Final Program

MONDAY • MAY 16 227
907 The Middle East Respiratory Syndrome Coronavirus
(MERS-CoV) Exhibits Bilateral Entry and Exclusively Apical
Egress in Well-Differentiated Human Airway Epithelial Cells/K.
Li, C.L. Wohlford-Lenane, P.B. McCray, Iowa City, IA, p.A4457
908 Mouse Models to Study Middle East Respiratory Syndrome
Disease Pathogenesis and Treatment/C.L. Wohlford-Lenane, K. Li,
D.K. Meyerholz, S. Perlman, P.B. McCray, Iowa City, IA, p.A4458
909 RIPK3 Regulates Type I IFN Mediated Immunity to Pulmonary
Influenza A Virus Infection/J. Downey, E. Pernet, F. Coulombe,
B. Allard, J. Jaworska, S. Qureshi, J.G. Martin, P. Joubert, M.
Divangahi, Montreal, Canada, p.A4459
910 Influenza A Infection Is Exacerbated in a Mouse Model of
Lung-Specific Transforming Growth Factor-A?
Over-Expression/B.J. Thomas, K. Kan-o, M. Tate, A. Mansell, J.A.
Elias, P.G. Bardin, Clayton, Australia, p.A4460
911 Severity of Type II Cell Depletion Influences the Recruitment of
Krt5+ Epithelial Cells Following Influenza A Virus Infection/M.
Yee, W. Domm, R.M. Kottmann, P.J. Sime, M. O’Reilly, Rochester,
NY, p.A4461
912 Interferons Suppress IL-1ß Dependent GM-CSF in Post-Influenza
Pneumococcal Infection of Human Lungs/K. Zscheppang, J. Berg,
D. Fatykhova, M. Tonnies, T. Bauer, P. Schneider, J. Neudecker, J.
Ruckert, S. Eggeling, M. Schimek, A. Gruber, N. Suttorp, S.
Hippenstiel, A. Hocke, Berlin, Germany, p.A4462
913 Characterisation of the Neutrophil in Respiratory Syncytial
Virus Bronchiolitis/G.L. Saint, R. Smyth, B.F. Flanagan, P.S.
McNamara, Liverpool, United Kingdom, p.A4463
914 Host Gene Expression Patterns Distinguish Disease Severity
in Respiratory Syncytial Virus Infected Infants/C.-Y. Chu, X.
Qiu, L. Wang, S. Bhattacharya, C. Slaunwhite, B. Tesini, D.
Francis, J. McGrath, G. Lofthus, A. Murphy, M.A. Formica, L.
Denmark, K. Schnabel, L. Shelley, J. Carnahan, A. Corbett, J.
Holden-Wiltse, D. Topham, A. Falsey, M. Caserta, T.J. Mariani, E.
Walsh, Rochester, NY, p.A4464
915 Respiratory Syncytial Virus Recruits Its Receptor, Nucleolin, to
the Cell Surface Prior to Viral Fusion and Mediates Viral Entry
by Toll-Like Receptor-4 Signaling/C. Griffiths, L. Bilawchuk, L.
Jensen, D.J. Marchant, Edmonton, Canada, p.A4465
916 RSV Pulmonary Infection Induces Human Anti-RSV Immune
Responses and Pathology in Humanized Mice/A. Sharma, B.
Sung, W. Wu, J. Huang, T. Tsao, X. Li, R. Gomi, M. Tsuji, S.
Worgall, New York, NY, p.A4466
917 Targeting Intracellular Potassium for the Control of
Respiratory Syncytial Virus/T. Moraes, W. Duan, M. Malhi, J.
Maynes, M.J. Norris, Toronto, Canada, p.A4467
918 Enterovirus D68 Lower Respiratory Tract Infection Causes
Elevated Airway Hyperreactivity in Fischer-344 Rats/P.M.
Brown, T.J. Harford, A. Belkadi, V. Agrawal, F. Rezaee, G.
Piedimonte, Cleveland, OH, p.A4468
919 Dendritic Cell-Mediated Lung Injury in Response to Aspergillus
in Chronic Granulomatous Disease: Protective Role of
Neutrophil-Derived Reactive Oxygen Species/R.E. Cagnina,
K.R. Michels, A. Bettina, Z. Zhang, M. Burdick, B. Mehrad,
Charlottesville, VA, p.A4469
920 Inter-Relationships Between Regulatory T Cells, Effector T
Cells, the PD-1 Signaling Pathway, and Immunomodulatory
Lung Dendritic Cells in Mice with Persistent Cryptococcal
Lung Infection/J.A. Roussey, S. Teitz-Tennenbaum, M.A.
Olszewski, J.J. Osterholzer, Ann Arbor, MI, p.A4470
921 Inhaled Corticosteroids Alter Pathogenicity Profile of Airway
Pathogens Pseudomonas Aeruginosa and Staphylococcus
Aureus/J. Joshua, A. Vyas, L.E. Crotty Alexander, San Diego, CA,
p.A4471
922 IFITM3 Regulatory SNP Increases Severe Human Influenza
Risk by Shifting Transcription Factor Occupancy/E.K. Allen, T.
Bhangale, P. Dogra, M. Ohlson, C. Oshansky, D. Finkelstein, B.
Youngblood, A.G. Randolph, C. Rosenberger, P.G. Thomas,
Memphis, TN, p.A7855
923 First Successful Expression of a Trimeric Human Fragment of
SP-A and Demonstration of Its Increased Efficacy in
Neutralisation of RSV Compared with Native Human SP-A/A.
Watson, C.M. Spalluto, N. Kronqvist, K. Staples, J. Johansson,
T.M.A. Wilkinson, J. Madsen, H. Clark, Southampton, United
Kingdom, p.A7856
924 Targeting Bruton’s Tyrosine Kinase Protects Mice from
Adverse Effects of Streptococcus Pneumoniae Induced
Pneumonia/A. Kurdowska, J.M. Florence, A. Jeffers, A. Krupa,
T.A. Tucker, Tyler, TX, p.A7857
925 Dissecting the Role of Macrophage-Mediated Killing of
Pneumocystis Murina/K.M. Dischert, D.R. Samuelson, T. Charles,
N.M. De La Rua, J.E. Shellito, New Orleans, LA, p.A7858
B107
POSTER DISCUSSION SESSION
TUBERCULOSIS: ISSUES DURING TREATMENT
2:15 p.m. - 4:15 p.m. MOSCONE CENTER
Room 3024 (West Building, Level 3)
Poster Viewing 2:15-3:00
Discussion 3:00-4:15
Chairing: M.C. Lipman, MD, London, United Kingdom
N.D. Walter, MD, Denver, CO
W.O. Worodria, MBChB, MMeD, PhD, Kampala, Uganda
1001 Sputum Is a Surrogate for Bronchoalveolar Lavage for
Monitoring Mycobacterium Tuberculosis Transcriptional
Profiles in TB Patients/B.J. Garcia, A.G. Loxton, G.M. Dolganov,
J.L. Davis, M.I. Voskuil, M. Strong, S. Leach, G. Walzl, G.K.
Schoolnik, N.D. Walter, Denver, CO, p.A4472
1002 Role of Tobacco Cessation as an Adjunct to Anti-Tuberculosis
Treatment in Pulmonary Tuberculosis: An Open-Label,
Randomized, Controlled Clinical Trial/S.K. Sharma, A. Mohan,
H. Mishra, A.D. Singh, S. Jhanhi, R.M. Pandey, P.B. Pallipamu,
B.K. Singh, R.N. Yadav, K. Dheda, G. Theron, A. Sengupta, New
Delhi, India, p.A4473
1003 Prediction of Post-Tuberculosis Lung Function Impairment/
E.W. Pefura-Yone, B. Moifo, F. Kouna, A.D. Balkissou, A.P.
Kengne, Yaounde, Cameroon, p.A4474
MONDAY AFTERNOON
ATS 2016 • San Francisco