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INTENSIVE CARE

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directly proportional to the level of surfactant that is present in<br />

the newborn [85].<br />

A review evaluated outcomes in infants given synthetic<br />

surfactant (pre-ventilatory or post-ventilatory) compared<br />

with control treatment which consisted of intratracheal<br />

administration of normal saline or air placebo. The different<br />

types of synthetic surfactant used in these trials were<br />

DPPC plus high density lipoprotein, powdered DPPC and<br />

phosphatidylglycerol and DPPC plus phosphatidylglycerol in<br />

saline. Studies also compared surfactant [86] given as either<br />

multiple or single doses to infants who were either premature<br />

(

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