Final Program
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WEDNESDAY • MAY 18 351<br />
1011 The Role of the Bone Morphogenetic Protein 9 in Endothelial<br />
Inflammation/C.G. Mitrofan, S. Appebly, N. Morrell, Cambridge,<br />
United Kingdom, p.A6589<br />
1012 The NF-kB Pathway Is Important for Phenotype and<br />
Proliferation of Pulmonary Microvascular Endothelial Cells and<br />
Lung Endothelial Progenitor Cells/D. Farkas, V. Kraskauskiene,<br />
A.A. Fowler, K. Islam, R. Natarajan, L. Farkas, Richmond, VA,<br />
p.A6590<br />
1013 Autocrine Regulation of Interleukin 33 Expression in Human<br />
Pulmonary Artery Endothelial Cells/T.C. Tsui, S. Boeder, E.C.<br />
Breen, T.D. Bigby, La Jolla, CA, p.A6591<br />
1014 TNFa Stimulates an Inflammatory Response in Human<br />
Pulmonary Microvascular Endothelial Cells (HPMECs): The<br />
Role of NF-kB and BET Proteins/A. Natsuki, J. Wort, F. Chung,<br />
I.M. Adcock, S. Mumby, London, United Kingdom, p.A6592<br />
D27<br />
POSTER DISCUSSION SESSION<br />
MACROPHAGES: RESOLVERS, RESPONDERS OR<br />
BOTH?<br />
9:00 a.m. - 11:00 a.m. MOSCONE CENTER<br />
Room 2014 (West Building, Level 2)<br />
Poster Viewing 9:00-9:45<br />
Discussion 9:45-11:00<br />
501 Requirement of IL-6 for Maximal M2 Macrophage<br />
Accumulation, and Growth of Ectopically Delivered B16<br />
Melanoma, in Mouse Lungs Upon Oncostatin M<br />
Overexpression/L. Izakelian, E. Ayaub, A. Dubey, S. Wong, F.<br />
Botelho, K. Ask, C.D. Richards, Hamilton, Canada, p.A6593<br />
502 Tumor-Associated Macrophages Induces Activation of STAT3<br />
on Small Cell Lung Cancer Cells/T. Iriki, K. Ohnishi, Y.<br />
Komohara, Y. Fujiwara, M. Takeya, H. Kohrogi, Kumamoto, Japan,<br />
p.A6594<br />
503 Modulation of Alveolar Macrophage Immune Function by Fatty<br />
Acid Ethyl Esters/T.W. Gauthier, X.D. Ping, L.A.S. Brown, Atlanta,<br />
GA, p.A6595<br />
504 Tissue-Resident Alveolar Macrophages Persist Over the<br />
Lifespan with Minimal Input from the Bone Marrow but Are<br />
Replaced by Monocyte-Derived Cells Upon Depletion/A.C. Mc<br />
Quattie-Pimentel, F.J. Gonzalez, C.-I. Chen, J.M. Walter, M. Chi, S.<br />
Soberanes, R. Piseaux, K.M. Ridge, H.R. Perlman, G.S. Budinger,<br />
A.V. Misharin, Chicago, IL, p.A6596<br />
505 Apoptosis Signal Regulating Kinase-1 Promotes<br />
Inflammasome Priming in Alveolar Macrophages/J.A. Kennedy,<br />
C.N. Immanuel, C. Luellen, B. Teng, E.A. Fitzpatrick, C.M. Waters,<br />
Memphis, TN, p.A6597<br />
506 Pulmonary Alveolar Proteinosis Is Driven by Reduced<br />
GM-CSF-Dependent Cholesterol Clearance by Alveolar<br />
Macrophages, Not an Inability to Catabolize Surfactant<br />
Phospholipids/A. Sallese, T. Suzuki, J. Bridges, A. Filuta, D.<br />
Black, C. Chalk, B. Carey, B.C. Trapnell, Cincinnati, OH, p.A6598<br />
507 TGFb1 Induced Mammalian Lung Fibrosis Requires TGFBR2<br />
Expression on Macrophages/X. Peng, R. Homer, J.A. Elias, E.<br />
Herzog, New Haven, CT, p.A6599<br />
508 Alveolar Macrophage Activation Pattern in Idiopathic<br />
Pulmonary Fibrosis (IPF): Bronchoalveolar Lavage (BAL)<br />
Transcriptome Analysis/C.M. Swaisgood, I. Arisi, F. Mariani, E.<br />
Puxeddu, M. Amicosante, D. Giovannini, M. Pallante, G. Paone, T.<br />
Flagg, M.L. Brantly, C. Saltini, Gainesville, FL, p.A6600<br />
509 Macrophage Mitochondrial Calcium Content Is Required for<br />
Pulmonary Fibrosis Development/L. Gu, A.J. Ryan, J.L.<br />
Larson-Casey, A.B. Carter, Birmingham, AL, p.A6601<br />
510 IL-6 Mediated Hyperpolarization of Profibrotic Macrophages Is<br />
Dependent on Spliced XBP1/E. Ayaub, K. Tandon, P.<br />
Parthasarathy, J. Murphy, P.S. Kolb, S. Lhotak, M.R.J. Kolb, M.D.<br />
Inman, R.C. Austin, C.D. Richards, K. Ask, Hamilton, Canada,<br />
p.A6602<br />
511 A Unique Human Alveolar Macrophage Polarization Phenotype<br />
Is Associated with Disease Progression in Idiopathic<br />
Pulmonary Fibrosis/L.M. Nicol, M. Brittan, J.A. Marwick, A.C.<br />
MacKinnon, R. Mills, P.A. McFarlane, W.A. Wallace, G. Stewart, J.<br />
Simpson, A.G. Rossi, S.E. Howie, J.T. Murchison, N. Hirani,<br />
Edinburgh, United Kingdom, p.A6603<br />
512 Transcriptional Signatures of Alveolar Macrophages in a<br />
Murine Model of Chronic Granulomatous Disease: Similarities<br />
to Sarcoidosis/A. Mohan, S.A. Gharib, A. Malur, M. McPeek, B.P.<br />
Barna, L.M. Schnapp, M.J. Thomassen, Greenville, NC, p.A6604<br />
513 Expression of CD71 on Alveolar Macrophages Reveals Distinct<br />
Cell Populations in Human Bronchoalveolar Lavage from<br />
Patients with Interstitial Lung Disease/S.J. Allden, R.J. Toshner,<br />
A.J. Byrne, C.M. Lloyd, T. Maher, Slough, United Kingdom,<br />
p.A6605<br />
514 Hypercapnia Increases Mortality of Influenza A Virus Infection<br />
in Mice and Viral Replication in Macrophages by a RIG-1- and<br />
MDA5-dependent Mechanism/M. Casalino Matsuda, A. Nair, M.<br />
Chi, K.L. Gates, G.S. Budinger, P.H. Sporn, Chicago, IL, p.A6606<br />
515 Mitochondrial Transfer Via Tunnelling Nanotubes (TNT) Is a<br />
Novel Mechanism by Which Mesenchymal Stromal Cells<br />
Enhance Macrophage Phagocytosis in In Vivo Models of Acute<br />
Lung Injury/M.V. Jackson, T.J. Morrison, D.F. McAuley, M.<br />
Matthay, C.M. O’Kane, A.D. Krasnodembskaya, Belfast, United<br />
Kingdom, p.A6607<br />
516 Monocyte-Derived Alveolar Macrophages Contribute to the<br />
Development of Lung Fibrosis and Persist in the Lung Over<br />
the Lifespan/A.V. Misharin, L. Morales-Nebreda, C.M. Cuda, P.A.<br />
Reyfman, S. Berdnikovs, A.C. McQuattie-Pimentel, F.J.<br />
Gonzalez-Gonzalez, R. Saber, C.-I. Chen, H.R. Perlman, G.S.<br />
Budinger, Chicago, IL, p.A6608<br />
517 Influenza A Virus Infection Leads to Excess Monocyte<br />
Recruitment and Severe Lung Injury in Juvenile Mice/<br />
B.M. Coates, K.L. Staricha, K.M. Ridge, Chicago, IL, p.A6609<br />
518 Opposing Heme Oxygenase-1 Expression Pattern in<br />
Macrophages Cause Different Cell Behaviors/C. Canetti, C.<br />
Freitas-Oliveira, A. Brogliato, M.M. Chaves, G. Sodre, C.F.<br />
Benjamim, R. Coutinho-Silva, Rio de Janeiro, Brazil, p.A6610<br />
WEDNESDAY MORNING<br />
ATS 2016 • San Francisco