Welcome to Hamilton We invite you to take a look at everything Hamilton has to offer. Hamilton, Ohio is the second largest city in the Cincinnati region and its downtown is experiencing a renaissance. Hamilton is a great place to play, learn, live, and work. Founded in 1791, Hamilton is a city filled with character and vitality. Hamilton is known for its pioneering spirit, a passion for baseball, and as the city of sculpture. Interested? Learn more at hamiltonohiobusiness.com/living-here.