INSIGHT

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Annual-Report-2016-Final

INSIGHT

2016 ANNUAL REPORT

KECK SCHOOL OF MEDICINE OF USC

DEPARTMENT OF OPHTHALMOLOGY


Gayle and Edward Roski made a transformative $25 million gift

in 2016 to endow and name the USC Roski Eye Institute, further

advancing the institute’s position as one of the nation’s leading

centers for advanced vision care, research and education.


Our gratitude to the Roski family is profound. With this gift, we will continue to

make progress toward our most ambitious goal — eliminating blindness.”

Rohit Varma, MD, MPH, Director, USC Roski Eye Institute


INSIGHT is the driving force behind

everything we do at the USC Roski

Eye Institute.

Insight begins with envisioning a future without blindness.

Insight grows by learning from each courageous patient.

Insight deepens through continual discovery and invention.

Insight triumphs when we come together to preserve vision.

Insight renews as each new generation seeks and serves.

INSIGHT 2016 provides a glimpse into the accomplishments of our 41st year.

We are deeply indebted to the patients, families, philanthropists, physicians,

scientists, researchers, caregivers, residents, technicians, entrepreneurs,

administrators, managers, and countless others who join us in our mission to

eliminate blindness. All of you make the USC Roski Eye Institute everything it is,

and everything it will be.

With gratitude,

Rohit Varma, MD, MPH

Dean, Keck School of Medicine of USC

May S. and John Hooval Dean’s Chair in Medicine

Grace and Emery Beardsley Chair in Ophthalmology

Director, USC Roski Eye Institute

(Opposite page, from left) Rohit Varma, Edward P. Roski Jr., Gayle Garner Roski, Robert Day,

Niki Nikias, USC President C.L. Max Nikias, and Mark Humayun give the USC “Fight On” sign.

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VISION IS OUR MISSION

PRESERVE. PROTECT. RESTORE.

Fulfillment of our mission is best expressed in the remarkable triumphs of our patients. Please read their stories in the pages ahead.

PRESERVE

The USC Roski Eye Institute diagnoses,

treats and manages the most complex

eye conditions, from in utero to

advanced age.

PROTECT

The USC Roski Eye Institute leads major

research in the epidemiology of eye

disease to help prevent blindness.

RESTORE

The USC Roski Eye Institute integrates

and applies emerging technologies to

develop new methods to restore sight

to the blind.

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INSIGHT

2016 ANNUAL REPORT

Patient Care 6

Research 18

Preserving Sight 32

Clinical Education 37

Publications 50

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MAJOR ACCOLADES

AND ACHIEVEMENTS

World’s 100 Most Influential

People in Ophthalmology

Awarded by The Ophthalmologist

From left, Carmen Puliafito, MD, MBA, Mark S. Humayun,

MD, PhD, and Farhad Hafezi, MD, PhD.

Nation’s Best Hospitals

for Ophthalmology

2016-17

Nationally Top Ranked Ophthalmology Program

2016 AAO LIFE

ACHIEVEMENT HONOR

AWARD

Rohit Varma, MD, MPH, director, USC Roski Eye Institute,

was presented with the award at the 2016 American

Academy of Ophthalmology conference in Chicago.

#2

IN RESEARCH FUNDING 2016

by the National Eye Institute

BEST DOCTORS IN AMERICA ®

2015-16

Four USC Roski Eye Institute faculty

named among the best

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National Medal of

Technology

and Innovation

The nation’s highest honor for

technology achievement

SUPER DOCTORS OF

SOUTHERN CALIFORNIA 2016

13 USC Roski Eye Institute faculty

named among the best

President Barack Obama and National Medal recipient Mark S.

Humayun, MD, PhD, co-director of the USC Roski Eye Institute

and director of the USC Institute for Biomedical Therapeutics.

#9

U.S. Ophthalmology

Residency Program 2016

by Doximity

NEW TEXTBOOKS FROM USC ROSKI EYE INSTITUTE FACULTY 2016

(Left to right) Advanced Glaucoma Surgery Editors: Ahmad A. Aref and Rohit Varma; Clinical Neuro-Ophthalmology: The Essentials

Authors: Neil R. Miller, Prem S. Subramanian and Vivek Patel; Corneal Collagen Cross-Linking (translated into Chinese) Authors: Farhad

Hafezi and J. Bradley Randleman; Corneal Cross-Linking Editors: Farhad Hafezi and J. Bradley Randleman; Intraocular Inflammation

Editors: Manfred Zierhut, Carlos Pavesio, Shigeaki Ohno, Fernando Orefice, Narsing A. Rao; Intraocular Lens Surgery Editor: J. Bradley

Randleman; Optical Coherence Tomography and OCT Angiography Authors: Darrin A. Landry and Amir H. Kashani.

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INSIGHT

Patient

Care

The USC Roski Eye Institute is dedicated

to managing or curing eye conditions by

applying the most advanced knowledge,

skills, technologies and methods.

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PATIENT CARE

HIGHLY SPECIALIZED CARE

FOR ADULTS AND CHILDREN

The USC Roski Eye Institute treats the full spectrum of eye

conditions — from the most common to the most complex.

CATARACTS

CORNEA AND

EXTERNAL DISEASES

Blepharitis, Bullous Keratopathy,

Chalazia/Styes, Conjunctivitis, Corneal

Dystrophies, Fuchs Endothelial

Dystrophy, Corneal Infection, Corneal

Scarring, Dry Eye Syndrome, Herpes

Keratitis, Keratoconus, Pterygium,

Ocular Rosacea

GLAUCOMA

Angle Closure Glaucoma, Open-Angle

Glaucoma, Congenital and Childhood

Glaucoma, Pseudoexfoliation

Glaucoma, Glaucoma Secondary to

Eye Trauma, Neovascular Glaucoma,

Normal Tension Glaucoma,

Pigment Dispersion Glaucoma,

Uveitic Glaucoma

LASER VISION CORRECTION

Anisometropia, Astigmatism,

Hyperopia, Keratoconus,

Myopia, Presbyopia

NEURO-OPHTHLAMOLOGY AND

ADULT STRABISMUS

Blepharospasm, Double Vision,

Hemifacial Spasm, Idiopathic

Intracranial Hypertension, Optic

Neuropathy, Papilledema, Stroke,

Temporal Arteritis, Thyroid Eye

Disease, Visual Field Defects

OCULAR ONCOLOGY

Anterior Segment and Iris Tumors,

Basal Cell Carcinoma, Conjunctival

Tumors, Conjunctival Melanoma,

Lid Tumors, Lymphoma, Melanoma,

Metastatic Lesions, Ocular Surface

Squamous Neoplasia, Optic Nerve

Lesions, Orbital Lesions, Sebaceous

Cell Carcinoma of the Lid, Squamous

Cell Carcinoma, Vascular Lesions,

Uveal Lesions

OCULOFACIAL

PLASTIC SURGERY

OPHTHALMIC MOLECULAR AND

IMMUNOPATHOLOGY

PEDIATRIC OPHTHALMOLOGY

SPECIALTY CONTACT LENSES

AND PROSE

UVEITIS AND OCULAR

INFLAMMATION

Chorioretinitis, Herpetic Uveitis,

HLA-B27 Iridocyclitis, Ocular

Tuberculosis, Toxoplasmosis, Vogt-

Koyanagi-Harada Disease

VITREORETINAL SURGERY

AND RETINAL DISEASE

Age-related Macular Degeneration

(Wet and Dry), Central Serous

Chorioretinopathy, Diabetic Macular

Edema, Diabetic Retinopathy, Macular

Hole, Macular Pucker, Posterior

Vitreous Detachment, Retinal

Detachment, Retinal Tears, Retinal

Vein Occlusion, Retinitis Pigmentosa

109,461

TOTAL

PATIENT VISITS

256

PEER-REVIEWED

PUBLICATIONS

WORLD WIDE

PATIENT CARE

36

ACTIVE RESEARCH GRANTS

$56.3

MILLION

FEDERAL GRANT EXPENDITURES

125

FACULTY MEMBERS

USCEYE.ORG

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Jessica Marquez

Congenital Glaucoma

Corneal Edema/

Cloudiness

OCULAR HISTORY

Previous treatment for glaucoma.

Failed corneal transplant left

significant scar tissue in right eye.

TREATMENT

Full thickness corneal transplant

and glaucoma valve revision.

OUTCOME

Cornea is clear in right eye. Vision

improved dramatically.

Growing up with severe vision problems, Jessica never thought of herself as different.

Legally blind for most of her life, Jessica Marquez began the battle to

save her vision as a young child. An extreme sensitivity to light and poor

eyesight led to a diagnosis of glaucoma and cloudy corneas in both eyes.

Over the years, treatment for Jessica’s condition included surgeries and

setbacks that took a further toll on her vision.

Jessica eventually came to the USC Roski Eye Institute in hopes that

her vision could be saved. A team of corneal, retinal and glaucoma

specialists examined Jessica and developed a comprehensive plan to

maximize the efficiency of treatment while reducing further trauma to

her eyes. Her eye pressure is now under control and her eyesight has

been preserved.

Despite having very little vision and enduring more than 40 eye

surgeries, Jessica has achieved remarkable success. With her parent’s

loving support, she kept her eyes on the future. She excelled in school,

eventually earning a master’s degree and becoming a professor who

teaches public speaking at Orange Coast College. “Education is power,”

Jessica says. “Don’t let anything stand in your way.”

Top image shows a normal optic

nerve head. Bottom image shows

damage to the optic nerve head from

glaucomatous cupping.

Alena Reznik, MD, Amir Kashani, MD, PhD, and Jonathan Song, MD, are

working together to preserve Jessica’s vision.

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I found great hope in the atmosphere here because

I always feel like I am part of the family.

Jessica Marquez”

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REVOLUTIONIZING

GLAUCOMA SURGERY

Ron Bache, BS

Rohit Varma, MD, MPH

Approved this year by the FDA,

the new XEN ® Glaucoma Treatment

System redefines surgical intervention

for glaucoma through the innovative

application of a permanent, flexible

implant that drains eye fluid to reduce

intraocular pressure.

Developed by USC alumnus and entrepreneur Ron Bache, ’91 with scientific

support from Rohit Varma, MD, MPH, the XEN gel stent was proven in large

clinical trials to be effective with minimal side effects. Surgical implantation

with a specially developed injector applicator simplifies and standardizes the

procedure for optimal results that are easily replicated.

This revolutionary intervention has great potential to preserve vision for the

nearly 80 billion people worldwide who are estimated to have or who will

develop glaucoma by 2020.

The XEN ® Glaucoma Treatment System reduces intraocular eye pressure with a tiny flexible stent that is implanted using an injector applicator.

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PATIENT CARE

J. Bradley Randleman, MD, performs the CXL procedure that uses a combination of ultraviolet-A light irradiation and application of riboflavin (vitamin B2) eye

drops to stabilize the cornea.

ADVANCING CORNEAL

CROSS-LINKING

Approved this year by the FDA, corneal cross-linking (CXL) is an innovative

procedure that provides effective treatment for keratoconus, an eye disease that

destroys vision by distorting the cornea into a cone shape.

J. Bradley Randleman, MD

In the clinic, J. Bradley Randleman, MD, was a principal investigator for two FDAsponsored

U.S. clinical trials demonstrating that CXL can stabilize the cornea and

halt the progression of the disease. In the field, Farhad Hafezi, MD, PhD, is leading

a clinical study on the incidence of keratoconus in Saudi Arabia, where the

disease is believed to be more prevalent.

Together, these USC Roski USC Eye Institute researchers are working to overcome

a disease that is the leading cause of severe visual impairment among children

and adults worldwide.

Farhad Hafezi, MD, PhD

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Adam Lyons

Keratoconus

OCULAR HISTORY

Good vision in left eye with contact

lens after corneal transplant 10 years

ago. Poor vision in right eye from

keratoconus. Contact lens intolerant.

TREATMENT

Underwent corneal crosslinking

(CXL), a new treatment

for keratoconus that stops the

progression of the disease and

can partially reverse some of the

corneal changes.

OUTCOME

In the healing phase and doing well.

Adam enjoys travel and outdoor activities with his family.

With his cornea changing shape from keratoconus, Adam’s vision in his

right eye worsened and he was no longer able to wear a contact lens.

Jonathan Song, MD, examined Adam and recommended an innovative

procedure called corneal cross-linking (CXL). The USC Roski Eye Institute

is the first site in the Los Angeles region to have the approved device and

offer CXL treatment.

CXL, recently approved by the FDA for use in the United States, is

the first and only treatment that can actually halt the progression of

keratoconus, and in some cases can partially reverse it. J. Bradley

Randleman, MD, performed the procedure on Adam, which consists of

dispersing riboflavin eye drops for 30 minutes followed by another 30

minutes of exposure to ultraviolet light.

The procedure was effective in helping to reshape the cornea. Adam’s

eye is healing well and his vision is improving.

Image of the cornea during CXL

treatment. The green glow of the

cornea results from the yellow riboflavin

drops fluorescing under the blue

ultraviolet light.

J. Bradley Randleman, MD, left,

performed the CXL procedure on

Adam’s right eye, and Jonathan

Song, MD, previously performed a

corneal transplant on his left eye.

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I’ve been in good hands throughout my exams, the corneal

transplant and the new corneal cross-linking treament.

Adam Lyons”

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EVALUATING FITNESS-

TRACKING EYEWEAR

Gloria Chiu, OD, FAAO, FSLS

“The result is

better vision

and better

fitness.”

Imagine if eyeglasses could provide an edge in improving overall health. An

innovative product that seamlessly integrates fitness-tracking technology into an

optical frame is being distributed through the USC Roski Eye Institute as part of a

pilot study.

The fashion-forward eyeglasses measure a wearer’s steps, calories burned,

distance traveled and activity, and connect wirelessly to track progress through

an accompanying smartphone application.

Gloria Chiu, OD, FAAO, FSLS, who leads the study’s eye care team, believes the

eyeglasses will provide more reliable and consistent tracking than wristbands

that are subject to vigorous hand movement or not being worn. The result is

better vision and better fitness.

The eyeglasses, developed by VSP Global in partnership with the USC Center for Body Computing, are shown here with a clear temple that reveals the hidden

accelerometer, magnetometer and gyroscope that provide biometric measurement.

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PATIENT CARE

The new Retinal Degeneration Center surrounds patients with advanced clinical care and breakthrough research.

LAUNCHING THE RETINAL

DEGENERATION CENTER

Children and adults who inherit retinitis pigmentosa (RP) and similar conditions

now have greater resources to help preserve their sight. The new Retinal Degeneration

Center at the USC Roski Eye Institute combines clinical care and research to deliver a

full spectrum of specialized care for these rare and potentially blinding diseases.

Hossein Ameri, MD, PhD

Through comprehensive ophthalmic electrophysiology testing, specialists diagnose

RP, cone dystrophy, Usher syndrome, Stargardt disease, Best disease, choroideremia

and achromatopsia, and then develop effective personalized treatment plans.

The center also conducts clinical and basic science research into gene therapy,

stem cell–based therapies and retinal prosthesis, including the Argus II retinal

prosthesis for advanced stages of RP. The result is better care today and more

possibilities for tomorrow.

Mark Borchert, MD

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PROVIDING OPHTHALMIC

PATHOLOGY EXPERTISE

Narsing A. Rao, MD

“The pathology

laboratory

is growing

to meet

increasing

needs.”

The USC Roski Eye Institute Ophthalmic Molecular and Immuno-Pathology

laboratory, one of the few in the country, continues to expand. It excels in the

study of delicate, often minute tissue samples, and provides an important resource

for clinicians, educators and researchers.

An eye pathology fellowship was inaugurated in 2016 with the appointment of fellow

Lei-Chi Wang, MD, an investigator from Taiwan, and a new eye pathology rotation

delivers more robust diagnostic training.

The laboratory also added a medical examiner to support forensic investigations. In

child abuse cases, for example, analysis of retinal bleeding can determine whether

abuse is recent or recurring.

In its scope and size, the pathology laboratory is growing to meet increasing needs.

Laboratory Director Narsing A. Rao, MD, promotes its local and global reach in clinical care,

education and research.

Images of an injured eye examined for a forensic

investigation.

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PATIENT CARE

SAVING SIGHT

VIRTUALLY ANYWHERE

The USC Roski Eye Institute is using virtual reality, artificial intelligence

and wearable sensors to provide on-demand, 24/7, global access to expert

eye care and information. This is made possible by becoming the first clinical

partner in the Virtual Care Clinic program being developed by the USC Center

for Body Computing.

Using a smartphone or tablet, patients can interact with “virtual doctor” avatars

of USC Roski Eye Institute specialists, watch videos explaining diagnosis and use

wearable sensors to track response to medication or treatments. On-demand

eye care will not only increase convenience for patients, but will also provide

access to the highest levels of ophthalmology expertise and care where it is

currently unavailable.

Top: Rohit Varma, MD, MPH, in the

Virtual Care Clinic photo scanning

booth. Bottom: “Virtual doctor”

avatars of Varma and Leslie Saxon,

MD, executive director of the USC

Center for Body Computing

Advanced technologies will connect USC Roski Eye Institute specialists with patients at any location.

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INSIGHT

Research

The USC Roski Eye Institute improves

lives through scientific discovery and

technical innovation that results in

new treatments that overcome visual

impairment and blindness.

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RESEARCH

President Barack Obama presented the National Medal of Technology and Innovation to Mark Humayun, MD, PhD, at the White House on May 19, 2016.

HONORING A PASSION

FOR INNOVATION

As a child, Mark S. Humayun decided to dedicate his life to studying ophthalmology

after helplessly watching his grandmother go blind. Decades later, he received

the nation’s highest technology award for leadership in bridging medicine and

engineering to help restore eyesight.

Humayun is best known for his role in developing Argus II, the only FDA-approved

retinal prosthesis system that enables people with certain blinding diseases to

regain some useful vision. Beyond pursuing further refinement of the artificial

retina, Humayun is leading a multi-university consortium to develop a stem cell

implant for age-related macular degeneration.

The knowledge produced

“by these Americans today

will carry our country’s

legacy of innovation

forward and continue

to help countless others

around the world.


President Barack Obama on the

recipients of the National Medal

of Technology and Innovation

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Active Research Funding

as of December 2016

PROJECT SOURCE PRINCIPAL INVESTIGATOR

Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease NIH Amir Kashani, MD, PhD

Functional Imaging in Hypoxic-Ischemic Retinal Disease NIH Amir Kashani, MD, PhD

Study of Subretinal Implantation of Human Embryonic Stem Cell-Derived RPE Cells in

Advanced Dry AMD

CIRM

Amir Kashani, MD, PhD

OCT Angiography Research Consortium (OARC)

Carl Zeiss Meditec,

Inc.

Amir Kashani, MD, PhD

Hyperspectral OCT System for Metabolic Retinal Imaging USC Amir Kashani, MD, PhD

Optimizing Stimulation Strategies for Cortical Visual Prostheses U.S. Army Andrew Weitz, PhD

Restoring Vision By Sheet Transplants of Retinal Progenitors and Retinal Pigment Epithelium

(RPE) Derived from Human Embryonic Stem Cells (hESCs)

CIRM

Biju Thomas, PhD

Studies on Functionality of iPS-RPE Transplanted in Immunodeficient RCS Rats

BrightFocus

Foundation

Biju Thomas, PhD

Parylene for Subconjunctival Patch Grafts and for Continuous Intraocular Pressure Sensors Whittier Foundation Damien Rodger, MD, PhD

An Experimental Approach to Maculopathy NIH David Hinton, MD

Research to Prevent Blindness Career Development Award RPB J. Martin Heur, MD, PhD

Mentoring for the Advancement of Physician-Scientists Award AGS Grace Richter, MD, MPH

Novel Ultra-Flexible Hybrid Circuits for Intracular Retinal Prostheses NIH James Weiland, PhD

Experimental and Clinical Investigations of Retinal Stimulation NIH James Weiland, PhD

INSPIRE: Bioelectronic Systems for Investigating Neural Plasticity NSF James Weiland, PhD

EFRI-BioFlex: Hybrid Polymer-Paper Based Multi-Sensor Implants for Continuous Remote

Monitoring

NSF

James Weiland, PhD

Human Connectomes in Low Vision, Blindness and Sight Restoration NIH James Weiland, PhD

Retinal Prosthesis Neural Imaging: Measuring the Impact of Crossmodal Plasticity on Visual

Restoration (Arnold O. Beckman Postdoctoral Fellow: Noelle Stiles)

Beckman Foundation James Weiland, PhD

Enhanced Biocompatible Materials for the Repair of Ocular Injuries U.S. Army John Whalen, PhD

Retinal Nanophotoswitch NSF Mark Humayun, MD, PhD

Phase 1 Safety Assessment of CPCB-RPE1, hESC-derived RPE Cell Coated Parylene

Membrane Implants, in Patients with Advanced Dry Age Related Macular Degeneration

CIRM

Mark Humayun, MD, PhD

Thermoresponsive Reversible Adhesive for Temporary Intervention of Ocular Trauma - II U.S. Army Mark Humayun, MD, PhD

Dual-frequency Intravascular Arrays for Functional Imaging of Atherosclerosis NIH Qifa Zhou, PhD

Characterizing Atherosclerosis by Integrated Multimodality Imaging System NIH Qifa Zhou, PhD

Elastographic Imaging of the Retina/Choroid in Age-Related Macular Degeneration NIH Qifa Zhou, PhD

High Resolution Elastography of Retina Under Prosthetic Electrical Stimulation NIH Qifa Zhou, PhD

Phase Resolved ARF Optical Coherence Elastography for Intravascular Imaging NIH Qifa Zhou, PhD

Mexican American Glaucoma Genetic Study NIH Rohit Varma, MD, MPH

African American Eye Disease Study NIH Rohit Varma, MD, MPH

Primary Open Angle African-American Glaucoma Genetics NIH Rohit Varma, MD, MPH

Research to Prevent Blindness (RPB) Unrestricted RPB Rohit Varma, MD, MPH

Novel Stem Cell Therapy for Dry Eye Syndrome with Enhanced Viability and Long-Term Efficacy

RPB

Sarah Hamm-Alvarez,

PhD

Tear fluid and serum levels of Cathepsin S and its endogenous inhibitor Cystatin C as

biomarkers for Sjögren's Syndrome

Microtubule-Based Transport in Lacrimal Gland Function

The Pediatric Eye Disease Consortium: a Pooled Analysis of Individual-Participant Data

from Population-based Studies

Helicobacter Pylori Infection and Primary Open-angle Glaucoma among Mexican

Americans: an Example of Microbiota-Gut-Brain Axis?

Long-term Outcomes and Genetic Basis of Early-onset Refractive Errors in Preschool

Children

Sjögren's Syndrome

Foundation

NIH

NIH

USC

USC

Sarah Hamm-Alvarez,

PhD

Sarah Hamm-Alvarez,

PhD

Xuejuan Jiang, PhD

Xuejuan Jiang, PhD

Xuejuan Jiang, PhD

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AGS (American Glaucoma Society) • CIRM (California Institute for Regenerative Medicine) • GSK (GlaxoSmithKline) NIH (National Institutes of Health) • NSF (National Science

Foundation) • RPB (Research to Prevent Blindness)


RESEARCH

EXPLORING THE BRAIN’S

ROLE IN BLINDNESS

By understanding how the brain responds to low vision and blindness, USC Roski

Eye Institute researchers strive to understand in unprecedented detail, the structural

and functional connections of the visual brain.

IN MEMORIAM

BOSCO TJAN, PhD

A $4 million, four-year study funded by the National Institutes of Health will

build upon the brain mapping techniques developed for the Human Connectome

Project. Our team of researchers will recruit more than 100 patients with macular

degeneration, retinitis pigmentosa and various optic nerve disorders, in their efforts

to study how individual brains adapt to visual disorders over time.

Deeper understanding of the visual brain holds great promise for future innovations.

If differences in the central visual pathways behind the retina and optic nerve caused

by eye disorders can be observed earlier, treatments to preserve vision can be

developed sooner.

Collaborating on study are Hossein Ameri, MD, PhD, Amir Kashani, MD, PhD,

Andrew Moshfeghi, MD, MBA, Vivek Patel, MD, and James Weiland, PhD.

Bosco Tjan, PhD, professor

of psychology at the USC

Dornsife College of Letters,

Arts and Sciences and

co-director of USC Dana

and David Dornsife’s Cognitive

Neuroimaging Center, died

tragically Dec. 2, 2016.

Tjan was a world-renowned

expert in the field of vision

loss research and was

principal investigator in the

study to discover how the

brain reacts to blindness.

Figure 1: Cortical thickness (medial view of the cortices).

During a tribute service on

USC University Park Campus,

he was remembered as an

insightful and generous

colleague, an outstanding

teacher, a prolific researcher

and an exceptional

collaborator.

He is survived by his wife

and son.

Figure 2: Cortical response (fMRI) to light (medial view of the cortices).

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The doctors worked with skill and earned my confidence,

and now I can see clearly again.


Mark Sweeney

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Mark Sweeney

Fuchs Dystrophy

and Cataracts

OCULAR HISTORY

Vision loss from Fuchs dystrophy

and cataracts caused difficulty with

driving and enjoying activities.

TREATMENT

Combined Descemet’s Membrane

Endothelial Keratoplasty (DMEK)

and cataract surgery.

OUTCOME

Complete restoration of vision one

month after each surgery.

Image of the eye shows corneal swelling

and cloudiness from Fuchs dystrophy.

Now that his vision has been restored, Mark has returned to outdoor activities and

and attending concerts with renewed excitement.

A continuing blur in his right eye led Mark Sweeney to contact

the USC Roski Eye Institute. Karen Morgan, MD, examined Mark and

determined that he had Fuchs dystrophy, a swelling and clouding of

the cornea. She began conservative treatment with eye drops, but

then determined that a more invasive approach was needed. J. Martin

Heur, MD, PhD, recommended combined DMEK and cataract surgery.

The procedure was successful, and within one month the vision in

Mark’s right eye not only was clear, but also corrected so he would

not need glasses. His vision began blurring in his left eye, so Mark

was excited and confident to have Heur repeat the procedure so he

would have sharp vision in both eyes. Mark was delighted to get back

to playing golf and seeing all the details at concerts at the Hollywood

Bowl —without wearing glasses. “I can finally see clearly,” Mark says.

“It’s truly amazing.”

Karen Morgan, MD, and J. Martin

Heur, MD, PhD, worked together to

restore and improve vision in both

eyes for Mark.

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Sarah Hamm-Alvarez (center) is surrounded by her research team (from left to right) Zhen Meng, Srikanth Janga, Maria Edman and Christina Fu.

“Our discovery

will help

diagnose and

treat Sjögren’s

syndrome.”

DETECTING DISEASE

WITH TEARDROPS

By discovering a biomarker in teardrops, Sarah Hamm-Alvarez, PhD, and her

research team may advance treatment of Sjögren’s syndrome. The disease can

have devastating effects as immune cells attack mucous membrane and fluidsecreting

glands. It starts with dryness in the eyes and mouth, but eventually

progresses to damage major organs. No single test exists to confirm Sjögren’s

syndrome, so diagnosis can take years.

“Our discovery will help diagnose and treat Sjögren’s syndrome more

effectively, particularly the dry-eye side effect of the disease,” said Hamm-

Alvarez. The promise of a simple tear-based test has the potential to improve

life for the four million people in the U.S. who have Sjögren’s syndrome.

Nine out of 10 patients are women who would be protected from the dire

consequences of the disease.

Sarah Hamm-Alvarez, PhD

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RESEARCH

A cortical visual prosthesis consists of a miniature video camera built into the nosepiece of eyeglasses, signal-processing electronics carried in a pocket and arrays

of microelectrodes implanted in the primary visual cortex. (Courtesy of Nature Publishing Group)

SEEING WITH THE BRAIN

— WITHOUT EYES

Electrical stimulation of the visual neurons could enable the blind to see

again—without using their eyes. Cortical visual implants use the brain to

“see” by capturing images on a video camera built into specialty eyeglasses

and relaying them to electrodes implanted in the visual cortex. A major

challenge is to precisely stimulate target nerve cells to provide accurate

vision. Andrew Weitz, PhD, and his research team developed a novel imaging

technique to map the patterns of cells activated by electrical stimulation.

They then identified stimulus waveform shapes that enable precise

stimulation of nerve cells in the retina for retinal implants. Now the team

is developing waveforms for the visual cortex. By enabling precise control

of patterns of neurons stimulated by cortical visual implants, they hope to

restore accurate vision to people who have lost their eyes.

“A novel

imaging

technique is

advancing

cortical

implants.”

Andrew Weitz, PhD

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In this figure, 15-20 MHz convex phased array will not only provide a larger viewing angle and field of view than traditional linear arrays, but it will also be better

at providing enough acoustic output and uniform acoustic field to generate dynamic vibration of retinal tissue over the traditional array. The phase array can be

changed focus beam by electronic scanning. Meanwhile, high resolution OCT can detect cell structure changes of the retina with ultrasonic stimulation.

REVERSING BLINDNESS

WITH ULTRASOUND

What if blindness could be reversed without surgery. Current methods for

restoring sight from lost retinal receptor cells involve implanting devices to

stimulate surviving retinal neurons.

Mark Humayun, MD, PhD

Ultrasound waves are known to stimulate sight-giving retinal neurons. Using

ultrasound to restore sight would require a specialized device to deliver ultrasound

waves and the ability to map stimulation patterns. USC Roski Eye Institute researchers

Mark Humayun, MD, PhD, and Qifa Zhou, PhD, are taking on these challenges.

Their goal is to develop ultrasonic single-element transducer/phased arrays for retinal

stimulation, and design an optimal stimulation paradigm to produce controllable,

consistent retinal responses with high spatiotemporal resolution — and provide in

vivo validation.

Qifa Zhou, PhD

Ultrasound therapies hold the promise of ending blindness on a scale far beyond

current methods.

26 usceye.org


Accelerating Progress through Collaboration

The USC Roski Eye Institute works closely with many individual researchers and organizations to advance vision science and

clinical ophthalmology. We gratefully acknowledge colleagues for their efforts in 2016.

RESEARCH

INDIVIDUALS

Bioengineering Initiative

COLLABORATOR

ORGANIZATION

Theodore Berger, PhD

USC (Biomedical Engineering)

Robert Chow, MD, PhD

USC (Zilkha Neurogenetic Institute)

Scott E. Fraser, PhD

USC (Biomedical Engineering)

Malancha Gupta, PhD

USC (Materials Science)

Hossein Hashemi, PhD

USC (Electrical Engineering)

Laurent Itti, PhD

USC (Computer Science)

Gianluca Lazzi, PhD

University of Utah, UT

Mark Liker, MD

USC (Neurosurgery)

Gerard Medioni, PhD

USC (Computer Science)

Ellis Meng, PhD

USC (Biomedical Engineering)

Alapakkam Sampath, PhD UCLA Brain Research Institute

Kirk Shung, PhD

USC (Biomedical Engineering)

Dong Song, PhD

USC (Biomedical Engineering)

Armand Tanguay, PhD

USC (Electrical Engineering)

Cross-Linking and Refractive Surgical Outcomes

COLLABORATOR

ORGANIZATION

William J. Dupps, MD, PhD USC (Biomedical Engineering)

Farhad Hafezi, MD, PhD

The USC Roski Eye Institute and ELZA

Institute, Switzerland

Marcony Santhiago, MD, PhD

University of Sao Paulo, Brazil and

Federal University of Rio de Janeiro

Giuliano Scarcelli, PhD

University of Maryland Fischell School

of Engineering, MD

Human Connectome Project

COLLABORATOR

ORGANIZATION

James T. Becker, PhD

University of Pittsburgh, PA

Adam L. Boxer, MD, PhD

USCF Memory and Aging Center

Kyle Chard, PhD

University of Chicago, IL

Kristi Clark, PhD

USC (Neurology)

Eric Deutsch, PhD

Institute for Systems Biology, WA

Ivo Dinov, PhD

University of Michigan, MI

James Duncan, PhD

Yale University, CT

Jerome Engel, MD

UCLA David Geffen School of Medicine

Ian Foster, PhD

University of Chicago, IL

Giovanni Frisoni, MD

IRCCS Fatebenefratelli, Italy

Gustavo Glusman, PhD

Institute for Systems Biology, WA

Dana Goldman, PhD

USC (Schaeffer Center for Health Policy

and Economics)

Gerig Guido, PhD

University of Utah, UT

Susan Hayflick, MD

Oregon Health & Science University, OR

Scott Holland, PhD

Cincinnati Children’s

Research Foundation, OH

Leroy Hood, MD, PhD

Institute for Systems Biology, WA

John Van Horn, PhD

USC (Neurology)

Carl Kesselman, PhD

USC (Industrial and Systems

Engineering)

Richard Leahy, PhD

USC (Electrical Engineering)

Robert Scott Mackin, PhD UCSF School of Medicine

Geoffrey T. Manley, MD, PhD UCSF School of Medicine

Tom Nichols, PhD

University of Warwick, United Kingdom

Yuko Y. Palesch, PhD

Medical University of South Carolina, SC

Nathan Price, PhD

Institute for Systems Biology, WA

Bruce Rosen, MD, PhD

Massachusetts General Hospital, MA

Howard Rosen, MD

USCF Memory and Aging Center

Seth Seabury, PhD

USC (Schaeffer Center for Health Policy

and Economics)

Yonggang Shi, PhD

USC (Neurology)

Olaf Sporns, PhD

Indiana University, IN

Michael Weiner, MD

Northern California Institute for

Research & Education, CA

Wenle Zhao, PhD

Medical University of South Carolina, SC

Imaging Initiative

COLLABORATOR

ORGANIZATION

Antonio Capone, MD

Oakland University, MI

Zhongping Chen, PhD

UCI Samueli School of Engineering, CA

Thomas Karnowski, PhD

Oak Ridge National Labs, TN

Michael Trese, MD

Oakland University, MI

George Williams, MD

Oakland University, MI

Mark Wong, PhD

National Aeronautics and Space

Administration, MD

Ocular Epidemiology

COLLABORATOR

ORGANIZATION

Stanley Azen, PhD

USC (Preventive Medicine)

Xiaoyi Gao, PhD

University of Illinois at Chicago, IL

James Gauderman, PhD

USC (Preventive Medicine)

Joanne Katz, ScD

Johns Hopkins University, MD

Ronald Klein, MD, MPH

University of Wisconsin-Madison, WI

Roberta McKean-Cowdin, PhD USC (Preventive Medicine)

Joan M. O’Brien, MD

University of Pennsylvania, PA

Jeremy Rotter, PhD

Los Angeles Biomedical Institute, CA

Kristina Tarczy-Hornoch, MD Seattle Children's Hospital, WA

Tien Wong, MD, PhD

National University of Singapore

Regenerative Medicine for Blinding Eye Diseases

COLLABORATOR

ORGANIZATION

Larry A. Couture, PhD

City of Hope, CA

Dennis Clegg, PhD

UCSB Center for Stem Cell Biology and

Engineering

Lincoln V. Johnson, PhD

UCSB Center for the Study of Macular

Degeneration

Population Health

COLLABORATOR

ORGANIZATION

Dana Goldman, PhD

USC (School of Pharmacy), USC (Sol

Price School of Public Policy)

Anupam Jena, MD, PhD

Harvard University, MA

Geoffrey Manley, MD, PhD UCSF School of Medicine

Mike Menchine, MD

USC (Department of Emergency

Medicine)

Sjögren’s Syndrome

COLLABORATOR

ORGANIZATION

Daniel Arkfeld, MD

USC (Department of Medicine)

Stratos Christianakis, MD USC (Department of Medicine)

Stan Louie, PhD

USC (School of Pharmacy)

Curtis Okamoto, PhD

USC (School of Pharmacy)

J. Andrew MacKay, PhD USC (School of Pharmacy)

Wendy Mack, PhD

USC (Department of Preventive

Medicine)

Kathleen Rodgers, PhD

USC (School of Pharmacy)

William Stohl, MD, PhD

USC (Department of Medicine)

Driss Zoukhri, PhD

Tufts University School of Dentistry, MA

27


Arnold Michels

Choroidal Melanoma

OCULAR HISTORY

Diagnosed with a choroidal

melanoma after continuous retinal

issues, detachments and bleeding.

TREATMENT

Patient decided to undergo plaque

brachytherapy (radiation implant)

to save the eye, regardless of impact

on vision.

OUTCOME

Cancer controlled. Tumor regressing.

No observable metastatic disease.

Left eye preserved with vision loss.

Arnold enjoys playing with his grandchildren, Olivia and Colin.

Losing an eye to cancer was a real possibility for Arnold Michels.

After a long and complicated history of retinal issues, detachments

and bleeding in his left eye, he finally learned why: he had choroidal

melanoma — eye cancer.

As an avid outdoorsman and photographer, Arnold first thought that he

would have to abandon his passion for hiking and introducing children to

nature as a volunteer. Without vision, he could not navigate the terrain.

After five difficult surgeries on his eye, Arnold came to the USC Roski

Eye Institute with a specific goal. Already blind in his left eye, he wanted

to avoid its removal. To achieve this goal, surgeons performed a long,

complex surgery in which they implanted a device that would precisely

target the tumor with radiation.

Retinal photograph of eye with a

malignant choroidal melanoma.

The procedure was a success. Arnold’s cancer is under control, the

tumor is shrinking and he has no sign of metastatic disease. Best of all,

he is delighted to still have his left eye. “They went above and beyond all

my expectations,” Arnold says.

Choroidal melanoma in the left eye after

trans-retinal prognostic biopsy.

Jesse Berry, MD, performed the

surgery that saved Arnold’s left

eye from cancer.

28 usceye.org



They went above and beyond all my expectations.


Arnold Michels

29


SERVING THE UNDERSERVED

AT LAC+USC

The USC Roski Eye Institute is the exclusive provider of vision care at the

LAC+USC Medical Center, the hub of a Los Angeles County health system

that serves 10 million people. This presents multiple opportunities to provide

a wide array of complex, clinical care that profoundly enhances people’s lives.

Recycle Vision

Recycle Vision, started by USC’s Jesse

Berry, MD, collects used eyeglasses

and logs prescriptions. They then

match prescriptions and give

eyeglasses to patients who otherwise

might not afford them.

55%

Eyeglass Prescriptions Not Filled

67%

Patients Concerned about Cost

300+

Pairs of Used Eyeglasses Provided

USC Roski Eye Institute residents, shown with ophthalmologist Jesse Berry, MD, follow patients

longitudinally throughout their residencies at LAC+USC for an exceptional clinical and personal experience.

The 600-bed Los Angeles County + USC Medical Center is one of the largest public hospitals in the country

and one of the premier academic teaching hospitals in the nation.

LAC+USC Ophthalmology

200 Patients per day

10 Surgeries per day

5 Ophthalmology subspecialties

30 usceye.org


RESEARCH

Vulnerable patients will benefit from greater access to eye care as new studies are launched and new healthcare policies are adopted.

IMPROVING ACCESS,

QUALITY AND EFFICIENCY

The USC Roski Eye Institute is at the heart of USC’s latest efforts to tackle the

challenges of healthcare system reform.

The newly established Keck-Schaeffer Initiative for Population Health Policy

is led by Seth Seabury, PhD, associate professor in the USC Department of

Ophthalmology and associate professor of research in the Leonard D. Schaeffer

Center for Health Policy and Economics. Its mission is to identify evidence-based

policies that improve access to care for underserved populations and increase the

value of the services provided.

This collaboration between the Keck School of Medicine of USC and the USC

Schaeffer Center will be the catalyst for new research and educational studies for

improving population health and healthcare delivery.

Seth Seabury, PhD

“We will strive

to use cuttingedge

research to

help improve

the health of

vulnerable

populations.”

31


INSIGHT

Preserving

Sight

The USC Roski Eye Institute champions

preventive care, engages in partnerships

and inspires philanthropy in our mission to

eliminate visual impairment and blindness.

32 usceye.org


PRESERVING SIGHT

IMPROVING

Life IN

RURAL

India

Clockwise from top: Srikiran Institute of Ophthalmology;

Chandrasekhar Sankurathri, MD; cataract patients on

post-op day one; 3rd-year resident Philip Storey, MD, MPH,

examines a patient; Storey and USC Assistant Professor

Jesse Berry, MD, during a rotation in India.

Chandrasekhar Sankurathri, MD, visiting professor of ophthalmology,

has dedicated his life to saving the vision of people who would

otherwise go blind.

In 1989, he established the nonprofit Sankurathi Foundation as a

memorial to his wife, son and daughter who were killed in an Air India

terrorist bombing on July 23, 1985. The mission was to “empower the

poor through better education, eye care and timely help to the needy.”

His mission expanded in 1993 with the opening of the Srikiran Institute of

Ophthalmology, named after his son. The eye hospital provides accessible

and affordable services to all “irrespective of race, religion, caste, age,

sex and other socioeconomic factors.”

From conducting preventive screenings to providing complex procedures,

often without charge, the hospital is improving the lives of people in

rural India.

PRESERVING VISION

In its 23 years, the nonprofit

Srikiran Institute of Ophthalmology

has achieved an impressive

record of service:

2,360 screening camps for adults

1,073 screening camps for

children

2,170,855 outpatient visits

208,577 surgeries

33


EYE

HEALTH IN

AMERICA

2050

FORECAST

SHEDDING LIGHT TO

PREVENT BLINDNESS

New National Eye Institute studies led by Rohit Varma, MD,

MPH, suggest that vision screening for refractive error and

early eye disease may reduce or prevent a high proportion

of individuals from experiencing unnecessary vision loss

and blindness. These findings will guide clinical care and

health policy designed to protect and preserve the vision

of all Americans.

VISUAL IMPAIRMENT AND BLINDNESS IN THE UNITED STATES, 2015-2050

VISUAL

IMPAIRMENT

AGE 40+

6.95

MILLION

BLINDNESS

AGE 40+

2.01

MILLION

VISUAL IMPAIRMENT

& BLINDNESS

AGE 40+ FROM UNCORRECTED VISION

16.4

MILLION

3.22

MILLION

1.02

MILLION

8.2

MILLION

529K

2015 2050

2015 2050

290K

2015 2050

THE NUMBER OF CASES IS EXPECTED TO DOUBLE BY 2050 *

VISUAL IMPAIRMENT

BLINDNESS

VISUAL IMPAIRMENT AND BLINDNESS BY GENDER, 2015-2050

BLINDNESS

VISUAL IMPAIRMENT

520K 1.05

MILLION

490K

960K

1.84

MILLION

1.38

MILLION

3.94

MILLION

3.02

MILLION

2015 2050

2015 2050

BURDEN OF BLINDNESS AND VISUAL IMPAIRMENT AMONG WOMEN IS HIGHER

AND EXPECTED TO INCREASE *

FEMALE

MALE

34 usceye.org


PRESERVING SIGHT

VISUAL IMPAIRMENT AND BLINDNESS BY RACIAL/ETHNIC GROUPS, 2015-2050

VISUAL IMPAIRMENT 2015 2050

NON-HISPANIC WHITE 2.3

MILLION

3.9

MILLION

AFRICAN AMERICAN 500K 1.1

MILLION

LATINO 300K 1.4

MILLION

ASIAN AND OTHER 100K 500K

BLINDNESS 2015 2050

NON - HISPANIC WHITE 700K 1.1

MILLION

AFRICAN AMERICAN 200K 500K

LATINO 100K 400K

ASIAN AND OTHER 20K 50K

THE LARGEST BURDEN WILL BE AMONG NON-HISPANIC WHITES AND IS EXPECTED TO INCREASE AMONG

OTHER GROUPS *

TWO STUDIES ON ADDITIONAL POPULATIONS PROVIDE MAJOR INSIGHTS

The largest U.S. epidemiological studies ever conducted on Chinese Americans and Latinos were published in 2016

by the USC Roski Eye Institute.

CHINESE AMERICAN EYE STUDY

KEY FINDINGS

• Greater prevalence of neovascular (wet) agerelated

macular degeneration

• Three times higher prevalence of visual

impairment among those with type II diabetes

than those without diabetes

LOS ANGELES LATINO EYE STUDY

KEY FINDINGS

• Significantly lower quality of life for those with

severe age-related macular degeneration in one

or both eyes

• Less access and utilization of health care may

contribute to quality of life decline

* For complete findings please refer to: Visual Impairment and Blindness in Adults in the United States: Demographic and Geographic Variations from

2015 to 2050. JAMA Ophthalmol. PMID: 27197072.

35


GIVING

GENEROUSLY

TOADVANCE

VISION CARE

The vibrant paintings by Gayle Garner Roski, an

accomplished watercolorist, have been exhibited in

museums and galleries from California to Scotland.

Gayle and Edward Roski took a bold step in 2016 to improve

vision and end blindness. They made a landmark $25

million gift to endow and name the USC Gayle and

Edward Roski Eye Institute at Keck Medicine of USC.

Their generosity was inspired by personal experiences

and deep concern for others. After Gayle Garner Roski,

a plein-air watercolorist, received cataract treatment at

the USC Eye Institute, her ability to see color and light

values improved dramatically. To help others fully enjoy

the gift of sight, they decided to make a major gift.

Their exceptional support will enable the USC Roski Eye

Institute to continue its powerful influence on vision

care, research and education around the world.

Edward and Gayle Roski accelerated the advancement of

clinical ophthalmology and vision science through their

landmark gift.

36 usceye.org


INSIGHT

Clinical

Education

The USC Roski Eye Institute equips and

emboldens generations of clinician-scientists

who revolutionize the diagnosis and treatment

of eye conditions and diseases.

37


Joseph Cocozza, assistant professor of research, instructs students in the new Ophthalmic Technician Education Program.

“OTEP joins

only 14 centers

nationwide

offering this

specialized

training. ”

ADVANCING

OPHTHALMIC

TECHNICIAN

EDUCATION

The USC Roski Eye Institute established a new Ophthalmic Technician

Education Program (OTEP), joining only 14 centers nationwide offering

this specialized training.

OTEP is a certificate program that integrates core academic knowledge

with clinical and occupational skill mastery. It includes classroom and

clinical experiences that prepare graduates to assist ophthalmologists

in the prevention, detection and treatment of vision impairments in

private practice offices, hospitals and community-based clinics. OTEP

students have clinical rotations at the USC Roski Eye Institute, LAC+USC

Medical Center and Children’s Hospital Los Angeles.

Joseph Cocozza, PhD,

co-directs the

Ophthalmic Technician

Education Program.

The U.S. Department of Labor projects a 21 percent increase in

ophthalmic medical positions by 2021. The new program is designed to

help meet this urgent need.

38 usceye.org


CLINICAL EDUCATION

SHARPENING SKILLS FOR

OCULOFACIAL

SURGEONS WORLDWIDE

The USC oculofacial surgical skills course brought together renowned faculty,

fellows, and residents in oculoplastics, ophthalmology, ENT, and plastic

surgery to learn from each other. American Society of Ophthalmic Plastic

and Reconstructive Surgery (ASOPRS) fellows from around the United States,

as well as visiting scholars from around the world participated. After brief

lectures, expert faculty rotated between fully equipped surgical stations that

included surgical oculoplastic instruments, an endoscope, a drill, ultrasonic

aspirator, plating material and a fresh cadaver head. Attendees learned new

approaches and practiced valuable skills that will improve patient care.

Sandy Zhang-Nunes, MD,

organized the oculofacial

surgical skills course with

USC Roski Eye Institute staff.

Michael Burnstine, MD

Director of the Oculofacial

plastics fellowship program.

Participants from all over the world came together to share valuable skills.

39


40 usceye.org


The PROSE procedure was a game changer. My eyes

are no longer miserable all the time.

Jeremy Falk”


Jeremy Falk

Stevens-Johnson

Syndrome

OCULAR HISTORY

Developed Stevens-Johnson

Syndrome after taking Bactrim to

treat an infection, resulting in

eye pain, dryness, light sensitivity

and irritation.

TREATMENT

Received custom-designed PROSE

(prosthetic replacement of the ocular

surface ecosystem) scleral devices.

OUTCOME

Improved comfort, vision and quality

of life.

The gas-permeable PROSE device creates

a smooth optical surface above the

cornea and bathes the ocular surface

with a reservoir of sterile saline. (Image

courtesy of Boston Sight®.)

Jeremy’s active lifestyle includes cycling and distance running.

Extreme light sensitivity and sore, bloodshot eyes made life difficult

for Jeremy Falk, an independent businessman, distance runner and

self-proclaimed “power nerd.” A terrible reaction to an antibiotic left

him with chronic, severe dry eyes. After years of seeking relief, he

finally found it at the USC Roski Eye Institute.

To compensate for the lack of tears, Gloria Chiu, OD, FAAO, FSLS,

initiated Boston Sight® PROSE (prosthetic replacement of the ocular

system) treatment, available at only 12 sites nationwide. Now Jeremy’s

eyes are protected and kept moist by a set of made-to-specification

removable scleral devices that cover the entire outer surface of

his eyes.

Initially, Jeremy was anxious about placing the lenses on his eyes.

After some training, coaching and practice, he mastered the process.

“Dr. Chiu was patient, gentle, professional and no nonsense,” Jeremy

says. “She changed my life.”

Jeremy’s eyes are much better, and life has returned to normal. Armed

with his “rock ‘n roll eyeball kit,” he faces the world with greater

confidence and a brighter outlook.

Gloria Chiu, OD, FAAO, FSLS, prescribed

and fitted the PROSE lenses that provide

relief for Jeremy’s eye condition.

With training, patients eventually master

application and use of the PROSE device.

41


SHARING

ADVICE

WITH FUTURE LEADERS

A FORMER USC RESIDENT RETURNS TO USC ROSKI EYE

INSTITUTE WITH INSIGHTS FOR SUCCESS.

On Career Choice

I took a biochemistry class at Francisco Bravo Medical Magnet High

“School, taught by USC’s Dr. Cocozza, that focused on the chemistry

behind ophthalmology. I knew from that point that ophthalmology

was what I wanted to do. ”

On Residency Training

My advice is to find a program that is best suited to your individual needs.

“If you’re looking for strong clinical and surgical training, and to be an

innovative leader, then USC is the place for you. ”

USC has one of the most challenging ophthalmology residency programs

“in the country, hands down. I left the program so confident, so prepared

to take on any challenge that came my way. ”

On USC Faculty

A very strong teaching component with LAC+USC Medical Center

“allows faculty to play a big role in the training and mentorship of

residents and fellows.


Sahar Bedrood, MD, PhD

Assistant Professor of Clinical Ophthalmology

MEDICAL SCHOOL| MD/PHD

Keck School of Medicine of USC

OPHTHALMOLOGY RESIDENCY

LAC+USC Medical Center

GLAUCOMA FELLOWSHIP

The Johns Hopkins Wilmer Eye Institute

RESEARCH

• Structural characteristics of the optic nerve

lamina cribrosa

• Glaucoma disruption of patients’ daily

functional ability

PROFESSIONAL ORGANIZATIONS

• American Glaucoma Society

• American Society of Cataract and Refractive Surgery

• Los Angeles Society of Ophthalmology

• Society of Heed Fellows

AWARDS

• Society of Heed Fellows Fellowship Award

• National Eye Institute ARVO Award

• P.E.O. Scholar Award

• Order of the Arete

• Remarkable Women of USC Award

42 usceye.org


CLINICAL EDUCATION

CELEBRATING

ADVANCEMENTS IN

OPHTHALMOLOGY

Nearly 400 ophthalmologists and optometrists attended the USC Roski Eye

Institute 41 st Anniversary Symposium at the Huntington Library in Pasadena.

The event’s distinguished speakers provided presentations on every subspecialty

of ophthalmology.

USC Roski Eye Institute faculty members at the 41 ST Anniversary Symposium.

Rohit Varma, MD, MPH, left, presented

Neil R. Miller, MD, the Frank B. Walsh Professor

of Neuro-Ophthalmology and professor of

ophthalmology, neurology, and neurosurgery,

Johns Hopkins Medical Institutions, with

the USC Roski Eye Institute Laureate Award

for 2016.

Preeminent vision experts shared their work with a

capacity crowd.

41 ST Anniversary

Symposium Distinguished

Ophthalmologists

Nisa Acharya, MD

Director, Uveitis Service and Uveitis

Fellowship, F.I. Proctor Foundation and

Professor of Ophthalmology, University of

California, San Francisco

Pravin U. Dugel, MD

Clinical Professor, USC Roski Eye Institute,

Keck School of Medicine of USC, Managing

Partner, Retinal Consultants of Arizona and

Founding Member, Spectra Eye Institute

Jonathan M. Holmes, MD

Joseph E. and Rose Marie Green Professor

of Visual Sciences and Professor of

Ophthalmology and Former Chair,

Department of Ophthalmology, College of

Medicine, Mayo Clinic

Mark S. Humayun, MD, PhD

Cornelius J. Pings Chair in Biomedical

Sciences, Professor of Ophthalmology,

Biomedical Engineering and Cell and

Neurobiology, Director of the USC Institute

for Biomedical Therapeutics and Co-

Director of the USC Roski Eye Institute,

Keck School of Medicine of USC

Sean Ianchulev, MD, MPH

Chief Medical Officer and Vice President,

Medical Affairs and Business Development,

Transcend Medical

Guy G. Massry, MD

Clinical Professor of Ophthalmology, Keck

School of Medicine of USC

Neil R. Miller, MD

Frank B. Walsh Professor of Neuro-

Ophthalmology and Professor of

Ophthalmology, Neurology and

Neurosurgery, Johns Hopkins Medical

Institutions

J. Bradley Randleman, MD

Professor of Ophthalmology and Director

of Cornea, External Disease and Refractive

Surgery, USC Roski Eye Institute, Keck

School of Medicine of USC

J. Timothy Stout, MD, PhD, MBA

Director, Cullen Eye Institute and Chair,

Department of Ophthalmology, Baylor

College of Medicine

Young Hee Yoon, MD, PhD

Professor of Ophthalmology, Asan Medical

Center, University of Ulsan, South Korea

43


PREPARING AND INSPIRING THE

NEXT LEADERS

NEW FULL-TIME FACULTY FOR 2016

Name Title Specialty

Sahar Bedrood, MD, PhD Assistant Professor of Clinical Ophthalmology Glaucoma

Kent Nguyen, OD, FAAO

Assistant Professor of Clinical Ophthalmology

Comprehensive Eye Care in Primary Care, Ocular

Disease, and Contact Lenses

J. Bradley Randleman, MD Professor of Clinical Ophthalmology

Corneal and External Diseases and Corneal

Cross-Linking

Seth Seabury, PhD

Associate Professor of Research

Ophthalmology

Ophthalmology Health Policy and Economics

Mahnaz Shahidi, PhD Professor of Ophthalmology Retinal Imaging

Lan Yue, PhD Assistant Professor of Research Ophthalmology Retinal Prosthesis

Qifa Zhou, PhD

Professor of Ophthalmology, Biomedical

Engineering

Biomedical Engineering Ophthalmic Elastography,

Ultrasonic Retinal and Brain Stimulation

NEW OPPORTUNITIES FOR 2016

Each year, positions open for six new residents and eight new fellows. Hundreds of outstanding candidates apply to train at

the USC Department of Ophthalmology.

VOLUNTARY RESIDENT ROTATION IN INDIA

Residents will complete two-week, on-site comprehensive

and subspecialty clinics at the Srikiran Institute of

Ophthalmology in rural Andhra Pradesh, India.

NEW FELLOWSHIP IN EYE PATHOLOGY

Fellows have extraordinary learning opportunities at USC’s

ophthalmic molecular and immuno-pathology laboratory,

one of the few in the United States.

The USC Roski Eye Institute residents and fellow train in four diverse and highly acute clinical and surgical settings: the USC Roski Eye Institute, Children’s Hospital

Los Angeles, Los Angeles County Hospital (LAC+USC Medical Center) and Veterans Administration Downtown Los Angeles Medical Center.

44 usceye.org


CLINICAL EDUCATION

INSPIRING CLINICAL EXCELLENCE THROUGH

GRAND

ROUNDS

Vivek Patel, MD, residency program

director (left), and first-year resident

Debarshi Mustafi, worked together on

the “Double Trouble” case.

THE USC ROSKI EYE INSTITUTE PRESENTS RESIDENTS WITH

COMPLEX CLINICAL CHALLENGES, AS DEMONSTRATED BY

THE CASE “DOUBLE TROUBLE” SUMMARIZED BELOW.

HISTORY

• Hispanic female, age 66, presents to

the emergency department with

worsening blurred vision over several

weeks and a one-year history of

intermittent binocular diplopia, pulsating

left-ear pain and tinnitus.

• PMH: HTN, DM Type 2, Dyslipidemia

Hyperthyroidism.

• ROS negative for headaches, nausea

or sudden loss of vision.

EXAM FINDINGS

• BCVA 20/20 OD, 20/30 OS, IOP WNL, no

RAPD, Ishihara color plates normal OU.

• Anterior segment exam on slit lamp only

notable for 2+ NSC of the lens OU.

• Dilated fundus exam: normal appearing

optic nerves with CDR 0.4 without

evidence of swelling or atrophy.

DIFFERENTIAL DIAGNOSIS

• Bilaterally swollen optic nerves with near

normal function. Elevated intercranial

pressure (ICP) would suggest obstruction

or abnormality. Normal ICP would suggest

diabetic papillopathy, optic perineuritis

or hypertensive papillopathy.

ADDITIONAL INVESTIGATIONS

• MRI brain with and without contrast

was obtained to better characterize

the etiology of the elevated ICP.

(See Figures 1 and 2.)

DIAGNOSIS

• Paraganglioma causing compression

of the left internal jugular vein.

• Jugular venous obstruction resulted in

impaired CSF absorption, leading

to elevated ICP.

• Sufficiently compartmentalized

CSF pressure may allow some

cases of elevated ICP to present

without papilledema.

TREATMENT

• Since malignant behavior is only seen in

4% of jugulotympanic paragangliomas,

treatment options include observation,

surgical resection with preoperative

embolization, radiotherapy and

radiosurgery.

• Patient was seen eight weeks after initial

visit. Stable nature of the symptoms led

us to monitor her with dilated fundus

exams and Humphrey visual fields at

subsequent visits. She is also being

followed by neurology and ENT services

as an outpatient for possible surgical

intervention if symptoms worsen.

THIS CASE ILLUSTRATES THE

IMPORTANCE OF THE CEREBRAL

VENOUS SYSTEM IN THE REGULATION

OF CSF PRESSURE AND NEUROIMAGING

FEATURES THAT CAN SUPPORT A

SUSPICION OF ELEVATED ICP.

Figure 1. Axial (left) and sagittal (right) cuts

demonstrate an absence of flattening of the

back of the globe or tortuosity of the optic nerve

that can be seen with elevated ICP.

Figure 2. MRI brain post-contrast, sequential

axial T1 images reveal an avidly enhancing

mass (blue arrow) measuring 23 x 15 x 24

mm (TV x AP x CC) within and expanding the

left jugular foramen, and enveloping the left

internal jugular vein (red arrow).

45


USC ROSKI EYE INSTITUTE

RESIDENTS AND FELLOWS 2016-17

PROGRAM

LEADERSHIP

Residents

Six exceptional residents are recruited each year from hundreds of applicants.

Third Year

Jiun L. Do, MD, PhD

Second Year

Stavros Moysidis, MD

Billy Pan, MD

Co-Chief Resident

Kelly Rue, MD Grace Shih, MD Philip Storey,

MD, MPH

Co-Chief Resident

from top left to right

Rohit Varma, MD, MPH

Director, USC Roski

Eye Institute

Vivek Patel, MD

Residency Program Director

Jesse Berry, MD

Associate Residency

Program Director

Malvin Anders, MD

Chief of Ophthalmology,

LAC+USC Medical Center

Walid F. Abdallah,

MD, PhD

First Year

On-Tat Lee, MD Natasha Naik, MD Ananth Sastry, MD Brandon Wong, MD Arman Zaman, MD

Christine Greer,

MD, MS

Arezu Haghighi, MD Ramon Lee, MD Debarshi Mustafi,

MD, PhD

Luv Patel, MD

Nadim Rayess, MD

Fellows and Clinical Instructors

The USC Roski Eye Institute offers clinical

fellowship training in six subspecialty areas,

including cornea and external disease,

glaucoma, neuro-ophthalmology, ophthalmic

plastic surgery, retina and uveitis.

Informal research fellowships are also awarded

by each service and laboratory independently.

The USC Roski Eye Institute attracts promising

academic ophthalmologists from around the

world who spend one or two years participating

in research programs. Many return to their

home countries where they assume positions

of national or international leadership.

Brian Do, MD

Vitreoretinal

Helen Merritt, MD

Oculo-Facial

Plastics

Kimberly Gokoffski,

MD, PhD

Neuro-Ophthalmology

Julia Nemiroff, MD

Medical Retina

Humair Khan, MD

Cornea

Nishant Soni, MD

Cornea

Julie Kwon, MD

Medical Retina

Jeffrey Tan, MD

Vitreoretinal

Jessica Maslin, MD

Glaucoma

Brian Toy, MD

Vitreoretinal

46

usceye.org


USC ROSKI EYE INSTITUTE FACULTY

CLINICAL EDUCATION

Hossein Ameri,

MD, PhD

Assistant Professor

Sahar Bedrood,

MD, PhD

Assistant Professor

Jesse Berry, MD

Assistant Professor

Mark Borchert, MD

Associate Professor

Angela Buffenn,

MD, MPH

Assistant Professor

Michael Burnstine,

MD

Clinical Professor

Gloria Chiu,

OD, FAAO, FSLS

Assistant Professor

Farzana Choudhury,

MBBS, MPH, PhD

Assistant Professor

David Cobrinik,

MD, PhD

Associate Professor

Joseph Cocozza, PhD

Assistant Professor

Cheryl Craft, PhD

Professor

Steven Dresner, MD

Clinical Professor

Charles Flowers Jr., MD

Associate Professor

Henry Fong, PhD

Associate Professor

Sarah Hamm-

Alvarez, PhD

Professor

J. Martin Heur,

MD, PhD

Associate Professor

Mark Humayun,

MD, PhD

Professor

Veronica Isozaki,

OD, FAAO

Assistant Professor

Shinwu Jeong, PhD

Assistant Professor

Xuejuan Jiang, PhD

Assistant Professor

Amir Kashani,

MD, PhD

Assistant Professor

Jonathan Kim, MD

Associate Professor

Tali Kolin, MD

Adjunct Associate

Professor

Linda Lam, MD, MBA

Associate Professor

Carlos Lastra Gonzalez, MD

Clinical Research

Instructor

Thomas Lee, MD

Associate Professor

Debbie Mitra, PhD

Assistant Professor

Karen Morgan, MD

Clinical Professor

Andrew Moshfeghi,

MD, MBA

Associate Professor

Arlanna Moshfeghi,

MD, MPH

Assistant Professor

A. Linn Murphree, MD

Professor

Sudha Nallasamy, MD

Assistant Professor

Kent Nguyen, OD, FAAO

Assistant Professor

Vivek Patel, MD

Associate Professor

Carmen Puliafito,

MD, MBA

Professor

J. Bradley

Randleman, MD

Professor

Narsing Rao, MD

Professor

Bibiana Reiser,

MD, MS

Assistant Professor

Alena Reznik, MD

Assistant Professor

Grace Richter,

MD, MPH

Assistant Professor

David Richardson, MD

Adjunct Assistant

Professor

Damien Rodger,

MD, PhD

Assistant Professor

Seth Seabury, PhD

Associate Professor

Mahnaz Shahidi, PhD

Professor

Jonathan Song, MD

Associate Professor

Biju Thomas, PhD

Assistant Professor

Paul Thompson, PhD

Professor

Arthur Toga, PhD

Provost Professor

Lernik Torossian

OD, FAAO

Assistant Professor

Rohit Varma, MD, MPH

Professor

James Weiland, PhD

Professor

Andrew Weitz, PhD

Assistant Professor

John Whalen, PhD

Assistant Professor

Lan Yue, PhD

Assistant Professor

Sandy Zhang-Nunes, MD

Assistant Professor

Qifa Zhou, PhD

Professor

47


USC ROSKI EYE INSTITUTE VOLUNTEER FACULTY

John Affeldt, MD

Soma Agarwal, MD

Rajat Agrawal,

MD, MS

Selwa Al-Hazzaa,

MD

Malvin Anders, MD

Richard Apt, MD

Gregory Bearman,

PhD

Joseph Boban, MD

Swaraj Bose, MD

Gerald Bowns, MD David Boyer, MD Brian Brown, MD Gerald Chader, Grace Chang, MD, Lawrence Chong, Michael Colvard,

PhD

PhD

MD

MD

Lauren Daskivich,

MD

Kenneth Diddie,

MD

Pravin Dugel, MD Gregg Feinerman, Wolfgang Fink, David Fuerst, MD Sam Goldberger, MD David Goldenberg,

MD

PhD

MD

Ronald Green, MD

Farhad Hafezi,

MD, PhD

Houman Hemmati,

MD, PhD

Lars Hertzog, MD Leif Hertzog, MD Alan Horsager, PhD Lynn Huang, MD,

MPH

John Hwang, MD

Sean Ianchulev,

MD, MPH

Karim Jamal, MD

Joseph Kim, MD

Michael Koss, MD

Derek Kunimoto,

MD

James Lambert,

PhD

Phillip Phuc Le,

MD, PhD

Grant Lee, MD

Garlan Lo, MD Jonathan Macy, MD Alan Mandelberg,

MD

Alfred Marrone, MD Guy Massry, MD William May, MD

Douglas McCreery,

PhD

Raghu Murthy, MD

48

usceye.org


CLINICAL EDUCATION

USC ROSKI EYE INSTITUTE VOLUNTEER FACULTY

Kami Parsa, MD

Artin Petrossians,

PhD

Dante Pieramici,

MD

Paul Prendiville,

MD

Harold Reaves, MD

Warren Reingold,

MD

Arvind Saini, MD

James Salz, MD

David Samimi, MD

Steve Schallhorn,

MD

Donald Schwartz,

MD, MPA

Donald Serafano,

MD

John Shammas,

MD

Marc Shomer, MD,

PhD

Holly Spanggord,

MD

Warren Stout, MD

Erik Tu, MD

Paul Urrea, MD,

MPH

Lee Wan, MD

Kenneth Wright,

MD

David Yu, MD

Christopher

Zoumalan, MD

49


INSIGHT

2016 Faculty

Publications

Faculty members at USC Roski Eye Institute

discover and disseminate vital information that

improves lives by contributing to the advancement

of ophthalmology and vision science.

1. Abdallah WF, Louie SG, Zhang Y, Rodgers KE, Sivok

E, G Sd, Humayun MS. Norleu3a(1-7) Accelerates

Clear Corneal Full Thickness Wound Healing. Invest

Ophthalmol Vis Sci. 2016 Apr 1;57(4):2187-94.

2. Adam MK, Rayess N, Rahimy E, Maguire JI, Hsu

J. Radial Versus Raster Spectral-Domain Optical

Coherence Tomography Scan Patterns for Detection

of Macular Fluid in Neovascular Age-Related

Macular Degeneration. Br J Ophthalmol. 2016

Apr;100(4):491-4.

3. Adams HH, Hibar DP, Chouraki V, Stein JL, Nyquist

PA, Renteria ME, Trompet S, Arias-Vasquez A,

Seshadri S, Desrivieres S, Beecham AH, Jahanshad

N, Wittfeld K, Van der Lee SJ, Abramovic L, Alhusaini

S, Amin N, Andersson M, Arfanakis K, Aribisala

BS, Armstrong NJ, Athanasiu L, Axelsson T, Beiser

A, Bernard M, Bis JC, Blanken LM, Blanton SH,

Bohlken MM, Boks MP, Bralten J, Brickman AM,

Carmichael O, Chakravarty MM, Chauhan G, Chen

Q, Ching CR, Cuellar-Partida G, Braber AD, Doan NT,

Ehrlich S, Filippi I, Ge T, Giddaluru S, Goldman AL,

Gottesman RF, Greven CU, Grimm O, Griswold ME,

Guadalupe T, Hass J, Haukvik UK, Hilal S, Hofer E,

Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia

T, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee

PH, Liao J, Liewald DC, Lopez LM, Luciano M, Macare

C, Marquand A, Matarin M, Mather KA, Mattheisen

M, Mazoyer B, McKay DR, McWhirter R, Milaneschi

Y, Mirza-Schreiber N, Muetzel RL, Maniega SM,

Nho K, Nugent AC, Loohuis LM, Oosterlaan J,

Papmeyer M, Pappa I, Pirpamer L, Pudas S, Putz

B, Rajan KB, Ramasamy A, Richards JS, Risacher

SL, Roiz-Santianez R, Rommelse N, Rose EJ, Royle

NA, Rundek T, Samann PG, Satizabal CL, Schmaal

L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith

AV, Sprooten E, Strike LT, Teumer A, Thomson R,

Tordesillas-Gutierrez D, Toro R, Trabzuni D, Vaidya

D, Van der Grond J, Van der Meer D, Van Donkelaar

MM, Van Eijk KR, Van Erp TG, Van Rooij D, Walton E,

Westlye LT, Whelan CD, Windham BG, Winkler AM,

Woldehawariat G, Wolf C, Wolfers T, Xu B, Yanek LR,

Yang J, Zijdenbos A, Zwiers MP, Agartz I, Aggarwal

NT, Almasy L, Ames D, Amouyel P, Andreassen

OA, Arepalli S, Assareh AA, Barral S, Bastin ME,

Becker DM, Becker JT, Bennett DA, Blangero J, van

Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM,

Brunner HG, Buckner RL, Buitelaar JK, Bulayeva

KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL,

Chen C, Cheng CY, Cichon S, Cookson MR, Corvin

A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM,

Davies GE, De Geus EJ, De Jager PL, de Zubicaray

GI, Delanty N, Depondt C, DeStefano AL, Dillman

A, Djurovic S, Donohoe G, Drevets WC, Duggirala

R, Dyer TD, Erk S, Espeseth T, Evans DA, Fedko IO,

Fernandez G, Ferrucci L, Fisher SE, Fleischman DA,

Ford I, Foroud TM, Fox PT, Francks C, Fukunaga M,

Gibbs JR, Glahn DC, Gollub RL, Goring HH, Grabe

HJ, Green RC, Gruber O, Gudnason V, Guelfi S,

Hansell NK, Hardy J, Hartman CA, Hashimoto R,

Hegenscheid K, Heinz A, Le Hellard S, Hernandez

DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann

W, Hofman A, Holsboer F, Homuth G, Hosten N,

Hottenga JJ, Pol HE, Ikeda M, Ikram MK, Jr CR,

Jenkinson M, Johnson R, Jonsson EG, Jukema

JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS,

Kochunov P, Kwok JB, Lawrie SM, Lemaitre H, Liu X,

Longo DL, Jr WT, Lopez OL, Lovestone S, Martinez

O, Martinot JL, Mattay VS, McDonald C, McIntosh

AM, McMahon KL, McMahon FJ, Mecocci P, Melle I,

Meyer-Lindenberg A, Mohnke S, Montgomery GW,

Morris DW, Mosley TH, Muhleisen TW, Muller-Myhsok

B, Nalls MA, Nauck M, Nichols TE, Niessen WJ,

Nothen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA,

Pandolfo M, Paus T, Pausova Z, Penninx BW, Pike

GB, Potkin SG, Psaty BM, Reppermund S, Rietschel

M, Roffman JL, Romanczuk-Seiferth N, Rotter JI,

Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt

R, Schofield PR, Sigurdsson S, Simmons A, Singleton

A, Sisodiya SM, Smith C, Smoller JW, Soininen

H, Srikanth V, Steen VM, Stott DJ, Sussmann JE,

Thalamuthu A, Tiemeier H, Toga AW, Traynor BJ,

Troncoso J, Turner JA, Tzourio C, Uitterlinden AG,

Hernandez MC, Van der Brug M, Van der Lugt A, Van

der Wee NJ, Van Duijn CM, Van Haren NE, Van TED,

Van Tol MJ, Vardarajan BN, Veltman DJ, Vernooij

MW, Volzke H, Walter H, Wardlaw JM, Wassink TH,

Weale ME, Weinberger DR, Weiner MW, Wen W,

Westman E, White T, Wong TY, Wright CB, Zielke

HR, Zonderman AB, Deary IJ, DeCarli C, Schmidt

H, Martin NG, De Craen AJ, Wright MJ, Launer

LJ, Schumann G, Fornage M, Franke B, Debette

S, Medland SE, Ikram MA, Thompson PM. Novel

Genetic Loci Underlying Human Intracranial Volume

Identified through Genome-Wide Association. Nat

Neurosci. 2016 Dec;19(12):1569-82.

4. Al Shamrani M, Al Hati K, Alkatan H, Alharby M,

Jastaneiah S, Song J, Edward DP. Pathological and

Immunohistochemical Alterations of the Cornea

in Congenital Corneal Opacification Secondary to

Primary Congenital Glaucoma and Peters Anomaly.

Cornea. 2016 Feb;35(2):226-33.

5. Albini TA, Puliafito CA. 8 Questions with Dr. Puliafito.

Interview with Thomas A. Albini, Md. Ophthalmic

Surg Lasers Imaging Retina. 2016 Apr 1;47(4):390-2.

6. Albreiki D, Al Belushi F, Patel V, Farmer J. When a

Temporal Artery Biopsy Reveals a Diagnosis Other

Than Temporal Arteritis: Eosinophilic Granulomatosis

with Polyangiitis. Can J Ophthalmol. 2016

Jun;51(3):e108-9.

7. Alhusaini S, Whelan CD, Sisodiya SM, Thompson PM.

Quantitative Magnetic Resonance Imaging Traits as

Endophenotypes for Genetic Mapping in Epilepsy.

Neuroimage Clin. 2016;12:526-34.

50 usceye.org


PUBLICATIONS

8. Ang M, Vasconcelos-Santos DV, Sharma K, Accorinti

M, Sharma A, Gupta A, Rao NA, Chee SP. Diagnosis

of Ocular Tuberculosis. Ocul Immunol Inflamm. 2016

Jul 5:1-9.

9. Ardestani A, Shen W, Darvas F, Toga AW, Fuster

JM. Modulation of Frontoparietal Neurovascular

Dynamics in Working Memory. J Cogn Neurosci. 2016

Mar;28(3):379-401.

10. Ashish N, Bhatt P, Toga AW. Global Data Sharing in

Alzheimer Disease Research. Alzheimer Dis Assoc

Disord. 2016 Apr-Jun;30(2):160-8.

11. Ashish N, Dewan P, Toga AW. The Gaain Entity

Mapper: An Active-Learning System for Medical Data

Mapping. Front Neuroinform. 2015;9:30.

12. Becker M, Guadalupe T, Franke B, Hibar DP, Renteria

ME, Stein JL, Thompson PM, Francks C, Vernes SC,

Fisher SE. Early Developmental Gene Enhancers

Affect Subcortical Volumes in the Adult Human

Brain. Hum Brain Mapp. 2016 May;37(5):1788-800.

13. Berry JL, Cobrinik D, Kim JW. Detection

and Intraretinal Localization of an ‘Invisible’

Retinoblastoma Using Optical Coherence

Tomography. Ocul Oncol Pathol. 2016 Apr;2(3):148-

52.

14. Berry JL, Shih G, Moysidis SN, Jubran R, Wong

K, Lee TC, Murphree AL, Kim JW. Patterns

of Subretinal Fluid Resolution in Group D Eyes

Treated with Chemoreduction: Experience from

the Children’s Hospital Los Angeles/University of

Southern California. Ophthalmic Genet. 2016 Mar

2:1-4.

15. Binder NR, Kruglyakova J, Borchert MS.

Strabismus in Patients with Cortical Visual

Impairment: Outcomes of Surgery and Observations

of Spontaneous Resolution. J aapos. 2016

Apr;20(2):121-5.

16. Blokland GA, Wallace AK, Hansell NK, Thompson

PM, Hickie IB, Montgomery GW, Martin NG,

McMahon KL, de Zubicaray GI, Wright MJ. Genome-

Wide Association Study of Working Memory Brain

Activation. Int J Psychophysiol. Epub 2016 Sep 23.

17. Boedhoe PS, Schmaal L, Abe Y, Ameis SH, Arnold

PD, Batistuzzo MC, Benedetti F, Beucke JC, Bollettini

I, Bose A, Brem S, Calvo A, Cheng Y, Cho KI,

Dallaspezia S, Denys D, Fitzgerald KD, Fouche JP,

Gimenez M, Gruner P, Hanna GL, Hibar DP, Hoexter

MQ, Hu H, Huyser C, Ikari K, Jahanshad N, Kathmann

N, Kaufmann C, Koch K, Kwon JS, Lazaro L, Liu Y,

Lochner C, Marsh R, Martinez-Zalacain I, Mataix-Cols

D, Menchon JM, Minuzzi L, Nakamae T, Nakao T,

Narayanaswamy JC, Piras F, Piras F, Pittenger C,

Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-

Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin

DF, Venkatasubramanian G, Walitza S, Wang Z, van

Wingen GA, Xu J, Xu X, Yun JY, Zhao Q, Thompson

PM, Stein DJ, van den Heuvel OA. Distinct

Subcortical Volume Alterations in Pediatric and Adult

Ocd: A Worldwide Meta- and Mega-Analysis. Am J

Psychiatry. Epub 2016 Sep 9

18. Borchert MS, Bruce S, Wirta D, Yoelin SG, Lee S,

Mao C, VanDenburgh A. An Evaluation of the Safety

and Efficacy of Bimatoprost for Eyelash Growth in

Pediatric Subjects. Clin Ophthalmol. 2016;10:419-29.

19. Brant Fernandes RA, Koss MJ, Falabella P, Stefanini

FR, Maia M, Diniz B, Ribeiro R, Hu Y, Hinton D, Clegg

DO, Chader G, Humayun MS. An Innovative Surgical

Technique for Subretinal Transplantation of Human

Embryonic Stem Cell-Derived Retinal Pigmented

Epithelium in Yucatan Mini Pigs: Preliminary Results.

Ophthalmic Surg Lasers Imaging Retina. 2016 Apr

1;47(4):342-51.

20. Bressler NM, Varma R, Mitchell P, Suner IJ, Dolan

C, Ward J, Ferreira A, Ehrlich JS, Turpcu A. Effect

of Ranibizumab on the Decision to Drive and Vision

Function Relevant to Driving in Patients with Diabetic

Macular Edema: Report from Restore, Ride, and Rise

Trials. JAMA Ophthalmol. 2016 Feb;134(2):160-6.

21. Brilliant MH, Vaziri K, Connor TB, Jr., Schwartz SG,

Carroll JJ, McCarty CA, Schrodi SJ, Hebbring SJ,

Kishor KS, Flynn HW, Jr., Moshfeghi AA, Moshfeghi

DM, Fini ME, McKay BS. Mining Retrospective Data

for Virtual Prospective Drug Repurposing: L-Dopa

and Age-Related Macular Degeneration. Am J Med.

2016 Mar;129(3):292-8.

22. Carr AR, Paholpak P, Daianu M, Fong SS, Mather

M, Jimenez EE, Thompson PM, Mendez MF. An

Investigation of Care-Based Vs. Rule-Based Morality

in Frontotemporal Dementia, Alzheimer’s Disease,

and Healthy Controls. Neuropsychologia. 2015

Nov;78:73-9.

23. Chadha N, Liu J, Maslin JS, Teng CC. Trends in

Ophthalmology Resident Surgical Experience from

2009 to 2015. Clin Ophthalmol. 2016;10:1205-8.

24. Chahal JS, Heur M, Chiu GB. Prosthetic

Replacement of the Ocular Surface Ecosystem

Scleral Lens Therapy for Exposure Keratopathy. Eye

Contact Lens. 2016 May 11.

25. Chiu GB, Theophanous C, Irvine JA. Prose Treatment

in Atypical Ocular Graft-Versus-Host Disease. Optom

Vis Sci. 2016 Nov;93(11):1444-8.

26. Cho A, Ratliff C, Sampath A, Weiland J. Changes in

Ganglion Cell Physiology During Retinal Degeneration

Influence Excitability by Prosthetic Electrodes. J

Neural Eng. 2016 Apr;13(2):025001.

27. Choi J, Dixon DM, Dansithong W, Abdallah WF, Roos

KP, Jordan MC, Trac B, Lee HS, Comai L, Reddy S.

Muscleblind-Like 3 Deficit Results in a Spectrum of

Age-Associated Pathologies Observed in Myotonic

Dystrophy. Sci Rep. 2016;6:30999.

28. Choudhury F, Varma R, Klein R, Gauderman WJ,

Azen SP, McKean-Cowdin R. Age-Related Macular

Degeneration and Quality of Life in Latinos: The Los

Angeles Latino Eye Study. JAMA Ophthalmol. 2016

Jun 1;134(6):683-90.

29. Colom R, Hua X, Martinez K, Burgaleta M, Roman

FJ, Gunter JL, Carmona S, Jaeggi SM, Thompson

PM. Brain Structural Changes Following Adaptive

Cognitive Training Assessed by Tensor-Based

Morphometry (Tbm). Neuropsychologia. 2016

Oct;91:77-85.

30. Conlon C, Asch S, Hanson M, Avins A, Levitan B, Roth

C, Robbins M, Dworsky M, Seabury SA, Nuckols

T. Assessing the Value of High-Quality Care for

Work-Associated Carpal Tunnel Syndrome in a Large

Integrated Health Care System: Study Design. Perm

J. 2016 Fall;20(4):87-95.

31. Couvy-Duchesne B, Ebejer JL, Gillespie NA, Duffy DL,

Hickie IB, Thompson PM, Martin NG, de Zubicaray

GI, McMahon KL, Medland SE, Wright MJ. Head

Motion and Inattention/Hyperactivity Share Common

Genetic Influences: Implications for Fmri Studies of

Adhd. PLoS One. 2016;11(1):e0146271.

32. Crawford KL, Neu SC, Toga AW. The Image and

Data Archive at the Laboratory of Neuro Imaging.

Neuroimage. 2016 Jan 1;124(Pt B):1080-3.

33. Cunningham SI, Shi Y, Weiland JD, Falabella P,

Olmos de Koo LC, Zacks DN, Tjan BS. Feasibility

of Structural and Functional Mri Acquisition with

Unpowered Implants in Argus Ii Retinal Prosthesis

Patients: A Case Study. Transl Vis Sci Technol. 2015

Dec;4(6):6.

34. da Cruz L, Dorn JD, Humayun MS, Dagnelie G,

Handa J, Barale PO, Sahel JA, Stanga PE, Hafezi F,

Safran AB, Salzmann J, Santos A, Birch D, Spencer

R, Cideciyan AV, de Juan E, Duncan JL, Eliott D,

Fawzi A, Olmos de Koo LC, Ho AC, Brown G, Haller

J, Regillo C, Del Priore LV, Arditi A, Greenberg RJ.

Five-Year Safety and Performance Results from the

Argus Ii Retinal Prosthesis System Clinical Trial.

Ophthalmology. 2016 Oct;123(10):2248-54.

35. Dagnelie G, Christopher P, Arditi A, da Cruz L,

Duncan JL, Ho AC, Olmos de Koo LC, Sahel JA,

Stanga PE, Thumann G, Wang Y, Arsiero M, Dorn JD,

Greenberg RJ. Performance of Real-World Functional

Vision Tasks by Blind Subjects Improves after

Implantation with the Argus(R) Ii Retinal Prosthesis

System. Clin Exp Ophthalmol. Epub 2016 Aug 6.

36. Daianu M, Mezher A, Mendez MF, Jahanshad N,

Jimenez EE, Thompson PM. Disrupted Rich Club

Network in Behavioral Variant Frontotemporal

Dementia and Early-Onset Alzheimer’s Disease. Hum

Brain Mapp. 2016 Mar;37(3):868-83.

37. DeBoer CM, Lee JK, Wheelan BP, Cable C, Shi W,

Tai YC, Humayun MS. Biomimetic Accommodating

Intraocular Lens Using a Valved Deformable

Liquid Balloon. IEEE Trans Biomed Eng. 2016

Jun;63(6):1129-35.

38. DeLoss KS, Le HG, Gire A, Chiu GB, Jacobs DS,

Carrasquillo KG. Prose Treatment for Ocular Chronic

Graft-Versus-Host Disease as a Clinical Network

Expands. Eye Contact Lens. 2016 Jul;42(4):262-6.

39. Deming JD, Pak JS, Shin JA, Brown BM, Kim MK,

Aung MH, Lee EJ, Pardue MT, Craft CM. Arrestin

1 and Cone Arrestin 4 Have Unique Roles in Visual

Function in an All-Cone Mouse Retina. Invest

Ophthalmol Vis Sci. 2015 Dec;56(13):7618-28.

40. Deming JD, Van Craenenbroeck K, Eom YS, Lee EJ,

Craft CM. Characterization of Antibodies to Identify

Cellular Expression of Dopamine Receptor 4. Adv

Exp Med Biol. 2016;854:663-70.

41. Dennis EL, Hua X, Villalon-Reina J, Moran LM,

Kernan C, Babikian T, Mink R, Babbitt C, Johnson

J, Giza CC, Thompson PM, Asarnow RF. Tensor-

Based Morphometry Reveals Volumetric Deficits in

Moderate=Severe Pediatric Traumatic Brain Injury. J

Neurotrauma. 2016 May 1;33(9):840-52.

42. Dinov ID, Heavner B, Tang M, Glusman G, Chard K,

Darcy M, Madduri R, Pa J, Spino C, Kesselman C,

Foster I, Deutsch EW, Price ND, Van Horn JD, Ames J,

Clark K, Hood L, Hampstead BM, Dauer W, Toga AW.

Predictive Big Data Analytics: A Study of Parkinson’s

Disease Using Large, Complex, Heterogeneous,

Incongruent, Multi-Source and Incomplete

Observations. PLoS One. 2016;11(8):e0157077.

43. Dugel PU, Layton A, Varma R. Diabetic Macular

Edema Diagnosis and Treatment in the Real World:

An Analysis of Medicare Claims Data (2008 to 2010).

Ophthalmic Surg Lasers Imaging Retina. 2016

Mar;47(3):258-67.

44. Duker JS, Puliafito CA. 8 Questions with Dr. Puliafito.

Ophthalmic Surg Lasers Imaging Retina. 2016

Mar;47(3):299-300.

51


45. Duncan JL, Richards TP, Arditi A, da Cruz L, Dagnelie

G, Dorn JD, Ho AC, Olmos de Koo LC, Barale PO,

Stanga PE, Thumann G, Wang Y, Greenberg RJ.

Improvements in Vision-Related Quality of Life in

Blind Patients Implanted with the Argus Ii Epiretinal

Prosthesis. Clin Exp Optom. Epub 2016 Aug 25.

46. Eandi CM, Charles Messance H, Augustin S,

Dominguez E, Lavalette S, Forster V, Hu SJ, Siquieros

L, Craft CM, Sahel JA, Tadayoni R, Paques M,

Guillonneau X, Sennlaub F. Subretinal Mononuclear

Phagocytes Induce Cone Segment Loss Via Il-1beta.

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USC ROSKI EYE INSTITUTE CME

2017 EVENTS

#Trending Topics in Ophthalmology

@ The Terranea 2017

FEBRUARY 3-4, 2017

Neuro-Ophthalmology & Oculoplastics

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MARCH 18, 2017

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USC Roski Eye Institute

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MAY 4, 2017

2017 Annual USC Roski Eye

Institute Symposium

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