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Scientific Facilities

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The New Genomics Core

The New Genomics Core Facility This summer saw the official introduction of a new Faculty of Medical Sciences Facility, the Genomics Core Facility (GCF). Made possible by funding from the MRC’s Clinical Research Capabilities and Technology Initiative and matched funding from the Research Investment Fund, the GCF has positioned itself as • a state-of-the-art single cell genomics facility • a fully integrated next-generation sequencing core facility The GCF Team The GCF is a small team lead by Dr Jon Coxhead (SESO) supported by Raf Hussain (research technician) and Dr Rachel Queen (ESO – bioinformatics). Jon and Raf have over 15 years experience in NGS, having worked with the technology from its inception. Rachel works in partnership with the Bioinformatics Support Unit and is tasked with implementing and supporting analytical methods specific to single cell ‘omics. The GCF’s academic lead is Prof Mike Briggs. Location and Laboratory Space The Facility is open to users across the University as well as external clients, and is located on the first floor, West Wing of the Institute of Genetic Medicine. Service delivery and R&D is split across three dedicated and temperature controlled labs: pre-PCR and single cell, a post-PCR and sample QC area, and an instrument room. Please get in touch if you would like a tour! Platforms and Services The GCF offers Illumina based NGS (x2 NextSeq 500s and a MiSeq) single cell sample preparation for genomic, transcriptomic and epigenomics (Fluidigm C1). Other platforms include, Laser Capture Micro-dissection (Leica LMD7) qPCR (Fluidigm BioMark HD and BioRad CFX 96 Touch) and ddPCR (QX200 AutoDG system). All platforms are fully operational. The NGS platforms have been very popular, so far delivering ~3000 Gb sequence data since service began in March 2016. Commitment to Customers Genomic-related technologies and methods are continuously evolving, never more so than in the field of single cell research. For the GCF, the last 12 months has been focused on infrastructure investment, training and service development and delivery. Maintaining cost effective, stable, cutting edge services is best done in partnership with customer feedback. The GCF is therefore looking forward to organising workshops and establishing both a ‘user-group’ and steering committee in the coming months, and is also happy to present at your lab meeting or local seminar series! Get in touch to find out more: jonathan.coxhead@newcastle.ac.uk

MRCT Drug Library and High Throughput Screening MRC Technology MRC Technology is an independent life science medical research charity that partners with academic, biotechnology, pharmaceutical, and charity organisations to move promising medical research forward into viable and accessible patient treatments. MRCT combine commercialisation and technology transfer/ IP management skills with diagnostic and drug discovery expertise, specialising in small molecule and therapeutic antibodies. Drug Libraries in the HTSF MRCT have supplied Newcastle University’s High Throughput Screening Facility (HTSF) with 20,000 compounds for research use. This complements the existing siRNA library held by the HTSF. For further information on running a screen with either the MRCT drug library or the siRNA library, please contact peter.banks@ncl.ac.uk. Business Voucher Scheme Newcastle University’s Business Voucher Scheme is designed to encourage interactions with UK business and other organisations, by supporting projects that will enable long-term, mutually beneficial collaborations. Organisations may be eligible for up to £5,000 of matched funding towards a range of University services, including accessing our Facilities. Find out more about the Business Voucher Scheme, or for more information please contact Linda Wilson (linda.wilson2@ncl.ac.uk).

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