194 MONDAY • MAY 16 P1455 P1456 P1457 P1458 P1459 P1460 P1461 P1462 P1463 P1464 P1465 P1466 P1467 Support Vector Machine Identifies a Set of Metabolites in Plasma that Predict Rapid FEV1 Decline in Humans and Mice/ H. Petersen, J. Sui, S. Plis, Y. Tesfaigzi, Albuquerque, NM, p.A4068 Association of Plasma Levels of sRAGE with 2-Year Radiographic Emphysema Progression/Y. Zhang, J.M. Bon, J.K. Leader, D. Chandra, P. An, Y. Chu, D.O. Wilson, C. Fuhrman, F.C. Sciurba, Pittsburgh, PA, p.A4069 Gender Differences in the Alteration of the Bronchoalveolar Lavage Cell Proteome in Response to Smoking and COPD/M. Yang, M. Kohler, H.K. Garberg, J. Grunewald, R. Karimi, F.S. Berven, M.C. Skold, A.M. Wheelock, Stockholm, Sweden, p.A4070 Endothelial Function and Endothelial-Derived Microparticles After Exercise in Patients with Chronic Obstructive Pulmonary Disease/D. Nieri, T. Neri, L. Malagrina, D. Guarino, S. Santerini, S. Antonelli, C. De Simone, G. De Cusatis, C. Spanu, C. Palombo, B. Vagaggini, A. Celi, P. Paggiaro, Pisa, Italy, p.A4071 Airway Inflammatory Mediator Determinants of COPD Exacerbation Severity and Resolution/R.V. Dy, C. Wrona, T. Murphy, S. Sethi, Buffalo, NY, p.A4072 Genomic Profiling of DNA-Damage Response in Lung Tissue Identifies Clinical Phenotypes of COPD/M. Sauler, J. Tedrow, J. Herazo-Maya, F.C. Sciurba, N. Kaminski, P.J. Lee, J.L. Gomez, New Haven, CT, p.A4073 Age, Sex and Genetic Factors Are Associated with Response to Ipratropium Among Individuals with Mild COPD in the Lung Health Study/M. Obeidat, N. Fishbane, N.N. Hansel, N. Rafaels, R.A. Mathias, I. Ruczinski, T.H. Beaty, K. Barnes, P.D. Pare, D.D. Sin, Vancouver, Canada, p.A4074 Transcriptomic Alterations Associated with Emphysematous Lung Destruction in Centrilobular and Panlobular Emphysema/J.J. Kantrowitz, D. Kinose, D.M. Vasilescu, T.-L. Hackett, C. Stevenson, J.C. Hogg, M. Lenburg, A. Spira, Boston, MA, p.A4075 Proteomics of Laser Capture Micro-Dissected Alveolar Tissue During Lung Development/G. Clair, P. Piehowski, T. Nicola, J.A. Kitzmiller, N. Ambalavanan, J. Carson, R. Corley, C. Ansong, Richland, WA, p.A4076 Enhanced Mass Spectrometry-Based Proteomics Can Be Used to Distinguish Differences in Protein Compositions of Acellular Emphysematous Versus Normal Lungs/F.E. Uhl, B. Zvarova, J.G. Fields, B. Deng, Y.W. Lam, D.J. Weiss, D.E. Wagner, Burlington, VT, p.A4077 Mouse Lung Developmental Gene Expression Profiling Study Identifies Novel Candidate Genes for Pulmonary Function/K. Ganguly, L. George, M. Irmler, A. Mitra, T.A. Thimraj, J. Beckers, S. Upadhyay, H. Schulz, G.D. Leikauf, Chennai, India, p.A4078 The Lung Connectivity Map: Characterizing Lung Specific Responses to Compound Perturbation/S. Corbett, E. Moses, T. Wang, J.D. Campbell, C. Perdomo, X. Lu, T. Natoli, R. Narayan, J. Rosains, A. Subramanian, M.E. Lenberg, A. Spira, Boston, MA, p.A4079 Proteomic Analysis Reveals Significant Epithelial Remodeling After In Vitro Exposure to Diacetyl Vapor/M.W. Foster, W.M. Gwinn, F.L. Kelly, D.M. Brass, J.W. Thompson, M.A. Moseley, D.L. Morgan, S.M. Palmer, Durham, NC, p.A4080 P1468 P1469 B59 SENP1 and Polycythemia: A Human Experiment in Nature at High Altitude/P. Azad, G.G. Haddad, La Jolla, CA, p.A7840 Epigenetic Modifications in Peripheral Blood of Human Infants Born and Raised at High Altitude/S. Krishnan, K. Nephew, M. Ivan, M.R. Martinez, F. Bonilla, C. Cabana, C.J. Llapur, R.S. Tepper, Indianapolis, IN, p.A7841 THEMATIC POSTER SESSION NOVEL GENES AND GENE EFFECTS IN COPD 9:00 a.m. - 4:15 p.m. MOSCONE CENTER Viewing: Posters will be on display for entire session. Area H, Hall D (North Building, Lower Level) Discussion: 11:00-11:45: authors will be present for individual discussion 11:45-12:45: authors will be present for discussion with assigned facilitators P1006 P1007 P1008 P1009 P1010 P1011 P1012 Association of XRCC5 Polymorphisms with COPD and COPD-Related Phenotypes in Han Chinese: A Case-Control Cohort Study/B. Wang, J. Yang, J. Xiao, B. Liang, H. Zhou, X. Ou, Y. Feng, Chengdu, China, p.A4081 Molecular Characterization of Novel Rare Variants of SERPINA1 Gene in Alpha-1 Antitrypsin Deficiency Patients from Spain/B. Martinez-Delgado, N. Matamala, B. Lara, R. Saez, S. Castillo, M. Molina, A. Texido, D. Retana, T. Fernandez, A. Otero, L. Lopez, I. Blanco, Madrid, Spain, p.A4082 Linking the COPD Susceptibility Gene Iron-Responsive Element Binding Protein 2 (IRP2) with Pathological Outcomes in Experimental COPD/S.M. Cloonan, K. Glass, M. Laucho-Contreras, A.R. Bhashyam, M. Cervo, M. Pabon, C. Konrad, F. Polverino, I.I. Siempos, E. Perez, K. Mizumura, M. Ghosh, H. Parameswaran, N. Williams, K.T. Rooney, Z.-H. Chen, M.P. Goldklang, G.-C. Yuan, S. Moore, D.L. DeMeo, T.A. Rouault, J.M. D'Armiento, E. Schon, G. Manfredi, J. Quackenbush, A. Mahmood, E.K. Silverman, C.A. Owen, A.M.K. Choi, New York City, NY, p.A4083 Decreased Histone Deacetylase 2 in Peripheral Blood Monocytes of Patients with Chronic Obstructive Pulmonary Disease/C. Tan, L. Xuan, S. Cao, G. Yu, H. Qi, H. Wang, Beijing, China, p.A4084 Role of R213G Polymorphism in Cigarette Smoke-Induced Acute Lung Injury/R. Gaurav, G.C. Mouradian, B.C. Hartman, J. Varasteh, C. Fratelli, E. Grayck, R.P. Bowler, Denver, CO, p.A4085 Non-Canonical WNT-5A Compromises Endogenous Lung Repair in COPD/H.A. Baarsma, W. Skronska-Wasek, K. Mutze, F. Ciolek, G. John-Schuster, M. Dagouassat, A. Gunther, J. Boczkowski, R. Smits, A.O. Yildirim, M. Konigshoff, Munich, Germany, p.A4086 Reduced Expression of the Epigenetic Regulator HMGN5 Enhances Susceptibility to Emphysema/T.M. Conlon, L. Merthan, V. Gailus-Durner, H. Fuchs, M. Hrabe De Angelis, T. Furusawa, M. Bustin, O. Eickelberg, A.O. Yildirim, Munich, Germany, p.A4087 ATS 2016 • San Francisco
MONDAY • MAY 16 195 P1013 P1014 P1015 P1016 P1017 P1018 Excessive Rac2 Activity in ZZ-Alpha-1 Antitrypsin Deficient Individuals and the Beneficial Effect of Alpha-1 Augmentation Therapy on Aberrant Neutrophil Degranulation/S.A. Landers, F. Gargoum, N. Lacey, M. White, E. Reeves, N.G. McElvaney, Dublin, Ireland, p.A4088 Differential Association of Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphism with Emphysema in HIV-Infected Compared to Uninfected Patients/A. Berical, K.A. McGinnis, L. Yu, C. Zhang, L. Leng, R. Bucala, K.A. Crothers, P.J. Lee, M. Sauler, New Haven, CT, p.A4089 Cytoskeletal and Mitochondrial Genes as New Targets in the Protection of Airway Epithelial Cells Against Cigarette Smoke/C. Kliment, Y. Liu, S. Claypool, R. Sihaye, D. Robinson, Baltimore, MD, p.A4090 Transforming Growth Factor Beta Affects MiRNA Expression in Control and COPD Fibroblasts/J. Ong, W. Timens, V. Rajendran, A. Algra, A. Spira, M. Lenburg, J. Campbell, D.S. Postma, A. Van Den Berg, J.L. Kluiver, C.A. Brandsma, Groningen, Netherlands, p.A4091 miR-199a-5p, miR-598 and miR-320a Are Regulated by NkB and Decreased in Monocytes of ZZ Individuals Receiving Alpha-1 Antitrypsin Augmentation Therapy/T.M. Hassan, T. Carroll, S. O’Neill, N.G. McElvaney, C.M. Greene, Dublin, Ireland, p.A4092 Muc5b Deficiency Worsens Airway Hyperreactivity in Allergen Challenged Mice/C.M. Evans, D. Raclawska, A. Stefanski, B.S. Bochner, W. Janssen, Aurora, CO, p.A7842 THEMATIC POSTER SESSION P1474 P1475 P1476 P1477 P1478 P1479 P1480 Effects of Repeated Carbon Black Nanoparticle Exposures on Healthy and Nitrogen Dioxide Pre-Damaged Mice Lungs/N. Schreiber, E. Kotte, B. Muller, Marburg, Germany, p.A4096 Targeting Sphingosine-1-Phosphate Lyase to Enhance Lung S1P and Reduce Experimental Cigarette Smoke-Induced Chronic Lung Injury and Remodeling/E. Beatman, C. Poirier, K.A. Serban, E. Berdyshev, J. Saliba, M. Justice, T. Ovarecz, D.J. Zambrowicz, K. Schweitzer, I. Petrache, Denver, CO, p.A4097 Cigarette Smoke Induces Human Airway Epithelial Senescence Via Growth Differentiation Factor 15 (GDF15) Production/ Q. Wu, D. Jiang, J.L. Matsuda, K. Ternyak, B. Zhang, H.W. Chu, Denver, CO, p.A4098 The Presence of Serotonin in Cigarette Smoke - A Possible Mechanism in Cigarette Smoke-Induced Airway Inflammation/Y. Cui, W.K.W. Lau, K.W.K. Liu, M.S.M. Ip, J.C.W. Mak, Hong Kong, Hong Kong Prc, p.A4099 Pathophysiologic Implications of E-Cigarette Exposure on Airway Epithelial Ion Transport and Mucociliary Clearance/M.D. Fain, V.Y. Lin, S.V. Raju, L. Tang, C. Fernandez, M. Mazur, J.E. Blalock, P.L. Jackson, S. Rowe, Birmingham, AL, p.A4100 Cigarette Smoke-Induced Downregulation of the Epithelial Cell Enriched WNT Receptor Fzd4 Contributes to Reduced Wnt/b-Catenin Signaling and Alveolar Epithelial Cell Proliferation in COPD/W. Skronska-Wasek, K. Mutze, H.A. Baarsma, D.E. Wagner, M. Stornaiuolo, M. Konigshoff, Munich, Germany, p.A4101 Impact of Tobacco Smoke on Upper Airway Dendritic Cell Accumulation and Their Regulation by Human Sinonasal Epithelial Cells/J.K. Mulligan, B.P. O’Connell, W. Pasquini, R. Mulligan, C. Atkinson, R. Schlosser, Charleston, SC, p.A4102 MONDAY MORNING B60 SMOKING AND PARTICULATES IMPACT ON LUNG HEALTH 9:00 a.m. - 4:15 p.m. MOSCONE CENTER Viewing: Posters will be on display for entire session. Area M, Hall D (North Building, Lower Level) Discussion: 11:00-11:45: authors will be present for individual discussion 11:45-12:45: authors will be present for discussion with assigned facilitators P1471 P1472 P1473 Identification of IGSF3, a Previously Uncharacterized Gene Linked to an Unusually Severe Case of Emphysema that Is Decreased Both In Vivo and In Vitro in Response to Cigarette Smoke/K. Schweitzer, N. Rush, N. Jinawath, R. Yonescu, A. Panoskaltsis-Moratori, C.A. Griffin, D.B. Pearse, I. Petrache, Denver, CO, p.A4093 Total Particulate Matter Concentration Skews the Gene Expression Pattern in Cigarette Smoke-Exposed Mice Towards an Inflammatory Phenotype: A Gene-Expression Study/ G. Vanderstocken, A. Dvorkin-Gheva, A.O. Yildirim, C.-A. Brandsma, M. Obeidat, Y. Bosse, J.A. Hassell, M.R. Stampfli, Hamilton, Canada, p.A4094 Effects of Straw Burning Particulate Matters to Pulmonary Fibrosis Mice Model and the Intervention of NAC/Y. Li, D. Weng, Shanghai, China, p.A4095 P1481 P1482 P1483 P1484 P1485 P1486 Differential and Tissue Specific Autophagic Responses to Cigarette Smoke Exposure/M.A. Pabon, F. Malick, K.C. Ma, K. Mizumura, S. Hisata, H.C. Lam, M. Choi, A.M.K. Choi, S.M. Cloonan, New York, NY, p.A4103 Hexadimethrine Bromide Prevents Acute Mortality in Rats After Inhalation of Sulfur Mustard Analog, 2-Chloroethyl Ethyl Sulfide (CEES)/N. Mariappan, M. Husain, I. Zafar, S. Ahmad, A. Ahmad, Birmingham, AL, p.A4104 Secondhand Smoke Diminishes Airway Epithelial Ion Transport In Vitro and In Vivo and Is Partially Blocked by Antioxidant Therapy/L.W. Rasmussen, H. Fortinberry, S. Byzek, L. Tang, S. Rowe, S.V. Raju, Birmingham, AL, p.A4105 Hydrogen Therapy Attenuates Bronchial Inflammation After Smoke Inhalation Injury in Sheep/B. Enkhataivan, S. Jacob, E. Lopez, S. Fukuda, K. Ihara, H. Hawkins, P. Enkhbaatar, R. Cox, Galveston, TX, p.A4106 Cigarette Smoke Alters the Biomechanical Properties of Airway Eithelial Cells/K. Brune, H. Lam, M. Wang, H.M. Yong, S.S. An, D.N. Robinson, V.K. Sidhaye, Baltimore, MD, p.A4107 Cadmium in the Peripheral Airways of Tobacco Smokers with and Without COPD/B. Levänen, B.-M. Sundblad, J. Ji, K. Midander, A. Julander, K.F. Che, K. Larsson, L. Palmberg, A. Linden, Stockholm, Sweden, p.A4108 ATS 2016 • San Francisco
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American Thoracic Society Internati
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TABLE OF CONTENTS ATS 2016 INTERNAT
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2 FRIDAY • MAY 13 PG2A CLINICAL P
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4 FRIDAY • MAY 13 Target Audience
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6 FRIDAY • MAY 13 11:15 Case Disc
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8 FRIDAY • MAY 13 Chairing: H.B.
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10 FRIDAY • MAY 13 10:25 Advanced
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12 FRIDAY • MAY 13 Objectives At
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14 SATURDAY • MAY 14 Abdominal Ul
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16 SATURDAY • MAY 14 PG17 BASIC
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18 SATURDAY • MAY 14 1:05 In What
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20 SATURDAY • MAY 14 10:30 Practi
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22 SATURDAY • MAY 14 Objectives A
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24 SATURDAY • MAY 14 10:10 Is My
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26 SUNDAY • MAY 15 Chairing: D.M.
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28 SUNDAY • MAY 15 Chronic Cough:
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30 SUNDAY • MAY 15 • understand
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32 SUNDAY • MAY 15 Target Audienc
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34 SUNDAY • MAY 15 Oral Presentat
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36 SUNDAY • MAY 15 9:15 Hyperpola
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38 SUNDAY • MAY 15 310 A Smartpho
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40 SUNDAY • MAY 15 103 Immunosupp
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42 SUNDAY • MAY 15 A26 POSTER DIS
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44 SUNDAY • MAY 15 822 Incidence
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46 SUNDAY • MAY 15 519 Maternal H
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48 SUNDAY • MAY 15 P14 P15 P16 P1
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50 SUNDAY • MAY 15 P1545 P1546 Fa
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52 SUNDAY • MAY 15 P60 P61 Facili
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54 SUNDAY • MAY 15 P149 P150 Faci
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56 SUNDAY • MAY 15 P749 P750 P751
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58 SUNDAY • MAY 15 Facilitator: P
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62 SUNDAY • MAY 15 P1295 P1296 P1
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66 SUNDAY • MAY 15 P91 Facilitato
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74 SUNDAY • MAY 15 Facilitators:
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76 SUNDAY • MAY 15 P997 P998 P999
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82 SUNDAY • MAY 15 P824 Facilitat
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86 SUNDAY • MAY 15 P1101 P1102 P1
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88 SUNDAY • MAY 15 P1423 P1424 P1
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96 SUNDAY • MAY 15 P450 P451 A74
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98 SUNDAY • MAY 15 P1562 P1563 P1
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100 SUNDAY • MAY 15 A80-A THEMATI
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102 SUNDAY • MAY 15 Facilitator:
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104 SUNDAY • MAY 15 11:00 a.m.-12
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106 SUNDAY • MAY 15 L1 U.S. FOOD
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108 SUNDAY • MAY 15 12:15 Post-Pr
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110 SUNDAY • MAY 15 MP406 MP407 M
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112 SUNDAY • MAY 15 clinician and
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114 SUNDAY • MAY 15 A86 BASIC •
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116 SUNDAY • MAY 15 Chairing: M.J
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118 SUNDAY • MAY 15 3:30 High Pre
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120 SUNDAY • MAY 15 102 Toll-Like
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122 SUNDAY • MAY 15 A103 POSTER D
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124 SUNDAY • MAY 15 719 Lactate R
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126 SUNDAY • MAY 15 1014 Determin
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128 SUNDAY • MAY 15 611 Plasma Mi
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130 SUNDAY • MAY 15 412 Daytime S
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132 SUNDAY • MAY 15 6:30 p.m. - 8
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134 MONDAY • MAY 16 SS111 SS112 S
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136 MONDAY • MAY 16 Target Audien
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138 MONDAY • MAY 16 9:40 Empoweri
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140 MONDAY • MAY 16 9:28 Endotoxi
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142 MONDAY • MAY 16 10:15 Adaptiv
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244 TUESDAY • MAY 17 C18 MINI SYM
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246 TUESDAY • MAY 17 415 Investig
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248 TUESDAY • MAY 17 207 Survival
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250 TUESDAY • MAY 17 906 Phenotyp
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252 TUESDAY • MAY 17 807 The Vali
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254 TUESDAY • MAY 17 515 Roles of
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256 TUESDAY • MAY 17 P383 P384 P3
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258 TUESDAY • MAY 17 Facilitator:
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260 TUESDAY • MAY 17 P199 P200 P2
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274 TUESDAY • MAY 17 P727 P728 P7
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276 TUESDAY • MAY 17 P774 P775 Fa
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278 TUESDAY • MAY 17 C53 THEMATIC
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280 TUESDAY • MAY 17 C55 THEMATIC
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282 TUESDAY • MAY 17 P1095 P1096
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288 TUESDAY • MAY 17 P546 P547 P5
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294 TUESDAY • MAY 17 P659 P660 P6
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298 TUESDAY • MAY 17 C70 THEMATIC
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302 TUESDAY • MAY 17 P928 P929 P9
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304 TUESDAY • MAY 17 P973 P974 Fa
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306 TUESDAY • MAY 17 Facilitator:
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308 TUESDAY • MAY 17 C80 THEMATIC
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310 TUESDAY • MAY 17 P98 P99 P100
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312 TUESDAY • MAY 17 • become a
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314 TUESDAY • MAY 17 The topics a
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316 TUESDAY • MAY 17 C85 BASIC
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318 TUESDAY • MAY 17 C89 BASIC
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320 TUESDAY • MAY 17 3:20 Pediatr
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322 TUESDAY • MAY 17 2:45 Long-Te
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324 TUESDAY • MAY 17 918 Sarcoido
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326 TUESDAY • MAY 17 410 Effectiv
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328 TUESDAY • MAY 17 710 Follista
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330 TUESDAY • MAY 17 509 A Mechan
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332 TUESDAY • MAY 17 806 Upper Ai
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334 WEDNESDAY • MAY 18 6:45 Acute
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336 WEDNESDAY • MAY 18 CLINICAL Y
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338 WEDNESDAY • MAY 18 Objectives
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340 WEDNESDAY • MAY 18 D9 BASIC
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342 WEDNESDAY • MAY 18 Oral Prese
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344 WEDNESDAY • MAY 18 10:15 Plas
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346 WEDNESDAY • MAY 18 419 A Nove
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348 WEDNESDAY • MAY 18 216 Simpli
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350 WEDNESDAY • MAY 18 815 Multip
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352 WEDNESDAY • MAY 18 D28 POSTER
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354 WEDNESDAY • MAY 18 720 Repeat
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356 WEDNESDAY • MAY 18 P389 Facil
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358 WEDNESDAY • MAY 18 P439 P440
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360 WEDNESDAY • MAY 18 P10 P11 P1
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362 WEDNESDAY • MAY 18 P52 P53 Fa
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364 WEDNESDAY • MAY 18 P95 P96 P9
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366 WEDNESDAY • MAY 18 P698 P699
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368 WEDNESDAY • MAY 18 D42 THEMAT
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370 WEDNESDAY • MAY 18 P748 Funge
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372 WEDNESDAY • MAY 18 P353 P354
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374 WEDNESDAY • MAY 18 P172 P173
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376 WEDNESDAY • MAY 18 P808 Facil
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378 WEDNESDAY • MAY 18 P526 P527
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380 WEDNESDAY • MAY 18 P579 P580
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