PHILADELPHIA SPINE RESEARCH SYMPOSIUM

3:05 p.m. S1.12: Aging Enhances the Degradative Response to Tail Compression and the Compression-induced
Reduction of Wnt Signaling in the Nucleus Pulposus Contributes to Degeneration
N Holguin, Washington University, St. Louis
3:20 p.m. D I S C U S S I O N
3:30 – 4:00 p.m. B R E A K
4:00 p.m. I N T R O D U C T I O N O F T H E P L E N A RY SPEAKER: Jill P. Urban, Oxford University
M Risbud, Thomas Jefferson University, Philadelphia
4:15 p.m. P L E N A RY LEC T U R E : Regulation of Disc Cell Behaviour by the Physico-Chemical Environment
J Urban, Oxford University
5:00 p.m. D I S C U S S I O N
5:20 – 7:30 p.m. W E LCO M E R E C E P T I O N A N D P O S T E R S E S S I O N I
T U E S D AY • N O V E M B E R 10, 2015
SYMPOSIUM 2
7:00 a.m. B R E A K FA S T
BIOMECHANICS, MODELING, AND DISEASE MECHANISMS
Discussion Leader: D Elliott, University of Delaware
7:55 a.m. Introduction
D Elliott, University of Delaware
8:00 a.m. S2.1: Invited Talk: Intervertebral Disc Degeneration: Osmolarity, Inflammation, and Regeneration
K Ito, University of Eindhoven, Netherlands
8:30 a.m. S2.2: Invited Talk: Solving Low Back Pain – If We Can’t Measure It, We Can’t Improve It
J Lotz, University of California, San Francisco
9:00 a.m. S2.3: Biomechanical Effects of Intervertebral Disc Degeneration on Vertebral Body Mineral Density:
A Finite Element Analysis
W Gu, University of Miami, Florida
9:15 a.m. S2.4: Finite Element Model Development and Validation of Healthy Human Lumbar Spines
R Haddas, Texas Tech University, Lubbock, Texas
9:30 a.m. S2.5: In-vivo Characterization of Human Lumbar Intervertebral Discs by Magnetic Resonance
Elastography: Diurnal Changes in Shear Stiffness and Relationship with Degeneration
B Walter, Ohio State University, Columbus
9:45 a.m. D I S C U S S I O N
10:00 a.m. – 10:15 a.m. B R E A K
10:15 a.m. S2.6: Invited Talk: Mechanobiology of the Intervertebral Disc: Characterization of the Tissue-specific
Effects of Whole-body Vibration in a Mouse Model
C Seguin, University of Western Ontario, London, Canada
10:45 a.m. S2.7: Progressive Spinal Kyphosis in Perlecan Deficient Mice
A Parajuli, University of Delaware
11:00 a.m. S2.8: Inflammatory Stimulation Alters Hydraulic Permeability and Compressive Moduli of Nucleus
Pulposus Cells in a Manner Dependent on F-actin Function
T Jacobsen, The Feinstein Institute for Medical Research, New York
11:15 a.m. D I S C U S S I O N
11:30 a.m. B OX E D LU N C H
12:00 p.m. – 2:00 p.m. O P T I O N A L TO U R O F CO N S T I T U T I O N C E N T E R (fee applies)