Final Program

MONDAY • MAY 16 207
L15
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE,
DIVISION OF LUNG DISEASES, NIH
ENDOTYPES AND PHENOTYPES: A BASIS FOR
PRECISION-BASED MEDICINE IN COPD, THE
SUBPOPULATIONS AND INTERMEDIATE OUTCOME
MEASURES IN COPD STUDY (SPIROMICS)
12:15 p.m. - 1:15 p.m. MOSCONE CENTER
Target Audience
Those with clinical or research responsibilities.
Room 2006/2008 (West Building, Level 2)
Objectives
At the conclusion of this session, the participant will be able to:
• understand and learn about imaging phenotyping of COPD;
• learn about molecular phenotyping of COPD;
• learn about clinical pheontyping of COPD.
SPIROMICS is an NHLBI sponsored study that supports the prospective
collection and analysis of phenotypic, biomarker, genetic, genomic, and clinical
data from subjects with COPD for the purpose of identifying subpopulations and
intermediate outcome measures. Participants in this session will learn about
new results from the SPIROMICS study that define new clinical subpopulations
related to COPD, clinically relevant endotypes that affect risk, and potential
intermediate markers that predict disease progression. The session will also
provide information for early stage investigators and the investigative
community on how to get involved with the study and access data.
Chairing: R.G. Barr, MD, DrPH, New York, NY
L. Postow, PhD, Bethesda, MD
12:15 Overview of SPIROMICS Design
R.G. Barr, MD, DrPH, New York, NY
12:25 Signficance of Large and Small Airway Phenotypes
M.K. Han, MD, MS, Ann Arbor, MI
12:40 Identifying COPD Subpopulations Based on Symptoms and
Molecular Signatures
P.G. Woodruff, MD, MPH, San Francisco, CA
12:55 SPIROMICS Imaging Phenotyping
E.A. Hoffman, PhD, Iowa City, IA
1:05 Identified Subpopulations Based on Unbiased Clustering
E. Bleecker, MD, Winston-Salem, NC
L16
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE,
DIVISION OF LUNG DISEASES, NIH
VIRUSES AND BACTERIA IN ASTHMA ACROSS THE
AGES
12:15 p.m. - 1:15 p.m. MOSCONE CENTER
Room 2002/2004 (West Building, Level 2)
Target Audience
Providers of lung health, medical fellows in training, graduate, post-doctoral
fellows and established scientists in basic research on lung biology, and
infectious disease.
Objectives
At the conclusion of this session, the participant will be able to:
• understand and learn new findings about the impact of nasal bacteria and
viruses on respiratory illness severity and response to azithromycin therapy
in preschool children with recurrent severe episodes of lower respiratory
tract symptoms;
• gain knowledge about differences in the bronchial bacterial microbiome in
patients with allergies and asthma and characterize modifications in the
microbiome associated with the use of inhaled corticosteroids in adults with
asthma;
• describe how treatment with inhaled corticosteroids alters the bronchial
virome in adults with asthma.
This session highlights findings from two AsthmaNet studies that investigated
effects of inhaled corticosteroids (ICS) on bacterial microbiome and virome in
adults and effects of the virome on respiratory illness severity and response to
azithromycin therapy in children. Findings elucidate how two components of the
microbiome - bacterial and viral - are impacted by treatment and how viruses
influence severity of respiratory illness and treatment response. Management
insights might emerge during the panel-audience discussion, e.g., composition
of the baseline airway bacterial microbiome may shape the response to viral
respiratory infection,as frequently one of the treatments prescribed is an ICS.
Chairing: W.W. Busse, MD, Madison, WI
J.P. Kiley, PhD, Bethesda, MD
12:15 Viral and Bacterial Determinants of Illness Severity and
Response to Azithromycin Therapy in Preschool Children
D.J. Jackson, MD, Madison, WI
12:30 Bronchial Bacterial Microbiome: Relationships to Allergy,
Asthma, and Inhaled Corticosteroid Treatment
Y.J. Huang, MD, Ann Arbor, MI
12:45 Bronchial Virome: Effects of Inhaled Corticosteroid Treatment
in Adults with Asthma
A. Shifren, MD, St. Louis, MO
1:00 General Discussion
W.W. Busse, MD, Madison, WI
L17
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE,
DIVISION OF LUNG DISEASES, NIH
EDUCATION RESEARCH IN SLEEP HEALTH AND
SLEEP-CIRCADIAN BIOLOGY
12:15 p.m. - 1:15 p.m. MOSCONE CENTER
Room 2016/2018 (West Building, Level 2)
Target Audience
Health care providers, researchers, educators, and public stakeholders
interested in innovative education tools, programs and platforms that will
transfer health information and scientific advances in sleep and circadian
biology to medical education, health care, and community-based settings.
MONDAY MID-DAY
ATS 2016 • San Francisco