Annual Report 2010 - JDRF Canada

Table of ContentsLetter from Leadership . . . . . . . . 1International Research Review. . . . . 2Canadian Clinical Trial Network . . . 10Our Donors . . . . . . . . . . . . 12Our Partners. . . . . . . . . . . 25Our Successes . . . . . . . . . . 27Awareness . . . . . . . . . . . 33Continued Support . . . . . . . . 35Canadian Research Funded in 2010 . 40Financial Review 2010 . . . . . . . 44Directors and Locations 2010 . . . . . 45Front Cover: Meghan, age 7, diagnosed at 6 years of age.Left: Demar, age 10, diagnosed at 6 years of age.The children, adults and families featured in this AnnualReport are all part of the JDRF Canada family.

International Research Review– function. When there were no regulatory T cellsto block them, the natural killer cells began theimmune attack that causes diabetes. The researchsuggests that drugs or therapies targeting thesecells could prevent diabetes or alter its course.nPOD Expands toEuropeJDRFI’s Network forPancreatic Organ Donorswith Diabetes (nPOD)program, a remarkablepharmaceutical companies.success in advancingresearch into the causesof type 1 diabetes, was expanded to Europe. nPOD ►►provides diabetes researchers worldwide with accessto pancreatic and other tissues from organ donors atall stages of diabetes. Researchers use the tissuesin studies that seek to answer key questions aboutthe underlying cause and characteristics of type 1diabetes. By expanding to Europe, nPOD can offerresearchers an additional pool of potential organdonors – including the important but less-studiedgroup with pre-diabetes, a stage of disease prior to ►►insulin-dependence. nPOD expects to be screeningabout 30 per cent of all organ donors in the UnitedStates by the end of 2011 – a key milestone for theprogram, and a huge help for researchers.Beta Cell TherapiesRegeneration PartnershipsJDRFI entered into three new partnerships tospeed the fast-developing field of regeneration,The early-stage research driven by JDRFIhas now attracted the attention of largedemonstrating its leadership in this new and highlypromising pathway of diabetes research. Theearly-stage research driven by JDRFI has nowattracted the attention of large pharmaceuticalcompanies who are committing funds andcapabilities to accelerate drug development forbeta cell regeneration.JDRFI will continueto explore innovativepartnerships and newfunding mechanisms toaddress gaps in type 1diabetes research.A research collaboration with Pfizer,Hadassah Medical Organization and TheHebrew University of Jerusalem to developdrugs that can regenerate insulin-producingcells. The program evaluates Pfizercompounds that promote cell regenerationand builds on unique beta cell regenerationmodels created by JDRFI-funded researchers.A unique agreement with the Genomics Instituteof the Novartis Research Foundation (GNF)to create a drug discovery and developmentplatform for beta cell proliferation, survival, andreprogramming. This is one of the largest andmost comprehensive collaborations in JDRFI’shistory, and marks a major opportunity towork with an experienced and highly regardedscientific partner to quickly translate discoveriesin research into new therapies.►►A collaboration with the Johnson & JohnsonCorporate Office of Science and Technologyto develop drug targets and pathways thatpromote beta cell survival and function. Theprogram funds research at academic andmedical research centres worldwide, creatingan “incubator” to support early-stage studies.By working with a company known for firstclassresearch and significant experience inthe commercialization of products, JDRFI islooking to increase the number of viable drugtargets identified and fundamentally advancethe pace of diabetes research.Pancreas Cells Change into Insulin-Producing Cells (Reprogramming)Researchers at the University of Geneva inSwitzerland showed that pancreas cells that donot normally produce insulin hold the potential tonaturally convert into cells that do.

International Research ReviewIn research in mice, alpha cells in the pancreas– specialized cells that produce glucagon, notinsulin – can spontaneously convert into insulinproducingbeta cells under specific conditions.The study showed the potential of these cells toadapt and produce insulin when needed – in thiscase, when the beta cells that normally produceinsulin were destroyed. The results were the firstto show that beta cell reprogramming can occurspontaneously, without genetic manipulation.Scientists may beable to harness thisconversion potentialto regenerate betacells in people with spontaneously.diabetes. This may beparticularly useful inpeople who have had diabetes for a long timeand have no, or very few, remaining beta cells.The results were the first to show thatbeta cell reprogramming can occurCritical Beta Cell Development GeneIdentifiedScientists identified a gene needed for cells tomature into insulin-producing cells and other celltypes in the pancreas.Researchers from the University of Californiaat San Francisco and McGill University showedthat mice lacking a certain gene were not able tomake insulin-producing cells (or most other cellsin the pancreas). They also found that in people,newborns who had a deficiency of that geneeventually developed diabetes. The researchprovides important new insights into beta celldevelopment. Most importantly, it boosts theprospects for one day being able to generate anabundant, renewable supply of insulin-producingcells to replace those killed off by the immuneattack that causes diabetes.Stress Hormone Linked to Cell GrowthA hormone responsible for the body’s stressresponse was linked to the growth of insulinproducing cells,suggesting new pathwaysto restore beta cells andcure diabetes.When researchers atthe Salk Institute forBiological Studies in California exposed betacells to a stress hormone and high levels ofsugar, the cells began to replicate. The findingsreinforce the potential of regeneration as a curefor diabetes, and provide insights for discoveringnew approaches to treat the disease.Treatment TherapiesTreatment-related research accounted for onethirdof JDRFI’s research funding in FY2010 andincluded programs and projects in our GlucoseControl and Complications Therapies portfolios.JDRFI’s Glucose Control program encompassesresearch designed to produce drugs, devices,and products that can help people with diabetesbetter manage their disease. Glucose Controlresearch is still in its infancy at JDRFI, butover the past five years, JDRFI has sped to theforefront of this area of science, thanks largely toits Artificial Pancreas Project (APP) – a crossfunctionaleffort to speed the development anduse of automated and semi-automated systemsto sense blood sugar and dispense insulin inresponse. In FY2010, JDRFI Glucose Controlresearch totalled an estimated $22 million(U.S.), approximately 90 per cent of which wascommitted to various aspects of the APP.Complications Therapies research includesscience aimed at preventing, slowing, orreversing the major complications of diabetes:eye disease, kidney disease, nerve disease,and cardiovascular disease. JDRFI has beenparticularly focused on eye disease, withseveral major advances in the past year that arebringing new treatments for macular edema and

International Research Reviewretinopathy. In FY2010, JDRFI funded more than$17 million (U.S.), with approximately 40 per centspent on diabetic eye disease.Complications TherapiesFirst New Diabetic Eye Disease Treatment in25 Years – A groundbreaking study identifiedthe first new treatment for people with diabeticeye disease in the last 25 years. The resultsshow it not only stops the progress of eyedisease, but improves vision – a huge step upfrom any other treatment now available. Thestudy, a Phase II clinical trial, showed that thedrug Lucentis, when combined with the currentstandard treatment of laser therapy, not onlyslows the progression of diabetic eye diseasebut can also actually improve vision. Thebreakthrough is the result of JDRFI researchinvestments over manyyears in partnership withJohns Hopkins UniversitySchool of Medicineand Genentech, which participants.licenses Lucentis in theUnited States.Eye Drops for Macular Edema – A clinical trialfound that a topical drug slows the progress ofa severe form of diabetic eye disease calledmacular edema. Because this potential treatmentcan be self-administered, it may also ease theburdens of health care costs and be more readilyused by patients.JDRF’s Artificial Pancreas Project establishedseveral partnerships with key industryDiabetic macular edema is a leading cause ofblindness in adults with diabetes. Last year,researchers at the Wilmer Eye Institute of JohnsHopkins University School of Medicine completed amulticentre clinical trial evaluating mecamylamine,a topical drug developed by JDRFI industry partnerCoMentis Inc. About 40 per cent of the people inthe trial showed significant improvement, includingvision, after using mecamylamine eye drops.Gene Therapy for Nerve Damage – The PhaseIII trial of a gene therapy developed by JDRFIindustry partner Sangamo BioSciences showedthat the therapy reverses and repairs diabeticnerve disease.The trial tested a gene therapy to treat nervedamage in the legs of people with peripheralsensory neuropathy(a common diabeticcomplication thatinvolves small nervefibres in the arms andlegs, often leading toa loss of sensationand motor function). The study showed thatthe drug can help re-grow nerves by promotingthe production of a specific protein linked tonerve growth and function. An increase in theseproteins may protect the nerves and repair nervedamage in people with diabetes. This would bea major improvement, since current treatmentsaddress only the pain associated with neuropathy.Glucose ControlArtificial Pancreas PartnershipsJDRFI’s Artificial Pancreas Project establishedseveral partnerships with key industry participantsto drive the development of a system to enablepeople with type 1 diabetes to achieve tighterblood glucose management, lead healthier lives,and reduce their risk for complications.JDRFI entered into an innovative, non‐exclusivepartnership with Animas Corp. to develop a firstgenerationartificial pancreas, an automatedinsulin delivery system to help people bettercontrol their diabetes. Animas is aJohnson & Johnson company and a leadingpump manufacturer. JDRFI also announced apartnership with BD (Becton, Dickinson andCo.), aimed at developing new insulin deliveryproducts to enhance insulin pumps. Advances inpump technology will not only lead to improvedglucose control but can also be incorporated intoan artificial pancreas. The partnerships were

International Research Reviewdramatic steps on the road to producing a readilyavailable artificial pancreas.Avoiding Overnight Lows – A first-generationartificial pancreas showed that it can safelycontrol the blood sugar of children and teenagerswith diabetes overnight – the most frighteningtime for children, teens, and their parentsbecause of the danger of unrecognized anduntreated low blood sugar.In a landmark study in children and teenagerswith type 1 diabetes, JDRFI researchers at theUniversity of Cambridgeshowed that using afirst-generation artificialpancreas systemovernight lowers therisk of low blood sugaremergencies whileimproving diabetescontrol overall. The system maintained the bloodsugar of the participants in safe and healthyranges throughout the night, even under anumber of differing conditions and situations,such as after they had eaten a particularly largedinner or after they had exercised.Continuous Glucose Monitor (CGM), insulin andglucagon researchers showed that an artificialpancreas system could successfully integratehormones like glucagon – underscoring its potentialto replicate all the functions of the pancreas.Researchers from Boston University andMassachusetts General Hospital showed thatA first-generation artificial pancreas showedthat it can safely control the blood sugarof children and teenagers with diabetesovernight.an artificial pancreas using two hormones –glucagon, as well as insulin – can decrease therisk of low blood sugar emergencies. Glucagonis a naturally occurring hormone that countersinsulin’s action; it raises blood sugar when peopleexperience dangerously low blood glucose levels,or hypoglycaemia. The production of glucagonis impaired in people with type 1 diabetes. Usingan insulin-plus-glucagon version of the artificialpancreas, all study participants achieved nearnormal blood sugar levels for more than 24 hourswithout experiencing hypoglycaemia.CGM Studies ShowBenefits of Regular UseResearchers confirmedthat regular CGM use– six days per weekor more – is the mostimportant factor inachieving better diabetes control; less importantis the age of the person using the monitor orother demographic, clinical, or psychosocialfactors. A second JDRFI study found that peoplewho continued using a CGM were able to sustaingood control long-term while experiencing a lowerrate of hypoglycaemia, a state of dangerouslylow blood sugar that can occur even with tightlymanaged type 1 diabetes.The research underscored the point that CGMs aremore than simply devices of convenience for peoplewith diabetes – they are tools that can substantiallyimprove blood sugar control in people of all ageswhen used regularly, without increasing the risk ofdangerous low blood sugar. The growing evidenceof CGMs’ benefits highlights the need for continuedresearch into a closed-loop artificial pancreas, asystem that uses CGM data to automatically deliverthe right amount of insulin at the right time. •

10Makyla, age 9, diagnosed at 17 months.

Canadian Clinical Trial NetworkThis past year marked a true milestone forJDRF Canada. With the launch of the JDRFCanadian Clinical Trial Network (CCTN),we have embarked upon a groundbreaking,100 per cent made-in-Canada approach toaccelerating the pace of development of newdiabetes treatments and technologies.As you know, Canada holds a unique place in theworld of diabetes. Since 1922, when Banting andBest first discovered insulin, Canadian scientistshave remained at the forefront of research intotype 1 diabetes. This country’s historically strongfocus on basic researchin diabetes, coupled withinvestments made bynon-profits like JDRF, haveresulted in a robust pipelineof diagnostic, preventativeand therapeutic opportunitieswhose potential to foreverchange the face of diabetes is limited only by ourability to test them in human clinical trials.The CCTN, formed through a partnership withthe Government of Canada’s Federal EconomicDevelopment Agency for Southern Ontario(FedDev), aims to break through these barriers.Through a combination of strategic investments inthe infrastructure required to support clinical trialsand by initiating a wide range of high-impact trials,the CCTN will create lasting benefits to familiesliving with diabetes and Canadian researchersalike. For our families, it means access tolate-breaking treatments and technologies byparticipating in clinical trials, and a chance to bedirectly involved in the research process. For ourresearchers, it means fewer delays getting theirresearch into clinical testing and an opportunityto keep their discoveries in Canada.The CCTN is a remarkable endeavour. It is aradical rethink of the way clinical research indiabetes is done in this country – a mix of academiccollaboration, industry partnership and governmentand non-profit cooperation. It is a mammothundertaking. In theyear since the CCTNwas announced,we’ve assembled aremarkable team. Ahighly experiencedteam of doctors,scientists and otherclinical support professionals at the RobartsResearch Institute will oversee the coordinationof the CCTN’s clinical trials; engineers andtechnicians at the University of Waterloo willperform research into advanced diabetes devices;and doctors and nurses from institutions all overSouthern Ontario, including the Hospital for SickChildren (SickKids), Children’s Hospital of EasternOntario, University of Western Ontario, UniversityHealth Network, and many more will carry outthe trials. Through the course of 2011, we will beenrolling individuals to participate in these trialsIt is the seed of an idea that, in the comingyear, JDRF will begin work on expandingnationwide, with the goal of a coast-to-coastresearch network.and hearing more about them as they open upto the public. The dozen projects currently indevelopment cover all of JDRF’s cure therapeuticareas – from testing innovations related to theArtificial Pancreas Project, to new immune-basedtherapies, through to management and treatment ofdiabetes complications, the CCTN will provide manyopportunities for you to directly participate in theresearch process.This initial effort, currently restricted to SouthernOntario, is just the beginning. It is the seed ofan idea that, in the coming year, JDRF will beginwork on expanding nationwide, with the goal of acoast-to-coast research network – a network thatwill change the Canadian research landscapeforever and stand as a testament to the worldclassresearchers in this country and the dreamsof JDRF volunteers, staff and supporters to pushforward to a cure. •

Our Donors12Joel, age 18, diagnosed at 14 years of age.

Boston Pizza Foundation - Cheryl Treliving, BCRaising dough for a cureAt Boston Pizza, they like to say that “doughraising isn’t strictly kept in the kitchen.”Puns aside, you know a company is seriousabout philanthropy when they raise more than$12.1 million for charity. Established in 1990, theBoston Pizza Foundation (BPF) raises funds tocontinually support, enrich and strengthen the livesof families in their communities across Canada.Their goal is to bringhappiness to Canadianfamilies in need, andwherever those Canadianfamilies are is where will find a cure.Boston Pizza wants tobe. “It is at the heart ofwho we are. It is not anaside,” says Cheryl Treliving, Executive Director ofBPF. “We recognize that Boston Pizza would notbe here without the support of our guests, and webelieve companies have a responsibility to give backto the community that made them successful.”JDRF is fortunate to be part of that community, andis one of three national charities supported by BPF.Since 2001, BPF has raised and donated almost$1.4 million to JDRF.The company’s involvement with JDRF initiallybegan because a corporate employee’s young sonwas diagnosed with type 1 diabetes. “Boston Pizzais like a small family. When Mike Cyr’s son wasThe wonderful thing about being involved withJDRF is that we see results, and I believe wediagnosed with type 1 diabetes, [co-owners]Jim Treliving and George Melville wanted tohelp at a personal level,” explains Cheryl. Thatyear, they sponsored their first Walk to CureDiabetes team, and for the past two decadesBoston Pizza has continued to support the Walkthrough corporate teams, sponsorship, and bothcorporate and in-kind donations.The BPF Invitational golf tournament is anotherhugely successfulfundraising event. Hostedby CIBC Wood Gundy atthe prestigious NorthviewGolf and Country Clubin Surrey, BC, thesell-out tournamentraised $440,000 in2010 (donated to JDRF and two other nationalchildren’s charities).Whether sponsoring a team for the Ride forDiabetes Research, buying a table at JDRF’sannual Galas, fundraising with heart-shaped pizzason Valentine’s Day, or supporting franchisees’ localcharitable events, BPF donates 98 per cent of allmoney raised. Boston Pizza covers virtually all oftheir Foundation’s administration and marketingcosts. “We are very proud of that,” says Cheryl. “Itshows our commitment to giving back.”Perhaps the biggest demonstration of thatcommitment was BPF’s additional $1 milliondonation to the ArtificialPancreas Project, nowbringing their totalcontributions to JDRFto over $2 million. BPFwas drawn to theidea of donatingto a particularresearch project.“We want to showour guests andour franchiseesthat the moneyis going tosomethingspecific –something thatwill dramaticallyimprove the livesof people withtype 1 diabetes,”says Cheryl.“This isn’t justresearch forresearch sake,” sheadds. “The wonderfulthing about being involvedwith JDRF is that we seeresults, and I believe wewill find a cure.” •

Brad and Angela Buchanan, BCMotivated by more than hopeFor many years, Brad Buchanan was familiarwith JDRF but, ironically, not with diabetes.In the early 2000s, he worked for Sun-RypeProducts and was responsible for the company’scharitable efforts with the Foundation. But itwasn’t until his 11 month old daughter, Amy, wasdiagnosed with type 1 diabetes in 2004 that Bradtruly came to understand the disease. “You don’tknow the cold, hardreality of what type 1diabetes means untilyou get a call telling youthat your child has it,” in fact.Brad says.JDRF impresses me because they are not justa feel-good charity. They offer hope groundedWith Brad’s volunteer efforts focusing on theTELUS Walk to Cure Diabetes and Angela’s onthe Gala, it is not surprising that a bit of familycompetition has developed. “The Walk likes to givethe Gala a run for its money,” admits Brad. Whiletop fundraising honours have bounced back andforth between the two events in recent years, thecity of Kelowna always shines in its generosity.Per capita, Kelowna donates more to JDRFthan the national average. “Families inKelowna are quitepassionate andget very involved inthe Foundation. Wetake a lot of pride in that,”says Angela.Having been impressed with the business side ofJDRF – “I liked how their message of hope was tiedto a realistic goal” – Brad decided to get involvedpersonally after Amy’s diagnosis. He and his wife,Angela, jumped in with both feet. Brad becameNational Walk Chair, eventually mentoring otherWalk Chairs across the country, and a member ofthe Board of Directors. Angela teamed with a smallgroup to found the first JDRF Gala in Kelowna andeventually became the Gala Chair. With Angela’shelp, the event, which started as a simple wine andcheese party, has grown into a glittering StarlightGala that raised more than $140,000 in 2010.Outreach is also an important part of theBuchanans’ work with JDRF. “Fundraising isimportant, but there is nothing more rewardingthan helping a family make it through their firstyear with diabetes,” says Angela. “Having livedthrough it myself, I know how important it is tohave support and hope.”Hope continues to motivate this family to fundraise,educate and advocate for the Foundation. “JDRFimpresses me because they are not just a feel-goodcharity. They offer hope grounded in fact,” saysBrad. “With millions invested in research, I don’t justhope a cure will happen. It will happen.” •

Frocktail Party - Jessica Oliver, ONDresses for successWhen you are young, single andsuccessful, the big city offers a lot ofexciting opportunities and entertainingdistractions. But when Jessica Oliver foundherself in her late 20s, comfortable in her careerand having recently achieved a personal goal ofrunning a marathon(raising more than$3,000 for JDRF!), shebegan wondering ifthere was a way to getinvolved in fundraisinginstead of just asking forsponsorship. “I was outfor dinner with a group of friends and I asked whatif, instead of talking about boy trouble and fashion,we engaged in something meaningful?”That “something” turned out to be the innovative,phenomenally successful Frocktail Party fundraiserfor JDRF. For the past two years, this chic soiréehas combined competitive shopping with anevening of music and dancing. Young, urbanprofessionals take part in an exciting silent auction,bidding on new and gently used donated frocksfrom some of Canada’s hottest fashion designers.These friends did not have much experiencewith event planning or soliciting major sponsors,but were very determined. “We weren’t goingto take no for an answer,” remembers Jessica.When I think back to what my sister wentthrough when she was little – and still has togo through today – it’s just not fair!“Oddly enough, we didn’t have to. We askedand people said yes. Once we got one dressdonated, more started flooding in. People wereextremely generous.”The team caught a big break when theyapproached Jen Foster, manager of The BurroughsBuilding in Toronto, looking for a venue. Living withtype 1 diabetes herself, Jennot only arranged a freevenue and beer donationsfor the inaugural event,but she also joined theorganizing committee.Frocktail Party tickets soldout in both 2009 and 2010, and raised a total of$56,000 for JDRF. “The events have exceeded allour expectations. We were overwhelmed by theresponse,” says Jessica.The Oliver family has a long history ofsupporting the Foundation. Frocktail’s successis particularly important to Jessica becauseher older sister, Vanessa, has lived with type 1diabetes for more than 25 years. “I can’tremember a time when we weren’t involved withJDRF,” says Jessica, who was only three when sixyear old Vanessa was diagnosed with the disease.One of her earliest and fondest memories is of herfather, Peter, living on a platform at the top of a flagpole for a week to raise funds and awareness fortype 1 diabetes.Jessica hopes thatfundraisers like Frocktail willlead to a cure for type 1diabetes. “When I thinkback to what my sisterwent through when shewas little – and still has togo through today – it’s justnot fair! A cure would meannever having anotherlittle kid having to knowwhat it means to livewith diabetes.”Jessica wouldparticularly like tothank Frocktail’s2010 sponsors:Svedka, Strut Wines,Labatt, Smartwater,SchwarzkopfProfessional, OPINails, FASHION,Depict PR, Oliver& Bonacini, and99 Sudbury. •

JD Sweid Foods - Doug Campbell, ONGiving is part of the corporate cultureWhen a small company is bought out by alarger company, it is easy for the cultureof one to be consumed by the other. Butwhen JD Sweid Foods purchased Elmira Poultry ofWaterloo in 2005, the larger Vancouver-based meatand poultry company not only kept Elmira’s traditionof supporting JDRF, they built on it.Elmira Poultry’s relationship with JDRF began about11 years ago, whenthe Foundation waschosen as the company’spreferred charity becauseseveral employeeshad type 1 diabetes.For many years, thecompany supported ateam in the Walk to Cure Diabetes. In the past,staff changes caused fundraising activities to waneslightly. However, when a new plant manager, DougCampbell, arrived in Waterloo, he took on the jobof re-energizing the charitable campaign.The funds we raise go towards improving thelives of kids with diabetes and their families.JDRF is a great charity because there is a lotof opportunity to find a cure.“Supporting charity is part of the culture of ourbusiness,” says Doug. “It is important that, as ateam, we are involved with organizations like JDRF.We need to feel like we are contributing and givingback to our community.”The TELUS Walk to Cure Diabetes is now thecentrepiece of JD Sweid’s fundraising activities inOntario. In addition to entering a team, the companychallenges other local businesses to form their ownteams and support the Walk with in-kind donations.The Gold Sneaker campaign – where the companychallenges its vendors to purchase $250 GoldSneaker Banners to post at the Walk – has alwaysbeen a major success. In 2010, JD Sweid soldmore than 25 Gold Sneaker Banners. After theWalk, vendors are also invited to a thank you lunch,a great awareness opportunity that has resultedin several new sponsorships for JDRF. Since thecompany’s involvementbegan 11 years ago, theyhave raised more than$130,000 for JDRF.“We’ve had very consistentsupport for the Walk fromour staff. It has become astaple in our annual calendar,” says Doug.Now, JD Sweid’s head office in Vancouver isgetting on the bandwagon. In 2010, their nationalsales manager arranged to purchase tables atJDRF’s Vancouver Gala. Doug hopes to increasefundraising coordination between the Ontario andWest Coast divisions.“Charitable work is a great morale booster. It is anopportunity to do something that isn’t about gettingsomething, it’s about giving back,” says Doug.Working with an organization like JDRF adds tothe pleasure they get from the giving. “The fundswe raise go towardsimproving the lives of kidswith diabetes and theirfamilies. JDRF is a greatcharity because thereis a lot of opportunityto find a cure.” •

Len Kerekanich, ABGiving thanks for what you don’t haveLen Kerekanich’s son does not have type 1diabetes, but he could develop the diseaseone day. Len remembers this fact every timehe hears a JDRF Youth Ambassador talk aboutwhat it is like to live with diabetes.“We still don’t know what triggers a child’sautoimmune system to turn against itselfand shut down theirpancreas’ ability toproduce insulin. It canhit anyone, anytime. Asthe father of a youngson, I look at donatingto JDRF as a proactivestep,” Len says.Len first became involved with the Foundation adecade ago, when a business colleague askedhis company, Rotating Right, to donate to a JDRFfundraising event. Attending a corporate breakfastfor the Walk to Cure Diabetes, Len was movedby the various speakers, and especially by thechildren. “The more I listened to their stories andlearned about JDRF, the more I thought this wouldbe a good cause to support,” he remembers.Participating in that first Walk in 2001, Len carriedhis son on his shoulders. Tyrel is now 14 years oldand taller than his dad, but they still walk side-bysideeach year to raise funds for JDRF. Most ofIt can hit anyone, anytime. As the father of ayoung son, I look at donating to JDRF as aproactive step.Len’s staff join them, motivated in part by theoffer of a paid vacation day for the employeewho raises the most funds.JDRF is a big part of Rotating Right. In additionto sponsoring Foundation events, such as theannual golf tournament and curling bonspiel,the company started its own fundraising golftournament for its customers and suppliers fiveyears ago. “Events like our golf tournamentand the barbecues thatwe hold to kick off theWalk are a great way toeducate people aboutdiabetes and raiseawareness of JDRF,”says Len.Len also supports the Gala every year, donatingand bidding on items for the auction, and buyingtables. He even hosted the company Christmasparty at the Gala one year, buying three tablesand inviting all of his staff.Whether he is organizing or participating in anevent, Len is always motivated by the peoplewho have a direct connection to type 1 diabetes.“It is so heartwarming when young children tellyou what it would mean to them to not live withdiabetes, and how much they appreciate yoursupport,” he says. “My commitment to JDRF isrenewed every time I speak to a family who liveswith diabetes.” •

Maureen Marshall & Jonathan Broer, ONFighting a family legacyMaureen Marshall was just a little girl whenher father, James, died from complicationsof type 1 diabetes at the age of 44.Familiar with the disease, she was able to spotthe classic signs in her children before they wereever diagnosed – Simon at age seven in 2005and Emma at age six in 2010. “Because we knewthe kids were at risk for diabetes, given their geneticbackground, we caughtit very early. Emmadidn’t even have to stayovernight at the hospitalwhen she was diagnosed,” to reality.Maureen says.I don’t want to sit back and wait. I want tobe part of something that will bring a cureGiven the predominant role of type 1 diabetes inthis family’s life, it is not surprising that Maureenand her husband, Jonathan Broer, would be eagerto help find a cure. “I don’t want to sit back and wait.I want to be part of something that will bring a cureto reality,” Maureen says.Jonathan participates in the annual Ride forDiabetes Research as a member of TD’s corporateteam. Last year, he became Chair of the MajorGift Committee. “It seemed a fairly natural fit.Since I work in the financial world, I come acrosscolleagues and clients who have the means to behelpful,” he says.Both Simon and Emma are Youth Ambassadors forthe Foundation. “It is something that they said theywanted to do, that they feltthey needed to,” Maureenexplains. “They can’t givemoney, but talking abouttheir disease is somethingthey can do to supportJDRF to find a cure.”While finding a cure is the family’s “number oneaim,” prevention is also an important goal. Theirmiddle son, 11 year old Benjamin, does not havediabetes, but Maureen and Jonathan recognize thatfamily history puts him at higher risk for the disease.stress would be lifted. When I think about themilestones my children will go through, what awonderful gift it would be to not have diabetes aspart of the equation.” •The family dove into JDRF activities, not onlyparticipating, but also taking leadership roles. Lessthan three months after Simon was diagnosed,the family joined their first TELUS Walk to CureDiabetes, which has now become an annualtradition. In 2006, Maureen became a volunteer onthe Walk committee and she has been Family WalkChair for Toronto for the past two years.Improved treatments – particularly the developmentof an artificial pancreas – are also on their wish list.“When my father was diagnosed with diabetes, hewas handed an early death sentence. That doesn’thave to be the case today, thanks to the incredibleadvances in therapies,” says Maureen.Still, a cure “would mean everything to me,” saysMaureen. “I would feel like this huge burden and

Maarika Paul, QCIf not me, who?In 30 B.C., a Jewish scholar asked, “If I amnot for myself, who will be for me? If I am notfor others, what am I?” Two thousand yearslater, Maarika Paul poses and answers the samequestions: “If I, as the mother of a child with type 1diabetes, do not get involved with JDRF, thenwhy should anyone else? I think everyone has anobligation to give to the community in some way.”Maarika’s way has been to throw herself, heart andsoul, into raising fundsfor diabetes research.Her first fundraising effortcame shortly after her son,Aleksi, was diagnosedwith type 1 diabetes sixyears ago, at the age of12. A colleague at BellCanada, where Maarika was Senior Vice-Presidentof Corporate Services, approached her with theidea of supporting the Ride for Diabetes Research.The inaugural goal was to enter eight teams – theyended up with 40. Last year, 75 teams participated.“Once people tried the Ride and realized how muchfun it is, it was easier to get them involved the nextyear,” she says. “The Ride is about so much morethan just raising funds. It’s about having fun, pureexhilaration and team spirit. When you can conveythat, people want to get involved.”The Ride is about so much more than justraising funds. It’s about having fun, pushingyourself to the limit, pure exhilaration andteam spirit.Since that first year, Maarika has been instrumentalin ensuring the success of the Ride, not just inMontreal, but also in Laval, Quebec City and acrossCanada. She solicited other corporations to joinBell in donating to or participating in the Ride, andas the co-chair of the 2010 Montreal Ride, helpedJDRF increase funds beyond the million dollar markfor the first time.Maarika’s hope is that JDRF will be able to turnthese funds into “the big prize: a cure for type 1diabetes.” In the interim, she is optimistic thatan artificial pancreas willsoon be able to help herson monitor his bloodsugar and manage hisinsulin needs. “Aleksiis like most teens –he doesn’t take careof himself as well ashe should. Wouldn’t it be great if there was asystem that could manage his diabetes for him?”As hopeful as she is for new treatment options,Maarika isn’t about to sit back and just wait fora miracle. “We can’t rely on others to do thework,” she says. “If we all make some smallcontribution – and it doesn’t have to be money, itcan be our time or skill – then those little thingswill make a huge difference.” •

Ryan & Karen Shay, ABInvesting in a cureAs the co-head of investment banking atCormark Securities, Ryan Shay knows agood investment when he sees one. That’swhy, he says, he became a major donor to JDRF.“There are a lot of worthy charitable organizationsout there,” says Ryan. “Our family supports theFoundation because it has one of the lowestadministration ratios of major charities, whichmeans our donations are going to work. JDRFsupports projects aroundthe world, and themoney goes where themost promising researchis being done – actualresearch that will find acure for type 1 diabetes.”As the father of a child with diabetes, Ryan alsosupports JDRF for personal reasons. “Whenour eight year old son, Ian, was diagnosed withdiabetes three years ago, we felt powerless.Volunteering with JDRF has given us a bit ofcontrol back. We feel like we are making adifference.”And what a difference he’s made! In 2009, Ryanand his wife, Karen, donated a Major Gift of$50,000 to the Foundation. In 2010, they set agoal to raise $100,000 for the TELUS Walk toCure Diabetes, promising to match any donationswith personal funds. When Ryan reached out toWhen our eight year old son, Ian, wasdiagnosed with diabetes three years ago, wefelt powerless. Volunteering with JDRF hasgiven us a bit of control back.friends and business associates for support, hesent along information about type 1 diabetesand explained the family’s personal connectionto the disease. “When people understand theeffect diabetes has on kids, it really resonateswith them,” he says. People not only offered theirmoral support, they generously opened up theirpocketbooks as well, helping the Shays surpasstheir fundraising goal.In addition to fundraising for the Walk, the Shayssupport Calgary’sannual Gala and Ryanjoined JDRF’s MajorGifts Committee. “Wehope to build on whatwe’ve been able to raiseand contribute in the yearsto come,” Ryan says.Karen remembers the first anniversary of Ian’sdiagnosis, when she and Ryan reviewed theirson’s record book of blood sugar levels andinsulin injections. “We counted 700 injectionsand 1,600 finger pokes to draw blood in the firstyear. From that point on, we were pretty muchcommitted to finding a cure.”To the Shays, a cure means freedom. “Freedomfor the kids who won’t have to check bloodsugar levels or count carbs or inject insulin.And freedom for the parents who won’t have tomanage the disease 24 hours a day.” •

Keith Skiffington, NSMaking a dream a realityMore than five years ago, Keith Skiffingtongot involved with JDRF for his now 13 yearold stepson, Bradley, who has type 1diabetes. He has stayed involved because of whathe discovered about the Foundation. “I’ve alwaysbeen very active in various charitable groups, butJDRF really impressed me from an organizationalstandpoint. The Foundation is well run and alean organization. The money we raise goes intoresearch, not bureaucracy,” he says.Lean doesn’t begin todescribe operations in2006, the year Keithand his wife, Kim,were Family Chairsfor the Halifax Walk toCure Diabetes. WithJDRF’s Halifax office closed for six months, theSkiffingtons spent evenings and weekends attheir kitchen table, pulling together mailing listsfrom out-of-date spreadsheets.It is a great experience to work with anorganization that is making a difference. Bybeing involved with JDRF, we will be part ofthe cure. That’s very exciting.Undeterred, the couple returned as Family Chairsthe following year, and their team, the Bradinators,was the largest in Halifax, with more than 50participants. Keith became the Walk Chair in 2008,Chapter Chair in 2009 and is now the National WalkFamily Chair. Keith’s company, Office Interiors,is one of the area’s largest sponsors, providingprinting for all JDRF events in Nova Scotia.One of Keith’s most impressive contributionswas the creation of the Dream Team for the2010 Walk. This fundraising idea encouragesbusinesses to form a team and use their contactsto raise funds. “It’s successful because it’s easy,”Keith explains. “All you have to do is lend meyour name and give me access to your contactlist.” Sometimes, it seems, the less you ask for,the more you receive. Not only did Keith’s DreamTeam raise over $23,000, but many key peoplealso joined the Walk and became active in otherways. “It can be hard to solicit businesses to getinvolved. This way, weare ‘back-dooring’ it.We are spreading thenews about JDRF andmore people are gettingactive,” he says. Keithadmits the conceptwasn’t his brainchild, butnow Dream Teams are being rolled out in JDRFChapters across Canada.Volunteering with JDRF is a family affair for theSkiffingtons. Bradley has been a Youth Ambassadorfor two years and last year Keith’s daughter, Halley,led the first Cyclebetes school event in Halifax,raising more than $12,000.“It is a great experience to work with anorganization that is making a difference,” saysKeith. “By being involved with JDRF, we will be partof the cure. That’s very exciting.” •

Myrna & Noah Weiszner, MBDecades of serviceWhen Myrna Weiszner’s daughter, TammyZechoval, was diagnosed with type 1diabetes more than 30 years ago, therewere no glucometers, no insulin pumps, and almostno hope. “I felt panicky that I had a little preschoolerwith this disease, and no one was doing much ofanything to find a cure,” remembers Myrna. Then,one night in 1985, a father-and-son team from theMontreal chapter of JDRF came to Winnipeg to makea small presentation about the Foundation’s work, andMyrna felt uplifted. “Theirwords were like magicto me. I loved the ideathat the Foundation wasfunding research, that theywere going to find out whattype 1 diabetes is about.”That night, the Winnipeg chapter of JDRF wasborn. Myrna joined a handful of people fromthat meeting to host a modest fundraiser – ananniversary party at a couple’s home – anddonated the proceeds to the Foundation. Withguidance from Tannis Richardson they set up anhonourary board of directors, and a few years later,they hosted their first Starry Starry Night Gala.Myrna has been an unfailing supporter of theFoundation’s evolution in Winnipeg. She has beenon the executive committee for many years and haschaired the Gala committee twice. With her husband,I truly believe that with enough resourcesdiabetes can be cured. If society wantssomething badly enough – like putting a manon the moon, they will get it. It is possible.Noah, and their company, Maples Dental Centre, theyare a Gala grand evening sponsor. Each year, theypurchase a grand evening table and then ask theirguests to purchase their tickets, thus doubling thefunds raised. Myrna is also instrumental in giving andprocuring auction prizes, participates in Fund A Cure,and always enters teams for both the TELUS Walk toCure Diabetes and the Ride for Diabetes Research.“Working with JDRF feels good,” Myrna says.“Everyone there is working towards the samegoal. It is beautiful to see.”Myrna is encouragedby the developments indiabetes research thatshe has witnessed overthe years. “Diabetesis a different diseasethan it was when Tammy was diagnosed. Theprogress is unbelievable.”She feels “realistically hopeful” that a curewill be found. “I truly believe that, with enoughresources, diabetes can be cured. If societywants something badly enough – like putting aman on the moon, they will get it. It is possible.”She hopes that JDRF researchers realizehow much people appreciate their efforts. Hermessage to them: don’t ever give up.When the cure is found, adds Noah, “It will be anice feeling to know that we made a difference.” •

Williams Family, ONA small group making a big differenceWhen 11 year old Josh Williams and hismother, Linda Sukk, speak at fundraisingevents for JDRF, the pair often quoteMargaret Mead: “Never doubt that a small group ofthoughtful, committed citizens can change the world;indeed, it’s the only thing that ever has.” For thepast five years, the Williams family has embodiedthis spirit of dedication and activism.The family participatedin their first Walk to CureDiabetes just one monthafter Josh, their middlechild, was diagnosedwith type 1 diabetes atage six. Joining walkersfrom Credit Valley Hospital in Mississauga, theywere “overwhelmed to see so many people andfeel their support.” Later that year, their eldest son,Zach, organized the first of many fundraisers at theboys’ elementary school. While a spokespersonfrom JDRF made a formal presentation aboutdiabetes, Josh sought to educate his youngclassmates about his disease.When you engage the Foundation, you feellike you are doing something. Meeting otherpeople who are passionate about this causemakes you feel uplifted. It gives you hope.The family’s fundraising and community engagementefforts have grown with each passing year. Inaddition to organizing ongoing activities at Joshand little sister Zoe’s elementary school, as well asZach’s high school (including annual Sneaker Daysand Walk teams), Josh’s father, Scott, is currently inhis second term as Peel Region’s Walk Chair andLinda is Family Chair. Josh is also an active YouthAmbassador for JDRF, speaking at a wide variety ofevents. Of all their JDRF activities, the TELUS Walkto Cure Diabetes continues to be their favourite.As much as this family has given to JDRF – andit has been considerable: $33,000 raised in thepast four years – Linda and Scott feel that theyhave received so much in return. “Gettinginvolved with JDRFwas very selfserving.We saw itas a positive outlet,especially for Josh,”says Scott. “When youengage the Foundation,you feel like you aredoing something. Meeting other people who arepassionate about this cause makes you feeluplifted. It gives you hope.”That hope is fuelled by new technologies andresearch. Even in Josh’s short life, he has benefitedfrom technological improvements, such as an insulinpump that automatically shuts off if his blood glucosedrops too low. “The work that JDRF supports ismaking a real difference now in the lives of peoplewith type 1 diabetes,” says Scott.“Each of us can make a difference,” adds Linda.“The harder we work, the closer we get tofinding a cure.” •

Our Partners25Front row: Shanan, age 13, diagnosed at 5 years of age; Ezekiel, age 6, diagnosedat 4½ years of age; Miguel, age 10, diagnosed at 2½ years of age; Joel, age 18,diagnosed at 14 years of age. Second Row: Michael, age 54, diagnosed at 14 yearsof age; Tammy, age 37, diagnosed at 4 years of age.

Our PartnersBagg FamilyFundraisersWhen Alison Bagg was diagnosed withtype 1 diabetes at the age of 10, herentire family made a commitment to raiseresearch dollars to help fund a cure. Fourteen yearslater, the Bagg Family Fundraisers are now knownfor some of the most creative and successful specialevents in and around Kingston, Ontario, and haveraised more than $500,000.In 2010, the Bagg Family Spring Fling Dine andDance celebrated its ninth anniversary, raisingmore than $50,000. The highlight of the eveningincluded an outstanding silent auction featuring workdonated by local artists and artisans. “I have a loyallist of contributors who donate year after year,”says Alison’s mother, Kelly. “It’s a combination ofmy arm-twisting and their generous communitymindednature.”Each year, Cuisine for a Cure – an evening ofwine, women and food – is such a “howling success”that tickets sell out almost instantly. Every memberof Alison’s former Queen’s University hockeyteam attends. “These young women, who startedcoming to the event to support Alison, are now totallycommitted to JDRF as their charity,” says Kelly.With virtually no costs or prep work required, theSwim for a Cure raises about $1,500 each year.The event involves a group of family, friends andneighbours, challenging each other to swim a milearound the Baggs’ cottage.“People ask me how long are we going to do this,”says Kelly. “I tell them: until there is a cure.” •Colliers International became involved withJDRF just six years ago but, each year, thecompany’s support grows and expands.Colliers’ Toronto office initiated the partnershipwith JDRF in 2005, first entering a team for theRide for Diabetes Research. Next, the Vancouveroffice came on board with two teams. Fuelledby a bit of healthy cross-country competition,the Toronto office entered 13 teams in the 2010Ride, but was beat for the third consecutive yearby Vancouver, which entered 20 teams! In 2010alone, Colliers employees nationwide – includingteams in Vancouver, Edmonton, Calgary, Ottawa,Toronto and Halifax – personally raised over$65,000 for diabetes research. In addition,corporately, Colliers donated $25,000 for the2010 Ride. Overall, Colliers has donated over$304,000 to the Foundation.“The more people that get involved, the moreawareness there is, and more people want tojoin in the next year,” says Susan Williams, VicePresident and Managing Director of Colliers RealEstate Management Services. Serving on theVancouver Ride Cabinet, Susan has found thatsome people are initially wary of fundraising, butare ultimately surprised at how easy it turns out tobe. Especially helpful are the Ride kick-off events,when JDRF representatives speak to employeesabout type 1 diabetes and Foundation-fundedresearch. “When the Youth Ambassadors talkabout what it’s like to live with diabetes and theirhope for a cure, the reaction is amazing. Thehuman touch makes all the difference.” •In 2010, TELUS stepped up their efforts tohelp JDRF find a cure for diabetes by renewingtheir three year commitment as title sponsorof the nationwide TELUS Walk to Cure Diabetesuntil 2014.More than 3,750 TELUS team members, friends,families and retirees participated in the 2010Walk, raising over $435,000 for JDRF. But thecompany’s commitment extends far beyond theWalk; overall, TELUS and their team membershave contributed more than $5 million to JDRFthrough various programs, including support forGalas across the country.JDRF is also pleased to announce a newpartnership with TELUS in the creation of anonline health platform. This e-health informationand care system will give Canadians withdiabetes and health care professionals secureaccess to relevant personal health information,as well as a variety of online tools to helppatients take charge of their own health. CalledTELUS health space, the platform will providethe key technology required for making the JDRFCanadian Clinical Trial Network (CCTN) a reality.TELUS’ relationship with JDRF reflects thecompany’s philosophy to “give where we live.”Globally, TELUS was given the 2010 FreemanPhilanthropic Services Award for OutstandingCorporation by the Association of FundraisingProfessionals (AFP), becoming the firstCanadian company to receive this prestigiousinternational recognition. •

Our Successes27Miguel, age 10, diagnosed at 2½ years of age.

TELUS Walk to Cure DiabetesThe TELUS Walk to Cure Diabetes ismore than a fundraising event – it is anannual celebration that brings togethertens of thousands of JDRF’s friends, families,and supporters for an amazing day of fun andoutdoor activities. As JDRF’s largest fundraisingprogram, the Walk is also an incredible opportunityfor families living with type 1 diabetes to enjoy awonderful day connecting with and supportingothers just like them.2010’s success demonstrates the popularityof the TELUS Walk as the event surpassedprevious years in both participation and revenuelevels. More than 48,000 Canadians joined theWalk at over 70 communities across Canada,raising over $7.5 million. We were able to meetour goals thanks to the incredible support andtireless efforts of families and corporate teams,as well as the commitment and generosity of ourcorporate sponsors.Corporate supportJDRF is particularly grateful to TELUS, the Walk’snational title sponsor. More than 3,750 TELUSteam members, friends and family participatedin the 2010 event and raised over $435,000. Thetelecommunications company also expandedtheir commitment to the overall Walk programby providing TELUS employee t-shirts and nylonbags to all Walk locations across the country. Inaddition, free TELUS Gaming Cards featuringthe JDRF logo were handed out to all registeredparticipants at the Walk. Proceeds of all TELUSgaming cards sold in November went to JDRF.We are very pleased that TELUS renewed theircommitment to JDRF as our national title sponsoruntil 2014. To date, TELUS has contributed morethan $5 million, and their support is significant asJDRF continues to accelerate the pace of research.JDRF also values the generous support of nationalsponsors LifeScan and Sun-Rype, who contributedmore than $1 million and $38,000, respectively, andhave donated supplies and participated as Walkteams for several years.Thanks to the incredible support of families andcorporate sponsors, the TELUS Walk to CureDiabetes continues to be JDRF’s largest fundraiser.We look forward to seeing you in 2011! •2010 Top 10 TELUS Walk to Cure DiabetesFamily Teams in CanadaTeam NameTeam ShayJoelle’s GangThe M & J TeamThe Miller’sTeam NickTeam RebeloTeam SamanthaSuper Team NielsRockin’ Ross’Olivia’s TribeCityCalgaryMontrealTorontoCalgaryKelownaMississaugaTorontoTorontoTorontoSaint JohnIn 2010, the Top 10 TELUS Walk to Cure DiabetesFamily Teams in Canada collectively raised over$415,000, an inspiring and impressive achievement!

Ride for Diabetes ResearchIn 2010, the Ride for Diabetes Research programcontinued to thrive and grow. A stationary bike-athon,the Ride requires teams of five to pedal for40 minutes in an energy-filled, inspirational event.The Ride brings corporate Canada together infriendly competition to see who can show the mostspirit and raise the most money. Coming into 2010,we were cautiously optimistic, but with hard workand perseverance, we enjoyed our most successfulyear to date in both revenue and participation.Across Canada, more than 21,000 peopleparticipated in 16 Rides, including two newlocations: Sudbury and Edmonton. TheEdmonton Ride raised an astonishing $130,000– approximately $80,000 over their goal – animpressive achievement for its first year!National Ride CabinetOur 2010 National Ride Cabinet – representedby TD Bank, RBC, Scotiabank, CIBC/INTRIA,National Bank Financial Group, Deloitte and MTSAllstream – continued to play a significant role inincreasing penetration across the country.While financial institutions still lead the way in thenumber of participants and dollars raised, othersectors are gaining momentum. In particular,we are seeing increased participation fromlegal, accounting, real estate, pharmaceutical,insurance, retail and health sectors.JDRF is fortunate in the level of senior managementsupport we enjoy across all sectors involved withthe Ride. Dedicated leadership volunteers, alongwith JDRF staff, form the winning partnership forcontinued success.Micro RidesAn exciting development was the Micro Ridesconcept that Scotiabank began in 2009 in CentralEastern Ontario. In 2010, Scotiabank expandedparticipation to other markets, along with otherfinancial institutions (TD and RBC) and companies.Overall, Micro Ride activity added approximately$175,000 to the Ride campaign.JDRF had set a target of $6.5 million for 2010 –an ambitious increase from the $6 million raisedin 2009. We are happy to confirm that the 2010Ride for Diabetes raised more than $7.1 million– an eight per cent revenue growth over theprevious year! The Ride’s ongoing success isa testament to the hard work of both staff andvolunteers, and proof that our model of grassrootsparticipation continues to draw strong support fromcorporate Canada. •Top 10 Corporate Rides for Diabetes ResearchParticipantsCompany NameTD BankRBCScotiabankNational Bank Financial GroupCIBC / INTRIA Items Inc.DeloitteBell CanadaPricewaterhouseCoopersBMO Financial GroupMacquarie Group FoundationIn 2010, these companies were the top 10 corporateparticipants in terms of dollars pledged. Together, theypledged $4 million toward diabetes research.

GalaIn communities across Canada, thousands ofJDRF supporters come together for an elegantevening to raise funds, connect and celebrate.For many of our volunteers, community partners,donors, sponsors, staff and guests, these Galas arethe social event of the year.JDRF Galas represent a core fundraising programfor the Foundation. In 2010, more than 3,000 peopleattended Galas in eight cities nationwide and raisedan impressive $2.2 million.Each Gala features a different theme. In Kelowna,guests “Celebrated our Successes” with a dazzlingStarlight Gala. Vancouver’s Rockin’ for Researchevent featured a “Night of a Million Wishes” theme.While Calgarians “Rev’d it up for Research” withraffles for champagne and a Harley, Edmontoniansrelaxed and enjoyed their “Denim and Diamonds”theme. At every event, guests enjoy a formal dinner,entertainment and dancing, plus the excitement of alive or silent auction.The Montreal Gala highlighted diabetes researchprogress in the company of guest of honour Mr. LouisVachon, President and Chief Executive Officer ofNational Bank Financial Group. “The 2010 BenefitEvening in Montreal was a magical event! Guestswere invited to come together and celebratebreakthroughs in diabetes research,” said DerekPatterson, Chairman of the Gala Committee inMontreal. “Events like this are important as theynot only raise money for the diabetes community inMontreal, but also help JDRF and everyone touchedby diabetes across Canada. A total of $630,000was raised by the very generous Montreal businesscommunity and families living with type 1 diabetes.It’s my hope that more funds for research will beraised in 2011, and we will find a cure for everyoneaffected by this disease.”The highlight of the evening is always JDRFCanada’s signature auction, Fund-A-Cure. Similar toa live auction, Fund-A-Cure provides guests with theopportunity to donate at the gift level of their choiceand receive a Fund-A-Cure Bear, as well as a taxreceipt for their contribution.We would like to thank the many volunteers andsupporters for their generosity, and for making thesevery special fundraising events possible.Planning and hosting an event of this high calibrerequires tremendous work and dedication. As thedriving force behind the Rockin’ for Research Galafor a dozen years, Vancouver’s Carol Hagan isone of the hardest working and most dedicatedvolunteers JDRF could hope for.Last year, the Gala raised more than $1 million, anastonishing climb from the $75,000 raised in its firstyear. “Twelve years ago, we were the new kid intown and it was a tough sell,” admits Carol. Now,tickets are quickly snapped up for the event, whichincludes a live band and one of the biggest auctionsin the city.The key to the Gala’s success is an organizedapproach, as well as lots of hours put in by a teamof about 15 volunteers. Work on the Novemberevent begins in January. Carol is in the JDRF officethree to five days a week, loving “the opportunity tobe creative and work with amazing people.”Carol’s dedication is motivated by the desire tohelp her 21 year old son and all others affected bytype 1 diabetes. “I’ve seen how many people thisdisease touches. Volunteering with JDRF makesme feel that I’ve made a worthwhile contribution totheir lives.” •

OutreachAdiagnosis of type 1 diabetes can often beconfusing and overwhelming. To supportindividuals and families through all stagesof life with type 1 diabetes, JDRF launched itsOutreach program in 2006. The program providesmeaningful social, emotional and practical supportand information to newly diagnosed children, adultsand their families. It is also a means by which theFoundation connects with families in order to shareinformation about research updates and otherprogress. Since its launch four years ago, Outreachhas grown and is now offered by all JDRF Chaptersacross Canada.Count Me InCount Me In is a very important Outreach initiativethat allows JDRF to build and maintain an accuratedatabase of Canadians living with type 1 diabetes.Currently, there is no system in place to capturethe number of Canadians affected by this disease,which is critical when advocating the governmentfor support. All participants of the Count Me Inprogram receive an Empowerment package, whichincludes information about diabetes research,government advocacy, support, special offers andfundraising opportunities. To date, more than 3,200individuals have registered with the program.Bag of HopeA very special initiative for children newlydiagnosed with type 1 diabetes, the Bag of Hopeis a complimentary kid-sized knapsack filled witha variety of educational and reference materials.Sponsored by Roche (Accu-Chek), the Bag ofHope also includes Rufus or Ruby, the Bearwith Diabetes, a plush friend designed to helpchildren under the age of 12 cope and learnabout insulin injections.Once a family receives a Bag of Hope, they becomepart of JDRF’s Family Network. The local JDRFChapter will pair them with a mentor family toshare information, experience and support. Sinceits Canada-wide launch in 2008, the mentoringprogram has introduced more than 1,200 familiesliving with diabetes to the Network.School Advisory ToolkitRecognizing that parents have special concernswhen sending a child with diabetes to school,JDRF recently formed a partnership withLifeScan Canada to develop a School AdvisoryToolkit. The toolkit will provide information onsuch topics as: Communicating with Schools,Diabetes Basics, Parent-School Relationship,Educate the Educator, and more.Outreach Volunteer NetworkStrengthening the volunteer force behind theOutreach program, JDRF’s recently created NationalOutreach Committee now meets bi-monthly.The Committee, which consists of all VolunteerOutreach Chairs from each region across Canada,provides direction on current Outreach programsand activities, shares best practices and discussesfuture initiatives.Diabetes Research SymposiumsFor the third year in a row, nationaly, JDRFDiabetes Research Symposiums offered familiesan opportunity to learn about the latest diabetesresearch funded by JDRF, hear motivationalspeakers and stay apprised of innovative scientificdiscoveries around diabetes.In 2010, JDRF held symposiums in 15 cities acrossthe country. Topics included diabetic retinopathy,stem cell therapies, the Edmonton Protocol, isletregeneration therapy, and gene delivery to improveislet cell transplantation.We are grateful to our national sponsors Bayer,Eli Lilly, Medtronic and Walmart for their support. •

Government RelationsIn 2009, JDRF and our supporters spoke up –and we were heard! We took our message tothe government and launched an historic newpartnership, continuing the development of severaldynamic initiatives.Canadian Clinical Trial Network (CCTN)In 2010, JDRF undertook the ambitious task ofdeveloping a world-class clinical trial network.Through an innovative partnership with theGovernment of Canada, and supported by$20 million in funding from the federal governmentand an additional $13.9 million from JDRF, theCCTN will set the standard for clinical trialsto speed advances in cures, therapies andtechnologies that will improve the lives of peoplewith type 1 diabetes.Already, the CCTN has announced that theUniversity of Waterloo will serve as the InformaticsCoordinting Centre. Now, clinical trials are beingselected and prioritized. JDRF has committed tolaunching three clinical trials related to the ArtificialPancreas Project.On December 1, 2010, we provided Members ofParliament (MPs) and Senators with an updateon the CCTN at an all-party breakfast meeting onParliament Hill. Funding for the CCTN was theresult of our efforts in lobbying the governmentover the last several years, and we will continueto work with MPs and government officials to buildupon this foundation for future successes.National Grassroots SubcommitteeWe recognize that no one can spread JDRF’smessage better than our volunteers. TheNational Grassroots Subcommittee is comprisedof volunteer advocates who are dedicated toincreasing JDRF’s voice and awareness with MPsacross the country. We already have more than3,265 active advocates across Canada!In 2010, we focused our efforts on identifyingRiding Captains, who are responsible fororganizing and directing JDRF’s grassrootsadvocacy for specific electoral ridings. Whenan “Action Alert” is sent out by JDRF, theRiding Captains will help marshal volunteersto communicate with all 308 MPs to spreadJDRF’s message.One of JDRF’s advocates even helped to spreadour message to outer space! At the requestof thirteen year old JDRF advocate, MyriamPaquin, astronaut Piers Sellers carried the JDRFflag into space on the space shuttle AtlantisSTS-132 in May 2010.Raise Your VoiceRaise Your Voice, JDRF’s writing campaign thatmobilized grassroots advocates across the country,continued in 2010. Families wrote to MPs toexpress thanks for their initial commitment to theCCTN and to encourage continued support.Pre-Budget Consultations 2010On August 13, 2010, JDRF participated in theStanding Committee on Finance Pre-BudgetConsultations in Ottawa. Andrew McKee, Presidentand CEO of JDRF, outlined the importance ofthe federal government continuing to supportthe science and technology industries througha significant and sustained commitment topartnerships between private and public sectorswhich promote cutting-edge research, innovationand commercialization.Our presentation of JDRF’s priorities was wellreceivedby members of the committee. Weare looking forward to other opportunities toengage government officials regarding increasedinvestment for type 1 research. •Hon. Gary Goodyear, Minister of State for Science and Technologyand the Federal Economic Development Agency for SouthernOntario, and Andrew McKee, President & CEO, JDRF Canada.

Awareness33Meghan, age 7, diagnosed at 6 years of age;Makyla, age 9, diagnosed at 17 months;Demar, age 10, diagnosed at 6 years of age;Ashlynn, age 8, diagnosed at 11 months.

Diabetes Awareness MonthNovember is always a high point in JDRF’scalendar, and in 2010, we celebratedNational Diabetes Awareness Month witha variety of exciting initiatives. These events andprograms raise awareness of our organization andsupport of those living with diabetes in Canada.One of our favourite activities is the annual videocontest. For the third year, JDRF invited youthaged 10 and older to submit a video of up to threeminutes in length sharing their personal stories,goals and accomplishments living with type 1diabetes. The top three videos selected by theLeadership Volunteer judging panel were postedonline at www.jdrf.ca, where the general public wereinvited to vote for their favourite. Congratulations toour first place winner, Alanna Nielsen!The theme of the 2010 video contest, “What areyou doing to champion the fight against diabetes?”carried over into JDRF’s social media initiatives.Visitors to the JDRF Diabetes Awareness Monthmicrosite (www.worlddiabetes.ca) were encouragedto share their photos, thoughts and inspirations onour new World Diabetes Day Canada Facebookpage (where they could also watch a video fromAndrew McKee), Twitter, YouTube and Flickr.Through these social media networks, JDRFrecognized and celebrated Diabetes Championsacross Canada. Champions are people touchedby diabetes, including friends and family, diabetesresearchers, healthcare practitioners, volunteers,diabetes educators, advocates, life sciencepartners, community leaders, role models, mentors,and elected officials, just to name a few.At the heart of the month is World Diabetes Day(November 14), a day designated by the UnitedNations to globally recognize and celebrate thoseliving with diabetes. For the third year in a row,JDRF partnered with the Canadian DiabetesAssociation (CDA) and Novo Nordisk for combinedinitiatives in communities throughout Canada.Eli Lilly also joined us in 2010 as a silver sponsor.Once again, buildings and monuments across thecountry were illuminated in blue on World DiabetesDay: the CN Tower in Toronto, Banting Housein London, the Northern Lights Casino in PrinceAlbert, Canada Place in Edmonton, Rogers Arena inVancouver, and many more. All cast a blue glow onthe night sky, commemorating the day and raisingawareness of diabetes.Local groups caught the spirit with their own uniqueblue-themed activities. Ancaster High Schooldeserves special recognition for setting a GuinnessWorld Record by creating the largest Macarenadance in honour of World Diabetes Day. All 1,861participants dressed in blue and dance in a circle,the international symbol for diabetes.Other awareness-raising initiatives included specialsupplements in Reader’s Digest, the Toronto Starand National Post on World Diabetes Day. Inaddition, we released our 2011 JDRF calendar,featuring core programs, outreach, advocacy, thirdpartyevents, profiles of Diabetes Champions, andways to get involved with JDRF. Calendars weredistributed through JDRF Chapters and Walmartpharmacies across Canada.JDRF would like to thank all of our sponsors,supporters, Champions and friends who madeWorld Diabetes Day and Diabetes AwarenessMonth a huge success! •

Continued SupportEzekiel, age 6, diagnosed at 4½ years of age;Miguel, age 10, diagnosed at 2½ years of age.35

Corporate DonorsJDRF wishes to thank the following companies for their outstanding corporate commitment to our mission to find a cure for diabetes and its complications throughthe support of research and/or for contributing products and services throughout the year.• Abbott Laboratories Limited• Aegon/Transamerica Life Canada• AGF Management Ltd.• Alberto-Culver Canada Inc.• AMG Medical Inc.• Armour Transportation• Astral Media• Auto Control Medical Inc.• Bayer HealthCare• BD Medical – Diabetes Care• Bell Canada• Black Press Group• BMO Financial Group• BOB FM• Bosa Development Corp• Boston Pizza Foundation• Calgary Herald• Ched Concept Restaurants and HospitalityServices• CIBC• CTV Ottawa• Colliers International• Corby Distilleries Ltd.• Crew Energy Inc.• CTVglobemedia Montreal• Deloitte.• Diabetes Express• Eli Lilly Canada• Ford Motor Company of Canada Limited• Global BC• Global Toronto• Hyatt Regency Vancouver• Intria• LifeScan Canada (OneTouch)• Loblaw Group of Companies• Longo’s• London Drugs• Macquarie Group Foundation• Medtronic of Canada• Myron Advertising + Design• National Bank Financial Group• Novo Nordisk Canada• Oliver & Bonacini Restaurants• Pfizer Consumer Healthcare• RBC Foundation• Piller’s• PricewaterhouseCoopers Canada• Reader’s Digest• Real Estate Weekly - Edmonton• Roche• Rogers Broadcasting Group• sanofi-aventis Canada Inc.• Scotiabank• Sheraton Ottawa Hotel• Silpada Designs• Sobeys Inc. – Edmonton• Spin Master Ltd.• Sun-Rype Products Ltd.• TD Bank• TELUS• The Barrie Advance• The Georgia Straight• UPS• Vinyl 95.3• Walmart Canada

Major DonorsRight Here, Right NowTransforming Lives Through ResearchJDRF’s Honour RollGift Amount $1,000,000• Marsha and Aubrey Baillie• Bonnie and Terry Jackson• Boston Pizza Foundation• TELUS and its Team MembersGift Amount $500,000 - $999,999• RBC FoundationGift Amount $250,000 – $499,999• CIBC• Cyclebetes• Galen Anderson-Dickie and the late Paul DickieGift Amount $100,000 – $249,999• A.W.B. Charitable Foundation• BMO Financial Group• Katherine and Neil Camarta• Audrey and Alex Davidson• Kim and Peter Enns• Carol and Larry Hagan• Robert Hindle and Family• The Josephson Family• Sheila and Irwin Lancit• Marie and Robert MacRae• Ofra and Steven Menkes• National Bank of Canada• Scotiabank Group of Companies• Karen and Ryan Shay• The Shiff Family• Rhoda and Robert Vineberg• 2 AnonymousGift Amount $50,000 – $99,999• AGF Management Ltd.• Alberta Building Trades Council CharitableFoundation• Armour Transportation Systems/The ArmourFamily• Sandie and Geoff Beattie• Brenda and Simon Benattar• Fondation Martin Brodeur• The Broer/Marshall Family• Janet and Tye Burt• Joanne and Douglas Cohen• CPI Canada• Michael Cruickshank• Deloitte & Touche Foundation Canada• Diabetes Canada Trust• The Economical Insurance Group• Isabel and Wayne Fox• Jason Kelly Classic Golf Tournament• The Leibel Family• Macquarie Group Foundation• The McKee Family• Maureen and Peter Oliver• Brian Randall Charity Golf Classic• Rotating Right Inc.• TD Bank• United Way of Greater Toronto• 3 AnonymousGift Amount $25,000 – $49,999• Abercrombie Foundation• Aegon/Transamerica Life Canada• Alberta Culture and Community Spirit• The Aquilini Family• Bagg Family Fundraisers; Spring Fling; Cuisinefor a Cure; Swim for a Cure• Bell Canada• BMO Mosaik MasterCard Affinity Program• Scott Bolton• The Bridle Bash Foundation• Canada Safeway Limited• Colliers International• Cottonwood Shots for Kids• Mary and Gordon Christopher Foundation• Evening for a Cure• Fifth Avenue Autohaus• Heather and Steve Frishling• Gail and Jimmy Garfinkle• Glenmore Audi• Grant Family Golf Tournament• Claire and Bryan Haynes

Major Donors• Jewish Community Foundation of Montreal• Juvenile Diabetes Golf Classic• Kelowna Golf and Country Club Ladies CharityGolf Tournament• Evelyn and David Kozloff• Karen and Lorn Kutner• Legends of the Game• Shelly and Alan Norris• Annette Oelbaum & Family – In Memory ofRonald Oelbaum• Office Interiors• Lois and Tim O’Neill• Pentian Construction• Regina JDRF Golf Tournament• Royal Oak Audi• sanofi-aventis Canada Inc.• Source Cable• South Centre Fine Cars• United Way of Calgary and Area• TD Securities• Norman Warner• ZLC Foundation Charity Golf Tournament• Dr. Sidney and Debra Zucker•Gift Amount $10,000 – $24,999• All Hockey International Ball Hockey Tournament• Robert C. and Barbara J. Armstrong• Atlantic Province Trucking Association• Avenir Sports Entertainment Ltd.• Mary Ann Azzarello• Barbecues Galore• The Big Give• BMO Employee Charitable Foundation• Flora and Nat Bosa• Lorna Bosher• Brass Hill Investments Limited• J. Edward Brockhouse• Marion and Michael Burnyeat• Canada’s Research-Based PharmaceuticalCompanies• Canadian Jewellers Association• Children’s Books for Charity• Collumbin Family Fund at the TorontoCommunity Foundation• Le Fondation communautaire juive de Montréal• Crown Plaza - Moncton• The Crystal Ball - Windsor• Stacey and Stuart Dalgleish• Kristan and Ashit Dattani• Davies Ward Phillips & Vineberg• Mary Jane Devine and Mike Cyr• Dinner with the Chiefs – Peel Regional Police• Ekota Central Ltd.• Electri-Tech Services Inc.• Father Michael Luchka Memorial Charity GolfTournament - Knights of Columbus• Ron Ferguson• Janis and Kenneth Finkelstein• Margot and Brian Fitzpatrick• Eldon and Anne Foote Foundation at EdmontonCommunity Foundation• The Frocktail Party• Ira Gluskin• Goodmans LLP• Mary and Robert Goodfellow• Grand Chapter of Alberta O.E.S. Foundation• Sandy and Tom Hansen• Haywood Securities Inc.• Lynn and Robert Hewett• Highrise Window Technologies Inc.• Dr. Wayne and Mrs. Rita Hildahl• Hindle and Associates• Prentice Lee and Angela Homer• Milan and Maureen Ilich Foundation• Independent Order of Foresters• Cindy Innes and the late Drew Innes• Jammin’ for JD• JD Sweid Foods• Journeys with Heart – Turquoise Turkey Tour• J. P. Morgan Securities Canada Inc.• Yvonne Kala• Jeffrey Kerbel• Shawn Kimel• Debbie and Danny Kornhauser• Peter Lyall and Teddi Orenstein Lyall• Tamara and Justin MacCormack• Majesta Irving Tissue• Manitoba Building Trades Golf Tournament• Manitoba Mustangs’ Charity Hockey Fund –Garth Lancaster• M. Ann Marshall• Maria and Ralph Matheson• Yolanda Stepien and Dan McLeod• James Morris• Louise and Ian Mummery• The Night to End Diabetes• Protech Chemicals Ltd.• Sharon and Norman Puhl• Jim Rager

Major Donors• Red Deer Central Lions Club• Redbourne Group Holdings Inc.• The Cyril and Dorothy, Joel and Jill ReitmanFamily Foundation• Greta and Peter Reiskind• Suzanne and Larry Ross• In Memory of Raymond H. Rudin• The Sabiston Family• Joey Saputo• Saskatchewan Provincial Building & TradesCouncil Golf Tournament• Irvine Schein Hockey Tournament• Blair Schultz• Jessica and Robert Shelley• Lorne Shiff• Standard Life• Sunlife Financial Services• Sun-Rype Products Ltd.• Tracy Cameron and Roland Susko• Tournament of Triumph – Hamilton PoliceServices• United Association of Plumbers and Pipefitters –Local 213• United Way of Ottawa• Vac Aero International Inc.• Kelly and Billy Vance• Rose and Wim VanderZalm• The Herschel Victor Foundation• Katharine and Tim Wall• Waterloo, Wellington, Dufferin & Grey Building &Construction Trades Council Golf Tournament• Welland Ball Hockey• Dr. Noah & Mrs. Myrna Weiszner• Andrew D. Wilkin• Beatrijs and Bruce Williams• 5 AnonymousThe Beta Society Legacy Gift Honour Roll• Richard Anstett• Marsha and Aubrey Baillie• Succession Fedora Giroux Beaudoin• Estate of Pauline Bergeron-Houle• Estate of John Spencer Bigham• M. Bjegovich• Estate of Beverley Pearl Bridge• Estate of H. Joyce Burtenshaw• Estate of Robert Chisholm• Estate of Ron Courneyea• Estate of Elizabeth Jean Dickson• Estate of Robert John Fischer• Estate of James Geddes• Carol and Larry Hagan• Estate of Marianne Hart• Estate of B.T. Hazelton• Estate of Ernestine Hopkins• Bonnie and Terry Jackson• Estate of Leah Kessler• Beverley Kinshella• Dorothy and Donald Lawless• Estate of Jean Templeton Lindsay• Estate of Lucy Lynn• Estate of Donald Edward McCarthy• Robert McLeish• Paula Mussman• Lorraine Pollock• Tannis and George Richardson• Estate of Theresa Helen Sansom• Estate of Martha Serrels• Estate of Bonnie Sheldon• Louise and Paul Shewfelt• Helaine and Allan Shiff• David Skelly• Estate of Margaret Cunard Smith• Estate of Elizabeth Stewart• Estate of Maureen Swaffer• Estate of Henry William Thomas Tansley• Margaret Taylor• Estate of Betty Ann Marion Vodden• Dr. and Mrs. D. Wright• 13 Anonymous

Canadian Research Funded in 2010Immune TherapiesCarlen, Peter, M.D.Priority Research GrantJuvenile Hypoglycemic Seizures, Consequences,Mechanisms and TreatmentUniversity Health Network, Toronto, ONOsundiji, Mayowa, Ph.D.Postdoctoral Fellowship AwardRole of VMH BAD in HypoglycemiaCounterregulationUniversity of Toronto, Toronto, ONWarnock, Garth, M.D., M.Sc.Characterization of PancreataCharacterization of T-cell Costimulatory Moleculesin Pancreata from IAPCDUniversity of British Columbia, Vancouver, BCBeta Cell TherapiesGaisano, Herbert, M.D.Priority Research GrantControlling Alpha-Cell Glucagon Secretion toOptimze Glycemic ControlUniversity of Toronto, Toronto, ONJohnson, James, Ph.D.Career Development AwardRegulation of the Beta-Cell Life Cycle by InsulinUniversity of British Columbia, Vancouver, BC40Johnson, James, Ph.D.Priority Research GrantRaf-1 in Beta-Cell Survival, Proliferation and InsulinSignalingUniversity of British Columbia, Vancouver, BCJohnson, James, Ph.D.Beta Cell SurvivalComprehensive High Content Screening to PreventBeta-Cell ApoptosisUniversity of British Columbia, Vancouver, BCKieffer, Timothy, Ph.D.Priority Research GrantTargetted Expression of Insulin to IntestinalEndocrine CellsUniversity of British Columbia, Vancouver, BCKieffer, Timothy, Ph.D.ProgenitorTransgenic Pigs with Insulin Producing Gut K-CellsUniversity of British Columbia, Vancouver, BCKorbutt, Greg, Ph.D.BioengineeringBioengineering a Highly Visualized Ectopic Site forIslet TransplantationThe Governors of the University of Alberta,Edmonton, ABLynn, Francis, Ph.D.Advanced Postdoctoral FellowshipThe Role of microRNA in Development of thePancreatic Beta CellUniversity of British Columbia, Vancouver, BCMacDonald, Patrick, Ph.D.Career Development AwardMetabolic and Immunologic Interactions in IsletGraft Function and LossThe Governors of the University of Alberta,Edmonton, ABMojibian, Majid, Ph.D.Postdoctoral Fellowship AwardEvaluation of Immunogenicity of Insulin ProducingGut K-CellsUniversity of British Columbia, Vancouver, BCNostro, Maria Christina, Ph.D.Post-doctoral Fellowship AwardDerivation of Functional Beta Cells from HumanEmbryonic Stem CellsUniversity Health Network, Toronto, ONRudnicki, Michael, Ph.D.Strategic Research AgreementInvestigation of Induction of Pancreas Regenerationby PeriostinUniversity Health Network, Toronto, ONSantamaria, Pere, M.D., Ph.D.Priority Research GrantRegenerative Capacity of the Diabetic NODPancreas upon Diabetes ReversalUniversity of Calgary, Calgary, AB

Canadian Research Funded in 2010Shapiro, James, M.D.Centre GrantIslet Protection, Regeneration and New Sites forImplantationThe Governors of the University of Alberta,Edmonton, ABSurapisitchat, James, Ph.D.Postdoctoral Fellowship AwardDifferentation of Functional Beta Cells from HumanEmbryonic Stem CellsUniversity Health Network, Toronto, ONVan Der Kooy, Derek, Ph.D.Priority Research Grant/Scholar AwardPancreatic Stem CellsUniversity of Toronto, Toronto, ONWarnock, Garth, M.D., M.Sc., F.R.C.P.C.Research Grant AwardImproving Islet Graft Survival by Blocking NegativeCostimulatory PathwaysSt. Michael’s Hospital, Toronto, ONWright, James, M.D., Ph.D.Research Grant AwardTilapia Islet Cell Biology-Characterization forXenotransplantationThe University of Calgary, Calgary, ABZandstra, Peter, Ph.D.BioengineeringEngineering Pancreatic Specifications from HumanPluripotent Stem CellTerrence Donnelly Centre for Cellular andBiomolecular ResearchUniversity of Toronto, Toronto, ONGlucose Control TherapiesAnderson, Colin, Ph.D.Research Grant AwardModulation of Co-Inhibitory Pathways in Toleranceand AutoimmunityThe Governors of the University of Alberta,Edmonton, ABDelovitch, Terry, Ph.D.Innate Immunity GrantNovel Strategies for Innate Immune Modulation ofType 1 DiabetesRobarts Research Institute, London, ONDutz, Jan, M.D., F.R.C.P.C.Mucosal ImmunityIntestinal Barrier Function and TLR Signaling inType 1 DiabetesUniversity of British Columbia, Vancouver, BCDutz, Jan, M.D., F.R.C.P.C.Strategic Research AgreementTreating Diabetes with Topical Calcipotriol-Adjuvanted VaccinationUniversity of British Columbia, Vancouver, BCLabrecque, Nathalie, Ph.D.Immune MemoryDelineating the Role of Memory T Cells inAutoimmune DiabetesHôpital Maisonneuve-Rosemont, Centre deRecherche, Montreal, QCLesage, Sylvie, Ph.D.Immune MemoryElimination of Pathogenic T Cells through a RareRegular T Cell SubsetHôpital Maisonneuve-Rosemont, Centre deRecherche, Montreal, QCMacPherson, Andrew, M.D., Ph.D.Mucosal ImmunityType 1 Diabetes Protection through CommensalIntestinal Bacterial ExposureMcMaster University, Hamilton, ONMontane, Joel, Ph.D.Postdoctoral Fellowship AwardPrevention of Diabetes by T Regulatory CellRecruitment to the IsletMcGill University Health Centre, Montreal Children’sHospital, Montreal, QCPiccirillo, Ciriaco, Ph.D.Priority Research GrantIntegrating Genetics with Markers of ImmuneResponseMcGill University Health Centre, Montreal Children’sHospital, Montreal, QC

Canadian Research Funded in 2010Polychronakos, Constantin, M.D.Priority Research GrantRare but Highly Penetrant Alleles in the Genetics ofType 1 DiabetesMcGill University Health Centre, Montreal Children’sHospital, Montreal, QCPolychronakos, Constantin, M.D.Priority Research GrantMechanisms Involved in Novel Genetic Associationswith Type 1 DiabetesMcGill University Health Centre, Montreal Children’sHospital, Montreal, QCRamanathan, Sheela, Ph.D.Innovative GrantRole of IL-15 in the Pathogenesis of T1D in theNOD MouseUniversité de Sherbrooke, Sherbrooke, QCSantamaria, Pere, M.D., Ph.D.Scholar AwardA Novel Vaccine for the Prevention and Cure ofType 1 DiabetesUniversity of Calgary, Calgary, ABSantamaria, Pere, M.D., Ph.D.Strategic Research AgreementPeptide-MHC-coated Paramagnetic Nanoparticlesas Anti-Diabetogenic VaccinesUniversity of Calgary, Calgary, ABSantamaria, Pere, M.D., Ph.D.Strategic Research AgreementPeptide MHC Class-I Coated Gold Nanoparticles forTreatment of T1D.University Technologies International, Inc., Calgary, ABTan, Rusung, M.D., Ph.D.Priority Research GrantMechanisms of Autoimmune Regulation by NaturalKiller CellsUniversity of British Columbia, Vancouver, BCThebault, Pamela, Ph.D.Postdoctoral Fellowship AwardRole of Memory T Cells in Pathogenesis of Type 1DiabetesHôpital Maisonneuve-Rosemont, Centre deRecherche, Montreal, QCComplications TherapiesBoright, Andrew, Ph.D., M.D.Research Grant AwardGenetic Studies of the SOD1 Locus and DiabeticNephropathyUniversity of Toronto, University Health Network,Toronto, ONCooper, Ellis, Ph.D.Priority Research GrantHyperglycemia-induced ROS Impairs SynapticTransmission in Autonomic GangliaMcGill University, Montreal, QCFernyhough, Paul, Ph.D.Priority Research GrantMechanism of Distal Axonal Degeneration inDiabetic Sensory NeuropathySt. Boniface General Hospital, Winnipeg, MBFernyhough, Paul, Ph.D.Strategic Research AgreementMuscarinic Receptor Antagonists for Treatment ofDiabetic NeuropathySt. Boniface General Hospital, Winnipeg, MBFernyhough, Paul, Ph.D.Strategic Research AgreementHigh Content Screening of Sensory NeuronsSt. Boniface General Hospital, Winnipeg, MBFernyhough, Paul, Ph.D.Strategic Research AgreementDevelopment of Therapeutic Candidates to TreatDiabetic NeuropathySt. Boniface General Hospital, Winnipeg, MBGeraldes, Pedro, Ph.D.Advanced Postdoctoral FellowshipRole of SHP-1 Regulating PDGF and EGF Actionsin Diabetic ComplicationsUniversité de Sherbrooke, Sherbrooke, QCMcBride, Heidi, Ph.D.Strategic Research AgreementInvestigations into the Rise and Fall of ROS in theHyperglycaemic StateUniversity of Calgary, Calgary, AB

Canadian Research Funded in 2010Pacaud, Danièle, M.D.Strategic Research AgreementCorneal Confocal Miscroscopy to Detect DiabeticNeuropathy in ChildrenUniversity of Calgary, Calgary, ABPerkins, Bruce, M.D.Strategic Research AgreementCorneal Nerve Fiber Density as a Biomarker ofEarly NeuropathyUniversity Health Network, Toronto, ONToth, Cory, M.D., F.R.C.P.C.Innovative GrantNFkB and RAGE-Mediated Changes in the Diabetic BrainUniversity of Calgary, Calgary, ABTouyz, Rhian, M.D., Ph.D.Centre GrantTOUYZ: NOX-derived ROS:Renal and VascularComplications of Type 1 DiabetesUniversity of Calgary, Calgary, ABZochodne, Douglas, M.D.Interconnecting and Synergistic PathwaysDiabetic Neuropathy, Neuoronal Insulin and itsInteraction with AGE-RAGEUniversity of Calgary, Calgary, ABPARTNERSHIPJDRF Canadian Clinical Trial Network (CCTN)International Government Grant/TransportfolioLondon, ONDixon, George, Ph.D.Component of International Government GrantEstablishment of the Canadian T1D Clinical TrialNetwork Coordinating CentreUniversity of Waterloo, London, ONCanadian Institutes of Health Research – Canada VPartnership ProgramOttawa, ONKieffer, Timothy, Ph.D.Beta Cell Regeneration for DiabetesRosenberg, Lawrence, Ph.D.Design and Development of an InnovativeBioengineered Process for the Production ofPancreatic Endocrine Tissue for Treatment ofDiabetes MellitusJDRF CLINICAL CENTRE FOR ISLETTRANSPLANTATIONUNIVERSITY OF ALBERTAJames Shapiro, M.D., Ph.D., Centre Director,University of Alberta, Edmonton, AlbertaJeffery Johnson, Ph.D., Co-DirectorJohn Elliott, M.D., Ph.D., Co-DirectorGreg Korbutt, Ph.D., Co-DirectorEdmond Ryan, M.D., Co-DirectorRay Rajotte, Ph.D., Co-DirectorDavid Bigman, M.D., Co-InvestigatorNorman Kneteman, M.D., Co-InvestigatorTo advance outcomes and minimize risk of clinicalislet transplantation, to study impact of successfulislet transplant in control of secondary diabeticcomplications, quality of life and cost-utility benefit,and to optimize recovery of islets to enhancesuccess with single donor islet transplants.

Financial Review 2010Consolidated Balance SheetAs at December 31, 2010AssetsCurrent Assets2010 ($) 2009 ($)Cash 6,047,285 1,705,429Short-term investments 1,062,093 7,786,082Accounts receivable 623,178 512,659Grant Receivable 691,177 —Prepaid expenses and other assets 80,386 186,5818,504,119 10,190,751Capital assets 433,156 521,894LiabilitiesCurrent Liabilities8,937,275 10,712,645Accounts payable, accrued liabilitiesand deferred support 994,190 738,502Deferred leasehold inducement 232,732 235,6141,226,922 974,116Net AssetsUnrestricted 7,624,853 9,653,029Restricted for endowment purposes 85,500 85,5007,710,353 9,738,5298,937,275 10,712,645Research, Education,and Advocacy 47.2%44Functional ExpensesManagement and General 5.5%CCTN Research 38.2%Fundraising 9.1%Consolidated Statement of Public Support, Other Revenues and ExpensesFor the year ended December 31, 20102010 ($) 2009 ($)Public Support RevenuesCampaigns 21,984,877 21,936,455Direct response 119,990 159,04322,104,867 22,095,498Other revenuesInvestment Income 44,416 30,019Unrealized gain on short-term investments 8,645 6,227CCTN grant revenue 5,691,177 —5,744,238 36,24627,849,105 22,131,744Less: Direct expenses (4,516,185) (4,593,992)23,332,920 17,537,752Other expensesResearch support 8,293,663 8,877,987CCTN Research 8,274,710 —Public education and advocacy 3,687,571 3,499,57720,255,944 12,377,564Supporting servicesManagement and general 1,402,324 1,144,088CCTN General 1,386,090 —Fundraising 2,316,738 2,051,3955,105,152 3,195,48325,361,096 15,573,047Surplus (deficit) for the year (2,028,176) 1,964,705Campaigns/Special Events79%Public Support and Other RevenuesDirect Response0.4%CCTN Grant Revenue20.4%Other Revenue0.2%Report of ManagementManagement is responsible for thepreparation of the Foundation’sfinancial statements and otherfinancial information in this report. Thisresponsibility includes maintainingthe integrity and objectivity of thefinancial records. The Foundationmaintains a system of internalcontrols designed to provideassurance that its records includethe transactions of its operations.The financial statements have beenreported on by the Foundation’sauditors, PricewaterhouseCoopersLLP, Chartered Accountants. TheBoard of Directors, through itsFinance Committee, is responsible fordetermining that management fulfillsits responsibilities in the preparation ofthe financial statements, and ensuresthe financial and operational controlsof the Foundation are adequate.The Audit Committee reviews thefinancial statements and meets withthe auditors. The auditors have fulland free access to management, theFinance Committee, and the AuditCommittee in carrying out their work.The data on this page has beenextracted and summarized fromthe audited financial statements.A complete set of financialstatements is available upon requestfrom the Finance department at(647) 789‐2002. Charitable businessnumber 11897 6604 RR0001. •

Directors and Locations 2010Board of Directors andOfficersAubrey Baillie, Chair of the BoardAlex Davidson, TreasurerDr. David Kozloff, SecretaryAndrew McKee, President & CEOMike CyrDarrin DavisSheldon FinkelsteinBryan HaynesMike HopkinsJudy M. HuntJonathan ListerMollie MillerSean MurrayPeter OliverLorne ShiffMatt VareyBruce WilliamsIn memory of Denis Pellerin,Board member 2007 - 2011National Support OfficeJuvenile Diabetes ResearchFoundation Canada2550 Victoria Park Avenue, Suite 800Toronto, ON M2J 5A9Toll Free: 1.877.CURE.533Atlantic RegionHalifax1658 Bedford Hwy. Suite 2055Bedford Place MallBedford, NS B4A 2X9Toll Free: 1.888.439.5373MonctonTel: (506) 852-4415Saint John, NB37 Neck RoadSummerville, NB E5S 1A2Tel: (506) 763-0001St. John’s, NLP.O. Box 76, 8 Track RoadMobile, NL A0A 3A0Tel: (709) 334-3312B.C. & Yukon RegionVancouver6450 Roberts Street, Suite 150Burnaby, BC V5G 4E1Toll Free: 1.877.320.1933VictoriaP.O. Box 37042 RPO Millstream2401 F Millstream RoadVictoria, BC V9B 0E8Tel: (250) 220-5857Kamloops347 West Seymour StreetKamloops, BC V2C 1E8Tel: (250) 374-0599Kelowna2095 Brentwood RoadKelowna, BC V1P 1H2Tel: (250) 765-7711North Central Alberta &NWT RegionEdmonton17321 – 108 Avenue NWEdmonton, AB T5S 1G2Tel: (780) 428-0343North Eastern OntarioRegionOttawa1600 Merivale Road, Suite 206Ottawa, ON K2G 5J8Toll Free: 1.866.796.5373Prairie RegionWinnipeg191 Lombard Avenue, Suite 1101Winnipeg, MB R3B 0X1Tel: (204) 953-4477ReginaP.O. Box 3924Regina, SK S4P 3R8Tel: (306) 543-5451SaskatoonRR4 Site 12 Box 8Prince Albert, SK S6V 5R2Tel: (306) 314-9533Quebec RegionMontreal615 Rene-Levesque Blvd. W.Suite 330Montreal, QC H3B 1P5Toll Free: 1.877.634.2238Southern Alberta RegionCalgary1608-17th Avenue S.W., Suite 204Calgary, AB T2T 0E3Tel: (403) 255-7100South Central OntarioRegionMississauga6620 Kitimat Road, Unit 1AMississauga, ON L5N 2B8Tel: (905) 608-8067Barrie1013 Bayfield Street NorthMidhurst, ON L0L 1X1Toll Free: 1.866.413.5373Hamilton202 – 180 James Street SouthHamilton, ON L8P 4V1Toll Free: 1.866.602.6662South Western OntarioRegionWaterloo684 Belmont Avenue W., Unit 103Kitchener, ON N2M 1N6Tel: (519) 745-2426London309 Commissioners Road, Unit A #2London, ON N6J 1Y4Tel: (519) 641-7006Windsor3347 Randolph AvenueWindsor, ON N9E 3E8Tel: (519) 972-6676Toronto Region2550 Victoria Park Avenue, Suite 800Toronto, ON M2J 5A9Toll Free: 1.877.CURE.53345

Juvenile Diabetes Research Foundation2550 Victoria Park Avenue, Suite 800Toronto, ON M2J 5A91.877.CURE.533 | 647.789.2000www.jdrf.ca