Alzheimer's Australia Vic | The Dementia Guide


The Dementia Guide – for people living with dementia, their families and carers.


People who have moderate Alzheimer’s disease but are unable take any

of the three drugs listed on page 45, might be offered memantine (e.g.

Ebixa, APO-Memantine, Memanxa). It is also becoming more common

to be offered memantine in the later stages of Alzheimer’s disease when

symptoms become more severe.

Memantine works by protecting brain cells from the harmful effects of a

natural substance called glutamate. People with Alzheimer’s disease often

have damagingly high levels of glutamate in their brains.

Possible benefits

Memantine can temporarily slow down the progression of symptoms in

people in the middle and later stages of Alzheimer’s disease. It may also

help with agitation or aggressive behaviour, and may improve language and


Possible side effects

Memantine usually has fewer side effects than the other three drugs,

although it can still cause dizziness, headaches, tiredness, increased blood

pressure and constipation.

Memantine is only available under the Pharmaceutical Benefit Scheme

(PBS) for moderately severe dementia. Speak to your doctor to find out

whether you are eligible for this drug.

For more information see Help Sheet, About dementia 9: Drug treatments

and dementia. Available at

Vascular dementia

The four drugs described in the previous section aren’t recommended for

vascular dementia unless this is part of mixed dementia with Alzheimer’s


It may be possible to slow down the progression of vascular dementia

by taking drugs that treat the underlying conditions. A doctor will often

prescribe drugs for people with vascular dementia who are at risk of having

a stroke or heart attack by treating high blood pressure, high cholesterol,

diabetes or heart problems.


Call the National Dementia Helpline on 1800 100 500

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