OpportunityAnalyzer: Respiratory Syncytial Virus (RSV) - Opportunity Analysis and Forecasts to 2024
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Research <strong>and</strong> Markets Report On <strong><strong>Opportunity</strong>Analyzer</strong>: <strong>Respira<strong>to</strong>ry</strong><br />
<strong>Syncytial</strong> <strong>Virus</strong> (<strong>RSV</strong>) <strong>Opportunity</strong> <strong>Analysis</strong> <strong>and</strong> <strong>Forecasts</strong> <strong>to</strong> <strong>2024</strong><br />
The report analyzes <strong>and</strong> presents an overview of " <strong><strong>Opportunity</strong>Analyzer</strong>: <strong>Respira<strong>to</strong>ry</strong><br />
<strong>Syncytial</strong> <strong>Virus</strong> (<strong>RSV</strong>) <strong>Opportunity</strong> <strong>Analysis</strong> <strong>and</strong> <strong>Forecasts</strong> <strong>to</strong> <strong>2024</strong> ” worldwide.<br />
Human respira<strong>to</strong>ry syncytial virus (<strong>RSV</strong>) is an enveloped, singlestr<strong>and</strong>ed, negativesense<br />
ribonucleic acid (RNA) pneumovirus belonging <strong>to</strong> the family of Paramyxoviridae. The virus<br />
was discovered in 1956, first as an isolate from a labora<strong>to</strong>ry chimpanzee displaying<br />
symp<strong>to</strong>ms of the common cold, <strong>and</strong> later from infants suffering from respira<strong>to</strong>ry disease.<br />
<strong>RSV</strong> can cause upper respira<strong>to</strong>ry tract infections (the common cold) <strong>and</strong> is the most<br />
important cause of lower respira<strong>to</strong>ry tract infections, such as bronchiolitis <strong>and</strong> pneumonia,<br />
in infants. <strong>RSV</strong> is also an important cause of hospitalizations <strong>and</strong> deaths in elderly adults.<br />
Today, Medimmunes Synagis (palivizumab) is the only licensed intervention for the<br />
prevention of <strong>RSV</strong> in infants at a high risk of severe infection. This humanized, mouse<br />
monoclonal antibody (mAb) was first approval in 1998, <strong>and</strong> while it is an efficacious<br />
prophylactic intervention, its short 20day halflife necessitates monthly dosing during the<br />
<strong>RSV</strong> season. Moreover, the high cost of Synagis limits its use <strong>to</strong> certain subgroups of infants<br />
who are at high risk of severe <strong>RSV</strong> infection, <strong>and</strong> it is not indicated for use in elderly adults,<br />
leaving a key population of highrisk individuals unprotected. Furthermore, due <strong>to</strong> the<br />
absence of effective <strong>RSV</strong>specific antivirals, the treatment of <strong>RSV</strong> infections is largely<br />
restricted <strong>to</strong> a number of supportive treatment options. GlobalData projects the global <strong>RSV</strong><br />
marketplace which, for the purposes of this report, comprises the seven major<br />
pharmaceutical markets (7MM; US, France, Germany, Italy, Spain, UK, Japan) <strong>to</strong><br />
experience unprecedented growth from 2014<strong>2024</strong>, driven by the arrival of novel<br />
approaches <strong>to</strong> prevention <strong>and</strong> management of <strong>RSV</strong>.<br />
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Highlights<br />
Key Questions Answered<br />
• Based on interviews with key opinion leaders (KOLs), GlobalData has identified the<br />
major unmet needs in the <strong>RSV</strong> marketplace. Will the leading pipeline agents fulfil<br />
these unmet needs during the forecast period (2014<strong>2024</strong>)?<br />
• What research <strong>and</strong> development (R&D) strategies will companies leverage <strong>to</strong>
compete in the future <strong>RSV</strong> marketplace?<br />
• Which patient population(s) are most likely <strong>to</strong> be targeted by novel <strong>RSV</strong> prophylactic<br />
<strong>and</strong> therapeutic agents?<br />
• What clinical <strong>and</strong> commercial fac<strong>to</strong>rs are likely <strong>to</strong> influence <strong>RSV</strong> product uptake in<br />
the 7MM?<br />
Key Findings<br />
• The global <strong>RSV</strong> marketplace which, for the purposes of this report, encompasses<br />
the sales of products for the prevention or treatment of <strong>RSV</strong> in the 7MM was worth<br />
approximately $640m in 2014. GlobalData projects the market <strong>to</strong> surpass $2.3bn in<br />
sales by <strong>2024</strong>, at a compound annual growth rate (CAGR) of 29.9% from 2014<br />
<strong>2024</strong>. The sales are projected <strong>to</strong> originate predominantly from the US (a 62% market<br />
share), followed distantly by the 5EU (a 29% market share).<br />
• The anticipated arrival of novel prophylactic mAbs that boast improved dosing<br />
criteria compared with Synagis, led by MedImmunes MEDI8897, will be a principal<br />
driver of <strong>RSV</strong> market growth across the 7MM. The licensure of the first adult vaccine<br />
<strong>to</strong> offer protection against <strong>RSV</strong>, Novavaxs <strong>RSV</strong>F Vaccine, will also stimulate rapid<br />
growth in a previously untapped segment of the marketplace.<br />
• A persistent lack of patient <strong>and</strong> physician awareness of <strong>RSV</strong> in adult patients <br />
specifically the infections substantial impact on morbidity <strong>and</strong> mortality in the<br />
elderly will serve as a key impediment <strong>to</strong> market growth from 2014<strong>2024</strong>.<br />
Scope<br />
• Overview of <strong>RSV</strong> infections, including epidemiology, etiology, pathophysiology,<br />
symp<strong>to</strong>ms, diagnosis, <strong>and</strong> current management strategies.<br />
• Topline <strong>RSV</strong> market revenue from 2014<strong>2024</strong>. Annual cost of therapy (ACOT) <strong>and</strong><br />
major pipeline product sales in this forecast period are included.<br />
• Key <strong>to</strong>pics covered include current treatment options, unmet needs <strong>and</strong><br />
opportunities, <strong>and</strong> the drivers <strong>and</strong> barriers affecting <strong>RSV</strong> product sales in the 7MM.<br />
• Pipeline analysis: comprehensive data split across different phases, emerging novel<br />
trends under development, synopses of innovative earlystage projects, <strong>and</strong> detailed<br />
analysis of latestage pipeline products.<br />
• <strong>Analysis</strong> of the current <strong>and</strong> future market competition in the global <strong>RSV</strong> market.<br />
Insightful review of the key industry drivers, restraints <strong>and</strong> challenges. Each trend is<br />
independently researched <strong>to</strong> provide qualitative analysis of its implications.<br />
Reasons <strong>to</strong> buy<br />
The report will enable you <strong>to</strong> <br />
• Develop <strong>and</strong> design your inlicensing <strong>and</strong> outlicensing strategies through a review<br />
of pipeline products <strong>and</strong> technologies, <strong>and</strong> by identifying the companies with the<br />
most robust pipeline.<br />
• Develop business strategies by underst<strong>and</strong>ing the trends shaping <strong>and</strong> driving the<br />
global <strong>RSV</strong> market.<br />
• Drive revenues by underst<strong>and</strong>ing the key trends, innovative products <strong>and</strong><br />
technologies, market segments, <strong>and</strong> companies likely <strong>to</strong> impact the <strong>RSV</strong> market in<br />
the future.
• Formulate effective sales <strong>and</strong> marketing strategies by underst<strong>and</strong>ing the competitive<br />
l<strong>and</strong>scape <strong>and</strong> by analyzing the performance of various competi<strong>to</strong>rs.<br />
• Identify emerging players with potentially strong product portfolios <strong>and</strong> create<br />
effective counterstrategies <strong>to</strong> gain a competitive advantage.<br />
• Organize your sales <strong>and</strong> marketing efforts by identifying the market categories <strong>and</strong><br />
segments that present maximum opportunities for consolidations, investments, <strong>and</strong><br />
strategic partnerships.<br />
Table of Contents<br />
1 Table of Contents 10<br />
1.1 List of Tables 15<br />
1.2 List of Figures 18<br />
2 Introduction 19<br />
2.1 Catalyst 19<br />
2.2 Related Reports 20<br />
2.3 Upcoming Related Reports 21<br />
3 Disease Overview 22<br />
3.1 Etiology <strong>and</strong> Pathophysiology 22<br />
3.1.1 Etiology 22<br />
3.1.2 Pathophysiology 26<br />
3.2 Symp<strong>to</strong>ms <strong>and</strong> Prognosis 28<br />
3.2.1 Symp<strong>to</strong>ms 28<br />
3.2.2 Prognosis 30<br />
3.3 Quality of Life 31<br />
3.4 Disease Management 31<br />
3.4.1 Diagnosis of <strong>RSV</strong> Infection 32<br />
3.4.2 Prevention of <strong>RSV</strong> Infection 34<br />
3.4.3 Treatment of <strong>RSV</strong> Infection 37<br />
4 Epidemiology 40<br />
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