BY Megan Torres

harlemchildrensociety.org
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Bipolar Disorder - Harlem Children Society

BY: Megan Torres

Mentor: Dr.brennan

CO-Mentor: mrs.Mc Mahon

Bronx Community college

g.w.carver


Overview

What is bipolar?

Statistics/Graphs

Risks

Symptoms

Rapid cycling/BP1 BP2

Diagnosis

Bipolar medication

Bipolar treatment

The FAT gene

Future

References

Acknowledgements

Thank you! =]


Bipolar disorder is a mental illness that

consists of quick mood shifts. It is also

known as manic depression because one

moment you can be happy, excited, hyper

and the next angry, frustrated or sad and

depressed. Sometimes bipolar disorder can

be dangerous for the patient as well as the

people surrounding them but only in

extreme cases. It is much more than shifts

between elation and depression.


The reason I am doing this disease is because

I personally know someone with the disease

and I would like to conduct experiments on

it and educate myself and others as much as I

can.


-More than 2/3 rds of people with bipolar have at least

one close relative with bipolar or depressive

disorders.

-2.6% or 5.7million adult(18 and older) Americans are

affected by bipolar disorder

-The median age of onset BP is age 25 but it can

happen at any age

-Almost an equal amount of men and women have BP

(it does not discriminate either)


Euthymic:pertainingtoa

normalmoodwhenyou

areneitherhighlyelated

orhighlydepressed


-Although men and women develop BP equally

women almost 3 times more than men

experience rapid cycling

-Women with BP have more depressive episodes

and more mixed episodes than do men with the

illness

-Bipolar disorder results in about 9 yrs. Reduction

in expected life span and 1 in 5 BP patients

commit suicide

-20% of adolescents with major depression

develop bipolar disorder within 5 yrs. Of the

onset of depression


General Population

1%

2 nd degree relative (aunt/uncle)

3-7%

Sibling

15-25%

Fraternal twin

15-25%

Identical twin

70%

One of your parents

15-30%

Two of your parents

50-75%


1. Unexplained aches and pains: caused by physical

stress, insomnia (sleep deprivation). People with

depression problems or bipolar have more of the

stress hormone cortisol

2. Weight loss or Weight gain: depressed people or

people with mental illnesses tend to not eat because

of appetite or rely on food to comfort them

3. Decreased or Increased appetite: due to medicine they

may be taking or effect on the brain.


4. Psychomotor agitation: an increase in

activity caused by mental tension. This

typically includes pacing, wringing hands,

finger or foot taping which is categorized

by restlessness.

6. Psychomotor retardation: referring to the

slowing of both thought and physical

activities as simple as brushing your teeth

or eating


Rapid cycling

-this describes a person who as four or more mania episodes a

year 10% to 20% of people with bipolar experience this

(a mania episode is a period of abnormally elevated mood that can disrupt

everyday life)

Bipolar 1

-Person with this experience at least I manic episode in their

lifetime

Bipolar 2

-this is similar to BP 1 but their “up” never reaches full on

mania


There are 4 main things doctors check for or go over to

diagnose bipolar disorder.

-A complete medical history and physical exam

-A complete psychiatric history

-Family history of medical and psychiatric history

-Evaluation of current symptoms


Mood stabilizers. These may delay or relieve episodes of mania or depression

They can help people go longer between mood episodes.

Antidepressants. These are often used with a mood stabilizer in people with

depressive episodes. If used alone, antidepressants may increase the chances of a

person with bipolar disorder switching into mania.

Antipsychotics. These are medicines that are mostly used to treat mania. They

may also be used to treat psychosis that can occur during severe episodes of

mania or depression. Patients with severe anxiety or agitation may also receive

antipsychotics. Antipsychotics may be used alone or with other medicines for

treating bipolar disorder.

Other medicines might be suggested by the healthcare provider when a person

with bipolar disorder cannot sleep or feels nervous.

Electroconvulsive therapy (ECT) is not a medicine. It is a medical treatment used

to help people with severe mania or depression. It can also help people who do

not do well with medicine.


To control symptoms of depression and

mania

To reduce number of times mania episodes

happen

To help people with bipolar feel the best

they can

To reduce symptoms that may still be a

problem


The FAT gene is a newly found gene that

scientists believe is a gene that plays a big

role in developing bipolar disorder. The

FAT gene is responsible for a protein

involved in connecting brain cells

together. A team of researchers from

Australia announced their findings on

this gene in January. The gene was

discovered because BP is an organic brain

disorder and was thought to be connected

to a gene, which lead them to

experiments.

"We are the first group in the world to

take a multi-faceted approach to

identify a bipolar risk gene - we used a

number of families, unrelated patients,

and therapeutic drug mouse models.

Each of these three lines of

investigation led us to a gene called

FAT." –Dr. Ian Blaire


.

Chromosome 13

FAT gene is

located on the 13 th

chromosome

position 13q33

Position q33 on chromosome 13


In the future I would like to conduct actual

experiments, such as using mice and

knocking out the FAT gene and observing

the results. I would also like to survey people

with BP and get their views on the disease

and life with the disease.


http://www.bipolar.com/

http://www.nimh.nih.gov/health/topics/bipolar‐disorder/index.shtml

http://www.webmd.com/bipolar‐disorder/guide/bipolar‐disorder‐symptoms‐types

http://mayoclinic.com/health/bipolar‐disorder/DS00356

http://www.ncbi.nlm.nih.gov/gene/79070?

ordinalpos=1&itool=EntrezSystem2.PEntrez.Gene.Gene_ResultsPanel.Gene_RVDocSum

http://www.bipolar.com/treatment_options/medicines.html

http://www.mayoclinic.com/health/electroconvulsive‐therapy/MY00129

^http://linkinghub.elsevier.com/retrieve/pii/S0165032702004627

^http://www.mental‐health‐matters.com/articles/article.php?artID=1176

^http://www.nimh.nih.gov/health/publications/bipolar‐disorder/what‐are‐the‐symptoms‐of‐bipolar‐disorder.shtml

^Kessler,RC;ChiuWT,DemlerO,WaltersEE(2005)."

Prevalence,severity,andcomorbidityoftwelve‐monthDSM‐IVdisordersintheNationalComorbiditySurvey

Replication(NCS‐R)".ArchGenPsychiat6:617–27.PMID15939839.

http://archpsyc.ama‐assn.org/cgi/content/full/62/6/617.

^"BipolarDisorder:Signsandsymptoms".MayoClinic.

http://www.mayoclinic.com/health/bipolardisorder/DS00356/DSECTION=2.

^NIMH∙BipolarDisorder∙CompletePublication

^NIMH∙BipolarDisorder∙CompletePublication

^http://www.pueblo.gsa.gov/cic_text/health/bipolar/bipolar.htm

^"BipolarDisorder:Complications".MayoClinic.

http://www.mayoclinic.com/health/bipolardisorder/DS00356/DSECTION=7.

^BergenM(1999).RidingtheRollerCoaster:LivingwithMoodDisorders.WoodLakePublishingInc..

ISBN9781896836317


I would like to thank.

-Dr. Brennan

-Mrs. McMahon

-Bronx Community College

-Eric Konadu

-Jordan Liz

-Patrick Mahoney

-Dr.Sat

-HCS staff

-Dr. Bondoc

- And all you

for listening!=]

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