Final Program

350 WEDNESDAY • MAY 18
815 Multiplexed Direct Genomic Selection Identifies Exonic,
Intronic, and Copy Number Variation in Surfactant-Associated
Genes Among Infants with Respiratory Distress Syndrome
(RDS) and Children with Interstitial lung Disease (chILD)/J.B.
Tam-Williams, W. Eldridge, D. Wegner, D. Alvarado, L. Nogee, A.
Hamvas, F.S. Cole, J. Wambach, St. Louis, MO, p.A6571
816 The Impact of Mesenchymal Stem Cell Therapy in
Bronchopulmonary Dysplasia: The Interaction Between
Inflammation and Oxidative Stress/C.R. Nitkin, T.L. Bonfield,
Cleveland, OH, p.A6572
817 Airway Reactivity in Preterm Infants Is Associated with
Increased Respiratory Morbidity in The First Year of Life/C.L.
Ren, R. Feng, S.D. Davis, E. Eichenwald, H.B. Panitch, J.K. Sharp,
J.S. Kemp, Indianapolis, IN, p.A6573
818 Imaging-Based Pulmonary Functional Measurements from
Self-Gated Neonatal Ultra-Short Echo-Time (UTE) Magnetic
Resonance Imaging (MRI)/N.S. Higano, A. Hahn, L.L. Walkup, R.
Thomen, S. Merhar, P.S. Kingma, J.A. Tkach, S. Fain, J.C. Woods,
Cincinnati, OH, p.A6574
819 Serum Brain-Derived Neurotrophic Factor (BDNF) Levels Can
Predict Bronchopulmonary Dysplasia in Neonates/S.L.
Simpson, M. Alejandro-Rodriguez, M.J. Allen, W.L. Spencer, S.
Worley, A.S. Tang, J.H. Peterson, G. Piedimonte, Cleveland, OH,
p.A6575
820 Outcomes in Neonates with Bronchopulmonary Dysplasia and
Tracheobronchomalacia/E.B. Hysinger, R. Shinohara, N.L.
Friedman, H. Zhang, H.B. Panitch, S.M. Kawut, Philadelphia, PA,
p.A6576
821 Factors Associated with Spontaeous Closure of the Patent
Ductus Arteriosus in the Premature Neonate/D. McCurnin, A.
Quinn, C. Blanco, L. McGill-Vargas, S.R. Seidner, San Antonio, TX,
p.A6577
822 Nutritional Follow-Up of Congenital Diaphragmatic Hernia
Survivors - The Sydney Children’s Hospital Experience/J. Mui,
A. Numa, A. Jaffe, S. Chuang, Randwick, Australia, p.A6578
823 Novel NPY-Mediated Effect on Proliferation, Migration and IL-6
Expression in Neonatal Pulmonary Fibroblasts Is Related to
Lung Growth After Intrauterine Growth Restriction/C.
Thangaratnarajah, K. Dinger, C. Vohlen, J. Nawabi, C. Klaudt, E.
Lopez, J. Dobner, K.-D. Nuesken, S. V. Hoersten, J. Doetsch, M.A.
Alejandre Alcazar, Cologne, Germany, p.A7899
D26
POSTER DISCUSSION SESSION
I’M ON FIRE- INFLAMMATION IN PULMONARY
VASCULAR DISEASE
9:00 a.m. - 11:00 a.m. MOSCONE CENTER
Room 3024 (West Building, Level 3)
Poster Viewing 9:00-9:45
Discussion 9:45-11:00
Chairing: F. Perros, PhD, Le Plessis Robinson, France
M.R. Nicolls, MD, Palo Alto, CA
L.C. Price, MBBS, London, United Kingdom
1001 Evidence of Dysregulated Humoral Immunity in Idiopathic
Pulmonary Arterial Hypertension/E. Groves, K. Zalewska, A.
Crosby, R.M. Salmon, Z. Wei, P.D. Upton, C. Hadinnapola, E.F.
McKinney, M. Southwood, H. Baxendale, J. Pepke-Zaba, N.W.
Morrell, M. Toshner, Cambridge, United Kingdom, p.A6579
1002 Elucidating the Role of Inflammation and Endothelial
Dysfunction in Chronic Thromboembolic Pulmonary
Hypertension and their Clinical Significance/C. Hadinnapola, M.
Southwood, J. HernA¡ndez - SA¡nchez, J. Cannon, D. Jenkins,
S.D. Preston, N. Screaton, K. Sheares, N.W. Morrell, M. Toshner,
J. Pepke-Zaba, Cambridge, United Kingdom, p.A6580
1003 Plasma 12- and 15-HETE Are Predictors of Survival in
Pulmonary Arterial Hypertension/N. Al-Naamani, K.D. Sagliani,
G.G. Dolnikowski, R. Warburton, D. Toksoz, U. Kayyali, N.S. Hill,
B.L. Fanburg, K.E. Roberts, I.R. Preston, Boston, MA, p.A6581
1004 Elevated Pulmonary Arterial Pressures Are Associated with
Changes in the Oral Microbiome and Reduction in Predicted
Nitrate and Nitrite Metabolism/C.D. Koch, A. Fitch, M.A. Simon,
R.R. Vanderpool, H. Spallek, S. Rehman, M.L. Saul, M.T. Gladwin,
A.R. Vieira, A.M. Morris, Pittsburgh, PA, p.A6582
1005 Hemodynamic Unloading Rapidly Reverses Perivascular
Inflammation in a Rat Model of PAH/K. Abe, I.F. McMurtry, M.
Oka, Fukuoka, Japan, p.A6583
1006 Pulmonary Adventitial Remodeling in Pulmonary
Hypertension: Fibroblast Responses to Changes in Matrix and
Interstitial Fluid/M.E. Yeager, K.L. Colvin, Aurora, CO, p.A6584
1007 Functional Reprogramming of Macrophages Through Targeted
Inhibition of Metabolic Pathways as a Strategy to Promote
Anti-Inflammatory Signaling in Pulmonary Hypertension/K. EL
Kasmi, S. Riddle, M. Li, A. D’Alessandro, H. Zhang, B.A. McKeon,
A. Flockton, M. Frid, K.C. Hansen, S. Pullamsetti, Q. Zhang, K.R.
Stenmark, Aurora, CO, p.A6585
1008 Adventitial Fibroblasts Shape the Local Microenvironment to
Induce and Sustain Alterations in Macrophage Metabolism as a
Critical Adaptation to Promote a Pro-Inflammatory and
Pro-Remodeling Phenotype/K. EL Kasmi, A. D’Alessandro, S.
Riddle, H. Zhang, M. Li, A. Anderson, K. Rawlinson, A. Flockton,
B.A. McKeon, K.C. Hansen, M. Frid, K.R. Stenmark, Aurora, CO,
p.A6586
1009 Patients with Exercise Induced Pulmonary Arterial
Hypertension Exhibit Coagulation System and Endothelial
Activation/A.B. Waxman, L.M. Grove, D.M. Systrom, J.A. Leopold,
R. Dweik, G.A. Heresi, S.C. Erzurum, M.A. Olman, Boston, MA,
p.A6587
1010 4-Methylthio-2-Oxobutyric Acid (MTOB), a Novel Small
Molecule and Inhibitor of CtBP1, Inhibits the Proliferative and
Pro-inflammatory Phenotype of Adventitial Fibroblast in
Pulmonary Hypertension/M. Li, B.A. McKeon, S. Kumar, M. Frid,
A. Flockton, S. Riddle, A. D’Alessandro, H. Zhang, M.A. Fini, K. El
Kasmi, Q. Zhang, K.R. Stenmark, Aurora, CO, p.A6588
ATS 2016 • San Francisco