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Pronounced: soe-RAF-e-nib
Classification: Multikinase Inhibitor
What do you mean by Sorafenib?
Sorafenib is a type of targeted therapy. This means it works by targeting
receptors specific to the cancer cells, therefore decreasing side effects caused
by damage to the healthy cells. Sorafenib actually works by targeting two
specific receptors, RAF kinase and VEGF receptors. Blocking the first receptor
(RAF kinase) slows down cell division and tumor growth. VEGF receptors are
responsible for angiogenesis, or the development of new blood vessels by and
for the tumor, so blocking these receptors essentially attacks the tumor's
source of nutrients.
It is mainly used to treat Kidney Cancer, Thyroid & Liver Cancer
Kidney cancer
If you or someone you know has been diagnosed
with kidney cancer, we can provide the information
you need, whether you're making a decision about
treatment, looking for support, or just need to
understand the basics.
The kidneys are two bean-shaped organs located on either side of the middle of
the back, just under the ribs. As well as filtering blood, the kidneys make three
important hormones, which are:

enin – helps regulate your blood pressure
calcitol – helps to control your body’s calcium levels
erythropoietin – stimulates your bone marrow to make red blood cells.
There are normally two kidneys in your body, but you can survive on one
alone. On top of each kidney is a tiny gland called the adrenal gland that
makes hormones. When cancer develops in one of your kidneys, the cells
change and grow in an abnormal way. A group of these cancer cells can
form a tumour. It can affect how your kidney works normally. Cancer of the
kidney is also known as renal cell cancer or renal cell adenocarcinoma. It is
the most common type of kidney cancer. More kidney cancers are being
diagnosed today due to improved abdominal scanning.
Thyroid Cancer:
A cancer in the butterfly shaped gland at the base of the neck (thyroid). The
Cause of thyroid cancer is poorly understood, but may involve a
combination of genetic and environmental factors. Some people have no
symptoms. Others may notice a lump in the neck.
Treatments, which are usually successful, include surgery, hormone
therapy, radioactive iodine, radiation and in some cases chemotherapy.

Liver Cancer:
Liver cancer, also known as hepatic cancer, is a cancer which starts in the
liver, rather than migrating to the liver from another organ or section of the
body. In other words, it is a primary liver cancer.
Cancers that originate elsewhere and eventually reach the liver are known
as liver metastasis or secondary liver cancers, and are most commonly from
cancer of the gastrointestinal (GI) tract (colon cancer), lung cancer, renal
cancer (cancer of the kidney), ovarian cancer and prostate cancer.

Sorafenib Dosage:
Sorafenib comes as a tablet to take by mouth. It is usually taken twice a day
and should be taken on an empty stomach, 1 hour before or 2 hours after
eating. Take sorafenib at around the same times every day. If you miss a dose,
skip the missed dose and take the next dose at the scheduled time. Do not try
to catch up or double the next dose.
The blood levels of this medication can be affected by certain foods and
medications, so they should be avoided. These include: warfarin,
dexamethasone, carbamazepine, rifampin, phenytoin, St. John's wort, and
phenobarbital. Be sure to tell your healthcare provider about all medications
and supplements you take.
Symptoms Of Sorafenib Tablets
There are a number of things you can do to manage the side effects of
sorafenib. Talk to your doctor or nurse about these recommendations. They
can help you decide what will work best for you. These are some of the most
common side effects:
High Blood Pressure
Nausea and/or Vomiting
Fatigue
Diarrhea
Decrease in Appetite
Hand Foot Syndrome
Skin, Hair & Nail Changes
Blood Counts
Liver Toxicity
GI Tear
Wound Healing
Heart Abnormalities
Bleeding, Stroke, Heart Attack

What should I know about storage and disposal of this
medication?
Keep this medication in the container it came in, tightly closed, and out of
reach of children. Store it at room temperature and away from excess heat and
moisture (not in the bathroom).Unneeded medications should be disposed of
in special ways to ensure that pets, children, and other people cannot consume
them. However, you should not flush this medication down the toilet. Instead,
the best way to dispose of your medication is through a medicine take-back
program. Talk to your pharmacist or contact your local garbage/recycling
department to learn about take-back programs in your community.
Sorafenib 200mg Tablet Frequently asked Questions
Is it safe to drive or operate heavy machinery when consuming?
If you experience drowsiness, dizziness, hypotension or a headache as sideeffects
when eating Sorafenat cancer medicine then it may not be safe to drive
a vehicle or operate heavy machinery. Pharmacists also advise patients not to
drink alcohol with medicines as alcohol intensifies drowsiness side-effects.
Please check for these effects on your body when using Sorafenat Tablet.
Always consult with your doctor for recommendations specific to your body
and health conditions.
Is Sorafenat Tablet safe to consume or apply when pregnant ?
Do not use Sorafenib 200mg if you are pregnant. It could harm the unborn
baby. Tell your doctor right away if a pregnancy occurs while either parent is
taking this medication.
Is this medicine safe while breastfeeding ?
It is not known whether sorafenib passes into breast milk or if it could harm a
nursing baby. You should not breast-feed while using Sorafenat Sorafenib
Tablets.
What should You avoid ?
Sorafenib can pass into body fluids (urine, feces, vomit). Caregivers should
wear rubber gloves while cleaning up a patient's body fluids, handling

contaminated trash. Wash hands before and after removing gloves. Wash
soiled clothing separately from other laundry.
Sorafenib Comes in Various Brands:
Sorafenat Sorafenib 200mg Tablets
Sorafenib Tosylate Medicine Details:
Brand Name: Sorafenat 200 mg
Content: Sorafenib 200 mg
Strength: 200 mg
Form: Tablets
Packing: Pack of 120 Tablets
Manufacturer: Natco Pharma Limited

Nexavar 200 mg Online Price
Nexavar 200mg Tablets Specification:
Brand Name: Nexavar Tablets
Content: Sorafenib 200mg
Strength: 200 mg
Form: Tablets
Manufacturer: Bayer
Packing: Pack of 60 Tablets
Sorafenib 200 mg Tablets Soranib Cipla

Soranib Sorafenib Tablets Specification:
Brand Name: Soranib Tablets
Contents: Sorafenib 200mg
Form: Tablets
Strength: 200mg
Manufactured By: Cipla India Ltd
Packing: Pack of 120 tabs
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