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038620.full

038620.full

ioRxiv preprint first posted online Feb. 2, 2016; doi: http://dx.doi.org/10.1101/038620. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It is made available under a CC-BY-NC-ND 4.0 International license. Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UKBiobank Jacqueline M. Lane 1, 2, 3 , Irma Vlasac 1,3 , Simon G. Anderson 4 , Simon Kyle 5 , William G. Dixon 6 , David A. Bechtold 7 , Shubhroz Gill 3 , Max A. Little 8 , Annemarie Luik 5 , Andrew Loudon 7 , Richard Emsley 9 , Frank AJL. Scheer 10 , Deborah A. Lawlor 11,12 , Susan Redline 10 , David W. Ray 13 , Martin K. Rutter 13,14* , Richa Saxena 1,2,3,10* * Equal contribution 1 Center for Human Genetic Research Massachusetts General Hospital, Boston, MA, 02114 USA 2 Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114 USA 3 Broad Institute, Cambridge, MA, 02142 USA 4 Cardiovascular Research Group, Institute of Cardiovascular Sciences, The University of Manchester, Manchester, M139PL UK 5 Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX12JD UK 6 Centre for Musculoskeletal Research Institute of Inflammation and Repair, The University of Manchester, Manchester, M139PL UK 7 Faculty of Life Sciences, The University of Manchester, Manchester, M139PL UK 8 Engineering and Applied Science, Aston University, Birmingham, B47ET UK 9 Institute of Population Health, The University of Manchester, Manchester, M139PL UK 10 Division of Sleep and Circadian Disorders, Brigham and Women’s Hospital, and Division of Sleep Medicine, Harvard Medical School, Boston, MA, 02115 USA 11 MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS81TH UK 12 School of Social and Community Medicine, University of Bristol, Bristol, BS81TH UK 13 Centre for Endocrinology and Diabetes, Institute of Human Development, The University of Manchester, Manchester, M139PL UK 14 Manchester Diabetes Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, M139PL UK Corresponding author R. Saxena, Center for Human Genetic Research, Massachusetts General Hospital,

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