07.11.2016 Views

essp05

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

BRINGING<br />

PHARMACY<br />

KNOWLEDGE<br />

AND STUDENTS<br />

TOGETHER<br />

Volume 2 | Edition 2 | April 2015<br />

www.epsa-online.org


EPSA Students' Science Publication<br />

INTRODUCTION<br />

,<br />

Dear friends,<br />

It is time for the second Edition of the ESSP (EPSA Students’ Science<br />

Publication) in this ‘academic year’! The ESSP has been established to give<br />

students who have performed scientific research, the opportunity to gain<br />

skills of scientific writing and thinking by publishing their abstract. They can<br />

be released by the professional support of EUFEPS (European Federation for<br />

Pharmaceutical Sciences). Again, very interesting abstracts have been sent in.<br />

This Edition will cover the topics: ‘Spectrometry investigation of the reaction<br />

between quercetin and stannous ions’, ‘Isolation of Membrane Proteins with<br />

Triton X-114 in Order to Analyze Their N-glycosylation’, ‘Correlation between<br />

salivary biochemical markers of stress, psychological indicators and physical<br />

activity levels in a student population’, ‘Drugability-ADME/Tox properties of<br />

amine arylideneimidazolone derivatives with confirmed action on bacterial<br />

multidrug resistance mechanisms’ and ‘Co-morbidity in Systemic Lupus<br />

Erythematosus: a study using the Clinical Practice Research Datalink’.<br />

Janice: ‘I love to work with so many enthusiastic students and to me it is a very<br />

valuable opportunity to be a part in their personal development. The aim of<br />

the ESSP is to develop new skills by using the feedback provided by EUFEPS<br />

in a constructive way. I would like to encourage all students to be proactive<br />

and work on your own skills, as they will be of high importance in your future<br />

carreer!’<br />

Janice Geers, Science Coordinator 2014-2015<br />

2


TABLE OF CONTENT<br />

Volume 2 | Edition 2 | April 2015<br />

Co-morbidity in systemic lupus erythematosus: a study using<br />

the Clinical Practice Research Datalink.<br />

A. Downing ................................................................................ 4<br />

Q&A of the author ........................................................................... 5<br />

Spectrophotometric investigation of the reaction between quercetin<br />

and stannous ions.<br />

I. Vasiljević, S. Mićić, V. Kuntić ................................................. 6<br />

Q&A of the author ........................................................................... 7<br />

Drugability-ADME/Tox properties of amine arylideneimidazolone<br />

derivatives with confirmed action on bacterial multidrug resistance<br />

mechanisms.<br />

K. Wyrzuc, E. Otrębska, S. Alibert, J. M. Pages, K. Witek,<br />

J. Handzlik, K. Kieć-Kononowicz .............................................. 8<br />

Q&A of the author ........................................................................... 9<br />

Correlation between salivary biochemical markers of stress,<br />

Psychological indicators and physical activity levels in a student<br />

population.<br />

M. Radiček, R. Lipovec ............................................................10<br />

Q&A of the author ......................................................................... 11<br />

Isolation of membrane proteins with Triton X-114 in order to analyze<br />

their N-glycosylation.<br />

N. Fekonja, H. Goričanec .........................................................12<br />

Q&A of the author ......................................................................... 13<br />

EUFEPS information ..................................................................... 15<br />

3


EPSA Students' Science Publication<br />

CO-MORBIDITY IN SYSTEMIC LUPUS<br />

ERYTHEMATOSUS: A STUDY USING THE<br />

CLINICAL PRACTICE RESEARCH DATALINK<br />

Anne Downing MPharm (Hons)<br />

Supervisor: Dr Alison Nightingale; thanks to Julia Snowball for extraction of data from the<br />

CPRD; other researchers: Amy Flynn, Lorraine Li, Kirstyn Udy & Sarah Wild<br />

Department of Pharmacy & Pharmacology, University of Bath, UK<br />

Background: Systemic lupus erythematosus (SLE) is an autoimmune disease<br />

characterised by fatigue, joint pain and skin rashes. Studies have clearly reported<br />

the lowered life expectancy and increased risk of cardiovascular disease (CVD)<br />

and polyautoimmunity in prevalent cases of SLE. Little information, however,<br />

is available from primary care research concerning co-morbidity in incident<br />

cases of SLE.<br />

Objectives: To calculate incidence rates of SLE in the UK, 2000-2012. To<br />

determine whether co-morbidity is more common in patients with SLE than the<br />

general population. To determine whether disease severity is associated with<br />

co-morbidity.<br />

Methods: Using the Clinical Practice Research Datalink (CPRD; the foremost<br />

database of anonymised general practice data), incidence rates of SLE were<br />

calculated and a matched cohort study was completed. The proportion of SLE<br />

cases and controls identified as prevalent and incident cases of co-morbidity<br />

(depression, CVD risk (measured as hypercholesterolaemia and hypertension),<br />

hypothyroidism and Sjögren’s Syndrome (SS)) were compared in the two year<br />

period of one year before and after first diagnosis. Mild and severe cases of<br />

SLE were also identified and proportions presenting with co-morbidity were<br />

compared.<br />

Results: 1756 incident SLE cases were identified. The age-standardised<br />

incidence rate for males was calculated as 0.99/100,000/year (95% Confidence<br />

Interval (CI) 0.95-1.03) and 6.45/100,000/year (95% CI 6.36-6.55) for females.<br />

The prevalence of depression, hypertension, hypothyroidism and SS were<br />

all found to be statistically significantly higher in SLE patients than controls,<br />

whilst hypercholesterolaemia was lower. SLE patients with mild disease<br />

were more likely to suffer from hypothyroidism or SS than those with severe<br />

disease. Those with severe disease were more likely to be an incident case of<br />

hypercholesterolaemia, or a prevalent or incident case of hypertension than<br />

mild SLE cases.<br />

Conclusions: This study re-emphasises the higher risk of CVD, polyautoimmunity<br />

and depression in patients with SLE. Routine screening for the co-morbidities<br />

reported upon and closer working practices between rheumatology specialists<br />

and general practitioners should be considered.<br />

4


Q&A OF THE AUTHOR<br />

General information about Anne Downing<br />

MPharm (Hons), University of Bath (graduated 2014).<br />

Why did you select this topic for your research?<br />

I am particularly interested in rheumatology and conducted<br />

this project as part of my final year studies, with the<br />

ethics agreements in place allowing this. The emphasis<br />

on patient outcomes in the study is important to me as a<br />

future pharmacist, as I will work to improve patient care in<br />

my future roles.<br />

Volume 2 | Edition 2 | April 2015<br />

How do you feel about having coped with the challenges that research can<br />

bring?<br />

Learning the IT skills required to manipulate the data was a challenge but was<br />

eased by working as a team with my four colleagues. We worked well together<br />

to efficiently extract and analyse data.<br />

What personal skills did you develop as a researcher during your research<br />

period?<br />

Primarily teamwork and communication skills; I had to learn to listen to my<br />

colleagues and negotiate the details and parameters of the study. I certainly<br />

need to continue to develop my skills to actively listen!<br />

Would you like to share anything else with the students in Europe? Any<br />

recommendations?<br />

No matter what the topic is, find something within it that interests you and<br />

pursue that.<br />

5


EPSA Students' Science Publication<br />

SPECTROPHOTOMETRIC INVESTIGATION<br />

OF THE REACTION BETWEEN QUERCETIN<br />

AND STANNOUS IONS<br />

Ivana Vasiljević, Svetlana Mićić, Vesna Kuntić<br />

Department of Physical Chemistry and Instrumental Methods, Faculty of Pharmacy,<br />

University of Belgrade, Belgrade, Serbia<br />

Introduction: Flavonoids are a large group of polyphenolic phytochemicals,<br />

extensively distributed in plants and consequently, in plant-based food and<br />

beverages. The most common and widely distributed flavonoid in plants is<br />

quercetin. Tin is present in food- and beverage-packaging materials, while<br />

tin(II)-chloride (stannous chloride) is used as food additive and preservative<br />

(E-512) in canned food.<br />

Objective: Flavonoids form complex compounds with many metal ions.<br />

Accordingly, it is expected that quercetin will form complex with stannous ions<br />

from additive E-512 and from cans. Significant concentration of tin in foods is<br />

found in canned fruits and vegetables, particularly in acidic foodstuffs, such<br />

as canned tomato sauce, fruit juices and wine. Thus, the aim of this research<br />

was to investigate the reaction between quercetin and stannous-ions under<br />

the conditions which are close to those found in tin cans and determine the<br />

stoichiometry of reaction and stability constant of complex.<br />

Materials and Methods: Reagents: quercetin, tin(II)-chloride (Merck, Germany),<br />

ethanol (Carl Roth, Germany). Turbidity of tin(II)-chloride solution was<br />

measured by Cyberscan WL TB1000 Turbidimeter, Singapore. The reaction<br />

was investigated by Orion (Thermo Scientific, USA) pH-meter with combined<br />

electrode and Beckman DU-650 UV-VIS Spectrophotometer (USA), using 1<br />

cm quartz cells. IR spectra were obtained on Nicolet iS10 FT-IR Spectrometer<br />

(Thermo Scientific, USA).<br />

Results: Although the stannous-chloride solution hydrolyze intensively, turbidity<br />

measurement showed that this solution can be used for spectrophotometric<br />

analysis. UV-VIS spectra (200 - 600 nm) of quercetin-tin(II) ions mixture exhibited<br />

a bathochromic shift (about 20 nm) compared to the absorption spectra of<br />

quercetin alone. IR spectra of mixture showed that bends characteristic for<br />

phenolic and carboxyl groups had been shifted. The pH of the mixture is lower<br />

than the pH of the quercetin and stannous chloride solutions alone, indicating<br />

hydrogen ion releasing. Job’s plot reveals that the stoichiometry of complex<br />

reaction between quercetin and stannous ions is 1:2, with stability constant<br />

K=2.37´103.<br />

Conclusion: Under the investigated conditions (pH=6.30; 50% ethanol)<br />

quercetin and stannous ion unambiguously form a complex. Thus, it can<br />

be assumed that chelation of quercetin with stannous ions would change<br />

antioxidant properties of quercetin from canned food and/or from food with<br />

stannous chloride as additive and preservative.<br />

6


Q&A OF THE AUTHOR<br />

General information about Alexandra Ivana Vasiljević<br />

University of Belgrade-Faculty of Pharmacy, Belgrade,<br />

Serbia<br />

Volume 2 | Edition 2 | April 2015<br />

Why did you select this topic for your research?<br />

Nowadays antioxidants are a hot topic even for people<br />

outside science. The most famous flavonoid quercetin,<br />

with well documented antioxidant properties, is widely<br />

distributed in fresh food and wine and helps us to stay<br />

healthy. For example, one glass of red wine a day brings<br />

benefits for our vascular system. This phenomenon, known as French paradox,<br />

occurs because of quercetin in wine. However, canned food may contain less<br />

amounts of quercetin, because of flavonoids capability to react with stannous<br />

ions. Therefore, I wanted to investigate that phenomenon and explore the<br />

conditions under which this reaction may occur.<br />

How do you feel about having coped with the challenges that research can<br />

bring?<br />

I have never really understood all the complexities behind a research and the<br />

hardships it could entail. At first, we did not progress very well and I felt pretty<br />

disappointed. Fortunately, my mentors showed great persistence and had a lot<br />

of new ideas. Finally, we had the results.<br />

What personal skills did you develop as a researcher during your research<br />

period?<br />

Firstly and most importantly, I improved my critical thinking. Accordingly, it<br />

taught me to be more patient and showed me how determination can guide us<br />

to accomplish whatever we want. I also improved my communication skills and<br />

confirmed that good cooperation with colleagues is a key to success.<br />

Would you like to share anything else with the students in Europe? Any<br />

recommendations?<br />

I would like to advise to all of them to always learn something new and involve<br />

themselves in research. It will provide them with a new impression about<br />

science work, totally different from perspective we usually gain at the faculty.<br />

Besides, it improves personal skills, broadens the horizons and eventually<br />

brings immense satisfaction.<br />

7


EPSA Students' Science Publication<br />

DRUGABILITY-ADME/TOX PROPERTIES OF<br />

AMINE ARYLIDENEIMIDAZOLONE DERIVATIVES<br />

WITH CONFIRMED ACTION ON BACTERIAL<br />

MULTIDRUG RESISTANCE MECHANISMS<br />

Karolina Wyrzuc a , Ewa Otrębska b , Sandrine Alibert b , Jean-Marie Pages b , Karolina Witek a ,<br />

Jadwiga Handzlik a , Katarzyna Kieć-Kononowicz a<br />

a<br />

Department of Technology and Biotechnology of Drugs, Jagiellonian University Medical<br />

College, Faculty of Pharmacy, Kraków, Poland<br />

b<br />

Facultés de Médecine et de Pharmacie, Transporteurs Membranaires, Chimiorésistance<br />

et Drug-Design, Marseille, France<br />

Bacterial multidrug resistance (MDR) is a major clinical and public health<br />

problem worldwide. Overexpression of efflux pumps is one of the mechanisms<br />

behind MDR which is widely spread among Gram-negative bacteria. A main<br />

strategy to circumvent the MDR is to co-administer efflux pump inhibitors<br />

(EPIs), independent compounds which are able to block efflux action of protein<br />

transporters of a drug [2]. The search for new EPIs, which are promising<br />

therapeutic agents is still a main topic of medicinal chemistry. A serie of<br />

piperazine arylideneimidazolone compounds 1-18 (Fig. 1) was evaluated on<br />

their EPI properties in two strains of Enterobacter aerogenes. The promising<br />

activity of a significant number of the compounds indicated their potential<br />

therapeutic future as antibiotics “adjuvants”. Thus, further investigations on<br />

their ADME/Tox properties should be the next step, which is of great importance<br />

in the search for new drugs.<br />

Ar<br />

O<br />

H<br />

N<br />

N<br />

1-18<br />

Amine<br />

Amine: (un)substituted piperazine, hydroxyethylamine<br />

Ar:(un)substituted benzene, naphthalene, fluorene, anthracen<br />

Taking this into account, the series of the arylideneimidazolone amine<br />

derivatives 1-18 were investigated in silico on their “drugability”, including<br />

physicochemical properties (clogP, logS, TPSA), toxic effects (service OSIRIS)<br />

and blood-brain barrier permission (models of Zhao, Norinder-Haeberlein or<br />

Lipinski) [1]. These studies showed low or moderate risk of mutagenic and<br />

tumorigenic effects for most of the compounds. The best activity was shown<br />

by the compounds with anthracene and naphthalene at position 5. Results<br />

however indicated that these two compounds also were mutagenic and<br />

tumorigenic.<br />

[1] Broccatelli F. et al., Adv Drug Deliv Rev. 2012, 64, 95-109.<br />

[2] Mahamoud A., et al.: Curr. Drugs Targets 7 (2006), 843-847.<br />

Partly supported by K/ZDS/003323<br />

8


Q&A OF THE AUTHOR<br />

General information about Karolina Wyrzuc<br />

Jagiellonian University Medical College, Department<br />

of Pharmacy, Poland<br />

Volume 2 | Edition 2 | April 2015<br />

Why did you select this topic for your research?<br />

My master thesis was also connected with bacterial<br />

resistance so I chose this topic to follow-up my previous<br />

results. I was impressed by my supervisor and I shared her<br />

interest in medical chemistry. As an active pharmacist, I<br />

noticed that nowadays antibiotic overuse is a problematic<br />

issue and I wanted to improve my knowledge of this topic. One of the strategies<br />

in battling antibiotic resistance is research and development of new antibiotics<br />

and compounds which are able to combat antibiotic resistance. Research<br />

results that I have obtained with my co-workers can be a step forward in this<br />

matter and I am very satisfied with it.<br />

How do you feel about having coped with the challenges that research can<br />

bring?<br />

At the beginning of my research I was very enthusiastic about the first results. As<br />

it turned out that they are not as good as I expected, I was really unmotivated.<br />

But then I realized that drug research and development is a long and difficult<br />

process. If every researcher would give up at the first step, will there be any<br />

new medicines in the future? I am now again optimistic and I hope that my<br />

results will contribute to development of drugs capable to combat bacterial<br />

resistance infections.<br />

What personal skills did you develop as a researcher during your research<br />

period?<br />

Accuracy, defining a problem and identifying the possible causes, working<br />

effectively under the pressure and to meet the deadlines, as well as collaborating<br />

on a project.<br />

Would you like to share anything else with the students in Europe? Any<br />

recommendations?<br />

Do not give up! Sometimes good results of your research are not the most<br />

important thing. Remember that during this work, everyday you develop<br />

yourself, gain new abilities and experience. Now you can think that this a small<br />

step forward but later you will realise how big it was.<br />

9


EPSA Students' Science Publication<br />

CORRELATION BETWEEN SALIVARY<br />

BIOCHEMICAL MARKERS OF STRESS,<br />

PSYCHOLOGICAL INDICATORS AND PHYSICAL<br />

ACTIVITY LEVELS IN A STUDENT POPULATION<br />

Renata Lipovec, Marija Radiček<br />

Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia<br />

Saliva is an oral fluid of complex composition that has a variety of functions in<br />

the oral cavity. CNS has the most important role in the regulation of salivation.<br />

Saliva as a sample is suitable for easy sampling and analytes are found in free,<br />

active form. Stress is a condition under which the inner (psychophysiological)<br />

balance of the organism is disturbed and it activates the hypothalamic-pituitaryadrenal<br />

cortex. A stressful situation does also stimulate the sympathetic neural<br />

system which causes a change in the secretion of salivary alpha amylase from<br />

salivary gland. Salivary cortisol can be used as indicator of the levels of free<br />

serum cortisol which reflects the biologically active fraction.<br />

The hypothesis of this study was - students with intensive daily physical activity,<br />

which causes stress to the body, are exposed to chronic stress compared to<br />

other students who have a minimum of physical activity. The study included 54<br />

healthy volunteer (N=54) students of the University of Zagreb, divided into two<br />

groups. One group of volunteers consisted from physically active volunteers<br />

(N=27) from the Faculty of Kinesiology - SK and the second group consisted<br />

from physically inactive volunteers (N=27) from other faculties - OS. The groups<br />

of respondents were balanced by gender; the first group of physically active<br />

subjects included 15 men and 12 women and the second group of physically<br />

inactive respondents composed of 14 men and 13 women, both groups aged<br />

19 - 26 years.<br />

There was a weak to moderate negative correlation between the concentration<br />

of salivary cortisol and sAA, but not statistically significant. Equal correlation was<br />

observed for all students regardless of physical activity. The best correlation<br />

between cortisol and sAA and the strongest statistical significance showed the<br />

group of students who had moderate physical activity - OS group. There was<br />

no statistically significant correlation between biochemical indicators of stress<br />

(sAA and salivary cortisol) and results obtained using psychological testing for<br />

both groups (SK and OS). Active and positive coping with stressful situations<br />

is observed in the group of physical education students on the basis of a single<br />

domain, psychological testing, coping with stressful situations. By comparing<br />

the biochemical and physiological parameters to stress we conclude with the<br />

statement that the two groups of students had equal results and that we find<br />

no objective basis on which we could be attributed to one group of chronic<br />

stress. Despite the very different physical activities no difference was seen<br />

between the student populations.<br />

10


Q&A OF THE AUTHOR<br />

General information about Marija Radiček<br />

University of Zagreb, Faculty of Pharmacy and<br />

Biochemistry<br />

Volume 2 | Edition 2 | April 2015<br />

Why did you select this topic for your research?<br />

The most common sample in clinical biochemistry is<br />

blood, so me and my colleague Renata decided to try to<br />

work with saliva. Our mentor prof. Dr.Sc. Vrkić gave us<br />

guidelines, provided with advantages and shortcomings<br />

of saliva as a sample, so we were interested even more to<br />

do research with it. Together we decided to work with the groups of students.<br />

One of the reasons was that we also are in this group and we thought that it<br />

could be interesting to study physical activities of the various students from<br />

different colleges, with different customs and engagements.<br />

How do you feel about having coped with the challenges that research can<br />

bring?<br />

We had a lot of obstacles from the first moment we started. First one was the<br />

collecting of the saliva. We worked with a huge group of people, and it was<br />

difficult to find a moment and to group all of those students because they all<br />

had different schedules and their own obligations. When we finally managed to<br />

collect our samples we started to work in a lab. Process of analysis lasted for<br />

a long time, it was demanding, we spent a lot of hours in the lab, but finally we<br />

find out what we wanted.<br />

What personal skills did you develop as a researcher during your research<br />

period?<br />

I think that the most diligent skill was the communication between people I<br />

collaborated with, but of course there are even greater things that are connected<br />

to our work, especially skills about the organisation, precision, significance, all<br />

of that helped us to do our research the best we could.<br />

Would you like to share anything else with the students in Europe? Any<br />

recommendations?<br />

Dear students, I just want to share my experience with all of<br />

you and to try to inspire you to do something similar or even<br />

better. I want to wish all of you a lot of determination and good<br />

luck with your researches. In the end, I just want to say thank<br />

you to all my participants, especially thanks to my colleague<br />

Renta Lipovec, who worked with me, and our mentor prof.<br />

Dr.Sc. Nada Vrkić who helped us to accomplish our wishes.<br />

11


EPSA Students' Science Publication<br />

ISOLATION OF MEMBRANE PROTEINS WITH<br />

TRITON X-114 IN ORDER TO ANALYZE THEIR<br />

N-GLYCOSYLATION<br />

Nina Fekonja, Helena Goričanec<br />

Department of Biochemistry and Molecular Biology, Faculty of Pharmacy and Biochemistry,<br />

Croatia<br />

Recent methods for the isolation of membrane proteins have not proved their<br />

sufficient effectiveness. Therefore, the aim of this study was to optimize the<br />

method of isolation of membrane proteins with Triton X-114 so they can be<br />

analyzed for N-glycosylation. For this purpose, cells were taken from the<br />

THP cell line. A key step was the purification of isolated proteins from excess<br />

detergent. Several methods were tested to determine which one gives the best<br />

results. Next step was releasing, isolation and labeling of N-linked glycans<br />

which thereafter were analysed by UPLC-HILIC chromatography.<br />

In the methods for purification of the isolated membrane proteins, 3 kDa<br />

centrifugal filters were used, along with various organic solvents (acetone,<br />

combinations of acetone/methanol and chloroform/methanol) which as a result<br />

gave a protein precipitate.<br />

The results obtained in this study, after purification of isolated proteins by spinfilters<br />

have not been satisfactory. Although the samples were purified from<br />

the detergent Triton X-114, the intensities of peaks in the chromatogram of<br />

glycosylation profiles were too close to the noise level of the instrument and<br />

therefore can not be used for reliable interpretation. Methods with organic<br />

solvents have shown better results. Their analysis gave stronger intensities of<br />

peaks and chromatograms with better resolution, because of a better protein<br />

purification. This study also shows that the amount of cells taken in the analysis<br />

affects the intensity of the chromatographic peaks.<br />

The importance of this study is linked to improving the isolation of membrane<br />

proteins which enable a better insight into their glycosylation. It can be essential<br />

because changes in glycosylation are increasingly used as diagnostic markers<br />

for many diseases.<br />

12


Q&A OF THE AUTHOR<br />

General information<br />

Nina Fekonja, 22, Nedelišće, Republic of Croatia,<br />

ninaa.fekonja@gmail.com, Faculty of Pharmacy and<br />

Biochemistry<br />

Helena Goričanec, 23, Hodošan, Republic of Croatia,<br />

helena.goricanec@gmail.com, Faculty of Pharmacy and<br />

Biochemistry<br />

Volume 2 | Edition 2 | April 2015<br />

Why did you select this topic for your research?<br />

This topic has already been a part of a project carried out<br />

at the Institute of Molecular Biology and Biochemistry at our University, so<br />

we joined. This topic attracted us because it is significant, since the existing<br />

methods for the isolation of membrane proteins are not good enough. If you<br />

read the abstract you can see why is it so important.<br />

How do you feel about having coped with the challenges that research can<br />

bring?<br />

To be honest, we were quite lucky and did not have many problems during the<br />

research. Despite of that, we were very excited while waiting for the results and<br />

when or if they turned out to be unsatisfying, we took that as a new challenge.<br />

What personal skills did you develop as a researcher during your research<br />

period?<br />

We have learned how to behave in a laboratory, how to identify a problem and<br />

how to think critically. Moreover, we have learned to be patient, to stick to the<br />

schedule and the most important - not to give up.<br />

Would you like to share anything else with the students in Europe? Any<br />

recommendations?<br />

We would like to recommend to all of the students who are interested in any<br />

kind of research, and they have an opportunity to do it in their college or<br />

anywhere else, to take a chance. They will learn a lot and it could also be a<br />

step towards new opportunities in the future.<br />

13


EPSA Students' Science Publication<br />

EUROPEAN FEDERATION FOR<br />

PHARMACEUTICAL SCIENCES (EUFEPS)<br />

The European Federation for Pharmaceutical Sciences is a voluntary<br />

association of pharmaceutical scientists, established in 1991 to advance<br />

research in the pharmaceutical sciences in Europe. This can be achieved by<br />

promoting cooperation between national, regional and European societies or<br />

associations which aim at the advancement of pharmaceutical sciences, and by<br />

promoting cooperation between and with other pharmaceutical organisations<br />

and between individual pharmaceutical scientists.<br />

The Mission<br />

EUFEPS exists to help to meet the challenges and seize the opportunities<br />

created by the consolidations occurring both within Europe and globally,<br />

driven on by a combination of rapid advances in science and technology,<br />

economic pressures, and by political will. Within this frame, EUFEPS’s role and<br />

contributions are amply expressed in its mission statement “EUFEPS serves<br />

and advances excellence in the pharmaceutical sciences and innovative drug<br />

research in Europe”. Spearheading a number of initiatives, EUFEPS works with<br />

its membership, throughout the nations of Europe.<br />

European Dimension<br />

EUFEPS is unique being the only pan-European organisation that represents,<br />

under one umbrella, all the pharmaceutical sciences and pharmaceutical<br />

scientists engaged in drug research and development, drug regulation and<br />

drug policy making. The existence of such an umbrella platform facilitates the<br />

highly innovative, integrative and interdisciplinary approaches that are essential<br />

if we, in Europe, are to deliver to our citizens safe, effective, economic and<br />

timely medicines. The ultimate benefits are an improving health, quality of life,<br />

and wealth of our continent.<br />

EUFEPS is recognised by the European Commission, as representing the<br />

integrative pharmaceutical sciences within Europe. EUEFPS is also recognised<br />

by the EMEA as a neutral scientific resource for independent opinions on draft<br />

regulatory guidelines, while EUFEPS works with other European organisations,<br />

such as EFPIA, to help identify and promote training to meet industrial<br />

needs. EUFEPS has the ambition to provide a forum for policy development<br />

in the pharmaceutical sciences, particularly in relations to the discovery and<br />

development of new drugs and their introduction into the market, but also as<br />

14


Volume 2 | Edition 2 | April 2015<br />

to medicines usage. This includes policies on and leadership development as<br />

to: research, education & training, profiling and regulatory affairs.<br />

In addition, EUFEPS plays an active and influential role also in the global arena.<br />

It is recognised by the USA FDA and it works actively with its sister organisation<br />

AAPS to develop co-sponsored meetings and workshops that run alternatively<br />

in Europe and the USA, and is developing links with Asian scientists. Through<br />

involvement with its Board of Pharmaceutical Sciences, EUFEPS is also<br />

working with FIP to advance the pharmaceutical sciences globally.<br />

Upcoming Conferences organised by EUFEPS:<br />

Safety paradigm for Medicines - Changes<br />

and Challenges from Drug Discovery to<br />

Usage<br />

April 27-28, 2015, Lisbon, Portugal<br />

For more information see: www.eufeps.org/conferences<br />

EuPAT7<br />

May 17-18, 2015, Graz, Austria<br />

organised by EUFEPS<br />

For more information see: www.qbdpat.org<br />

EUFEPS Annual Meeting 2015<br />

June 15-17, 2015, Geneva, Switzerland<br />

For more information see www.eufeps.org<br />

Science: “Strategies to improve the<br />

quality and performance of modern drug<br />

delivery systems”<br />

September 10-12, 2015, Helsinki, Finland<br />

For more information see www.eufeps.org<br />

15

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!