Monday, 1 September 2008 - European Heart Journal

302 Perspectives in heart failure treatment
P1961 Registry of Heart Failure (HF) and Acute Myocardial
Infarction (AMI) for andalucia: incidence of hf in acute
myocardial infarction and treatment with
antialdosteronic drugs
A. Martinez1 , M. Anguita2 , M. Jimenez Mena3 , J. Fenandez De
Bobadilla4 , R. Munoz4 on behalf of RAICIAM. 1Hospital Universitario Virgen
del Rocio, Sevilla, Spain; 2Hospital Universitario Reina Sofia, Cordoba, Spain;
3 4 Hospital Clinico Virgen de la Victoria, Malaga, Spain; Pfizer, Madrid, Spain
Objective: There is an interest in determining the incidence of Heart Failure (HF)
in patients suffering Acute Myocardial Infarction (AMI), and in assessing the therapeutic
approach, after the publication of the EPHESUS trial (Eplerenone Post-
Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) in which a
mortality benefit for Eplerenone in patients with AMI, left ventricular ejection fraction
(LVEF) ≤ 0.40 and clinical signs of HF/diabetes mellitus was demonstrated.
The objective of the analysis was to determine the incidence of HF in AMI, the
profile of this HF subpopulation, the proportion of patients fitting in EPHESUS
profile and the use of antialdosteronic drugs.
Methods: The first 20 patients admitted with AMI in every hospital participating in
the registry were included. Analysed variables: gender, age, cardiovascular risk
factors, previous morbidities, variables related to the acute event, analytic data,
revascularization procedures and therapeutic approach. Follow-up six months after
discharge was also registered. Incidence of HF at admission and during admission
was evaluated. Profile of HF patients was assessed and compared with
the non-HF population. Prevalence of EPHESUS criteria and the use of antialdosteronic
drugs in this population was assessed.
Results: 906 patients, 71% males, 29% females; age: 67±13 years were included
in the registry. Incidence of HF was 20,4% (n=184 out of 902) and 13,7%
(n=119 out of 866 patients) at admission and at discharge respectively. HF was
more frequent for women (40%) than for men (25%) and HF patients were older
(73 vs 64). Previous HF was more prevalent in those with present heart failure
(21% vs 3%: p