Department of Medicine - Surgery - University of Minnesota

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in its earliest stages, beforeconventional tests are positiveor symptoms are present.Additionally, blood samplesare collected for geneticscreening that may identifyindividuals at risk for atherosclerosis.This will leadto earlier intervention andreduction of complicationsover time.Educational ProgramsThe cardiology fellowship program,headed by Leslie Miller,M.D, is one of the most highlyregarded and competitivecardiology fellowship trainingprograms in the country. Fellowsrotate through the fourtraining sites including Universityof Minnesota MedicalCenter, HCMC, the VA MedicalCenter, and Abbott NorthwesternHospital, to gain exposureto different types of patientcare delivery systems anddiverse patient populations.All types of advanced trainingin subspecialty areas, suchas interventional catheterization,electrophysiology, heartfailure, and vascular diseaseand prevention are alsooffered within the program.In addition, medical studentsand residents from the Universityof Minnesota, as wellas from around the country,rotate on the inpatient andconsult services, helping tocare for patients with cardiovasculardisease.The fellowship programincludes approximately eighthours per week of conferencesdirected specifically for thefellows, including didacticlectures on core topics in cardiology,interactive sessionson topics such as EKG interpretation,as well as a seminarformat for review of researchin progress. Fellows may alsoelect to pursue the master’s inpublic health in clinical trialdesign and execution duringtheir third or fourth year,as well as clinical or basicresearch in one of the numerouslabs within the cardiovasculardivision or the LilleheiHeart Institute.Research ProgramsResearch in the CardiovascularDivision has been focusedon both clinical and basic scienceareas of cardiovasculardisease. Basic research isconducted by Jay Zhang, M.D.,Robert Bache, M.D., DorisTaylor, M.D., Yuqing Huo,M.D., Jennifer Hall, M.D.,and Yingjie Chen, M.D..The Cardiovascular Divisionis heavily involved in clinicaland translational research.The new Lillehei Clinical TrialCenter opened in June 2003and includes nine patientexam rooms, areas for phlebotomy,a core chemistry lab,and a procedural area fornon-invasive tests, such asechocardiography, exercisetesting, and carotid ultrasound.Research coordinatorshelp staff with over 45 clinicaltrials conducted by cardiologyfaculty, including both NIHand industry-sponsored trials.Anne Taylor, M.D. was thenational PI on the importantAfrican American HeartFailure Trial (A-HEFT) whichshowed the benefit of addingHydralazine and NitratesThis year, the center will be initiatinga number of clinical trials in stemcell therapy.to heart failure therapy inAfrican Americans. Thistherapy, which adds a nitricoxide donor and an anti-oxidant,demonstrates importantgenomic differences inresponse to drugs.Center for Cardiac Repairand RecoveryThe Medical School has createda new Center for CardiacRepair and Recovery. Thedirector of this center is DorisTaylor, Ph.D. The center willFacultyProfessorsInder Anand, M.D. (VAMC)Richard Asinger, M.D. (HCMC)Robert Bache, M.D.David Benditt, M.D.Henry Blackburn, M.D., M.S. (Emeritis)Jay N. Cohn, M.D.Daniel Duprez, M.D., Ph.D.Arthur From, M.D.Steven Goldsmith, M.D. (HCMC)Richard Grimm, M.D., Ph.D. (HCMC)Charles Herzog, M.D. (HCMC)Donald Hunninghake, M.D. (Emeritis)Russell Luepker, M.D.Keith Lurie, M.D.John McBride, M.D. (Regions)Edward McFalls, M.D. (VAMC)Leslie W. Miller, M.D. (Director)Murray J. Murray, M.D.Anne Taylor, M.D.Doris Taylor, M.D.Naip Tuna, M.D.Kamil Ugurbil, Ph.D.Kyuhyun Wang, M.D. (HCMC)Yang Wang, M.D. (Emeritis)E. Kenneth Weir, M.D. (VAMC)Carl White, M.D.Robert Wilson, M.D.Jianyi Zhang, M.D., Ph.D.Associate ProfessorsAlan Bank, M.D.Y.S. Chandrashekhar, M.D. (VAMC)James Daniel, M.D. (ANW)Gladwin Das, M.D.Charles Gornick, M.D. (ANW)Timothy Henry, M.D. (ANW)Alan Hirsch, M.D. (ANW)David Homans, M.D. (PNMC)John Lessor, M.D. (ANW)James Lillehei, M.D., M.S.Michael Mooney, M.D. (ANW)Gordon Pierpont, M.D. (VAMC)Scott Sakaguchi, M.D.Valerie Ulstad, M.D. (HCMC)Dennis Zhu, M.D. (Regions)Assistant ProfessorsSelcuk Adabag, M.D. (VAMC)Adrian Almquist, M.D. (ANW)Woubeshet Ayenew, M.D. (HCMC)Fouad Bachour, M.D. (HCMC)Bradley Bart, M.D. (HCMC)Alan Berger, M.D.Andrew Boyle, M.D.Toni Bransford, M.D.Yingjie Chen, M.D., Ph.D.Monica Colvin-Adams, M.D.Kevin Graham, M.D. (ANW)(Continued on page 41)39
Division of Cardiology40AResearch Highlight: Alan Berger, M.D.Alan Berger, M.D. has recently been awarded a KO8 awardby the NIH for his research on outcomes with AcuteMyocardial Infarction (MI) in the elderly. Berger is a graduateof Georgetown and Yale, and he has a joint appointment in the Schoolof Public Health, Department of Epidemiology. His primary mentor isRussell Luepker, M.D., M.S. His research interests include use of the largeMinnesota Heart Study to examine trends in outcomes with Acute MI inMinnesota. He is also involved in use of intravascular ultrasound to definethe presence and extent of coronary intimal thickening and atherosclerosisin patients with coronary artery disease, including patients who haveundergone heart transplantation. He lectures internationally on thesetopics. In addition, he will be involved with the interpretation of the new64-slice CT scanner, which will become an important method to screenpatients with chest pain or high risk of coronary disease.focus on the use of cell-basedtherapy, including differenttypes of stem cells (bonemarrow-derived as well asskeletal muscle) for cardiacand vascular repair. Thecenter will also be involved inthe development of gene therapywith the cells as the vectorfor gene delivery that mayallow substantial improvementin cardiovascular repairover cells alone.This year, the center willbe initiating a number ofclinical trials in stem celltherapy. The first will be withthe use of autologous bonemarrow mononuclear cells forpatients with acute MI, followedby trials with skeletalmyoblasts and pro-angiogenicendothelial progenitor cellsin patients with heart failurethat undergo elective cardiacsurgery, including insertion ofmechanical assist devices forrefractory heart failure. Use ofcell therapy in patients on theheart transplant list will allowexamination of the heart atexplant to determine percentengraftment and effects ofcell therapy.The center is also investigatinga novel Beta-2 AR agonist,Clenbuterol that induces skeletalmuscle hypertrophy andmay have a direct role in stemcell mobilization in patients
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