54 SUNDAY • MAY 15 P149 P150 Facilitator: P151 P152 P153 P154 P155 P156 P157 P158 Facilitator: P159 P160 P161 Allergen Sensitization and Obstruction Indices of Allergic Asthmatics with High IgE (30-700 IU/ml) in an Urban Population: Super-obese (BMI 40 Kg/m²) vs Normal BMI (BMI =18-25 Kg/m²)/M. Ahmad, N. Tambe, T. Thakur, J. Zacharias, A. Sharma, E. Schulman, Philadelphia, PA, p.A1433 Comparison of COPD Related Breath VOCs Assessed by a Compact High-Resolution Closed-Loop GC-IMS and by Standard GC-MS/O. Holz, M. Allers, A. Gaida, S. Schuchardt, J.M. Hohlfeld, S. Zimmermann, Hannover, Germany, p.A1434 L.E. Crotty Alexander, MD, San Diego, CA Study on the Grass Pollen Allergen Sensitization Mode and Their Relationships with Bronchial Hyperresponsiveness Patients with Asthma and/or Allergic Rhinitis in Southern China/W. Luo, B. Sun, Guangzhou, China, p.A1435 Sex Hormones Impact Asthma Severity and Lung Function in Adult Men and Women/J.G. Zein, M.D. DeBoer, W.G. Teague, S. Comhair, M. Castro, W.W. Busse, N.N. Jarjour, E.R. Bleecker, W.C. Moore, S.E. Wenzel, W.J. Calhoun, B. Gaston, S.C. Erzurum, Cleveland, OH, p.A1436 Investigation of Possibility as the Biomarker and the Function of Intelectin-1 (ITLN-1) in Bronchial Asthma Airway/T. Watanabe, K. Chibana, T. Shiobara, Y. Horigane, A. Takemasa, Y. Ishii, Mibu town Tochigi prefecture, Japan, p.A1437 Lung Function Is Predicted by Resistin and Resistin: Adiponectin Ratio in Asthma/L.G. Wood, D. Ballantyne, H. Scott, L. McDonald-Wicks, P.G. Gibson, New Lambton Heights, Australia, p.A1438 Nasal Polyps and Airway Hyperresponsiveness Determine Outcome of Adult-Onset Asthma; a 5 Year Prospective Follow-Up Study/G. Westerhof, H. Coumou, S. De Nijs, E. Weersink, E.H. Bel, Amsterdam, Netherlands, p.A1439 Bronko Test® Sputum Colour as a Marker of Neutrophilic Bronchitis in Adults with Asthma/J.L. Simpson, A. Lochrin, L.G. Wood, P.G. Gibson, New Lambton, Australia, p.A1440 Peripheral Blood Basophils as a Biomarker in Patients with Adult Bronchial Asthma/S. Ohta, A. Tanaka, A. Fujiwara, Y. Uchida, R. Manabe, H. Furukawa, N. Kuwahara, Y. Fukuda, T. Kimura, T. Homma, K. Hirai, Y. Miyata, M. Jinno, M. Yamamoto, Y. Watanabe, T. Yokoe, H. Sagara, Tokyo, Japan, p.A1441 Changes in Skin Prick Test Reactivity: A 20-Year Longitudinal Study/J.S. Nielsen, H. Meteran, C.S. Ulrik, C. Porsbjerg, V. Backer, Copenhagen, Denmark, p.A1442 T. Suzuki, MD, Aizuwakamatsu, Japan Lack of Allergy Diagnostics in Severe Asthmatic Patients in Germany/J. Schreiber, K. Garg, Magdeburg, Germany, p.A1443 Raised Serum IgG4 as a Marker for Th2 Mediated Inflammation in Persistent Asthma/A. Rashidian, S. Sazgar, J. Mejia, T. Tyner, B. Abejie, V.V. Jain, J.J. Vempilly, Fresno, CA, p.A1444 Ability of Exhaled Nitric Oxide to Discriminate for Airflow Obstruction Among Frequent Exacerbators of Clinically Diagnosed Asthma/L. Jalota, R. Allison, J. Vempilly, V.V. Jain, Fresno, CA, p.A1445 P162 P163 P164 P165 P166 P167 P168 P169 A39 Dynamic Models of Exhaled Nitric Oxide/P. Muchmore, S.P. Eckel, Los Angeles, CA, p.A1446 Bone Density Is Inversely Correlated with Plasma Levels of Platelet Factor 4 (PF4, CXCL4) in Severe Asthma/M.W. Johansson, C.C. Chow, M.D. Evans, L.C. Denlinger, N.N. Jarjour, D.F. Mosher, S. Fain, M.L. Schiebler, Madison, WI, p.A1447 Fractal Dimension as a Global Index of Air Trapping/G. Marin, S. Bommart, N. Molinari, L. Knabe, Y. Cabon, I. Vachier, C. Devautour, A. Bourdin, Montpellier, France, p.A1448 The Twitch and the Refractory Period: Testing the Allergic Inflammatory Response in the Lung/J.J. Pothen, M.E. Poynter, L.K.A. Lundblad, J.H.T. Bates, Burlington, VT, p.A1449 Mucin Secretion in Asthmatics with Osmotic Airway Hyperresponsiveness/J.M. Perelman, E. Nekrasov, D. Naumov, A. Prikhodko, G. Makarova, E. Ushakova, V. Kolosov, Blagoveshchensk, Russian Federation, p.A1450 Clinical Significance of Symptoms in Smokers with Preserved Spirometry/P.G. Woodruff, R.G. Barr, E.R. Bleecker, S.A. Christenson, D.J. Couper, J.L. Curtis, N. Gouskova, N.N. Hansel, E.A. Hoffman, R. Kanner, E. Kleerup, S.C. Lazarus, F.J. Martinez, R. Paine, III, S.I. Rennard, D.P. Tashkin, M.K. Han, San Francisco, CA, p.A7779 Fetuin-B (FETUB): A Plasma Biomarker Candidate Related to the Severity of Lung Function in COPD/W.-Q. Diao, B. He, N. Shen, Beijing, China, p.A7780 Indices of Pulmonary Function in a Nonhuman Primate Model of Nonatopic Asthma: Contribution of Lung Growth to Airway Hyperresponsiveness/C.M. Royer, K. Chun, E.S. Schelegle, L.A. Miller, J.P. Capitanio, Davis, CA, p.A7781 THEMATIC POSTER SESSION EOSINOPHILIC AIRWAYS DISEASE 9:00 a.m. - 4:15 p.m. MOSCONE CENTER Viewing: Posters will be on display for entire session. Area G, Hall D (North Building, Lower Level) Discussion: 11:00-11:45: authors will be present for individual discussion 11:45-12:45: authors will be present for discussion with assigned facilitators Facilitator: P724 P725 P726 I. Ito, MD, PhD, Kyoto, Japan Serum High Density Lipoprotein (HDL) Cholesterol and Large HDL Particles Are Negatively Correlated with Blood Eosinophils in Atopic Asthma/A.V. Barochia, M. Kaler, R. Cuento, E.M. Gordon, P. Theard, D. Figueroa, N. Weir, M. Sampson, A.T. Remaley, S.J. Levine, Bethesda, MD, p.A1451 Eosinophils in Broncho-Alveolar Lavage in Young Children with Wheezing/G. Gut, K. Armoni-Domany, E. Sadot, E.M. Fireman, Y. Sivan, Tel Aviv, Israel, p.A1452 Type 2 Cytokines IL-5 and IL-13 Act Synergistically on Eosinophils but Only IL-13 Induces Airway Hyperreactivity and Goblet Cell Metaplasia in Murine Asthma/H. Beckert, S. Reuter, H. Meyer-Martin, S. Korn, R. Buhl, Mainz, Germany, p.A1453 ATS 2016 • San Francisco
SUNDAY • MAY 15 55 P727 P728 P729 P730 P731 P732 P733 P734 A40 Both Eosinophilic and Neutrophilic Inflammation Were Associated with Pulmonary Function in Ex-Smokers with Asthma/T. Nagasaki, H. Matsumoto, T. Oguma, H. Inoue, T. Iwata, T. Tajiri, Y. Kanemitsu, Y. Izuhara, H. Sunadome, I. Ito, A. Niimi, M. Mishima, Kyoto, Japan, p.A1454 Correlation Between Sputum Eosinophilia and Exhaled Nitric Oxide/J. Lee, J.-W. Paeng, D.-C. Choi, B.-J. Lee, Seoul, Korea, Republic of, p.A1455 Patients with Difficult to Control Eosinophilic Granulomatosis with Polyangiitis of a Vasculitis Clinical Center in Sao Paulo, Brazil/E.P. Oliveira, J. Pinaffi, M.S. Tavares, L.K. Dourado, C.S.V. Barbas, Sao Paulo, Brazil, p.A1456 Long-Term Outcome and Prognostic Factors of Chronic Eosinophilic Pneumonia: Fujiyama Cohort Study/Y. Suzuki, S. Imokawa, M. Toyoshima, K. Yokomura, H. Nakamura, S. Kuroishi, N. Koshimizu, Y. Ohyama, K. Furuhashi, T. Fujisawa, N. Enomoto, N. Inui, Y. Nakamura, T. Yamada, T. Shirai, M. Masuda, H. Hayakawa, T. Suda, Hamamatsu, Japan, p.A1457 Fluid Shear Stress Modulates Changes in Cell Morphology in Human Eosinophils/K. Son, M. Small, L. Janssen, Hamilton, Canada, p.A1458 Association Between Early Improvements in Lung Function and Asthma Control with Reslizumab and the Annual Rate of Asthma Exacerbations/E.D. Bateman, J. Zangrilli, M. Germinaro, S. Weiss, M. Castro, Cape Town, South Africa, p.A7782 Effect of Reslizumab Treatment on Rescue Systemic Corticosteroid Use in Patients with Asthma and Elevated Blood Eosinophils: Results from a Pooled Analysis of Two Phase 3, Placebo-Controlled Trials/P. Bardin, K. Murphy, M. Garin, Melbourne, Australia, p.A7783 The Circadian Clock Regulates Allergic Lung Inflammation: Implications for Asthma/H. Durrington, A. Loudon, D. Ray, Manchester, United Kingdom, p.A7784 THEMATIC POSTER SESSION EPITHELIAL REGULATION OF INFLAMMATION 9:00 a.m. - 4:15 p.m. MOSCONE CENTER Viewing: Posters will be on display for entire session. Area G, Hall D (North Building, Lower Level) Discussion: 11:00-11:45: authors will be present for individual discussion 11:45-12:45: authors will be present for discussion with assigned facilitators Facilitator: P735 P736 R. Wu, PhD, Davis, CA The Effect of IL-13 and IL-33 on the Efficacy of Albuterol on Airway Hyperresponsiveness in a Mouse Model of Asthma/R.G. Townley, S. Agrawal, M.R. Hanna, B. Chang, N. Nettagul, Omaha, NE, p.A1459 PERK Inhibition Improves Permeability in Mechanical Stretch-Induced Epithelial Injury/T. Dolinay, N. Yehya, G. Gray Lawrence, S.S. Margulies, Philadelphia, PA, p.A1460 P737 P738 P739 P740 P741 P742 P743 P744 P745 Facilitator: P746 P747 P748 Heat-Shock Accelerates Human Lung Epithelial Wound Healing by Activating Expression of Fibroblast Growth Factor (FGF)-1: Implications for Idiopathic Pulmonary Fibrosis (IPF)/J.D. Hasday, R.G. Scheraga, C. Thompson, M. Tulapurkar, M.J. Cowan, J. Sun, R. Cai, C. Logun, N.W. Todd, J. Shelhamer, S.P. Atamas, I.G. Luzina, Baltimore, MD, p.A1461 L-citrulline Prevents Asymmetric Di-methyl Arginine Uncoupling of Nitric Oxide Synthase in Primary Human Airway Epithelial Cells/D.E. Winnica, H. Grasemann, L.G. Que, B. Freeman, K. Wasil, S.E. Wenzel, F. Holguin, Pittsburgh, PA, p.A1462 Intranasal Elastase Induces Mucus Accumulation and Alterations in Lung Mucus Proteome in Mice/J.A. Fernandez-Blanco, A. Ermund, A.M. Rodriguez-Pineiro, J. Root, C. McCrae, A. Astrand, G.C. Hansson, Molndal, Sweden, p.A1463 Relationship of ER Stress to Type 2 Inflammation in Asthma/K.L. Jung, S.A. Christenson, S. Nerella, O.D. Solberg, C.P. Nguyen, P.G. Woodruff, N.R. Bhakta, San Francisco, CA, p.A1464 TWEAK Induced Chemokine, MCP-1, RANTES and IL-8 Production in Human Bronchial Epithelial Cells/K. Matsuno, N. Harada, A. Ishimori, S. Harada, T. Takeshige, J. Ito, R. Atsuta, K. Takahashi, Tokyo, Japan, p.A1465 Histamine Stimulates Mucus Secretion Through IL-4 Induced TMEM16A in Human Nasal Epithelium/H.-J. Cho, Y.H. Lee, C.-H. Kim, J.-H. Yoon, Seoul, Korea, Republic of, p.A1466 Regulation of Dipeptydyl Peptidase-4 (DPP4) Expression in Bronchial Epithelial Cells (BECs)/K. Chibana, T. Shiobara, T. Watanabe, Y. Horigane, A. Takemasa, Y. Ishii, Mibu Machi, Tochigi prefecture, Japan, p.A1467 Chloride Ion Transport and Localization of TMEM16A in IL-13-Induced Goblet Cell Metaplasia/M. Kondo, K. Hara, M. Tsuji, K. Takeyama, E. Tagaya, J. Tamaoki, Tokyo, Japan, p.A1468 Bronchial Epithelial Cells Expression of IL-17A and IL-17F in Asthma and COPD/T. Morimoto, S.G. Smith, J.P. Oliveria, S. Beaudin, A. Schlatman, K. Howie, C. Obminski, G. Nusca, R. Sehmi, G.M. Gauvreau, P.M. O’Byrne, Hamilton, Canada, p.A1469 A.L. Linderholm, PhD, Davis, CA Airway Progenitor Clone Formation Is Enhanced by Y-27632-Dependent Changes in the Transcriptome/S.D. Reynolds, C. Rios, A. Wesolowska-Andersen, M. Pinter, C. Happoldt, G.M. Solomon, D.P. Nichols, M.A. Seibold, Columbus, OH, p.A1470 Alternaria Alternata Induces Pulmonary Inflammation in In Vivo and In Vitro Models of Asthma: Relative Contribution of Th2 Cytokines/K. Hilliard, M. Caniga, I. Kariv, R. De Waal Malefyt, H. Chen, M. Salmon, M. Cicmil, Boston, MA, p.A1471 The Physiological Glucocorticoid (GC), Hydrocortisone, Limits Selected Actions of Synthetic GC in Human Airway Epithelium/D. Radojicic, C.R. Keenan, A.G. Stewart, Parkville, Australia, p.A1472 SUNDAY MORNING ATS 2016 • San Francisco
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American Thoracic Society Internati
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TABLE OF CONTENTS ATS 2016 INTERNAT
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2 FRIDAY • MAY 13 PG2A CLINICAL P
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104 SUNDAY • MAY 15 11:00 a.m.-12
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106 SUNDAY • MAY 15 L1 U.S. FOOD
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108 SUNDAY • MAY 15 12:15 Post-Pr
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110 SUNDAY • MAY 15 MP406 MP407 M
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112 SUNDAY • MAY 15 clinician and
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114 SUNDAY • MAY 15 A86 BASIC •
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116 SUNDAY • MAY 15 Chairing: M.J
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118 SUNDAY • MAY 15 3:30 High Pre
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120 SUNDAY • MAY 15 102 Toll-Like
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122 SUNDAY • MAY 15 A103 POSTER D
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124 SUNDAY • MAY 15 719 Lactate R
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126 SUNDAY • MAY 15 1014 Determin
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128 SUNDAY • MAY 15 611 Plasma Mi
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130 SUNDAY • MAY 15 412 Daytime S
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132 SUNDAY • MAY 15 6:30 p.m. - 8
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134 MONDAY • MAY 16 SS111 SS112 S
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136 MONDAY • MAY 16 Target Audien
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138 MONDAY • MAY 16 9:40 Empoweri
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140 MONDAY • MAY 16 9:28 Endotoxi
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142 MONDAY • MAY 16 10:15 Adaptiv
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144 MONDAY • MAY 16 Oral Presenta
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146 MONDAY • MAY 16 624 Neonatal
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148 MONDAY • MAY 16 118 Compariso
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150 MONDAY • MAY 16 912 Should Pa
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152 MONDAY • MAY 16 1015 Resverat
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154 MONDAY • MAY 16 718 Health Re
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156 MONDAY • MAY 16 P152 Facilita
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158 MONDAY • MAY 16 B35 THEMATIC
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160 MONDAY • MAY 16 P252 P253 P25
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162 MONDAY • MAY 16 P406 P407 P40
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164 MONDAY • MAY 16 P320 Bilatera
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166 MONDAY • MAY 16 B40 THEMATIC
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168 MONDAY • MAY 16 P528 P529 Fac
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172 MONDAY • MAY 16 B44 THEMATIC
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224 MONDAY • MAY 16 320 Sensitivi
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226 MONDAY • MAY 16 113 COPD Subt
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228 MONDAY • MAY 16 1004 Health C
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230 MONDAY • MAY 16 609 Skeletal
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232 MONDAY • MAY 16 5:00 p.m. - 7
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234 TUESDAY • MAY 17 Chairing: D.
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236 TUESDAY • MAY 17 CLINICAL YEA
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238 TUESDAY • MAY 17 This session
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240 TUESDAY • MAY 17 bronchiectas
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242 TUESDAY • MAY 17 Target Audie
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244 TUESDAY • MAY 17 C18 MINI SYM
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246 TUESDAY • MAY 17 415 Investig
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248 TUESDAY • MAY 17 207 Survival
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250 TUESDAY • MAY 17 906 Phenotyp
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252 TUESDAY • MAY 17 807 The Vali
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254 TUESDAY • MAY 17 515 Roles of
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298 TUESDAY • MAY 17 C70 THEMATIC
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324 TUESDAY • MAY 17 918 Sarcoido
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326 TUESDAY • MAY 17 410 Effectiv
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328 TUESDAY • MAY 17 710 Follista
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330 TUESDAY • MAY 17 509 A Mechan
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332 TUESDAY • MAY 17 806 Upper Ai
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334 WEDNESDAY • MAY 18 6:45 Acute
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336 WEDNESDAY • MAY 18 CLINICAL Y
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338 WEDNESDAY • MAY 18 Objectives
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340 WEDNESDAY • MAY 18 D9 BASIC
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342 WEDNESDAY • MAY 18 Oral Prese
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344 WEDNESDAY • MAY 18 10:15 Plas
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346 WEDNESDAY • MAY 18 419 A Nove
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348 WEDNESDAY • MAY 18 216 Simpli
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350 WEDNESDAY • MAY 18 815 Multip
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352 WEDNESDAY • MAY 18 D28 POSTER
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354 WEDNESDAY • MAY 18 720 Repeat
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356 WEDNESDAY • MAY 18 P389 Facil
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360 WEDNESDAY • MAY 18 P10 P11 P1
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362 WEDNESDAY • MAY 18 P52 P53 Fa
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364 WEDNESDAY • MAY 18 P95 P96 P9
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366 WEDNESDAY • MAY 18 P698 P699
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368 WEDNESDAY • MAY 18 D42 THEMAT
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374 WEDNESDAY • MAY 18 P172 P173
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376 WEDNESDAY • MAY 18 P808 Facil
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386 WEDNESDAY • MAY 18 P1036 P103
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388 WEDNESDAY • MAY 18 P1062 P106
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390 WEDNESDAY • MAY 18 11:45 Intr
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398 WEDNESDAY • MAY 18 D88 BEHAVI
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