Final Program

SUNDAY • MAY 15 95
P422
P423
P424
P425
P426
P427
P428
The Anti-Fibrotic Effect of Endostatin-Derived Peptide Is
Mediated by the Urokinase Pathway Via Binding to Enolase-1
and Urokinase Plasminogen Activator Receptor/T. Nishimoto, T.
Takihara, L. Mlakar, Y. Su, R. Chambers, C. Feghali-Bostwick,
Charleston, SC, p.A2395
Chitinase 3-Like-1 and Its Receptors in Hermansky-Pudlak
Syndrome-Associated Lung Disease/Y. Zhou, C.H. He, E.
Herzog, X. Peng, C.-M. Lee, T. Nguyen, M. Gulati, B. Gochuico, W.
Gahl, M. Slade, C.G. Lee, J.A. Elias, Providence, RI, p.A2396
Epithelial Mesenchymal Transition: Is It Still Relevant to
Pulmonary Fibrosis?/E.S. Baker, D. Kass, Pittsburgh, PA, p.A2397
Involvement of the b-catenin-Inhibitor ICAT and Non-Canonical
Signaling in Idiopathic Pulmonary Fibrosis/K. Rydell-Tormanen,
X.-H. Zhou, O. Hallgren, J. Einarsson, L. Eriksson, A.
Andersson-Sjoland, G. Westergren-Thorsson, Lund, Sweden,
p.A2398
WISP1 Mediates IL6-Dependent Proliferation in Healthy and
IPF-Derived Primary Human Lung Fibroblasts/S. Klee, M.
Lehmann, D.E. Wagner, H.A. Baarsma, M. Konigshoff, Munich,
Germany, p.A2399
Aberrant Activation of Wilms’ Tumor 1 Protein Regulates
Pulmonary Fibrosis/V. Sontake, S.K. Shanmukhappa, B.
DiPasquale, G. Bhanuprakash Reddy, E.S. White, S.K. Madala,
Cincinnati, OH, p.A2400
PM2.5 May Play an Important Role in the Pathogenesis of
Pulmonary Fibrosis by Initiating Oxidative Stress,
Inflammation and TGF-b Signaling/Y. Hu, D. Weng, Shanghai,
China, p.A2401
P436
P437
P438
P439
P440
P441
P442
P443
FGF2 Overexpression Decreases Bleomycin-Induced
Pulmonary Fibrosis/R. Guzy, L. Li, S. Cilvik, S. House, D. Ornitz,
Chicago, IL, p.A2409
Apoptotic Challenge Evokes Differential Response
Mechanisms of Idiopathic Pulmonary Fibrosis Fibroblasts/
S. Bui, S.D. Nathan, M. Chhina, S. Khandhar, G. Grant, Manassas,
VA, p.A2410
The GPCR Repertoire Changes in Lung Fibroblasts Treated
with TGFIb and in Fibroblasts of Patients with Idiopathic
Pulmonary Fibrosis/A.V. Michkov, K. Sriram, N. Aroonsakool,
P.A. Insel, La Jolla, CA, p.A2411
Estimation of the True GM-CSF Autoantibody Concentration in
the Sera of Healthy Subjects/K. Shiiya, Y. Itoh, A. Hashimoto, R.
Tazawa, K. Nakata, Niigata, Japan, p.A2412
Glucose Uptake in TGFb-Induced Fibroblast Differentiation/I.
Azuelos, B. Selvarajah, E. Forty, M. Plate, D. Anastasiou, P.
Mercer, R. Chambers, London, United Kingdom, p.A2413
The IL-33/ST2 Axis Is Upregulated in Fibrotic Lung
Disease/R.J. Toshner, S.J. Allden, A.J. Byrne, C.M. Lloyd, T.M.
Maher, London, United Kingdom, p.A2414
Differential Role of Phospholipase D in Regulating EMT and
Fibroblast Differentiation in Bleomycin-Induced Pulmonary
Fibrosis/V. Suryadevara, L.S. Huang, E.V. Berdyshev, A.M. Tager,
T. Royston, V. Natarajan, Chicago, IL, p.A2415
Role of Epithelial to Mesenchymal Transition (EMT) in
Idiopathic Pulmonary Fibrosis/G. Cholankeril, S. Morais, S.
Swami, J. Meharg, P. Dubielecka, Providence, RI, p.A2416
SUNDAY MORNING
P429
Myofibroblast Populations in IPF: Novel Differences in Gene
Expression and Functionality/S.M. Walsh, J.C. Worrell, A. Fabre,
R. Kane, M.P. Keane, Dublin, Ireland, p.A2402
P444
Limp2 Mediates Prdx6 Delivery to Lamellar Bodies in
AP3-Deficient Cell and Mouse Models/S. Kook, P. Wang, S.
Guttentag, Nashville, TN, p.A2417
P430
P431
P432
P433
P434
Impairment of Chaperone-Mediated Autophagy Promotes the
Development of Pulmonary Fibrosis/Q. Yin, J.L. Schneider, R.E.
Gongora, A.M. Cuervo, C.G. Sanchez, New Orleans, LA, p.A2403
Repetitive Intradermal Bleomycin Injections Evoke Th2
Cytokine-driven Lung Function Decline and Pulmonary
Fibrosis/S.K. Madala, B. Singh, V. Sontake, Cincinnati, OH, p.A2404
c-Jun-N-Terminal Kinase 1 in Airway Epithelial Cells Augments
Fibrotic Airway Remodeling by Limiting Epithelial
Restitution/J. Van Der Velden, D.E. Wagner, K.G. Lahue, J.D.
Nolin, S. Abdalla, S.M. Hoffman, J.F. Alcorn, C.G. Irvin, J.T. Jones,
D.G. Chapman, V. Anathy, Y.W. Lam, R.J. Davis, D.J. Weiss, Y.
Janssen-Heininger, Burlington, VT, p.A2405
The Role of HMGB1 and MIP3A in the Pathogenesis of
Idiopathic Pulmonary Fibrosis/Y.D. Zhao, K. Lin, E. Granton, A.
Yu, H.Z.H. Yun, M.O. Wu, L. Wu, J. Granton, M. De Perrot,
Toronto, Canada, p.A2406
The Role of Extracellular Heat Shock Protein 90 Alpha
on Pulmonary Fibrosis/H. Dong, L. Luo, C. Huang, Z. Xie, Y. Le,
S. Cai, Guangzhou, China, p.A2407
P435 Could Infection Be a Significant Factor in IPF?/L. Rodriguez, S.
Bui, S.D. Nathan, H. Mani, G. Grant, Fairfax, VA, p.A2408
P445
P446
P447
P448
P449
Macitentan Prevents Pulmonary Fibrosis Progression and
Secondary Pulmonary Hypertension Induced by TGF-b1
Overexpression in Rats/P.-S. Bellaye, C. Shimbori, K. Ask, J.
Gauldie, M. Iglarz, M.R.J. Kolb, Hamilton, Canada, p.A2418
Atrial Natriuretic Peptide Attenuates Bleomycin-Induced
Pulmonary Fibrosis in Mice/A. Okamoto, K. Konishi, T. Nojiri, H.
Hosoda, T. Tokudome, K. Asai, K. Hirata, K. Kangawa, Suita,
Japan, p.A2419
New Promising Therapy for Idiopathic Pulmonary Fibrosis and
Its Application Using Wound Healing Facilitator
Stannioclaicn-1 (STC1)/S. Ohkouchi, M. Ono, M. Ichinose, H.
Kurosawa, Sendai, Japan, p.A2420
Targeting the Hedgehog Signaling Pathway as Therapy for
Pulmonary Fibrosis/B. Hu, Z. Wu, D. Bai, J. Liu, T. Liu, S.H.
Phan, Ann Arbor, MI, p.A2421
The Co-Ordinated Expression of VEGF-Axxxa and VEGF-Axxxb
Isoforms Are Important in the Development and Progression of
Pulmonary Fibrosis/S.L. Barratt, T. Blythe, C. Jarrett, K. Ourradi,
G.I. Welsh, D.O. Bates, A.B. Millar, Bristol, United Kingdom,
p.A2422
ATS 2016 • San Francisco