Objectives

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Vasopressin

Objectives• During this session we will discuss:• Class• Actions• Indications• Contraindications• Dosing/Routes• How supplied• Side effects


• Pituitary hormoneClass:


Actions:• Hormone (ADH).• Activates V1 receptors to cause selectivevasoconstriction to skin, skeletal muscle,intestine, and fat with relatively less constrictionof coronary, cerebral and renal vascular beds.• Also activates V2 receptors to reabsorb H2Ofrom renal tubules.


V1 and V2 Receptors• Specific molecular sites or structures on orin cells that vasopressin's react or to whichthey bind in order to modify the function ofthe cells.


Action• No ß activity so no ↑ in myocardial o2consumption• During CPR: ↑ blood flow (oxygenation) toheart and brain in cardiac arrest


Indications:• Adults: VF/pulseless VT andasystole/PEA; may replace 1 st and 2 nddose of epinephrine• Not yet recommended for peds cardiacarrest.


Dosing/Routes:• 40 units IVP/IO• One time dose• Half life 10-20 minutes


How supplied:• 20 units in 1 ml vial (you will need 2 vialsfor your initial dose)


Contraindications:• Allergy• Responsive pt with a Blood Pressure


Side effects/adverse reactions:• HTN• Tremor, pallor• Sweating• Abd. Cramps, nausea• Ref: MWLCEMS Protocol and 2000 Mosby’s Nursing Drug Reference Book


Case Study• You are treating a Cardiac Arrest patientwho has an IO established and CPR inprogress. Pt is in VF and there is no pulse.You and your team have decided to giveVasopressin. What is the dose you willgive?


Answer• 40 units of Vasopressin• I will need to get 2 vials of Vasopressinsince each vial only has 20 units


• You have continued the resuscitativeefforts and it is now time for another roundof meds. You are going to give how muchmore Vasopressin?

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