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Challenges Food-Waters - Quality Austria

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UPLC Throughput<br />

©2010 <strong>Waters</strong> Corporation<br />

HPLC: Total run time<br />

5.5 min<br />

UPLC: Total run time<br />

1.5 min<br />

XTerra MS C 18<br />

2.1 x 50 mm, 3.5 µm<br />

0.3 mL/min<br />

ACQUITY UPLC BEH C 18<br />

2.1 x 50 mm, 1.7 µm<br />

0.6 mL/min<br />

� Validated assay for risperidone/9-hydroxyrisperidone in human plasma<br />

� 2mM aq. NH 4OAc (pH 9.0) / methanol gradient<br />

� 3x improvement in LOQ<br />

� >3x improvement in run time

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