception about Tuesday morning’s TechnicalCommittee Meeting. The committee felt it would be helpfulfor Harry to discuss briefly the purpose of the TechnicalCommittee.The role and future of the Technical Committee was thendiscussed. A more defined framework of the relationshipbetween the technical and executive committees was discussed,and it was agreed that the serving President wouldserve as this liaison. The specific nature of this relationshipwill evolve over the next year.Flemming Cassee had introduced the idea of solicitinginput from the membership via an online survey. Flemmingwill generate a list of questions that will be discussed bythe executive committee in the coming weeks.The 2012 Program committee worked was discussed.IRSS submitted 3 proposals last spring, of which 1 wasaccepted this year (Emerging Mechanistic Targets in LungInjury Induced by Combustion-Generated Particles, byAndy Ghio and Marc Fariss). Jim Wagner urged all executivecommittee members to either initiate a proposal orsolicit and champion one from the membership. Ian Gilmourindicated he has already received some preproposals.Specialty Sections can submit proposals toeach 5 categories (Symposia, Workshops, Roundtables,Historical Highlights, and CE courses). A goal of submittingto every category was proposed.The meeting was adjourned at 8:00 am.Ian Gilmour inquired of the possibility to move the businessmeet offsite next year. The current venue in the conferencecenter(s) is shared space with other SS officer meetings,making the room very noisy at times, with limited foodoptions. Officers agreed to look into an external site and apossible breakfast or lunch meeting in 2013.Jim Wagner reported on the Mary Amdur fund, which hada pre-meeting balance of $42,839. This year, Council determinedthat the Executive Committee could use 4% ofthe balance to provide for the Mary Amdur Student Award.The committee discussed the possibility of using funds foran international student travel award. Further discussionswill take place this year, and include original Amdur Fundfounders.Ian Gilmour proposed that descriptions for applicationsprocess for the Amdur and IRSS student awards be betterdelineated. Presently students can be eligible for bothawards with the application for the Amdur requiring aspecific write-up. Revised wording for the applicationdescriptions will be worked on this year and extended tothe general membership for comment.
HIGHLIGHTS OF THE 52nd ANNUAL MEETING & TOXEXPOMONDAY, March 11, 2013, 8:00—9:00 amMARY AMDUR STUDENT AWARD FUNDFor more information and to make donations please visit:http://www.toxicology.org/ai/csot/specific_funds.asp#maryPlenary Opening Lecture: Nobel Laureate Bruce A. Beutler will present “Genetic Analysis of Innate ImmuneSensing”. He is the Regental Professor and Director of the Center for the Genetics of Host Defenseat the University of Texas Southwestern Medical center. Dr. Beutler will be inducted as a 2013SOT Honorary member at the Sunday Award Ceremony.INHALATION AND RESPIRATORY SPECIALTY SECTIONCurrent OfficersIssues of InterestIndoor and outdoor air pollutionPresidentMichael KleinmanVice PresidentIan GilmourVice President-electelectUrmila KodavantiOccupational exposure to airborne contaminantsTherapeutic drug delivery by inhalationDeposition, pharmacokinetics, and systemsimpact of inhaled materialsInteractions between inhaled materialsand biogenic allergic stimuliSecretary/TreasurerAmie LundPast PresidentJames WagnerCouncilorMitchell CohenAirway injury from systemic toxicantsCardiopulmonary toxicology and hostsusceptibility variations due to inhaledsubstancesCouncilorAimen FarrijCouncilorStephen GarrettCouncilorWillie McKinney, Jr.Postdoc RepresentativeJaime CyphertStudent RepresentativeSamantha Snow
INHALATION AND RESPIRATORY SPECIALTY SECTIONPurposeFor more than 30 years, the IRSS has providedleadership to the inhalation and respiratoryscientific community by:IRSS Sponsored and Endorsed SessionsSession Title:Session Type:Recent Developments in Cardiovascular Physiology –Based ToxicologyContinuing EducationChairperson: Travis Knuckles Co‐Chair: David McGuinnLocation: Room 214 Time: Sun, Mar 10 @ 8:15 amServing as the focal point for SOT membersinterested in inhalation toxicology and respiratorybiology to understand the impact of airbornechemicals/particles on the body.Creating programs and educational activitiesthat emphasize the latest developments andinnovations in cardiopulmonary toxicology.Translating and disseminating new knowledgeand emerging concepts in respiratory toxicologyto stimulate growth in the field of inhalationand respiratory toxicology.Partnering with other specialty sections/SIGsto broaden the understanding of systemic effectsof inhaled toxicants and the impact ofrespiratory diseases on other organ systems.Acting as an expert resource for SOT’s missionto advocate for public and research policy.Session Title:Session Type:Inhaled Mixtures: A Mode‐of‐Action Framework Applied to the Criteria AirPollutantsWorkshopChairperson: Elizabeth Owens Co‐Chair: Christal BowmanLocation: Grand Ballroom C2 Time: Mon, Mar 11 – 9:15AMSession Title:Session Type:Predictive Toxicology Paradigms for Understanding Carbon Nanotube Toxicityin the LungSymposiumChairperson: James Bonner Co‐Chair: André NelLocation: Room 214 A&B Time: Mon, Mar 11 – 9:15AMSession Title:Session Type:Diesel and Gasoline Exhaust and CancerHistorical HighlightsChairperson: Annemoon van Erp Co‐Chair: Jacob MacDonaldLocation: Room 206 Time: Mon, Mar 11 – 12:10PMSession Title:Session Type:Role of metabolic Syndrome and Perivascular Adipose in Exposure‐InducedVascular DysfunctionSymposiumChairperson: Daniel Conklin Co‐Chair: Matthew CampenLocation: Grand Ballroom C3 Time: Mon, Mar 11 – 2:00PMSession Title:Session Type:From Inhaled Particles to Cardiovascular Disease and Toxicity: Evidence fromStudies in VolunteersSymposiumChairperson: Flemming Cassee Co‐Chair: Howard KipenLocation: Room 214 C&D Time: Tues, Mar 12 – 9:00AMSession Title:“Air”‐ing on the Side of Caution: Anticipating Impacts of Emerging Issues in theHealth Effects of Air PollutionMembership BenefitsNetwork with inhalation and respiratory toxicologistsfrom industry, government, and academia.Present your work in sponsored and selectivespecialty sessions.Awards presented at the annual BusinessMeeting for:- Paper of the Year- Best Annual Meeting Abstracts- Doctoral Student- Post -Doctoral Student- Mary O. Amdur Student Award- Merit Awards for Young and CareerInvestigatorsSession Type:WorkshopChairperson: Aimen Farraj Co‐Chair: Michelle BellLocation: Room 217 C&D Time: Tues, Mar 12 – 1:30PMSession Title:Session Type:Pulmonomics, the Exposome, and Microbiomes in ImmunotoxicologyWorkshopChairperson: Marc Williams Co‐Chair: Joachim PleilLocation: Room 214 C&D Time: Wed, Mar 13 – 9:00AMSession Title:Session Type:Mechanistic Role(s) of Cytochrome(s) P450 in Oxidative Stress and Inflammation:New Opportunities for Drug DiscoverySymposiumChairperson: Bhagavatula Moorthy Co‐Chair: Jose ManautouLocation: Room 214 C&D Time: Wed, Mar 13 – 1:30PMSession Title:Session Type:Challenging the Limits of Nonclinical Safety Assessment of Pediatric MedicinesWorkshopChairperson: Jeffrey Moffit Co‐Chair: Merle PauleLocation: Room 217 A&B Time: Wed, Mar 13 – 1:30PMSession Title:Session Type:Role of Air Pollution as a Risk Factor for Central Nervous System Diseases andDisordersSymposiumChairperson: Deborah Cory‐Slechta Co‐Chair: Michelle BlockLocation: Room 214 C&D Time: Thur, Mar 14 – 9:00AMReception and Awards MeetingTuesday, March 12, 2013 ‐ 6:00 ‐ 7:00 PMLone Star Ballroom C ‐ Grand HyattComplimentary hors d’oeuvres served
MINUTES OF LAST YEAR’S TECHNICAL COMMITTEEMEETING—MARCH 2012This meeting was convened at 7:00 AM in the San FranciscoMoscone Convention Center in an overfilled room. Followinga brief introduction as to the purpose of this committee, includingthe highlighting of innovations and issues in inhalationtoxicology, we heard two very interesting and timelypresentations.The first presentation by Dr. Dan Angelini, a Senior NationalResearch Council Associate at the Edgewood Chemical BiologicalCenter, was an overview of “Stem Cells in PulmonaryInjury.” Dr. Angelini discussed, in addition to the history ofstem cells, pulmonary injury in terms of acute lung injury(ALI) and acute respiratory distress syndrome (ARDS) -what it is, including its pathology, and what are its causes.The current medical treatments for ALI/ARDS are limited,and the mortality rate remains high at approximately 40% inthe United States. Most current therapies are considered tobe supportive, and recent studies suggest that stem cellscould present a novel therapeutic option.The second presentation by Dr. Jan Moser, a Battelle contractorsupporting the Chemical Security Analysis Center(CSAC) of the Department of Homeland Security (DHS)wason “Modeling the Public Health Consequences of Releaseand Dissemination of Toxic Chemicals.”Dr. Moser, who haspreviously made presentations to this group, describedCSAC’s mission, which is to identify and characterize thechemical threat against the American Homeland and theAmerican Public. She described the threat from toxic chemicalsand presented the Chemical Terrorism Risk Assessment(CTRA), the Chemical Infrastructure Risk Assessment(CIRA), and the hazard assessment process. Modeling methodsused at CSAC such as the Hazard Prediction AssessmentCapability (HPAC), the Consequences AssessmentTool Set (CATS), the Facilities Weapons of Mass DestructionDecision Analysis Center (FacDAC), and Quick Urbanand Industrial Complex (QUIC) Dispersion Modeling werediscussed, along with the CARVER + Shock method used toassess vulnerabilities in the food sector, from “Farm to Table”.The meeting room was packed, and there was a hugeamount of interest in state-of-the-art information on the potentialof stem cell therapy in pulmonary injury, and CSAC/DHS activities to combat the threat of chemical attacksDan Angelini (NRC Senior Associate, ECBC)Jan Moser (CSAC/DHS), presentation at technical committee meetingthrough regulatory and science and technology efforts.If you are involved in exciting inhalation toxicity research andare interested in presenting to this group at next year’s technicalcommittee meeting, please contact me.See you in San Antonio in 2013.Respectfully submitted, Harry SalemInhalation and Respiratory SpecialtySection Technical Committee MeetingWednesday, March 13, 2013 7:30-8:30AMRoom 203A on the Concourse Levelof the Convention Center1. Welcome2. "Animal Models in Pulmonary Toxicity Assessment" -Juergen Pauluhn3. Discussion Itemsa. We have a request by the Department ofHomeland Security (DHS) to establish a relevant definitionof poisonb. Other issues to discuss?c. Set up teams to address issues4. Adjourn