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Illinois Poison Center letter on reformulation of infant acetaminophen

Illinois Poison Center letter on reformulation of infant acetaminophen

Illinois Poison Center letter on reformulation of infant acetaminophen

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DATE: November 10, 2011TO:FROM:RE:Health Care Professionalsong>Illinoisong> ong>Poisonong> ong>Centerong>Reformulation of Infant Acetaminophen ProductsThe recent changes to the concentration of brand and generic pediatric acetaminophenproducts have led to several phone calls to the ong>Illinoisong> ong>Poisonong> ong>Centerong> involvingtherapeutic errors and patient or health care provider confusion. These products werepreviously available in a concentration of 80mg per 0.8 ml (500mg per 5ml) in varioussizes. Recently the infant acetaminophen products have been reformulated such thatthey are now equivalent to children's acetaminophen liquid concentrations (160mg/5ml).As the transition between the differing formulation advances, both concentrations ofinfant's acetaminophen products may be intermingled on store shelves. The ong>Illinoisong>ong>Poisonong> ong>Centerong> staff is noticing two types of therapeutic errors with the formulationchange:1) A clinician recommends dosing liquid infant acetaminophen drops based on the80mg/0.8 ml while the parent or caregiver uses the "new" 160mg/5ml concentration--thechild will receive less than a therapeutic dose (under-dose by about 66%).2) A clinician recommends dosing liquid infant acetaminophen drops based on the"new" 160mg/5ml, while the parent or caregiver uses the "old" 80mg/0.8ml formulation--the child is at a risk of acute or chronic overdose of acetaminophen.During this time of product transition we urge all pharmacists, physicians and nurses toensure patients and caregivers carefully check product concentration and closely followdosing instructions either on the package itself or as directed by a health careprofessional. Patients or caregivers should be counseled to consult their primary careprovider or pharmacist if there are any questions or confusion during product purchaseor administration.Should an error occur during administration of any medication, the ong>Illinoisong> ong>Poisonong> ong>Centerong>is available to health care providers and/or the general public for consultation 24 hoursa day, 365 days a year at 1-800-222-1222.Click here to download the chart entitled “Call the ong>Illinoisong> ong>Poisonong> ong>Centerong> for…” whichwill reacquaint you and your professional colleagues with the full spectrum of poisoncenter services we provide. Please feel free to forward it to your colleagues and post ahard copy at all workstations for quick reference. We look forward to a continuedworking relationship with you in the future!


Regards,Arthur Kubic PharmDAnthony Burda BPharm, DABATMichael Wahl MD, FACEPCarol DesLauriers PharmD, DABATwww.illinoispoisoncenter.orgipcblog.org1-800-222-1222

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