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Appointment with the dean - University of Rochester Medical Center

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ROCHESTER MEDICINE<br />

UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY FALL / WINTER 2002<br />

WHAT ANSEL ADAMS SAW IN ROCHESTER<br />

ALUMNI ORTHOPÆDISTS KEEP ALL-STARS IN THE GAME


Cover photo:<br />

Charles G. Cochrane, M.D.<br />

(M ’56, B ’51), by Ansel<br />

Adams. Courtesy <strong>of</strong> <strong>the</strong><br />

Department <strong>of</strong> Rare Books<br />

and Special Collections,<br />

Rush Rhees Library<br />

(Ansel Adams Collection)


Attract<br />

<strong>the</strong> best and <strong>the</strong> brightest.<br />

This issue <strong>of</strong> <strong>Rochester</strong> Medicine shows that <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> <strong>Rochester</strong> knows how to do just<br />

that, whe<strong>the</strong>r it’s medical students, faculty, or<br />

even freelance photographers.<br />

On <strong>the</strong> cover and inside this issue, you’ll<br />

see what happened when we attracted <strong>the</strong> best<br />

and brightest — Ansel Adams — to our<br />

university 50 years ago to shoot photographs for<br />

a university publication. Adams shot more than<br />

200 photographs here, including many at <strong>the</strong><br />

School <strong>of</strong> Medicine and Dentistry, and came to<br />

see <strong>Rochester</strong> as a second home. His <strong>Rochester</strong><br />

work won awards and was exhibited twice —<br />

a testament to his ability to make art out <strong>of</strong><br />

science.<br />

In <strong>the</strong> realm <strong>of</strong> research, you’ll read<br />

about a <strong>Medical</strong> <strong>Center</strong> researcher who<br />

followed new evidence to explore an area <strong>of</strong><br />

<strong>the</strong> brain never before implicated in autism.<br />

Patricia Rodier’s bright idea was overlooked at<br />

first because it was so unusual, but now her<br />

work looks to be a promising new direction in<br />

unlocking <strong>the</strong> mystery <strong>of</strong> what causes autism.<br />

She has attracted a large, multi-disciplinary<br />

team <strong>of</strong> researchers and has won several<br />

significant grants to expand her investigations.<br />

You’ll also read about alumni who have<br />

helped athletes such as Roger Clemens and<br />

Peter Caru<strong>the</strong>rs reach <strong>the</strong> pinnacle <strong>of</strong> <strong>the</strong>ir<br />

sports, and who help teams such as <strong>the</strong><br />

Houston Astros stay healthy or recover from<br />

injury. Our look at alumni who are team<br />

physicians includes <strong>the</strong> first female medical<br />

director <strong>of</strong> a Division I, Big 10 athletic department,<br />

and an alumnus who had to face <strong>the</strong><br />

hardest test <strong>of</strong> <strong>the</strong> pr<strong>of</strong>ession: <strong>the</strong> paralysis <strong>of</strong><br />

an athlete on <strong>the</strong> football field.<br />

And you’ll meet <strong>the</strong> new <strong>dean</strong> <strong>of</strong> <strong>the</strong><br />

School <strong>of</strong> Medicine and Dentistry — one <strong>of</strong><br />

<strong>the</strong> best and brightest clinical researchers<br />

around. David Guzick earned a Ph.D. and M.D.<br />

simultaneously, did his OB/GYN internship and<br />

residency at Johns Hopkins <strong>University</strong> and was<br />

most recently <strong>the</strong> chair <strong>of</strong> <strong>the</strong> Department <strong>of</strong><br />

Obstetrics and Gynecology here at <strong>Rochester</strong>.<br />

His impressive background is proving especially<br />

valuable as <strong>the</strong> <strong>Medical</strong> <strong>Center</strong> puts renewed<br />

energy into clinical research.<br />

The varied stories in this issue are a<br />

refreshing reminder <strong>of</strong> why we work so hard<br />

to attract great talent to <strong>Rochester</strong>. That’s why<br />

it’s so exciting to be here and study here.<br />

And that’s why our alumni are able to make<br />

such a difference in <strong>the</strong> communities where<br />

<strong>the</strong>y work and live.<br />

Jay H. Stein, M.D.<br />

Senior Vice President & Vice Provost for Health<br />

Affairs, <strong>Medical</strong> <strong>Center</strong> & Strong Health CEO<br />

FALL / WINTER 2002 1


Since<br />

I became Dean in April, virtually<br />

everyone I meet asks, “What’s it like being<br />

Dean?” I usually answer, “Well, it’s a little bit<br />

different than being Chair <strong>of</strong> Ob/Gyn.”<br />

Actually, it’s a lot different — more than<br />

I thought. For one thing, as a faculty member<br />

or Chair, <strong>the</strong>re are some things you just take<br />

for granted, such as <strong>the</strong> library and <strong>the</strong><br />

vivarium. But you can no longer do this as<br />

Dean; all <strong>of</strong> a sudden, <strong>the</strong> vivarium’s issues are<br />

your issues (not to mention such things as <strong>the</strong><br />

budget, freezing pipes and falling bricks!).<br />

Ano<strong>the</strong>r difference is that <strong>the</strong> scope <strong>of</strong><br />

intellectual, clinical and educational activities<br />

is much broader than I fully appreciated as<br />

a Chair. When I interviewed for <strong>the</strong> position<br />

as Dean, I was asked to meet <strong>with</strong> <strong>the</strong> people<br />

who are responsible for <strong>the</strong> major academic,<br />

clinical and operational functions <strong>of</strong> <strong>the</strong><br />

<strong>Medical</strong> <strong>Center</strong> — department chairs, center<br />

directors and <strong>the</strong> heads <strong>of</strong> finance, library,<br />

public relations, etc. There were more than<br />

50 names! At first I thought, “There must be<br />

some mistake!” But indeed, everyone was<br />

responsible for a significant entity <strong>with</strong>in<br />

<strong>the</strong> <strong>Medical</strong> <strong>Center</strong>.<br />

So I began my journey through <strong>the</strong><br />

<strong>Medical</strong> <strong>Center</strong>, meeting <strong>with</strong> many <strong>of</strong> our<br />

leading scientists, educators, clinicians and<br />

administrators one by one. I expected to hear<br />

all about what people want more <strong>of</strong> — space,<br />

money, faculty and staff. But instead, what<br />

I heard was excitement about <strong>the</strong>ir work and<br />

about <strong>the</strong> future.<br />

Needless to say, we face a number <strong>of</strong><br />

challenging problems: declining reimbursement<br />

for patient care, increasing regulatory<br />

constraints and higher cost for education,<br />

<strong>the</strong> constant challenges <strong>of</strong> external funding<br />

for research, and <strong>the</strong> need to improve community<br />

health in <strong>the</strong> face <strong>of</strong> tightening<br />

2<br />

ROCHESTER MEDICINE<br />

government budgets. Despite this, our scientists<br />

were animated in <strong>the</strong>ir enthusiasm about<br />

a variety <strong>of</strong> basic and clinical research projects.<br />

Our educators were excited about <strong>the</strong> dynamic<br />

changes that have been introduced by <strong>the</strong><br />

Double Helix Curriculum, about <strong>the</strong> wonderful<br />

students we are attracting to <strong>the</strong> School, and<br />

about <strong>the</strong> improvements in many <strong>of</strong> our residency<br />

and fellowship programs. Our clinicians<br />

pointed to a diverse array <strong>of</strong> new patient care<br />

programs designed to improve clinical<br />

outcomes. And our community health pr<strong>of</strong>essionals<br />

were optimistic about <strong>the</strong> effect <strong>of</strong><br />

Project Believe — our initiative to make<br />

<strong>Rochester</strong> <strong>the</strong> healthiest community by 2020 —<br />

on <strong>the</strong> health <strong>of</strong> our region's population.<br />

Confronted <strong>with</strong> <strong>the</strong> breadth and diversity<br />

<strong>of</strong> <strong>the</strong> work in which faculty and staff are<br />

engaged at <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> <strong>Medical</strong><br />

<strong>Center</strong> and <strong>the</strong> enormity <strong>of</strong> <strong>the</strong> serious missions<br />

to which we are pledged — providing compassionate<br />

and technically superb patient care,<br />

educating <strong>the</strong> next generation <strong>of</strong> physicians,<br />

dentists and biomedical scientists, generating<br />

new basic and applied knowledge that will<br />

improve our ability to prevent and treat illness,<br />

and improving <strong>the</strong> health status <strong>of</strong> our<br />

community — I stand in awe and wonder at<br />

<strong>the</strong> enormity <strong>of</strong> <strong>the</strong> challenge. I am highly<br />

optimistic about our ability to meet <strong>the</strong>se<br />

challenges, however, because <strong>of</strong> <strong>the</strong> unique<br />

characteristics <strong>of</strong> our institution and <strong>the</strong><br />

momentum that we have already generated.<br />

We are unique in <strong>the</strong> energy, commitment<br />

and vision <strong>of</strong> our leadership. President<br />

Jackson and Dr. Stein have brought toge<strong>the</strong>r<br />

<strong>the</strong> hospital and <strong>Medical</strong> <strong>Center</strong> under one<br />

strategic plan, administration and budget, and<br />

thus created a powerful force for <strong>the</strong> future.<br />

Not only are we breaking new ground nationally<br />

as an academic medical center, but we<br />

are becoming increasingly important as an<br />

economic entity <strong>with</strong>in <strong>the</strong> community. We are<br />

now <strong>the</strong> region’s second largest employer and<br />

are rapidly becoming an important economic<br />

engine for <strong>the</strong> future <strong>of</strong> <strong>Rochester</strong>. As a result<br />

<strong>of</strong> our research enterprise and <strong>the</strong> creation <strong>of</strong><br />

biotechnology companies based on our discoveries<br />

and innovations, <strong>the</strong>re has been, and will<br />

continue to be, job creation and o<strong>the</strong>r positive<br />

ripple effects on our region.<br />

What an exciting time for <strong>the</strong> <strong>University</strong><br />

and <strong>the</strong> <strong>Medical</strong> <strong>Center</strong>! I am thrilled to have<br />

an opportunity to serve as Dean <strong>of</strong> <strong>the</strong> School<br />

<strong>of</strong> Medicine and Dentistry.<br />

In this issue <strong>of</strong> <strong>Rochester</strong> Medicine,<br />

you’ll find examples <strong>of</strong> <strong>the</strong> breadth and diversity<br />

<strong>of</strong> work associated <strong>with</strong> our school. I feel<br />

privileged to be part <strong>of</strong> it.<br />

David S. Guzick, M.D., Ph.D.<br />

Dean <strong>of</strong> <strong>the</strong> School <strong>of</strong> Medicine and Dentistry


CONTENTS<br />

ROCHESTER MEDICINE<br />

FEATURES<br />

10 <strong>Appointment</strong> <strong>with</strong> <strong>the</strong> <strong>dean</strong>: Taking multi-tasking to new heights<br />

12 The Univeristy landscape as Ansel Adams saw it — a photo essay<br />

26 Called to <strong>the</strong> cause <strong>of</strong> autism research<br />

30 Pioneers in <strong>the</strong> field— orthopædists as team physicians<br />

4 <strong>Medical</strong> <strong>Center</strong> rounds<br />

34 School news<br />

39 Alumni news<br />

48 Class notes<br />

55 In memoriam<br />

DEPARTMENTS<br />

<strong>Rochester</strong> Medicine is published by: The <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> <strong>Medical</strong> <strong>Center</strong>,<br />

Department <strong>of</strong> Public Relations and Communications, in conjunction <strong>with</strong><br />

<strong>the</strong> Department <strong>of</strong> <strong>Medical</strong> Alumni Relations and Development<br />

Director <strong>of</strong> Public Relations and Communications Teri D’Agostino<br />

Editor Mark Liu<br />

Contributing Writers Travis Anderson, Lori Barrette, Karin Gaffney, Leslie Orr,<br />

Germaine Reinhardt, Tom Rickey, and Leslie White<br />

Art Director Mitchell Christensen<br />

Photographers Randy Tagg and Vince Sullivan<br />

Editorial Assistant Rita J. Ciarico<br />

Director <strong>of</strong> Development for <strong>Medical</strong> Alumni Programs Christopher Raimy<br />

Associate Director <strong>of</strong> <strong>Medical</strong> Alumni Relations Christina Mancini<br />

For questions or comments, contact:<br />

Department <strong>of</strong> Alumni Relations and Development<br />

300 East River Road, <strong>Rochester</strong>, NY 14627<br />

1–800–333–4428 585–273–5954 Fax 585–461–2081<br />

E-mail address: <strong>Rochester</strong>MedicineMagazine@urmc.rochester.edu<br />

FALL / WINTER 2002 3


medical center rounds<br />

4<br />

Tiny<br />

camera pill can<br />

Imagine a vitamin-pill size camera that could<br />

travel through your body taking pictures,<br />

helping diagnose a problem your doctor previously<br />

would have found only through surgery.<br />

No longer is such technology <strong>the</strong> stuff <strong>of</strong><br />

science-fiction films. Strong Memorial Hospital<br />

is one <strong>of</strong> only a few locations in New York State<br />

where doctors are using this innovative technology<br />

to diagnose problems in <strong>the</strong> small<br />

intestines.<br />

The Given Diagnostic Imaging System,<br />

developed by an Israeli-based company and<br />

approved by <strong>the</strong> FDA last year, is now available<br />

to patients at Strong. The device is a miniature<br />

video camera and transmitter built in to a<br />

capsule that is swallowed by <strong>the</strong> patient.<br />

For years, doctors have used small<br />

cameras attached to fiber-optic tubes to look<br />

inside <strong>the</strong> digestive tract and diagnose illnesses.<br />

These tests, such as endoscopy and<br />

ROCHESTER MEDICINE<br />

find problems<br />

that o<strong>the</strong>r tests<br />

colonoscopy, allow for views <strong>of</strong> <strong>the</strong> esophagus,<br />

stomach and colon, but <strong>the</strong> small intestine is<br />

too long and out <strong>of</strong> <strong>the</strong> reach <strong>of</strong> those diagnostic<br />

instruments. Often, patients whose problems<br />

appeared to stem from <strong>the</strong> small intestine —<br />

problems like suspected internal bleeding or unexplained<br />

abdominal pain — were subject to surgery<br />

to diagnose <strong>the</strong> problem. The new, tiny pill-camera<br />

actually travels through <strong>the</strong> small intestine,<br />

snapping pictures at a rate <strong>of</strong> two per second.<br />

The images are transmitted wirelessly from <strong>the</strong><br />

camera to a small pack <strong>the</strong> patient wears like a<br />

belt. During its eight-hour trip through <strong>the</strong> digestive<br />

tract, <strong>the</strong> battery-powered pill uses a wide-angle<br />

lens to transmit about 50,000 images capable <strong>of</strong><br />

identifying growths, internal bleeding and o<strong>the</strong>r<br />

problems. The pill eventually passes through <strong>the</strong><br />

colon and is eliminated naturally and safely.<br />

“It’s an amazing breakthrough and holds<br />

great promise as a tool for diagnosing patients<br />

miss<br />

<strong>with</strong> specific problems,” says Uma Sundaram,<br />

M.D., chief <strong>of</strong> <strong>the</strong> Digestive Disease Unit at<br />

Strong. “Though it won’t replace <strong>the</strong> technology<br />

we currently use to diagnose problems<br />

above and below <strong>the</strong> small intestine, it is<br />

a tremendous asset for helping us visualize<br />

an area previously beyond our reach, short <strong>of</strong><br />

surgery. It could prove a great benefit to<br />

patients as a less invasive procedure, especially<br />

in cases where we can limit <strong>the</strong> need for<br />

surgery for patients who are already experiencing<br />

abdominal pain or internal bleeding.”<br />

Strong is currently screening patients to<br />

identify appropriate cases where patients might<br />

benefit from <strong>the</strong> new diagnostic device.


A better prostate<br />

procedure<br />

Urologists from <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong><br />

<strong>Medical</strong> <strong>Center</strong> are providing an alternative<br />

to open surgery for men <strong>with</strong> prostate cancer:<br />

removal <strong>of</strong> <strong>the</strong> gland through laparoscopic<br />

surgery. This technique is minimally invasive<br />

and growing more popular because it <strong>of</strong>fers<br />

a quicker recovery compared to traditional<br />

surgery. The <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> was<br />

<strong>the</strong> first in <strong>the</strong> state, and one <strong>of</strong> only nine<br />

academic medical institutions nationwide,<br />

to <strong>of</strong>fer this procedure.<br />

“I believe this will become <strong>the</strong> standard<br />

for prostate surgery in <strong>the</strong> near future,” said<br />

surgeon Jean Joseph, M.D., an assistant<br />

pr<strong>of</strong>essor <strong>of</strong> urology. “It gets patients back<br />

to <strong>the</strong>ir normal lives much faster.”<br />

Joseph trained <strong>with</strong> world-renowned<br />

surgeon Bertrand Guillonneau, M.D., who<br />

developed <strong>the</strong> new procedure. In <strong>the</strong> United<br />

States, one in 10 men gets prostate cancer,<br />

making it one <strong>of</strong> <strong>the</strong> most common forms<br />

<strong>of</strong> cancer among men age 45 and up.<br />

Surgical removal <strong>of</strong> <strong>the</strong> prostate has<br />

long been <strong>the</strong> “gold standard” treatment for<br />

men <strong>with</strong> cancer confined to <strong>the</strong> prostate<br />

gland. Laparoscopy, also known as keyhole<br />

surgery, uses long, slender instruments inserted<br />

into <strong>the</strong> abdominal cavity and manipulated<br />

outside <strong>of</strong> <strong>the</strong> body. A voice-command robot<br />

is used to guide an internal camera, allowing<br />

a magnified view <strong>of</strong> internal organs and<br />

surgical instruments throughout <strong>the</strong> procedure.<br />

Since <strong>the</strong> procedure was developed, in 1998,<br />

studies have shown that men recover more<br />

quickly, <strong>with</strong> a shortened hospital stay. Patients<br />

also have less pain and incontinence following<br />

<strong>the</strong> laparoscopic procedure.<br />

“Patients benefit from <strong>the</strong> fact that we<br />

use smaller incisions and have significantly<br />

less blood loss,” said Joseph.<br />

Radiation expert<br />

joins homeland<br />

security effort<br />

P. Andrew Karam, Ph.D., <strong>the</strong> <strong>University</strong>’s radiation<br />

safety <strong>of</strong>ficer, is one <strong>of</strong> <strong>the</strong> founding<br />

members <strong>of</strong> a new Homeland Security<br />

Committee to help prevent or cope <strong>with</strong> a<br />

potential terrorist incident involving radiation,<br />

such as <strong>the</strong> detonation <strong>of</strong> a radioactive “dirty<br />

bomb.”<br />

The committee was created by <strong>the</strong><br />

Health Physics Society (HPS) to help <strong>the</strong> public,<br />

government <strong>of</strong>ficials and emergency personnel.<br />

Karam, a radiation expert who is a frequent<br />

spokesman for scientific societies on radiation<br />

risks and issues, is one <strong>of</strong> several HPS <strong>of</strong>ficials<br />

who helped create <strong>the</strong> committee. In June,<br />

Karam and o<strong>the</strong>r committee members met in<br />

Tampa, Fla., at <strong>the</strong> annual meeting <strong>of</strong> HPS to<br />

discuss homeland security.<br />

Karam also is helping to organize a new<br />

HPS group, Radiation Safety Without Borders,<br />

designed to enhance radiation safety around<br />

<strong>the</strong> world. The new group plans to <strong>of</strong>fer advice<br />

to o<strong>the</strong>r nations about safe storage and transportation<br />

<strong>of</strong> radioactive materials and keeping<br />

materials out <strong>of</strong> <strong>the</strong> wrong hands.<br />

“It’s like <strong>the</strong> group Doctors Without<br />

Borders; we’re using our expertise to help<br />

people in o<strong>the</strong>r countries,” says Karam. “This<br />

will help keep <strong>the</strong> whole world safer as well.”<br />

medical center rounds<br />

Respiratory specialists<br />

study New York City<br />

firefighters<br />

<strong>Rochester</strong> researchers who specialize in<br />

studying <strong>the</strong> effects <strong>of</strong> tiny particles on <strong>the</strong><br />

lungs have been chosen to study respiratory<br />

symptoms in 300 New York City firefighters and<br />

to take part in a survey and follow-up study <strong>of</strong><br />

6,000 Manhattan residents.<br />

The study is one <strong>of</strong> several announced<br />

by Tommy G. Thompson, secretary <strong>of</strong> <strong>the</strong><br />

Department <strong>of</strong> Health and Human Services,<br />

to address health concerns in <strong>the</strong> wake <strong>of</strong> <strong>the</strong><br />

Sept. 11 terrorist attacks.<br />

<strong>Rochester</strong> scientists led by Guenter<br />

Oberdoerster, pr<strong>of</strong>essor <strong>of</strong> environmental<br />

medicine, are working <strong>with</strong> researchers from<br />

New York <strong>University</strong> and Columbia <strong>University</strong>,<br />

thanks to $1.2 million in funding from <strong>the</strong><br />

National Institute <strong>of</strong> Environmental Health<br />

Sciences.<br />

Oberdoerster already leads an $8.3million<br />

effort funded by <strong>the</strong> Environmental<br />

Protection Agency to study <strong>the</strong> link between<br />

exposure to urban air particles and poor<br />

health. The team focuses on <strong>the</strong> health effects<br />

<strong>of</strong> ultrafine particles, <strong>the</strong> tiniest <strong>of</strong> particles that<br />

we regularly brea<strong>the</strong> into our lungs. In hightraffic<br />

areas, 1 million such particles pack into<br />

<strong>the</strong> amount <strong>of</strong> air contained in just one<br />

thimble.<br />

FALL / WINTER 2002 5


medical center rounds<br />

Program brea<strong>the</strong>s life into lung research<br />

In keeping <strong>with</strong> its mission to expand research,<br />

<strong>the</strong> <strong>Medical</strong> <strong>Center</strong> has launched <strong>the</strong> Lung<br />

Biology and Disease Program, which unites<br />

a dozen top scientists from various departments<br />

onto one floor <strong>of</strong> <strong>the</strong> <strong>University</strong>’s newest<br />

building at <strong>the</strong> west end <strong>of</strong> <strong>the</strong> campus. The<br />

program, which also serves as an umbrella for<br />

as many as 40 researchers, became fully operational<br />

in June. Recruitment <strong>of</strong> new faculty, and<br />

some construction and laboratory setups, will<br />

continue throughout <strong>the</strong> year.<br />

The new program focuses attention on<br />

<strong>the</strong> lungs and related, modern-day health<br />

concerns: toxic exposures due to pollution<br />

and chemicals; asthma and o<strong>the</strong>r chronic lung<br />

ailments; respiratory infections; and lung<br />

cancer. It will allow <strong>the</strong> scientists — once<br />

separated geographically and by pr<strong>of</strong>essional<br />

discipline — to work more effectively as <strong>the</strong>y<br />

investigate lung disease from <strong>the</strong> molecular<br />

stage to how it strikes patients, young and old,<br />

and <strong>the</strong> most promising treatments.<br />

Richard Phipps, Ph.D., pr<strong>of</strong>essor <strong>of</strong> environmental<br />

medicine, oncology, microbiology,<br />

immunology and pediatrics, has been<br />

Vitamin E, a compound thought to play a role<br />

in preventing prostate cancer, interferes <strong>with</strong><br />

two proteins that play a central role in <strong>the</strong> development<br />

<strong>of</strong> <strong>the</strong> disease, say <strong>Rochester</strong> scientists.<br />

Researchers led by Shuyuan Yeh, Ph.D.,<br />

assistant pr<strong>of</strong>essor in <strong>the</strong> departments <strong>of</strong><br />

Urology and Pathology, found that vitamin E<br />

interferes <strong>with</strong> <strong>the</strong> ability <strong>of</strong> prostate cancer<br />

6<br />

ROCHESTER MEDICINE<br />

appointed director <strong>of</strong> <strong>the</strong> new program. Phipps,<br />

whose research for 19 years at <strong>Rochester</strong> has<br />

focused on lung disease and immunology, has<br />

a patent pending on a new way <strong>of</strong> immunizing<br />

against a serious infection that afflicts patients<br />

<strong>with</strong> cystic fibrosis and HIV.<br />

“Each organ has its own unique aspects<br />

in terms <strong>of</strong> how it gets injured and how it is<br />

repaired,” Phipps says. “We think it’s going<br />

to be very productive to focus on <strong>the</strong> lung from<br />

many different angles, as opposed to <strong>the</strong><br />

approach <strong>of</strong> studying diseases only at a fundamental<br />

level and <strong>the</strong>n applying that to <strong>the</strong> lung.”<br />

<strong>Rochester</strong> has been a leader in this field<br />

for years. In <strong>the</strong> 1980s, for instance, scientists<br />

here were instrumental in developing what is<br />

now a standard <strong>the</strong>rapy for premature<br />

infants — a liquid medication called surfactant<br />

that helps tiny, underdeveloped lungs work<br />

better. More recently, in environmental medicine,<br />

<strong>the</strong> EPA awarded <strong>the</strong> <strong>Medical</strong> <strong>Center</strong> (as<br />

one <strong>of</strong> five sites nationally) an $8 million grant<br />

to study <strong>the</strong> link between exposure to urban air<br />

particles and poor health. The association<br />

between air pollution and increased death rates<br />

cells to make both prostate-specific antigen<br />

(PSA) and <strong>the</strong> androgen receptor. Yeh showed<br />

that in prostate cancer cells exposed to<br />

vitamin E, <strong>the</strong> PSA level drops significantly—<br />

as much as 80 to 90 percent, which is a sign<br />

<strong>of</strong> slowed cancer cell growth. Researchers<br />

also saw a 25 to 50 percent decrease in <strong>the</strong><br />

number <strong>of</strong> cancer cells. Under certain conditions,<br />

is well documented, but now scientists are<br />

racing to identify which particles are toxic and<br />

why <strong>the</strong>y cause lung disease.<br />

The combined brainpower <strong>of</strong> cell biologists,<br />

immunologists and clinicians should<br />

result in new treatments. The lung program<br />

will maintain close ties <strong>with</strong> Strong Memorial<br />

Hospital’s pulmonary and critical-care divisions,<br />

and will give <strong>the</strong> <strong>Medical</strong> <strong>Center</strong> greater<br />

access to <strong>the</strong> newest drugs being tested in clinical<br />

trials. A state-<strong>of</strong>-<strong>the</strong>-art facility in <strong>the</strong><br />

basement <strong>of</strong> <strong>the</strong> new research building will also<br />

open avenues in gene <strong>the</strong>rapy and o<strong>the</strong>r<br />

modern approaches to lung disease.<br />

At this point, <strong>the</strong> lung biology program<br />

is funded by existing research grants, including<br />

a $1.5 million training grant, directed by Mark<br />

Frampton, M.D., for pre- and postdoctoral<br />

students that was renewed by <strong>the</strong> NIH late last<br />

year. In addition, <strong>the</strong> NIH has invited a group <strong>of</strong><br />

pediatric lung researchers, led by Frank<br />

Gigliotti, M.D., to apply for money to investigate<br />

<strong>the</strong> disease process that causes pneumocystic<br />

pneumonia, a very active area <strong>of</strong> research<br />

nationally.<br />

Vitamin E makes prostate cancer cells vulnerable<br />

<strong>the</strong> vitamin killed <strong>of</strong>f 90 percent <strong>of</strong> cancer cells.<br />

The work shows that <strong>the</strong> cancer cells are<br />

vulnerable in a way previously unknown.<br />

While <strong>the</strong> research was done in <strong>the</strong> laboratory<br />

and not in humans, it takes on added<br />

significance because studies in people have<br />

already shown that vitamin E may help prevent<br />

prostate cancer. But just how it might play


Cardiologist uses new technology<br />

to close holes in heart<br />

A <strong>Rochester</strong> cardiologist is among a handful<br />

in <strong>the</strong> state using a new product to repair holes<br />

between <strong>the</strong> chambers <strong>of</strong> <strong>the</strong> heart in both<br />

children and adults. The new method doesn’t<br />

involve traditional surgery, leaves no scar,<br />

and reduces hospital stays from several weeks<br />

to several hours.<br />

Daniel Miga, M.D., director <strong>of</strong> pediatric<br />

interventional cardiology at Golisano Children’s<br />

Hospital at Strong, is one <strong>of</strong> only two doctors in<br />

upstate New York <strong>of</strong>fering <strong>the</strong> procedure.<br />

Using a device called <strong>the</strong> Amplatzer<br />

Septal Occluder, Miga can close an atrial septal<br />

defect — a hole located between <strong>the</strong> left and<br />

right atria in <strong>the</strong> heart — <strong>with</strong>out resorting to<br />

surgery. The technique <strong>of</strong> cardiac ca<strong>the</strong>terization<br />

advances a ca<strong>the</strong>ter into <strong>the</strong> heart through<br />

blood vessels to obtain blood samples, take<br />

detailed pictures and detect and correct<br />

congenital abnormalities <strong>of</strong> <strong>the</strong> heart. These<br />

are some <strong>of</strong> <strong>the</strong> most common congenital heart<br />

defects, accounting for 6 percent to 10 percent<br />

<strong>of</strong> all heart defects.<br />

“These devices make a huge difference<br />

for patients,” Miga says. “It’s safe, effective, and<br />

a protective role has been unclear.<br />

The team also found that one traditional<br />

anti-androgen drug, hydroxyflutamide,<br />

had little effect on <strong>the</strong> human metastatic<br />

prostate cancer cells tested in <strong>the</strong>ir study. But<br />

when vitamin E was added to <strong>the</strong> mix, cancer<br />

cell growth slowed dramatically.<br />

“This is exciting and quite promising,<br />

but until we do fur<strong>the</strong>r studies in people, we<br />

can’t really recommend that every man take<br />

vitamin E to prevent <strong>the</strong> disease,” says Edward<br />

Messing, M.D., a co-author and pr<strong>of</strong>essor and<br />

can eliminate <strong>the</strong> need for surgery and a large<br />

incision in <strong>the</strong> chest.”<br />

Even for <strong>the</strong> healthiest patients, Miga<br />

says traditional open-heart surgery means<br />

spending several days in <strong>the</strong> hospital and<br />

enduring a significant amount <strong>of</strong> pain, <strong>with</strong><br />

a recovery period that lasts for weeks. That’s<br />

not <strong>the</strong> case <strong>with</strong> <strong>the</strong> Amplatzer Septal<br />

Occluder. The procedure takes about two hours<br />

and most patients go home <strong>the</strong> same morning<br />

<strong>with</strong> only a few restrictions.<br />

With <strong>the</strong> Amplatzer Septal Occluder,<br />

a patient is generally sedated under anes<strong>the</strong>sia.<br />

After <strong>the</strong> patient is asleep, a tube is inserted<br />

in a vein in <strong>the</strong> groin. The next step is to insert<br />

a ca<strong>the</strong>ter and navigate it through <strong>the</strong> body’s<br />

largest veins until it reaches <strong>the</strong> heart. After<br />

fur<strong>the</strong>r testing, including ultrasound imaging,<br />

ano<strong>the</strong>r ca<strong>the</strong>ter is used to insert <strong>the</strong> device,<br />

which springs open around <strong>the</strong> hole in <strong>the</strong><br />

heart. It builds a new wall where <strong>the</strong> opening<br />

was and, for <strong>the</strong> next several months, <strong>the</strong> heart<br />

tissue grows around it to fortify it.<br />

For more information about <strong>the</strong><br />

Amplatzer Septal Occluder, call 585 – 273 – 2160.<br />

chair <strong>of</strong> <strong>the</strong> Department <strong>of</strong> Urology. O<strong>the</strong>r<br />

authors on <strong>the</strong> paper include graduate students<br />

Yu Zhang and Jing Ni; local high school<br />

student Eugene Chang; and Chin-Rang Yang,<br />

Ph.D., <strong>of</strong> <strong>the</strong> Department <strong>of</strong> Radiation Oncology.<br />

The scientists also caution that different<br />

forms <strong>of</strong> vitamin E produce different results.<br />

The team found that a type known as vitamin E<br />

succinate, also known as alpha-tocopheryl<br />

succinate, was most effective in halting prostate<br />

cancer cells in <strong>the</strong> laboratory. Yeh’s team also<br />

has found that vitamins D and E may work in<br />

medical center rounds<br />

concert, <strong>with</strong> vitamin E helping to boost <strong>the</strong><br />

effectiveness <strong>of</strong> vitamin D in killing cancer cells.<br />

Messing is also heading <strong>the</strong> local<br />

portion <strong>of</strong> a study designed to test whe<strong>the</strong>r<br />

ei<strong>the</strong>r vitamin E or selenium, or a combination,<br />

prevents prostate cancer. It’s <strong>the</strong> largest<br />

clinical trial yet <strong>of</strong> <strong>the</strong> disease, which strikes<br />

about <strong>the</strong> same number <strong>of</strong> men—approximately<br />

200,000 — as <strong>the</strong> number <strong>of</strong> women<br />

in <strong>the</strong> United States who get breast cancer.<br />

The findings appeared in Proceedings <strong>of</strong><br />

<strong>the</strong> National Academy <strong>of</strong> Sciences.<br />

FALL / WINTER 2002 7


medical center rounds<br />

Controversial transfusion method<br />

saves lives, lowers costs<br />

Removing white cells from blood before use in<br />

a transfusion most likely saved <strong>the</strong> lives <strong>of</strong> 50<br />

to 60 heart surgery patients at Strong Memorial<br />

Hospital since 1998 and also reduced <strong>the</strong> cost<br />

<strong>of</strong> treatment. These results, and a review <strong>of</strong> this<br />

scientifically proven but controversial procedure<br />

— leukocyte-reduced transfusions —<br />

appeared in <strong>the</strong> September 2002 issue <strong>of</strong> <strong>the</strong><br />

American Journal <strong>of</strong> Clinical Pathology.<br />

Research shows that many complications<br />

<strong>of</strong> surgery are not due to bad luck,<br />

surgical accidents, inadequate hand-washing<br />

or antibiotic-resistant bacteria, but ra<strong>the</strong>r to<br />

previously unrecognized adverse effects <strong>of</strong> transfused<br />

white cells on <strong>the</strong> patient’s immune<br />

system. The presence <strong>of</strong> foreign transfused white<br />

cells compromises <strong>the</strong> ability to fight <strong>of</strong>f <strong>the</strong><br />

bacteria in our bodies and <strong>the</strong> environment.<br />

Lead author Neil Blumberg, M.D.,<br />

director <strong>of</strong> <strong>the</strong> Transfusion Unit and Blood<br />

Bank at Strong Memorial Hospital <strong>of</strong> <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> <strong>Rochester</strong> <strong>Medical</strong> <strong>Center</strong>, says<br />

o<strong>the</strong>r medical institutions will almost certainly<br />

save money and reduce patient complications<br />

if <strong>the</strong>y switch from using unmodified blood<br />

to leukocyte-reduced blood.<br />

But some in <strong>the</strong> medical community<br />

remain unconvinced. Organizations such<br />

as <strong>the</strong> American Hospital Association and<br />

American <strong>Medical</strong> Association have opposed<br />

recommendations from <strong>the</strong> FDA and o<strong>the</strong>rs for<br />

universal leukocyte-reduction, claiming it<br />

would inflate costs unnecessarily. Leukocytereduction<br />

adds $25 to $35 to <strong>the</strong> price <strong>of</strong> each<br />

unit <strong>of</strong> blood. The FDA does not mandate<br />

universal leukocyte-reduction <strong>of</strong> transfusions.<br />

For two decades, doctors at Strong<br />

Memorial have been world leaders in scientific<br />

and clinical studies <strong>of</strong> this “transfusion<br />

immunomodulation” effect. Strong was among<br />

<strong>the</strong> first hospitals in <strong>the</strong> nation to use leuko-<br />

8<br />

ROCHESTER MEDICINE<br />

cyte-reduced blood in cardiac surgery, starting<br />

in July 1998. The FDA’s Blood Products Advisory<br />

Committee advocated this approach in<br />

September 1998. The Health and Human<br />

Services Advisory Committee on Blood Safety<br />

and Availability voted overwhelmingly in favor<br />

<strong>of</strong> universal leukocyte-reduction for transfusions<br />

in January 2001, based on randomized<br />

trials suggesting that it could lower death rates<br />

by as much as 50 to 60 percent in heart surgery.<br />

Most American Red Cross blood centers provide<br />

only leukocyte-reduced transfusions, as do<br />

many o<strong>the</strong>r blood centers.<br />

To address <strong>the</strong> controversy, Blumberg<br />

and his colleagues sought to analyze <strong>the</strong><br />

economic consequences and clinical outcomes<br />

<strong>of</strong> <strong>the</strong>ir early adoption <strong>of</strong> this technology.<br />

Using existing data at Strong, <strong>the</strong>y<br />

studied two groups: patients undergoing cardiac<br />

surgery from July to December 1998 using leukocyte-reduced<br />

blood, versus a control group from<br />

<strong>the</strong> same period in 1997 who were transfused<br />

<strong>with</strong> unmodified blood. To reduce bias in <strong>the</strong><br />

data, Blumberg included only adults <strong>with</strong><br />

similar demographic characteristics whose<br />

surgeries were performed by two surgeons <strong>with</strong><br />

established practices, co-authors George Hicks Jr.,<br />

M.D. (M ’71, R ’78), and William Risher, M.D.<br />

In addition to improved outcomes, <strong>the</strong><br />

cost <strong>of</strong> treating <strong>the</strong> recipients <strong>of</strong> leukocytereduced<br />

blood dropped by about $1,700 in each<br />

case despite <strong>the</strong> effects <strong>of</strong> cost inflation and new<br />

technologies. Blumberg attributed <strong>the</strong> savings<br />

to fewer hours in <strong>the</strong> ICU, less use <strong>of</strong> antibiotics<br />

and a decrease in length <strong>of</strong> stay.<br />

By July 2000, Strong Hospital began<br />

using leukocyte-reduced blood for all hospitalized<br />

patients. Despite <strong>the</strong> expense <strong>of</strong> <strong>the</strong> filters,<br />

<strong>the</strong> overall cost savings in cardiac surgery<br />

alone are estimated at between $500,000 and<br />

$1 million a year, Blumberg says.<br />

On May 9, celebrations for <strong>the</strong> new <strong>Medical</strong><br />

Research building were held simultaneously<br />

in <strong>Rochester</strong>, Boston, Los Angeles, and New<br />

York City. The <strong>Rochester</strong> events were broadcast<br />

on closed-circuit TV to <strong>the</strong> o<strong>the</strong>r sites.<br />

Far right: Architect’s rendering <strong>of</strong> proposed<br />

second <strong>Medical</strong> Research Building, and <strong>the</strong><br />

completed facility, below.<br />

Above right: Ling Lam, M.D. (M ’93), and Anouk<br />

Amzel, M.D., raise a glass at <strong>the</strong> May 9 event in<br />

New York City to celebrate <strong>the</strong> opening <strong>of</strong> <strong>the</strong><br />

second <strong>Medical</strong> Research Building at <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> <strong>Rochester</strong> <strong>Medical</strong> <strong>Center</strong>. Similar<br />

celebrations took place in Boston and Los<br />

Angeles, <strong>with</strong> <strong>the</strong> main events in <strong>Rochester</strong>.<br />

Below right (from left): Gilbert Forbes, M.D.<br />

(BS ’36, M ’40), Robert Brent, M.D., Ph.D. (BS ’48,<br />

M ’53, P ’55), and Robert Su<strong>the</strong>rland (Ph.D. ’66)<br />

helped celebrate <strong>the</strong> opening <strong>of</strong> <strong>the</strong> second<br />

<strong>Medical</strong> <strong>Center</strong> building—<strong>the</strong> MRB-X—at<br />

a New York City event on May 9. The three<br />

also got down to business as members <strong>of</strong> <strong>the</strong><br />

<strong>Medical</strong> Alumni Council, which held its spring<br />

meeting in conjunction <strong>with</strong> <strong>the</strong> event.


State grants $30 million to URMC<br />

On Sept. 23, New York Governor George E.<br />

Pataki and o<strong>the</strong>r government leaders presented<br />

<strong>the</strong> <strong>Medical</strong> <strong>Center</strong> <strong>with</strong> a $30 million grant in<br />

support <strong>of</strong> <strong>the</strong> <strong>Medical</strong> <strong>Center</strong>’s biomedical<br />

research strategic plan. It’s <strong>the</strong> largest single<br />

contribution yet to <strong>the</strong> <strong>Medical</strong> <strong>Center</strong>’s tenyear<br />

initiative to establish <strong>Rochester</strong> as a<br />

national hub for biomedical technology.<br />

<strong>University</strong> President Thomas H. Jackson<br />

and <strong>Medical</strong> <strong>Center</strong> CEO Jay H. Stein, M.D.,<br />

accepted <strong>the</strong> grant at a festive news conference<br />

held in <strong>the</strong> atrium <strong>of</strong> <strong>the</strong> Arthur Kornberg<br />

<strong>Medical</strong> Research Building.<br />

“Today is a significant day for <strong>Rochester</strong><br />

and <strong>the</strong> State <strong>of</strong> New York,” Jackson said to <strong>the</strong><br />

hundreds <strong>of</strong> employees and reporters ga<strong>the</strong>red<br />

for <strong>the</strong> announcement. “This is not only<br />

important to <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong>, but<br />

to <strong>the</strong> entire community and region.”<br />

According to Stein, <strong>the</strong> <strong>Medical</strong> <strong>Center</strong><br />

requested funds in order to develop <strong>the</strong> mechanisms<br />

to transfer new discoveries from medical<br />

laboratories to <strong>the</strong> private sector. Specifically,<br />

funds were requested to:<br />

• develop space to house biotech companies that<br />

commercialize discoveries made in <strong>Medical</strong><br />

<strong>Center</strong> laboratories.<br />

• provide start-up capital needed to create business<br />

strategies, secure facilities and fur<strong>the</strong>r<br />

develop breakthrough ideas coming from<br />

<strong>Medical</strong> <strong>Center</strong> laboratories.<br />

•<br />

help finance <strong>the</strong> construction and/or renova-<br />

medical center rounds<br />

tion <strong>of</strong> <strong>the</strong> <strong>Medical</strong> <strong>Center</strong>’s new research<br />

laboratories, space critical to <strong>the</strong> recruitment<br />

<strong>of</strong> top-level scientists and technicians.<br />

Through new construction jobs and fulltime,<br />

permanent jobs, plus jobs created in<br />

spin<strong>of</strong>f companies and related vendors, it is<br />

estimated that <strong>the</strong> <strong>Medical</strong> <strong>Center</strong>’s research<br />

initiative will increase regional employment by<br />

3,565 jobs. And <strong>the</strong> effort is projected to import<br />

$45 million in venture capital into <strong>Rochester</strong><br />

and increase royalties paid to <strong>the</strong> <strong>University</strong>.<br />

“This $30 million granted by <strong>the</strong> State<br />

<strong>of</strong> New York will take biotechnology to a new<br />

level, boosting New York’s economy <strong>with</strong> <strong>the</strong><br />

promise <strong>of</strong> new jobs, and fostering lifesaving<br />

medical breakthroughs,” Stein said.<br />

FALL / WINTER 2002 9


10<br />

<strong>Appointment</strong> <strong>with</strong> <strong>the</strong> <strong>dean</strong><br />

Taking<br />

multi-tasking<br />

to new heights<br />

ROCHESTER MEDICINE<br />

David Guzick, M.D., Ph.D., remembers flopping into bed<br />

after his first 36-hour shift as an OB/GYN intern at Johns<br />

Hopkins and thinking, “I’ve never learned so much<br />

in my life. I don’t know if I’ll survive this, but if I do,<br />

at least I’m going to know what I’m doing.”<br />

Guzick did more than survive. He went on to publish more than<br />

100 research articles, establish <strong>the</strong> most successful in vitro fertilization<br />

program in <strong>the</strong> Pittsburgh region, chair <strong>the</strong> Department <strong>of</strong> Obstetrics and<br />

Gynecology at <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> <strong>Medical</strong> <strong>Center</strong> for seven years<br />

and — this year — become <strong>the</strong> ninth <strong>dean</strong> <strong>of</strong> <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong><br />

School <strong>of</strong> Medicine and Dentistry.<br />

His definition <strong>of</strong> “<strong>dean</strong>,” though, might sound a bit different.<br />

Beyond his administrative duties, Guzick says his goal is to maintain his<br />

clinical skills, continue to train residents, work <strong>with</strong> faculty members on<br />

<strong>the</strong>ir research projects and continue his own research. In short, Guzick<br />

has no intention <strong>of</strong> wearing out <strong>the</strong> carpet under his desk.<br />

“Some people don’t do well <strong>with</strong> many balls in <strong>the</strong> air,” he says.<br />

“<br />

I don’t think I can survive unless <strong>the</strong>re are several balls in <strong>the</strong> air.”<br />

Guzick has been juggling for a long time now. Growing up in<br />

Brooklyn, he earned a spot as <strong>the</strong> shooting guard on his high school<br />

varsity basketball team while only a freshman, yet studied hard enough<br />

to graduate a year early. At age 20, he embarked on a combined M.D.-Ph.D.<br />

program at New York <strong>University</strong>, earning a Ph.D. in economics and an M.D.<br />

simultaneously. At <strong>the</strong> <strong>University</strong> <strong>of</strong> Texas Southwestern <strong>Medical</strong> School,<br />

he was named an assistant pr<strong>of</strong>essor while still a fellow — an extremely<br />

unusual occurrence.<br />

Even back in those early days as an OB/GYN intern, he somehow<br />

found a way to fit research into his schedule. As a physician <strong>with</strong> a Ph.D.<br />

in econometrics under his belt, Guzick was very popular among faculty<br />

researchers who had data sets needing to be analyzed. So, his typical<br />

on-call shift might have involved taking care <strong>of</strong> patients in Labor and<br />

Delivery, <strong>the</strong>n a jaunt across <strong>the</strong> street to <strong>the</strong> computer lab to toss <strong>of</strong>f<br />

some methodological analyses <strong>of</strong> how classification systems affect treatment<br />

outcomes, <strong>the</strong>n a sprint back to <strong>the</strong> ward if something was needed.<br />

“He was <strong>the</strong> only one trying to do two things at once,”<br />

says Ana Murphy, M.D., division director <strong>of</strong> Reproductive Endocrinology<br />

and Infertility at Emory <strong>University</strong>. Murphy was a second-year resident<br />

at Johns Hopkins Hospital when Guzick started his internship <strong>the</strong>re,


and <strong>the</strong> two have crossed paths many times in <strong>the</strong> subsequent two decades.<br />

Murphy remembers Guzick as <strong>the</strong> rare intern she could always count on.<br />

“Interns are usually quite lost and get flustered easily,” she says.<br />

But not Guzick. In fact, Murphy found herself thinking, “I hope to be just<br />

as cool, calm, collected and unflappable as David.”<br />

Not bad for someone who hadn’t even intended to practice medicine.<br />

Guzick’s original plan was to work in health policy. He pursued<br />

an M.D. because he felt that medical credentials would help. But once<br />

he got a taste <strong>of</strong> clinical work, he was hooked.<br />

“I liked <strong>the</strong> reality and practical aspects <strong>of</strong> surgery, as well as <strong>the</strong><br />

personal interactions <strong>of</strong> medical practice,” he says. “I realized that policy<br />

analysis, on a full-time basis, would be too abstract for me.”<br />

Nowhere was <strong>the</strong> personal interaction <strong>of</strong> medicine more rewarding<br />

than in <strong>the</strong> world <strong>of</strong> in vitro fertilization (IVF). Though just a fellow at<br />

<strong>the</strong> time, Guzick and a faculty member at <strong>the</strong> <strong>University</strong> <strong>of</strong> Texas started<br />

an IVF program in 1984, when many people were still skeptical that <strong>the</strong><br />

procedure could work.<br />

“With IVF, I felt on <strong>the</strong> pioneering edge,” Guzick says. “There was<br />

this ‘wow’ factor, that this was a technically amazing feat. It seemed in<br />

<strong>the</strong> realm <strong>of</strong> science fiction.”<br />

At <strong>the</strong> <strong>University</strong> <strong>of</strong> Pittsburgh School <strong>of</strong> Medicine, as director <strong>of</strong><br />

<strong>the</strong> Division <strong>of</strong> Reproductive Endocrinology and <strong>the</strong> Assisted Reproduction<br />

Program, Guzick created his own “wow” factor. Essentially starting from<br />

scratch, he worked seven days a week to establish and continuously<br />

improve an IVF program at Magee-Women’s Hospital. Under his leadership,<br />

<strong>the</strong> program had <strong>the</strong> highest pregnancy rates in <strong>the</strong> surrounding<br />

three-state region.<br />

“He was well known as a national figure,” says Kathy Hoeger, M.D.,<br />

associate pr<strong>of</strong>essor <strong>of</strong> OB/GYN at <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> School <strong>of</strong> Medicine<br />

and Dentistry. “Certainly in OB/GYN in general, he was well known.”<br />

When <strong>Rochester</strong> recruited Guzick to chair <strong>the</strong> Department <strong>of</strong><br />

Obstetrics and Gynecology in 1995, he became an important mentor to<br />

Hoeger and many o<strong>the</strong>rs. Guzick’s ability to help faculty members write<br />

grants — and his willingness to meet on weekends and after hours to<br />

help — was crucial to his goal <strong>of</strong> refocusing <strong>the</strong> department on clinical<br />

research.<br />

“There’s a great deal <strong>of</strong> insight that someone like him can lend,”<br />

says Hoeger. “He helps you formulate your own ideas better. And knowing<br />

<strong>the</strong> intricacies <strong>of</strong> <strong>the</strong> NIH is invaluable — it’s nothing you can read in<br />

a textbook or call <strong>the</strong> NIH to ask.”<br />

When Guzick came <strong>with</strong> his clinical research focus, Hoeger says<br />

department members were wary because <strong>the</strong>y didn’t know how <strong>the</strong> new<br />

approach would fit in <strong>with</strong> <strong>the</strong> Department’s previous focus on basicscience<br />

research. But that didn’t deter Guzick. According to Hoeger, Guzick<br />

simply jumped in and showed how to do it.<br />

“He did it basically by example,” she says. “He challenged people<br />

to think about how to apply <strong>the</strong>ir research to a clinical study and how that<br />

would advance what <strong>the</strong>y know.”<br />

In doing so, says Jim Woods, M.D., <strong>the</strong> new chair <strong>of</strong> OB/GYN at<br />

<strong>Rochester</strong>, Guzick “invigorated <strong>the</strong> department <strong>with</strong> <strong>the</strong> excitement <strong>of</strong><br />

clinical research. It was a transformation <strong>of</strong> attitude from ‘I’m too busy<br />

to write grants’ to ‘I want to write grants.’ ”<br />

As <strong>dean</strong>, Guzick is in <strong>the</strong> position to make clinical research a true<br />

force throughout <strong>the</strong> <strong>Medical</strong> <strong>Center</strong>. Now that <strong>Rochester</strong> has built two<br />

new basic-science research buildings, <strong>the</strong> obvious next step is to bolster its<br />

clinical research while continuing to support and enhance basic research.<br />

“The medical school contains 700 or so clinical faculty who are<br />

seeing patients. I believe <strong>the</strong> school side <strong>of</strong> things and <strong>the</strong> hospital side<br />

<strong>of</strong> things can work toge<strong>the</strong>r,” says Guzick.<br />

Woods says that strong clinical research can affect not only patient<br />

perceptions <strong>of</strong> <strong>the</strong> <strong>University</strong> but its national and international reputation:<br />

“If you build a strong research environment, you’ll attract good<br />

investigators. They’ll be better teachers and clinicians who are aware <strong>of</strong><br />

very modern medicine. That will attract <strong>the</strong> best residents, which will<br />

attract <strong>the</strong> best medical students.”<br />

CONTINUED page 57<br />

FALL / WINTER 2002 11


The <strong>University</strong> Landscape<br />

Ansel Adams turned <strong>the</strong> sights<br />

<strong>of</strong> <strong>Rochester</strong> into works <strong>of</strong> art.<br />

Ansel Adams, <strong>the</strong> famed nature photographer, was<br />

bored. It was 1952, and <strong>the</strong> 50-year-old Adams was<br />

confiding to friends that he had hit a creative<br />

impasse and was lacking inspiration — a shocking<br />

development for someone so dedicated to his craft.<br />

But <strong>the</strong>n a call came.<br />

by Mark Liu<br />

AADAMS NSEL<br />

The <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> was looking for<br />

someone to take photographs for a new brochure.<br />

The <strong>University</strong> wanted to combine its men’s and<br />

women’s campuses, and it needed a special publica-<br />

tion to help raise money to build new dormitories,<br />

a dining center and academic buildings.<br />

photo courtesy <strong>of</strong> The Democrat and Chronicle and <strong>Rochester</strong> Museum and Science <strong>Center</strong>


And so he came, far from his haunts in <strong>the</strong> rocky peaks<br />

<strong>of</strong> Yosemite, to <strong>the</strong> autumnal banks <strong>of</strong> <strong>the</strong> Genesee.<br />

Nobody can be sure what role his <strong>Rochester</strong> visit might<br />

have played in re-energizing Adams, but it did get him<br />

behind a camera at a time when, as he wrote to<br />

a friend: “I have had no burning desire to make a picture<br />

in a long time.” It did lead to more than 200 photographs<br />

— work so impressive that <strong>the</strong> <strong>University</strong><br />

decided to pay an extra $1,000 (in 1952 dollars) for<br />

exhibit prints, so it could display <strong>the</strong>m in <strong>the</strong> main<br />

library. And it did result in a beautifully conceived publication<br />

that helped <strong>the</strong> <strong>University</strong> meet its goal and<br />

integrate its campus.<br />

Photo courtesy <strong>of</strong>: Department <strong>of</strong> Rare Books and Special Collections, Rush Rhees Library (Ansel Adams Collection)<br />

ABOVE<br />

Dr. Joe Howland,<br />

former pr<strong>of</strong>essor <strong>of</strong><br />

Radiation Biology<br />

and Chief <strong>of</strong> Division,<br />

Atomic Energy<br />

Project, Cancer<br />

Research.<br />

LEFT<br />

Ansel Adams, earlier<br />

in his career.<br />

FALL / WINTER 2002 13


14<br />

Now, 50 years later, <strong>the</strong> Ansel Adams photographs<br />

<strong>of</strong>fer a glimpse into <strong>the</strong> history <strong>of</strong> <strong>the</strong> <strong>University</strong><br />

through <strong>the</strong> eyes <strong>of</strong> one <strong>of</strong> <strong>the</strong> greatest artists ever<br />

to peer through a lens. Included are a half dozen<br />

shots <strong>of</strong> <strong>the</strong> <strong>Medical</strong> <strong>Center</strong> and its people,<br />

including faculty, a medical intern and <strong>the</strong> first <strong>dean</strong><br />

<strong>of</strong> <strong>the</strong> School <strong>of</strong> Medicine and Dentistry —<br />

Nobel laureate George Whipple.<br />

That <strong>the</strong> photographs are fascinating is little<br />

surprise. What is more <strong>of</strong> a surprise is <strong>the</strong> inspiration<br />

Adams seemed to gain from <strong>the</strong> <strong>University</strong>.<br />

Initially he had planned to stay only one or two<br />

weeks, but he ended up working on <strong>the</strong> project<br />

for a month. In <strong>Rochester</strong> Review magazine<br />

<strong>the</strong> following year, he explained that he had<br />

expected to stay just a short while: “But your<br />

<strong>University</strong>,” he said, “turned out to be about<br />

10 times as large and interesting as I had expected.”<br />

The connection that brought Ansel Adams to<br />

<strong>Rochester</strong> was Beaumont and Nancy Newhall.<br />

Beaumont Newhall, <strong>the</strong>n curator <strong>of</strong> <strong>the</strong> George<br />

Eastman House and <strong>the</strong> International Museum <strong>of</strong><br />

Photography in <strong>Rochester</strong>, had been a curator at <strong>the</strong><br />

Museum <strong>of</strong> Modern Art in New York, where he and<br />

his wife had become close friends <strong>with</strong> Adams.<br />

Nancy Newhall and Adams collaborated on<br />

numerous photography books and exhibitions. At<br />

times <strong>the</strong>y wrote several letters a day to each o<strong>the</strong>r.<br />

ROCHESTER MEDICINE<br />

RIGHT<br />

Charles G. Cochrane, M.D. (M ’56, B ’51), recounts sitting for this photo:<br />

I was cramming down a sandwich in Bill’s lunch room, prior to attending<br />

a conference, when in walked a strange-looking smiling fellow who<br />

balanced <strong>the</strong> loss <strong>of</strong> hair on <strong>the</strong> top <strong>of</strong> his head <strong>with</strong> a huge growth<br />

<strong>of</strong> beard. He walked straight up to me and asked if he could take my<br />

picture. I replied in <strong>the</strong> negative as I was so short <strong>of</strong> time. He retorted<br />

that it was for <strong>the</strong> <strong>University</strong>. Since I was devoted to <strong>the</strong> school that<br />

provided me so much, I assented to <strong>the</strong> photograph ra<strong>the</strong>r than <strong>the</strong><br />

conference. Little did I know what he wanted.<br />

He marched me to <strong>the</strong> surgical suites and asked that I don surgical<br />

scrubs, and in response to my question regarding time, responded<br />

that an hour should do. I tempered my annoyance <strong>with</strong> <strong>the</strong> thought that<br />

I could send to my parents, who had been so supportive <strong>of</strong> my schooling,<br />

a copy <strong>of</strong> <strong>the</strong> photo or <strong>the</strong> negative.<br />

After <strong>the</strong> promised hour and endless flashes <strong>of</strong> <strong>the</strong> camera,<br />

he announced we were done. I <strong>the</strong>n sought my reward, asking for<br />

a negative or a copy <strong>of</strong> <strong>the</strong> photo. He looked me straight in <strong>the</strong> eye<br />

and <strong>the</strong>n broke into a loud laugh that I can hear to this day. It was<br />

obvious my education was not in <strong>the</strong> realm <strong>of</strong> photography.<br />

But after my humiliation, he added that he would see what he could do,<br />

and <strong>with</strong>in a month or so, I received a copy <strong>of</strong> a positive, toge<strong>the</strong>r <strong>with</strong><br />

<strong>the</strong> name <strong>of</strong> <strong>the</strong> bearded, smiling intruder on my sacred lunch-time:<br />

Ansel Adams. The latest I have seen <strong>of</strong> Ansel Adams’ work in galleries,<br />

<strong>the</strong> cost per print was out <strong>of</strong> sight, which explains <strong>the</strong> laugh in response<br />

to my question. I also have found that his negatives are tightly held<br />

in museums such as that at <strong>the</strong> <strong>University</strong> <strong>of</strong> Arizona. We learn in<br />

various ways.<br />

Photo courtesy <strong>of</strong>: Department <strong>of</strong> Rare Books and Special Collections, Rush Rhees Library (Ansel Adams Collection)


SPRING / SUMMER 2002 15


16<br />

ROCHESTER MEDICINE


By this time, Adams had established himself in <strong>the</strong><br />

small world <strong>of</strong> art photography, but he still needed<br />

to do commercial work.<br />

“<br />

Photography, as an art form, was fairly new,” says<br />

Melissa Mead, librarian at <strong>the</strong> <strong>University</strong>’s Rare<br />

Books and Special Collections, where a set <strong>of</strong><br />

<strong>the</strong> prints is archived. “You didn’t make a lot <strong>of</strong><br />

money out <strong>of</strong> it.”<br />

Photo courtesy <strong>of</strong>: Department <strong>of</strong> Rare Books and Special Collections, Rush Rhees Library (Ansel Adams Collection)<br />

ABOVE<br />

Conducting a medical<br />

research project.<br />

LEFT<br />

Dr. George Whipple,<br />

Nobel laureate and<br />

first <strong>dean</strong> <strong>of</strong> <strong>the</strong><br />

School <strong>of</strong> Medicine<br />

and Dentistry.<br />

FALL / WINTER 2002 17


18<br />

Adams arrived in <strong>Rochester</strong> in September and<br />

stayed in <strong>the</strong> Newhalls’ house — <strong>with</strong>out <strong>the</strong>m,<br />

initially, because <strong>the</strong>y were out <strong>of</strong> town. A letter<br />

from Adams to <strong>the</strong> Newhalls, dated Sept. 30,<br />

documents an eventful first few weeks. Adams had<br />

to contend <strong>with</strong> Pinky, <strong>the</strong> Newhalls’ chicken-wingstealing<br />

cat (“I gave Pinky <strong>the</strong> old Judo treatment”);<br />

a fender-bender <strong>with</strong> a drunk driver; a short circuit<br />

that knocked <strong>the</strong> lights out in <strong>the</strong> house; and<br />

borrowed camera equipment that malfunctioned<br />

and had to be replaced.<br />

But he had better luck <strong>with</strong> <strong>the</strong> actual work. Though<br />

he at first lamented <strong>the</strong> conception for <strong>the</strong> brochure<br />

as “completely nebulous,” this actually meant he<br />

had <strong>the</strong> freedom to proceed <strong>the</strong> way he thought<br />

best. Adams decided to approach his task as if he<br />

were creating pictures for an exhibition. With that<br />

in mind, he threw himself into <strong>the</strong> <strong>University</strong><br />

community. He met <strong>with</strong> researchers and faculty<br />

and even attended an autopsy at Strong Memorial<br />

Hospital. He would rise before six (for <strong>the</strong> early<br />

light) and work through <strong>the</strong> morning, pausing only<br />

for a steak breakfast at a diner. Lunch was never a<br />

problem, as he was much in demand as a dining<br />

guest — especially among scientists at Eastman<br />

Kodak Company.<br />

ROCHESTER MEDICINE<br />

RIGHT<br />

Dr. J. Edward<br />

H<strong>of</strong>fmeister, former<br />

<strong>dean</strong> <strong>of</strong> <strong>the</strong> College<br />

<strong>of</strong> Arts and Science<br />

and pr<strong>of</strong>essor <strong>of</strong><br />

geology, by <strong>the</strong><br />

Genesee river.<br />

Photo courtesy <strong>of</strong>: Department <strong>of</strong> Rare Books and Special Collections, Rush Rhees Library (Ansel Adams Collection)


SPRING / SUMMER 2002 19


20<br />

ROCHESTER MEDICINE


The <strong>Rochester</strong> brochure was far removed from his<br />

first love <strong>of</strong> nature photography, yet Adams felt<br />

engaged by <strong>the</strong> work. Writing to <strong>the</strong> Newhalls,<br />

he called <strong>the</strong> job “a fine thing for me; chiefly<br />

because it points <strong>the</strong> way to <strong>the</strong> ultimate use <strong>of</strong><br />

what talents I have.”<br />

Really, it was good timing. As Adams put it:<br />

“<br />

Honestly, as time goes on, I feel less and less interested<br />

in <strong>the</strong> making <strong>of</strong> pictures and more interested<br />

in <strong>the</strong> use <strong>of</strong> <strong>the</strong>m … At this time, <strong>the</strong> problems <strong>of</strong><br />

<strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> are much more important<br />

to me than any picture (photographic) could<br />

ever represent …”<br />

Photo courtesy <strong>of</strong>: Department <strong>of</strong> Rare Books and Special Collections, Rush Rhees Library (Ansel Adams Collection)<br />

ABOVE<br />

The Genesee County<br />

landscape.<br />

LEFT<br />

Dr. W. Albert<br />

Noyes, Jr., former<br />

chairman <strong>of</strong> <strong>the</strong><br />

department <strong>of</strong><br />

chemistry and <strong>dean</strong><br />

<strong>of</strong> <strong>the</strong> graduate<br />

school.<br />

FALL / WINTER 2002 21


22<br />

The brochure, called “Creative Change,” was<br />

printed in 1953. It contained dozens <strong>of</strong> faculty<br />

portraits, scenes <strong>of</strong> researchers in action, and<br />

glimpses <strong>of</strong> campus life. But <strong>the</strong> photographs went<br />

beyond mere documentation. The <strong>University</strong> administration,<br />

quoted in a newspaper article, said that<br />

“<br />

Adams has done much to establish <strong>the</strong> true image<br />

<strong>of</strong> <strong>the</strong> institution.” The administration lauded<br />

Adams’s ability to “interpret <strong>the</strong> spirit <strong>of</strong> <strong>the</strong> university<br />

in visual images.”<br />

That ability to capture <strong>the</strong> spirit <strong>of</strong> his subjects —<br />

whe<strong>the</strong>r <strong>the</strong>y be a granite mountain, a celebrity or<br />

an unknown medical student — is, <strong>of</strong> course, why<br />

Ansel Adams is considered an artistic genius.<br />

Months after his stay in <strong>Rochester</strong>, Adams was back<br />

to his prolific self. In a letter to Nancy Newhall<br />

dated December 17, 1952, he wrote: “Made<br />

7 subjects today!” He also said that Time magazine<br />

had commissioned him to make photographs for<br />

an upcoming story. Apparently, he was excited<br />

about <strong>the</strong> prospect. He wrote: “Let’s do a real job<br />

on it!!!!!!” Adams had arrived in <strong>Rochester</strong> bored<br />

<strong>with</strong> making photographs. Months later, <strong>the</strong> thought<br />

<strong>of</strong> upcoming work elicited six exclamation points.<br />

A year later, <strong>the</strong> periodical U.S. Camera released its<br />

annual publication <strong>of</strong> what it considered <strong>the</strong> year’s<br />

best photography from around <strong>the</strong> world. Eight <strong>of</strong><br />

Adams’s <strong>Rochester</strong> photographs appeared in <strong>the</strong><br />

magazine.<br />

And 50 years later, last winter, <strong>the</strong> <strong>University</strong> once<br />

again displayed <strong>the</strong> exhibit prints in its main<br />

library — proud as ever to show how a great artist<br />

captured <strong>the</strong> spirit <strong>of</strong> its people and places.<br />

ROCHESTER MEDICINE<br />

RIGHT<br />

The Rush Rhees<br />

Library dome.<br />

Photo courtesy <strong>of</strong>: Department <strong>of</strong> Rare Books and Special Collections, Rush Rhees Library (Ansel Adams Collection)


FALL / WINTER 2002 23


24<br />

ROCHESTER MEDICINE


The <strong>University</strong> <strong>of</strong> <strong>Rochester</strong>’s Department <strong>of</strong><br />

Rare Books and Special Collections houses <strong>the</strong><br />

Ansel Adams collection. The Department, located<br />

on <strong>the</strong> second floor <strong>of</strong> <strong>the</strong> Rush Rhees Library on<br />

<strong>the</strong> River Campus, has more than 200 photographs<br />

Adams took at <strong>the</strong> <strong>University</strong>.<br />

Anyone interested in seeing <strong>the</strong> collection<br />

can make an appointment <strong>with</strong> Rare Books by<br />

calling 585–275–4477.<br />

The Rare Books Department has collections<br />

<strong>of</strong> unique, rare and special research materials<br />

including books, manuscripts, photographs, maps,<br />

prints, broadsides, and o<strong>the</strong>r printed ephemera.<br />

The department has about 100,000 books and more<br />

than two miles <strong>of</strong> manuscript material.<br />

photo courtesy <strong>of</strong>: Department <strong>of</strong> Rare Books and Special Collections, Rush Rhees Library (Ansel Adams Collection)<br />

ABOVE<br />

Ansel Adams, right,<br />

displays his camera<br />

at <strong>the</strong> George<br />

Eastman House<br />

<strong>with</strong> good friends<br />

Nancy and Beaumont<br />

Newhall, in 1968.<br />

LEFT<br />

Howard Hanson,<br />

<strong>the</strong>n head <strong>of</strong> <strong>the</strong><br />

Eastman School <strong>of</strong><br />

Music and worldrenowned<br />

composer.<br />

FALL / WINTER 2002 25<br />

photo by Jim Laragy, courtesy <strong>of</strong> <strong>the</strong> Democrat and Chronicle


Called to <strong>the</strong> Cause<br />

Patricia Rodier has traveled an unlikely route<br />

to become a national leader in autism research.<br />

by Mark Liu<br />

The lecture that would change <strong>the</strong> life <strong>of</strong> Patricia M.<br />

Rodier, Ph.D., began typically enough. A pediatric<br />

ophthalmologist was describing eye motion defects<br />

in children impaired by thalidomide, <strong>the</strong> morning-<br />

sickness drug linked to birth defects in <strong>the</strong> 1960s.


But when <strong>the</strong> researcher mentioned a surprise finding — <strong>the</strong> percentage<br />

<strong>of</strong> thalidomide victims who had autism was about 30 times greater than<br />

in <strong>the</strong> general population — Rodier felt dizzy and began to hyperventilate,<br />

a major epiphany at hand. As an embryologist, Rodier suddenly was<br />

making a connection between autism and <strong>the</strong> early weeks <strong>of</strong> pregnancy,<br />

when <strong>the</strong> neurons for <strong>the</strong> eyes and o<strong>the</strong>r sensory organs are beginning to<br />

develop. That connection was in direct conflict <strong>with</strong> <strong>the</strong> common suspicion<br />

that autism, as a disorder that affects high-level functions such as speech,<br />

must originate later in gestation. Yet <strong>the</strong> spark <strong>of</strong> discovery was <strong>the</strong>re.<br />

“I was in a state <strong>of</strong> wild euphoria,” says Rodier, pr<strong>of</strong>essor <strong>of</strong> OB/GYN<br />

at <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> School <strong>of</strong> Medicine and Dentistry.<br />

Rodier had done no work on autism, but that lecture in 1994 led her<br />

in a whole new direction, along a twisting, turning path <strong>of</strong> detective-like<br />

scientific inquiry. Her findings were met <strong>with</strong> initial skepticism by some<br />

scientists, in part because <strong>the</strong>y were unique. Now, though, <strong>with</strong> multiple<br />

grants and more and more publications, Rodier and her team are being<br />

recognized as researchers on <strong>the</strong> forefront <strong>of</strong> tracking down <strong>the</strong> biological<br />

causes <strong>of</strong> autism.<br />

“It’s really <strong>the</strong> first group in <strong>the</strong> history <strong>of</strong> <strong>the</strong> literature to look<br />

at <strong>the</strong> embryology <strong>of</strong> autism,” says Eric London, M.D., vice president for<br />

medical affairs at <strong>the</strong> National Alliance for Autism Research. “They were<br />

<strong>the</strong> first to do hypo<strong>the</strong>sis-driven research into <strong>the</strong> roots <strong>of</strong> autism. In that<br />

respect, it’s revolutionary.”<br />

Of Mice and Men<br />

Getting to those revolutionary findings has taken insightful work, some<br />

good luck and <strong>the</strong> contributions <strong>of</strong> many different types <strong>of</strong> researchers.<br />

The science was only part <strong>of</strong> <strong>the</strong> challenge. Since autism was first<br />

documented in 1943, researchers have had to contend <strong>with</strong> a continuum<br />

<strong>of</strong> misunderstandings surrounding <strong>the</strong> disorder. Autism was typically seen<br />

as a behavioral problem because <strong>of</strong> symptoms such as severely limited<br />

speech and facial expressions, fixation on a single activity, and an inability<br />

to interpret emotions. Consequently, scientists looked for behavioral causes.<br />

In <strong>the</strong> ’60s and ’70s, psychologists actually believed that autism was caused<br />

by bad mo<strong>the</strong>ring. One treatment was to take <strong>the</strong> child from <strong>the</strong> parents.<br />

It also was labeled an extremely rare disorder — and that meant<br />

less funding for research. In fact, <strong>the</strong> National Alliance for Autism<br />

Research was founded in 1994, <strong>the</strong> year Rodier began studying autism,<br />

by a couple who wanted to donate money for autism research but couldn’t<br />

find an appropriate organization. Today, it’s estimated that autism or one<br />

<strong>of</strong> its related disorders occurs in at least one in every 625 births, <strong>with</strong> some<br />

estimates as high as one in 150 children. That would make it much more<br />

prevalent than Down’s syndrome, and certainly more common than was<br />

thought when Rodier began her autism research.<br />

Still, Rodier was determined to follow her epiphany wherever it led.<br />

The first thing she had to determine was whe<strong>the</strong>r <strong>the</strong> anomalies found<br />

in thalidomide victims <strong>with</strong> autism were present in everyone <strong>with</strong> autism.<br />

While lack <strong>of</strong> speech and facial expressions are commonly known<br />

symptoms in autism, minor symptoms such as slight malformation <strong>of</strong><br />

<strong>the</strong> ears also had been documented. Rodier hunted down <strong>the</strong> few studies<br />

that looked at such anomalies and realized that <strong>the</strong>y were, in fact, symptoms<br />

in many cases <strong>of</strong> autism, not just thalidomide-induced autism. The<br />

key finding was that thalidomide victims <strong>with</strong> autism had anomalies <strong>with</strong><br />

<strong>the</strong>ir ears — which begin forming 20 days after conception — but no<br />

problems <strong>with</strong> <strong>the</strong>ir arms or legs, which start to form on <strong>the</strong> 24th day.<br />

So, <strong>the</strong> thalidomide results indicated that <strong>the</strong> damage that leads to autism<br />

must occur between days 20 and 24. The researchers in <strong>the</strong> thalidomide<br />

study had been puzzled because <strong>the</strong>y thought that no brain development<br />

occurred that early. But Rodier, as an embryologist, knew o<strong>the</strong>rwise.<br />

Just a few months after reading up on <strong>the</strong> literature, Rodier learned<br />

that John Romano, M.D., <strong>the</strong> legendary pr<strong>of</strong>essor who built <strong>the</strong> <strong>University</strong><br />

<strong>of</strong> <strong>Rochester</strong> <strong>Medical</strong> <strong>Center</strong>’s Department <strong>of</strong> Psychiatry from <strong>the</strong> ground<br />

up, had preserved brain samples <strong>of</strong> someone who had suffered from autism.<br />

In fact, he had been keeping <strong>the</strong>m in a lab for decades, hoping someone,<br />

some day, would have a good idea <strong>of</strong> what to look for in <strong>the</strong> tissue.<br />

“Romano was an expert in neural anomalies, which many<br />

psychiatrists are not,” says Rodier. He found her hypo<strong>the</strong>sis promising<br />

enough to give her <strong>the</strong> samples. She hoped to find evidence <strong>of</strong> neural<br />

FALL / WINTER 2002 27


problems in <strong>the</strong> brain stem, <strong>the</strong> earliest section<br />

<strong>of</strong> <strong>the</strong> brain to develop. Rarely had anyone<br />

suspected <strong>the</strong> brain stem in autism. O<strong>the</strong>r<br />

researchers had examined <strong>the</strong> higher-function<br />

cortex when examining autistic brains, <strong>with</strong><br />

little results. Here was a perfect chance for<br />

Rodier to test her hypo<strong>the</strong>sis — provided she<br />

had a dose <strong>of</strong> good luck. Romano’s lab had<br />

pathology samples, useful only if one <strong>of</strong> <strong>the</strong><br />

sliced samples happened to be from <strong>the</strong> correct<br />

part <strong>of</strong> <strong>the</strong> brain stem.<br />

“As fate would have it, one <strong>of</strong> <strong>the</strong> samples<br />

was where we wanted to look,” says Rodier.<br />

Patricia M. Rodier, Ph.D.<br />

Her team went to work and made a major<br />

find. Two key structures — <strong>the</strong> facial nucleus,<br />

which controls <strong>the</strong> muscles that create facial expressions, and <strong>the</strong> superior<br />

olive, important in processing auditory information — were practically<br />

nonexistent. The facial neurons numbered about 400 cells, compared <strong>with</strong><br />

a control brain that numbered 9,000. Because <strong>the</strong> functions <strong>of</strong> <strong>the</strong>se structures<br />

corresponded to <strong>the</strong> symptoms <strong>of</strong> autism, Rodier believed she was<br />

onto something.<br />

Next, Rodier measured <strong>the</strong> distance to o<strong>the</strong>r structures <strong>of</strong> <strong>the</strong> brain<br />

to verify that <strong>the</strong> brain was normal in size. Her hypo<strong>the</strong>sis was that <strong>the</strong> tiny<br />

facial nucleus and bits <strong>of</strong> superior olive were not small because <strong>the</strong> whole<br />

brain had failed to form, but that <strong>the</strong>y were small while most structures<br />

were normal. But a surprise was waiting for her.<br />

Essentially, an entire band <strong>of</strong> tissue between <strong>the</strong> affected structures<br />

was missing as well. Suddenly, Rodier had ano<strong>the</strong>r visceral reaction —<br />

she heard a roaring in her ears as she recognized what she was seeing.<br />

She had read a paper on mice genetically altered to study <strong>the</strong> effect <strong>of</strong><br />

a certain gene, and <strong>the</strong> abnormal brain stem <strong>of</strong> <strong>the</strong>se mice matched <strong>the</strong><br />

pattern she was seeing in <strong>the</strong> autistic brain.<br />

The mice were known as “knockout” mice because <strong>the</strong>y had been<br />

engineered to block <strong>the</strong> expression <strong>of</strong> a gene — in this case, a gene called<br />

HOXA1. By looking in a place that o<strong>the</strong>rs hadn’t, Rodier had pinpointed<br />

a gene that could very well be involved in autism.<br />

This left her <strong>with</strong> a thrilling prospect for research but also some<br />

major obstacles. Rodier was trained as a psychologist and embryologist.<br />

She had no experience in genetics and — as a basic scientist — no access<br />

to patients <strong>with</strong> autism.<br />

Rodier marked her calendar for <strong>the</strong> following year’s NIH “State <strong>of</strong><br />

<strong>the</strong> Science on Autism” conference in Washington, D.C., hoping for more<br />

lecture inspiration.<br />

Meeting <strong>of</strong> Minds<br />

What she found at <strong>the</strong> conference was bitter disappointment. As she went<br />

from lecture to lecture, Rodier could find no one who was studying <strong>the</strong><br />

28<br />

ROCHESTER MEDICINE<br />

etiology <strong>of</strong> autism. Even more surprising, she couldn’t find any clinicians<br />

who might have access to a population <strong>of</strong> patients to study.<br />

“I was crushed <strong>with</strong> disappointment,” she says. “I was just so upset.”<br />

On a c<strong>of</strong>fee break, someone asked Rodier where she was from.<br />

When she said <strong>Rochester</strong>, <strong>the</strong> man said that a friend <strong>of</strong> his, a developmental<br />

pediatrician, was moving <strong>the</strong>re and might want to meet <strong>with</strong> her.<br />

Rodier thought little <strong>of</strong> <strong>the</strong> encounter and soon was sitting in<br />

Washington’s National Airport, waiting to return home.<br />

Then a woman approached. She recognized Rodier from <strong>the</strong><br />

conference, and <strong>the</strong> two got to talking. The woman, Susan Bryson, Ph.D.,<br />

was a clinical psychologist in Canada who had just finished collecting<br />

data on malformations in autistic children. What made <strong>the</strong> study unique<br />

was its completeness: Bryson had collected data on autistic children, <strong>the</strong>ir<br />

siblings and developmentally disabled children <strong>with</strong>out autism <strong>with</strong>in<br />

a contained geographic area in Nova Scotia. Comparisons among <strong>the</strong>se<br />

groups could fur<strong>the</strong>r distinguish precisely which malformations correlated<br />

to autism. Bryson knew she had good data, but she wasn’t sure how best<br />

to proceed <strong>with</strong> analyzing it. By <strong>the</strong> end <strong>of</strong> <strong>the</strong> flight back from <strong>the</strong> conference,<br />

she knew: She would work <strong>with</strong> Rodier.<br />

Their finding — that ear anomalies are <strong>the</strong> most prevalent malformations<br />

in autism — supported <strong>the</strong> finding <strong>of</strong> ear anomalies in <strong>the</strong><br />

thalidomide cases. This implied that <strong>the</strong> thalidomide cases resembled<br />

autism <strong>with</strong> o<strong>the</strong>r causes, which meant <strong>the</strong> early-gestation timeframe<br />

for autism made sense. So <strong>the</strong> HOXA1 gene was still a prime suspect —<br />

but Rodier had no way to test it.<br />

Only a few months later, Rodier received a call from <strong>the</strong> developmental<br />

pediatrician who had just moved to <strong>Rochester</strong>. Susan Hyman, M.D.,<br />

had started working in <strong>the</strong> Department <strong>of</strong> Pediatrics at <strong>Rochester</strong>, bringing<br />

<strong>with</strong> her an extensive research background in developmental disabilities.<br />

When Rodier described her ideas, Hyman was eager to provide <strong>the</strong> clinical<br />

piece <strong>of</strong> <strong>the</strong> puzzle by recruiting families for studies.<br />

Rodier made contact <strong>with</strong> Denise Figlewicz, Ph.D., associate pr<strong>of</strong>essor<br />

<strong>of</strong> neurology at <strong>Rochester</strong>, who specialized in molecular genetics. Her<br />

research interest — degenerative diseases <strong>of</strong> <strong>the</strong> nervous system — was far<br />

afield from autism, but Rodier’s work intrigued her, so she signed on.<br />

Through effort and a series <strong>of</strong> chance encounters, Rodier had<br />

assembled a roster <strong>of</strong> specialists in several fields to work on <strong>the</strong> same<br />

hypo<strong>the</strong>sis. Now, <strong>the</strong> ensemble group had drawing power. When Rodier<br />

spoke at ano<strong>the</strong>r NIH conference on her suspicions about HOXA1,<br />

biochemist Lorraine Gudas, Ph.D. — one <strong>of</strong> <strong>the</strong> first people in history<br />

to sequence HOXA1 — approached her excitedly.<br />

“She came up and said, ‘Oh, do I have ideas for experiments for<br />

you,’ ” says Rodier.<br />

Ano<strong>the</strong>r scientist, Christopher Stodgell, Ph.D., turned down <strong>of</strong>fers<br />

from bigger labs to join <strong>the</strong> burgeoning multidisciplinary team.<br />

“It was a big risk,” Stodgell says <strong>of</strong> <strong>the</strong> decision to join <strong>the</strong> team<br />

in 1996, at a time when it was just getting <strong>of</strong>f <strong>the</strong> ground. “But I was<br />

drawn by <strong>the</strong> eclectic nature <strong>of</strong> <strong>the</strong> people I’d be working <strong>with</strong>.”


Rodier couldn’t have proceeded <strong>with</strong>out such a diverse group<br />

<strong>of</strong> scientists, but most researchers don’t have such a luxury.<br />

“It’s actually very unusual,” says Stodgell, whose background<br />

was in behavioral pharmacology. “Most people in a particular area stick<br />

<strong>with</strong> people studying <strong>the</strong> same thing. The multidisciplinary approach takes<br />

a tremendous amount <strong>of</strong> effort to work because you’re pulling toge<strong>the</strong>r<br />

people from different disciplines but also different interests.”<br />

Very quickly, Stodgell was reveling in <strong>the</strong> chance to learn new skills,<br />

such as molecular genetic techniques. The team embarked on <strong>the</strong><br />

painstaking task <strong>of</strong> sequencing <strong>the</strong> DNA <strong>of</strong> patients and searching for a<br />

variant <strong>of</strong> HOXA1 that could be linked to autism. No one had ever discovered<br />

a HOXA1 variant in any mammal, and most researchers assumed<br />

that variants couldn’t be found. Their reasoning was that a change to<br />

a gene so important in early development would be lethal to <strong>the</strong> organism.<br />

Over many months, <strong>the</strong> researchers checked thousands <strong>of</strong> bases<br />

<strong>with</strong>in <strong>the</strong> genetic code <strong>of</strong> study volunteers, but all matched <strong>the</strong> normal<br />

sequence. Then one day, Jennifer Ingram, a toxicology graduate student,<br />

noticed a single base substitution in <strong>the</strong> sequence <strong>of</strong> a boy <strong>with</strong> autism.<br />

The same substitution appeared in family members and in several o<strong>the</strong>r<br />

people <strong>with</strong> autism, and <strong>the</strong> change in sequence was <strong>of</strong> a type that might<br />

block <strong>the</strong> functioning <strong>of</strong> <strong>the</strong> gene — in effect, doing what researchers had<br />

done genetically to create “knockout” mice. The potential connection to<br />

autism was clear, and <strong>the</strong> team published <strong>the</strong> finding in 2000.<br />

Fur<strong>the</strong>r examination, though, confirmed that <strong>the</strong> team had plenty<br />

more work ahead. The variation does not appear only in people <strong>with</strong> autism,<br />

so some o<strong>the</strong>r genes must be involved. And it’s possible that <strong>the</strong> more<br />

Technical associate Melanie O’Bara and Patricia M. Rodier, Ph.D.<br />

significant gene is down <strong>the</strong> line — one that is “turned on” by HOXA1.<br />

Still, <strong>the</strong> team had made a key finding — one that strongly<br />

supported Rodier’s original hypo<strong>the</strong>sis implicating early development<br />

in autism. The attention and grants began to increase. Just as important,<br />

so did <strong>the</strong> ideas for a multitude <strong>of</strong> studies.<br />

A Wide Net and a Full Plate<br />

Rodier’s team keeps growing as its research broadens. An experimental<br />

psychologist, Mark Stanton, is now involved, as is Marilyn Miller, <strong>the</strong><br />

researcher who first inspired Rodier <strong>with</strong> <strong>the</strong> thalidomide study. Lowell<br />

Weitkamp, M.D., a population geneticist in <strong>the</strong> Department <strong>of</strong> Psychiatry<br />

at <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> School <strong>of</strong> Medicine and Dentistry, also has<br />

been involved in analyzing data and planning experiments.<br />

Research continues on HOXA1, as well as on toxic substances —<br />

such as valproic acid — that might have a connection to autism. Beyond<br />

that, <strong>the</strong> team is branching out into treatment studies.<br />

“The more you know about <strong>the</strong> neurobiology, <strong>the</strong> more you know<br />

about good behavioral treatments,” she says.<br />

A good example is <strong>the</strong> team’s taste project, which is testing evidence<br />

that people <strong>with</strong> autism have an abnormal or reduced sense <strong>of</strong> taste and<br />

smell, leading to an unhealthy diet. If this turns out to be true, clinicians<br />

might suggest changes in <strong>the</strong> way <strong>the</strong>ir patients’ food is spiced so <strong>the</strong>y’ll<br />

eat better. Ano<strong>the</strong>r clinical study, conducted in Nova Scotia and <strong>Rochester</strong>,<br />

is examining symptoms in children <strong>with</strong> autism to see if <strong>the</strong>se symptoms<br />

are truly associated <strong>with</strong> autism, to fur<strong>the</strong>r pinpoint potential causes.<br />

These projects are a long way from those first studies Rodier<br />

conducted, which shows <strong>the</strong> power <strong>of</strong> ga<strong>the</strong>ring scientists from very<br />

different realms to work on a single idea.<br />

“The greatest mistake researchers make is <strong>the</strong>y don’t cast a wide net<br />

and see what o<strong>the</strong>r kinds <strong>of</strong> evidence exist,” says Rodier.<br />

Rodier admits that, having spawned such a large research effort,<br />

it’s hard to slow down — especially when <strong>the</strong>re are so many leads to follow.<br />

“Research is a kind <strong>of</strong> calling, and it’s easy to become obsessed,”<br />

she says. “It can be hard to turn <strong>the</strong> science <strong>of</strong>f. I’m well aware <strong>of</strong> it.<br />

It’s a common topic <strong>of</strong> discussion <strong>with</strong> my doctor,” she says, smiling.<br />

After all, for researchers getting results, <strong>the</strong> rewards <strong>of</strong> <strong>the</strong> work are<br />

hard to measure. Perhaps nobody knows this better than Stodgell. Several<br />

years ago, Stodgell hosted a visit from a <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> assistant<br />

pr<strong>of</strong>essor <strong>of</strong> clinical and social psychology, Loisa Bennetto, Ph.D., and<br />

ended up marrying her. The two now do research toge<strong>the</strong>r — Bennetto is<br />

heading a study <strong>of</strong> <strong>the</strong> neurological problem that keeps people <strong>with</strong> autism<br />

from being able to imitate facial expressions.<br />

They’re taking <strong>the</strong> term “multidisciplinary” to a whole new level.<br />

FALL / WINTER 2002 29


Pioneers in <strong>the</strong><br />

FIELD<br />

2 0 3 0 4 0 5 0 4 0 3 0<br />

Team physicians star in <strong>the</strong> world <strong>of</strong> sports medicine<br />

by Mark Liu


2 0 3 0 4 0 5 0 4 0 3 0<br />

Long before pr<strong>of</strong>essional sports had team physicians,<br />

long before sports medicine was even a pr<strong>of</strong>ession,<br />

Arthur Pappas, M.D. (M ’57), was icing players’ knees and<br />

examining <strong>the</strong>ir aching bones. Pappas, an orthopaedist,<br />

is in his 25th and final year as <strong>the</strong> team physician for<br />

<strong>the</strong> Boston Red Sox. Early in his career, he was a leader in<br />

using film — and digital imaging later on — to analyze<br />

athletes’ movements and design special regimens to keep<br />

those athletes healthy. In an era <strong>of</strong> “no-pain, no-gain”<br />

thinking, Pappas advocated prevention in sports medicine.<br />

“ He’s considered a pioneer,” says Elizabeth Arendt, M.D. (B.S. ’75, M ’79, R ’84),<br />

also an orthopaedic surgeon for athletes. “Sports medicine was built on<br />

<strong>the</strong> back <strong>of</strong> probably 20 or so men, primarily doing orthopaedics.”<br />

Those men helped paved <strong>the</strong> way for women like Arendt. In 1991,<br />

Arendt became <strong>the</strong> first female medical director <strong>of</strong> a Division I, Big 10<br />

athletic department. She’s <strong>the</strong> medical director at <strong>the</strong> <strong>University</strong> <strong>of</strong><br />

Minnesota for both men’s and women’s varsity athletics and <strong>the</strong> primary<br />

orthopaedic consultant to many <strong>of</strong> <strong>the</strong> teams, including men’s basketball<br />

and track and field and all <strong>of</strong> <strong>the</strong> women’s sports.<br />

From her high-pr<strong>of</strong>ile work, Arendt was asked to be <strong>the</strong> team physician<br />

for women’s USA Hockey, which took her to Finland in 1990 and Lake<br />

Placid in 1992 for <strong>the</strong> World Games. Some years later, in 1998, many <strong>of</strong><br />

those athletes went on to win gold medals <strong>with</strong> <strong>the</strong> U.S. Olympic team.<br />

In 1992, President Clinton named Arendt to <strong>the</strong> 12-person President’s<br />

Council on Physical Fitness and Sports.<br />

The two orthopaedists are among two dozen or so alumni working<br />

in <strong>the</strong> field <strong>of</strong> sports medicine. With <strong>Rochester</strong>’s sports medicine program<br />

now a full division, one alumnus has estimated that <strong>Rochester</strong>-trained<br />

physicians treat more than 25,000 athletes a year.<br />

2.5 Pounds <strong>of</strong> Prevention<br />

For Pappas, interest in sports injuries came in part from first-hand experience.<br />

As an undergraduate at Harvard <strong>University</strong>, Pappas was a lineman<br />

and linebacker on <strong>the</strong> football team until he suffered a shoulder injury<br />

in his senior year. That ended his football career, but after medical school<br />

at <strong>Rochester</strong> and time as a Navy doctor in Be<strong>the</strong>sda, Md., his orthopaedics<br />

Pedro Martinez <strong>with</strong><br />

Arthur Pappas, M.D.<br />

career took <strong>of</strong>f. He returned to Harvard in <strong>the</strong> 1960s to work in athletics,<br />

eventually becoming <strong>the</strong> football team’s chief physician. He also began<br />

treating pr<strong>of</strong>essional athletes from <strong>the</strong> New England Patriots, Boston<br />

Celtics, Boston Bruins and <strong>the</strong> Red Sox. Word-<strong>of</strong>-mouth referrals brought<br />

him more and more athlete patients.<br />

“Team physicians existed, but not in <strong>the</strong> sense that we now know<br />

<strong>the</strong>m,” says Pappas. Individual specialists in fields such as urology,<br />

internal medicine and surgery would do some work <strong>with</strong> teams, as needed.<br />

“<br />

It was more <strong>of</strong> a hobby for doctors,” he explains.<br />

Pappas was named chair <strong>of</strong> orthopaedic surgery at <strong>the</strong> <strong>University</strong><br />

<strong>of</strong> Massachusetts <strong>Medical</strong> <strong>Center</strong> in 1972, where he specialized in sports<br />

medicine and pediatric orthopaedics. Six years later he also became<br />

medical director for <strong>the</strong> Boston Red Sox. On top <strong>of</strong> his regular practice,<br />

Pappas began attending home games and spring training to work <strong>with</strong><br />

<strong>the</strong> players.<br />

But it was through his research that he began to contribute to<br />

<strong>the</strong> sport. He began by studying <strong>the</strong> throwing motion.<br />

“The whole performance <strong>of</strong> a pitch is unnatural — that whole<br />

overhand motion,” he says, citing <strong>the</strong> stress on structures around <strong>the</strong><br />

shoulder joint.<br />

He perfected <strong>the</strong> use <strong>of</strong> high-speed photography and computer<br />

models to analyze where <strong>the</strong> stress is greatest. By breaking down <strong>the</strong><br />

motion into 150 separate phases per second, he learned that <strong>the</strong> large<br />

muscles around <strong>the</strong> shoulder actually were less important than <strong>the</strong><br />

smaller muscles in maintaining a proper throwing motion. Eventually,<br />

Eastman Kodak Company in <strong>Rochester</strong> helped Pappas <strong>with</strong> an imaging<br />

FALL / WINTER 2002 31


2 0 3 0 4 0 5 0 4 0 3 0<br />

Not all play<br />

It sounds glamorous enough: Hobnobbing <strong>with</strong> All-Star pitchers and NFL<br />

quarterbacks, working behind <strong>the</strong> scenes in <strong>the</strong> locker room and back<br />

<strong>of</strong>fice, operating on a player and reading <strong>the</strong> details in <strong>the</strong> next day’s<br />

newspaper. But physicians who take on <strong>the</strong> role <strong>of</strong> team physician will<br />

tell you it’s not as romantic as it sounds.<br />

“It’s an awful lot <strong>of</strong> time that you’re not in control <strong>of</strong>,” says David<br />

Lintner, M.D. (M ’86, R ’91). As <strong>the</strong> head team physician and medical<br />

director for <strong>the</strong> Houston Astros and team physician for <strong>the</strong> newest NFL<br />

team, <strong>the</strong> Houston Texans, Lintner says he’s responsible for <strong>the</strong> health <strong>of</strong><br />

players at all times. If <strong>the</strong>re’s an after-hours car accident, a middle-<strong>of</strong><strong>the</strong>-night<br />

eye injury, an early morning bout <strong>of</strong> food poisoning involving<br />

a player, Lintner’s pager beeps (naturally, his pager is always on).<br />

On game days, he arrives early and stays late.<br />

And in an instant, <strong>the</strong> thrill <strong>of</strong> being part <strong>of</strong> high-level competition<br />

can transform into tragedy. Two years ago, Wayne Sebastianelli, M.D.<br />

(M ’83, R ’88), director <strong>of</strong> athletic medicine for Division I powerhouse<br />

Penn State <strong>University</strong>, was in his place on <strong>the</strong> sidelines <strong>of</strong> a football game<br />

against Ohio State when a player made a tackle <strong>with</strong> his head down.<br />

Immediately, Sebastianelli knew <strong>the</strong>re was a problem.<br />

“I told my trainer, ‘This isn’t good,’ and I ran out on <strong>the</strong> field,”<br />

says Sebastianelli.<br />

The player, Adam, was lying on <strong>the</strong> field in a completely unnatural<br />

way, <strong>with</strong> legs scissored out and arms flopping. Sebastianelli<br />

immobilized him <strong>with</strong> <strong>the</strong> tools <strong>of</strong> <strong>the</strong> trade — sandbags and tape —<br />

and used a backboard to lift him.<br />

A burst fracture <strong>of</strong> <strong>the</strong> fifth cervical vertebrae, an injury<br />

Sebastianelli likens to a nutcracker cracking a nut, left 18-year-old Adam<br />

paralyzed from <strong>the</strong> shoulders down. Bone fragments had partially<br />

crushed his spinal cord, leaving a less than 1 percent chance that<br />

he would ever walk again. In a heartbeat, a player considered an eventual<br />

NFL starter could do nothing but lie in a hospital bed.<br />

Sebastianelli had to make <strong>the</strong> call to Adam’s family, who had seen<br />

<strong>the</strong> injury happen on TV.<br />

Two weeks later, Sebastianelli got a call from Adam’s fa<strong>the</strong>r, who<br />

was at Adam’s bedside. “My son moved his toe! My son moved his toe!”<br />

he yelled into <strong>the</strong> phone.<br />

Sebastianelli decided to help coordinate Adam’s treatment, on top<br />

<strong>of</strong> his typical 80- to 90-hour workweek. He talked almost every day <strong>with</strong><br />

<strong>the</strong> director <strong>of</strong> rehabilitation and worked closely <strong>with</strong> <strong>the</strong> family to help<br />

<strong>the</strong>m deal <strong>with</strong> <strong>the</strong> tragedy. And he visited Adam whenever he could.<br />

Adam was in traction, <strong>with</strong> pins in his skull and still no feeling below his<br />

neck, so Sebastianelli would greet him <strong>with</strong> a kiss on <strong>the</strong> forehead.<br />

It became <strong>the</strong> standard greeting at every visit, from one ex-football<br />

player to ano<strong>the</strong>r.<br />

CONTINUED page 57<br />

32<br />

ROCHESTER MEDICINE<br />

technique that could capture 1,000 phases per second instead <strong>of</strong> 150.<br />

He likens it to a symphony. If all <strong>the</strong> instruments are playing as<br />

<strong>the</strong>y should, things are fine. But when one instrument begins to weaken,<br />

<strong>the</strong> o<strong>the</strong>rs try to compensate.<br />

“This brings <strong>the</strong> symphony out <strong>of</strong> tune,” he says. Ballplayers tend<br />

to be more in tune <strong>with</strong> sweat than symphonies, so <strong>the</strong> exercises Pappas<br />

developed to streng<strong>the</strong>n smaller muscles were a tough sell at first. But<br />

pitchers, especially, began to recognize <strong>the</strong> benefits. The most dedicated,<br />

says Pappas, was Roger Clemens when he was <strong>with</strong> <strong>the</strong> Red Sox. Pappas<br />

went through <strong>the</strong> video images <strong>of</strong> Clemens’ pitching motion <strong>with</strong> him and<br />

explained <strong>the</strong> ideal motion, <strong>the</strong>n developed stretches and exercises especially<br />

for him.<br />

“He worked on <strong>the</strong> programs during <strong>the</strong> <strong>of</strong>f-season and <strong>the</strong> season,”<br />

says Pappas. It’s one reason he feels that Clemens, a starter for <strong>the</strong> New<br />

York Yankees at age 40, has had such a long and successful career.<br />

O<strong>the</strong>r pitchers — Mike Flanagan, Jim Palmer, Dennis Eckersley—<br />

also benefited from individualized programs. Soon, Pappas’s reputation<br />

spread beyond baseball and Boston. In late 1982, pairs skaters Kitty and<br />

Peter Carru<strong>the</strong>rs came to Pappas for help. Peter had developed a debilitating<br />

problem <strong>with</strong> his right shoulder — <strong>the</strong> one he used for lifts and<br />

throws. Several doctors told him he needed surgery, which would have<br />

ended <strong>the</strong> Carru<strong>the</strong>rs’ hopes <strong>of</strong> competing in <strong>the</strong> 1984 Olympic Games.<br />

Someone recommended <strong>the</strong>y see Pappas, who took a high-speed<br />

video <strong>of</strong> <strong>the</strong>ir skating. Immediately, he noticed that Peter was flaring his<br />

shoulder forward on lifts instead <strong>of</strong> setting it back in alignment <strong>with</strong> his<br />

hip and back.<br />

“He just looked at my problem in a different light,” says Peter.<br />

“ First <strong>of</strong> all, he had a pr<strong>of</strong>ound understanding <strong>of</strong> <strong>the</strong> biomechanics <strong>of</strong><br />

figure skating. He looks at not just <strong>the</strong> injury but he also understands<br />

why it happens and how to keep it from happening again.”<br />

The injury had weakened <strong>the</strong> whole area around <strong>the</strong> shoulder,<br />

so Pappas recommended special lifting exercises. But <strong>the</strong>y weren’t what<br />

Carru<strong>the</strong>rs expected. Pappas was suggesting nothing more than 2.5-pound<br />

wrist weights to streng<strong>the</strong>n small muscles in <strong>the</strong> back. Carru<strong>the</strong>rs wasn’t<br />

skeptical, though, because as he puts it, Pappas “was just a mountain <strong>of</strong><br />

knowledge.”<br />

Carru<strong>the</strong>rs had been feeling <strong>the</strong> pain for two years, but <strong>with</strong>in three<br />

weeks <strong>of</strong> beginning Pappas’s exercise, <strong>the</strong> pain was gone. “And I haven’t<br />

had a problem since,” he says.<br />

A year later, Kitty and Peter Carru<strong>the</strong>rs won <strong>the</strong> silver medal in pairs<br />

figure skating at <strong>the</strong> Olympic Games in Sarajevo.<br />

“Certainly our Olympic medal partly goes to him,” says Carru<strong>the</strong>rs.<br />

Bucking <strong>the</strong> System<br />

Like Pappas, Arendt was participating in sports long before working<br />

in <strong>the</strong>m. Growing up in <strong>the</strong> Chicago area, Arendt says she played sports<br />

“<br />

nonstop.”


The alumni lineup: Wayne Sebastianelli, M.D.<br />

(M ’83, R ’88), Elizabeth Arendt, M.D. (B.S. ’75,<br />

M ’79, R ’84), and Arthur Pappas, M.D. (M ’57),<br />

<strong>with</strong> baseball player Roger Clemens when<br />

he played for <strong>the</strong> Red Sox.<br />

In fact, one <strong>of</strong> her earliest and least known honors is Chicago’s<br />

citywide championship in ping-pong and horseshoes for ages 11 to 14.<br />

“ Now, I can’t even get a horseshoe to <strong>the</strong> pit,” she jokes.<br />

But she has managed to do something far more demanding:<br />

make a mark in <strong>the</strong> male-dominated world <strong>of</strong> sports medicine. Arendt<br />

began her residency at <strong>the</strong> School <strong>of</strong> Medicine and Dentistry in 1979, at a<br />

time when, according to Ken DeHaven, M.D., pr<strong>of</strong>essor and associate chair<br />

<strong>of</strong> orthopaedics and director <strong>of</strong> athletic medicine, “It was still an unusual<br />

thing for a woman to go into this field.”<br />

DeHaven says that less than three percent <strong>of</strong> orthopaedic surgeons<br />

in <strong>the</strong> country were women. Women working <strong>with</strong> athletes was rarer still.<br />

Arendt, though, was used to surprising people. As a high school<br />

student, she came to <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> for a tour, intent on<br />

majoring in biology. Her guide asked, “Do you want to see <strong>the</strong> labs?<br />

Or research equipment?” Arendt replied, “ I want to see <strong>the</strong> athletic facilities<br />

and meet <strong>the</strong> athletic director.”<br />

Once enrolled, she was asked to teach volleyball at <strong>Rochester</strong>, <strong>the</strong>n<br />

run <strong>the</strong> intramural teams. In her junior year, she helped start a women’s<br />

varsity volleyball program, <strong>the</strong>n was asked to be <strong>the</strong> student athletic<br />

trainer—<strong>the</strong> first time a woman held that position. At <strong>the</strong> time, <strong>the</strong> training<br />

rooms were <strong>of</strong>f limits to women. Arendt changed that in a hurry. In her<br />

senior year, she received <strong>the</strong> Murle Spurrier Award, in its inaugural year,<br />

given to <strong>the</strong> woman making <strong>the</strong> largest contribution to female sports.<br />

Arendt also was elected to <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> Sports Hall <strong>of</strong> Fame.<br />

“I felt like I graduated from <strong>the</strong> athletic department, not biology,”<br />

says Arendt.<br />

It was excellent preparation for her chosen field — provided she<br />

could find a place to study.<br />

“Not a lot <strong>of</strong> people had a sports medicine service,” says Arendt.<br />

And not a lot <strong>of</strong> programs were as advanced as <strong>Rochester</strong>’s sports medicine<br />

rotation.<br />

“Very few had it as organized, <strong>with</strong> an expert like Ken DeHaven,<br />

who was actually treating people and doing arthroscopy,” she explains.<br />

“<br />

So, from an educational standpoint, we could really learn.”<br />

Arendt was <strong>Rochester</strong>’s second female resident in orthopaedics, after<br />

Rosemarie Morwessel, M.D. (R ’82), who has gone on to treat pr<strong>of</strong>essional<br />

tennis players from her practice in Mobile, Ala. Her clients have included<br />

CONTINUED page 57<br />

FALL / WINTER 2002 33


school news<br />

New <strong>dean</strong>s begin in <strong>the</strong><br />

new school year<br />

Tana Grady-Weliky, M.D., has been appointed<br />

<strong>the</strong> senior associate <strong>dean</strong> for medical education.<br />

She replaces Lindsey Henson, M.D.<br />

Grady-Weliky is an alumna <strong>of</strong> Duke <strong>University</strong><br />

School <strong>of</strong> Medicine and completed an internship<br />

and residency at Harvard before serving<br />

a fellowship in psychopharmacology at <strong>the</strong><br />

National Institute <strong>of</strong> Mental Health. Prior to<br />

being recruited to <strong>Rochester</strong>, she served in a<br />

variety <strong>of</strong> academic posts at Harvard <strong>Medical</strong><br />

School, Georgetown <strong>University</strong> <strong>Medical</strong> School<br />

and Duke <strong>University</strong> <strong>Medical</strong> School.<br />

Grady-Weliky has been at <strong>Rochester</strong><br />

for four years. Prior to this appointment, she<br />

served as <strong>the</strong> associate <strong>dean</strong> for undergraduate<br />

medical education here.<br />

While directing <strong>the</strong> general psychiatry<br />

residency program at Duke, Grady-Weliky<br />

helped to develop a combined residency in<br />

internal medicine and psychiatry, parlaying<br />

<strong>the</strong> new program into a respected, nationally<br />

competitive experience for physicians. This<br />

program helped to set a national trend toward<br />

combined training programs.<br />

Ano<strong>the</strong>r <strong>Rochester</strong> faculty member,<br />

David Lambert, M.D., has been named <strong>the</strong> new<br />

associate <strong>dean</strong> for undergraduate medical<br />

education. Lambert, a graduate <strong>of</strong> Dartmouth<br />

<strong>Medical</strong> School, did his residency training<br />

34<br />

ROCHESTER MEDICINE<br />

at Harvard in <strong>the</strong> New England Deaconess<br />

program.<br />

After serving on <strong>the</strong> faculty <strong>of</strong><br />

Georgetown <strong>University</strong> <strong>Medical</strong> <strong>Center</strong>, Lambert<br />

joined <strong>the</strong> medicine faculty at <strong>Rochester</strong> in<br />

1994. He also has served as <strong>the</strong> clerkship<br />

director for <strong>the</strong> core clinical rotation in<br />

internal medicine.<br />

Alumnus Webster H.<br />

Pilcher named Chair <strong>of</strong><br />

Neurosurgery<br />

The School <strong>of</strong> Medicine and Dentistry turned<br />

to one <strong>of</strong> its own and named Webster H.<br />

Pilcher, M.D., Ph.D. (M ’83, Ph.D. ’83), to chair<br />

its neurosurgery department.<br />

Pilcher’s long-time association <strong>with</strong> <strong>the</strong><br />

<strong>Medical</strong> <strong>Center</strong> made him a natural choice for<br />

<strong>the</strong> position, says Jay H. Stein, M.D., Senior Vice<br />

President and Vice Provost for Health Affairs.<br />

“For <strong>the</strong> past 25 years, Dr. Pilcher has<br />

been part <strong>of</strong> <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> <strong>Medical</strong><br />

<strong>Center</strong> as a student, faculty member, researcher<br />

and talented neurosurgeon,” says Stein. “Now<br />

Dr. Pilcher can apply his collective experience<br />

<strong>with</strong>in this institution to <strong>the</strong> great benefit <strong>of</strong><br />

our students, residents, patients and<br />

researchers.”<br />

Pilcher has brought hope to thousands<br />

<strong>of</strong> patients needing brain surgery for various<br />

ailments including tumors, cysts and epilepsy.<br />

He is nationally recognized for his epilepsy<br />

surgery work, and is one <strong>of</strong> <strong>the</strong> few specialists<br />

in <strong>the</strong> region able to perform a complicated<br />

epilepsy surgery, where damaged brain cells<br />

are removed to help reduce a patient’s seizures.<br />

Pilcher helped lead <strong>the</strong> effort to establish<br />

Strong Health’s Epilepsy <strong>Center</strong>, a multi-disciplinary<br />

approach to treating <strong>the</strong> ailment.<br />

“After conducting an extensive national<br />

search, it became clear that Dr. Pilcher was<br />

<strong>the</strong> best neurosurgeon to lead <strong>the</strong> department<br />

forward as Chair,” says David S. Guzick, M.D.,<br />

Ph.D., <strong>dean</strong> <strong>of</strong> <strong>the</strong> School <strong>of</strong> Medicine and<br />

Dentistry. “He has proven his ability to build<br />

a nationally eminent, interdisciplinary<br />

program in epilepsy, and has <strong>the</strong> respect <strong>of</strong> his<br />

peers as a superb neurosurgeon. Moreover, <strong>with</strong><br />

his scientific background, he has articulated<br />

plans for <strong>the</strong> development <strong>of</strong> several key areas<br />

<strong>of</strong> neurosurgery that will foster <strong>the</strong> translation<br />

<strong>of</strong> laboratory results to clinical outcomes. We<br />

are highly enthusiastic about <strong>the</strong> opportunity<br />

to help him build <strong>the</strong>se important clinical and<br />

academic neurosurgical programs.”<br />

In his new role, Pilcher will oversee<br />

a staff <strong>of</strong> five full-time neurosurgeons as well<br />

as two full-time and one part-time researcher.<br />

Initially, he plans to focus on enhancing<br />

two programs <strong>with</strong>in <strong>the</strong> department, neurooncology<br />

and movement disorders, by<br />

facilitating translation <strong>of</strong> promising research<br />

into clinical care.<br />

“It is my goal to build upon <strong>the</strong> already<br />

tremendous talent we currently have in <strong>the</strong><br />

department, and look to expand in those areas<br />

where <strong>the</strong>re is both a community need and an<br />

expertise here,” Pilcher says. “I hope to provide<br />

an efficient means for our faculty, residents and<br />

students to take <strong>the</strong> outstanding research being<br />

performed at <strong>the</strong> Frank P. Smith Neurosurgical<br />

Laboratory and our o<strong>the</strong>r Departmental laboratories<br />

and apply it to improve patient care.”<br />

Pilcher has served on <strong>the</strong> faculty <strong>of</strong><br />

<strong>the</strong> <strong>University</strong> since 1990, most recently as an<br />

associate pr<strong>of</strong>essor <strong>of</strong> neurosurgery. He earned<br />

both his medical degree and Ph.D. from <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> <strong>Rochester</strong> <strong>Medical</strong> <strong>Center</strong>, and<br />

completed his surgical internship and neurosurgery<br />

residency through <strong>the</strong> <strong>University</strong> <strong>of</strong><br />

<strong>Rochester</strong> as well. He was a fellow in neurosurgery,<br />

focusing on epilepsy and tumor<br />

surgery at <strong>the</strong> <strong>University</strong> <strong>of</strong> Washington in<br />

Seattle. Pilcher is board-certified in neurosurgery.<br />

He received his bachelor’s in<br />

anthropology from Colgate <strong>University</strong>, and<br />

received a D.M.D. in dentistry from Columbia<br />

<strong>University</strong>.<br />

A member <strong>of</strong> <strong>the</strong> American Association<br />

<strong>of</strong> Neurological Surgeons, <strong>the</strong> Congress <strong>of</strong>


The Right Bid Buys<br />

George Engel’s Desk<br />

George Engel, M.D., gave his beloved desk to <strong>the</strong><br />

Office <strong>of</strong> Alumni Relations and Development<br />

<strong>with</strong> instructions that it be sold after his death<br />

to benefit <strong>the</strong> School <strong>of</strong> Medicine and Dentistry.<br />

With <strong>the</strong> establishment <strong>of</strong> <strong>the</strong> George L. Engel<br />

Memorial Lectureship, Alumni Relations has<br />

decided to auction <strong>the</strong> desk to help fund <strong>the</strong><br />

lecture.<br />

Built in <strong>the</strong> 1950s for Engel by famed<br />

furniture designer Tage Frid, this desk was<br />

a staple in Engel’s <strong>of</strong>fice. At this desk he worked<br />

long hours, counseled many students and drew<br />

many <strong>of</strong> his famous doodles.<br />

Here’s a chance to own a piece <strong>of</strong><br />

School history. To bid, you can ei<strong>the</strong>r call<br />

800–333–4428 or go to <strong>the</strong> Web site (where<br />

you’ll also find rules and more information)<br />

at: www.urmc.rochester.edu/smd/alumni/<br />

engeldesk.htm.<br />

Neurological Surgeons and <strong>the</strong> Neurosurgical<br />

Society <strong>of</strong> America, Pilcher also serves as an<br />

investigator in three active grants, two <strong>of</strong> which<br />

are focused on epilepsy surgery. He is a frequent<br />

lecturer and presenter at neurosurgery conferences<br />

nationwide and has published numerous<br />

papers and abstracts and contributed to physician<br />

textbooks on neurosurgery.<br />

Clinical research gets<br />

boost <strong>with</strong> Pearson<br />

appointment<br />

By David Guzick, Dean <strong>of</strong> <strong>the</strong> School <strong>of</strong><br />

Medicine and Dentistry<br />

It is <strong>with</strong> great pleasure that I announce <strong>the</strong><br />

appointment <strong>of</strong> Thomas A. Pearson, M.D., M.P.H.,<br />

Ph.D., as <strong>the</strong> new senior associate <strong>dean</strong> for<br />

clinical research. He will be responsible for<br />

putting into place <strong>the</strong> infrastructure required<br />

to support and enhance <strong>the</strong> conduct <strong>of</strong> clinical<br />

and population research at <strong>the</strong> <strong>Medical</strong> <strong>Center</strong>.<br />

Dr. Pearson’s talent and energy in this area<br />

have been aptly demonstrated as chair <strong>of</strong><br />

Community and Preventive Medicine, where<br />

he has worked collaboratively <strong>with</strong> clinical<br />

departments to provide training resources for<br />

potential researchers and promote <strong>the</strong>ir ability<br />

to design and carry out clinical research and<br />

trials. In this role, he obtained <strong>the</strong> K30 award<br />

for training clinical investigators.<br />

Dr. Pearson received his M.D., Master’s<br />

in Public Health and Ph.D. in epidemiology,<br />

all from Johns Hopkins <strong>University</strong>. He has<br />

completed residency training in preventive<br />

medicine and in internal medicine and has<br />

completed fellowship training in cardiovas-<br />

school news<br />

cular medicine and cardiovascular pathology,<br />

also at Johns Hopkins. After joining <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> <strong>Rochester</strong> in 1997, his Department<br />

<strong>of</strong> Community and Preventive Medicine has<br />

greatly expanded research programs in health<br />

services research, epidemiology, public health<br />

practice, and behavioral medicine. His department<br />

now has over 110 graduate students<br />

studying toward Master’s in Public Health and<br />

Ph.D. degrees in health services research and<br />

policy. He is director <strong>of</strong> <strong>the</strong> Clinical Research<br />

Curriculum Program, training more than<br />

60 clinicians in clinical research methods.<br />

He is especially active in <strong>the</strong> Double Helix<br />

curriculum, and directs <strong>the</strong> first course in<br />

<strong>the</strong> M.D. curriculum, entitled: “Mastering<br />

<strong>Medical</strong> Information.” Dr. Pearson’s research<br />

deals <strong>with</strong> <strong>the</strong> causes and prevention <strong>of</strong> heart<br />

disease at <strong>the</strong> individual, community, national,<br />

and international levels. He is <strong>the</strong> Principal<br />

FALL / WINTER 2002 35


school news<br />

Investigator on three grants from <strong>the</strong> NIH,<br />

one from <strong>the</strong> CDC, and o<strong>the</strong>rs from industry.<br />

Dr. Pearson will be initiating a strategic<br />

planning process for clinical research to identify<br />

current capabilities, determine resource<br />

needs and develop a plan that will chart our<br />

course to achieve preeminence in this critical<br />

institutional endeavor. We look forward to<br />

an exciting and energizing outcome.<br />

NOTE: In November, Pearson received an<br />

honorary doctorate from <strong>the</strong> <strong>University</strong> <strong>of</strong><br />

Umeä in Sweden.<br />

Symposium<br />

honors alumnus<br />

and anniversary<br />

William H. Bowen, B.D.S., M.Sc., Ph.D., D.Sc.<br />

(Mas ’59), was honored at a two-day symposium<br />

in May at <strong>the</strong> <strong>Medical</strong> <strong>Center</strong>, part <strong>of</strong> a<br />

celebration <strong>of</strong> 75 years <strong>of</strong> postgraduate dental<br />

training at <strong>the</strong> <strong>University</strong>.<br />

The symposium, whose <strong>the</strong>me was<br />

“<br />

The Impact <strong>of</strong> Research on <strong>the</strong> Future <strong>of</strong><br />

Dentistry,” drew alumni and faculty.<br />

<strong>Rochester</strong>’s Dental Research Fellowship<br />

Program was <strong>the</strong> first postgraduate program<br />

in this country to support research and training<br />

<strong>of</strong> dentists in <strong>the</strong> phases <strong>of</strong> dentistry related to<br />

<strong>the</strong> basic sciences. It was established by George<br />

Whipple, M.D., first <strong>dean</strong> <strong>of</strong> <strong>the</strong> school.<br />

The training program developed into<br />

<strong>the</strong> Department <strong>of</strong> Dentistry and Dental Research<br />

in <strong>the</strong> School <strong>of</strong> Medicine and Dentistry. An<br />

M.S. program <strong>with</strong> a major in Dental Science<br />

was created in 1951 in coordination <strong>with</strong> <strong>the</strong><br />

Eastman Dental <strong>Center</strong>, and Bowen was one<br />

<strong>of</strong> <strong>the</strong> early graduates <strong>of</strong> this program.<br />

Bowen, recognized as a world leader<br />

in dental research, is <strong>the</strong> Welcher Pr<strong>of</strong>essor <strong>of</strong><br />

Dentistry at <strong>the</strong> <strong>Center</strong> for Oral Biology and<br />

pr<strong>of</strong>essor <strong>of</strong> microbiology, immunology, and<br />

environmental medicine.<br />

36<br />

ROCHESTER MEDICINE<br />

From left: Drs. William H. Bowen, Robert Burne (Ph.D. ’87) and<br />

Kurt Schilling (Ph.D. ’89) share a moment at <strong>the</strong> symposium where<br />

Bowen was honored.<br />

Pichichero gift will<br />

support research<br />

Michael E. Pichichero, M.D. (M ’76), and his<br />

wife, Angela Pichichero, have recently made<br />

a group <strong>of</strong> generous<br />

gifts to <strong>the</strong> <strong>Medical</strong><br />

<strong>Center</strong>. One gift will<br />

support several pediatric<br />

research awards to<br />

honor Frank A. Disney,<br />

M.D., and Burtis B.<br />

Breese, M.D., for work in<br />

infectious diseases,<br />

Thomas Putnam, M.D., for surgery, and<br />

Thomas Gayeski, M.D., Ph.D., for anes<strong>the</strong>sia and<br />

pain management. In recognition, Golisano<br />

Children’s Hospital at Strong’s Pediatric<br />

Ambulatory Care <strong>Center</strong> will be renamed <strong>the</strong><br />

Michael and Angela Pichichero Pediatric<br />

Ambulatory Care <strong>Center</strong>.<br />

The Pichicheros also endowed <strong>the</strong> chair<br />

<strong>of</strong> <strong>the</strong> director <strong>of</strong> <strong>the</strong> David H. Smith <strong>Center</strong> for<br />

Vaccine Biology and Immunology. The current<br />

director is Tim Mosmann, Ph.D. In addition,<br />

Dr. and Mrs. Pichichero established <strong>the</strong> Porter<br />

Anderson Endowed Fellowship in vaccine<br />

immunobiology <strong>with</strong>in <strong>the</strong> Department <strong>of</strong><br />

Microbiology and Immunology.<br />

Pichichero is a pr<strong>of</strong>essor <strong>of</strong> microbiology<br />

and immunology, pediatrics and medicine at<br />

<strong>the</strong> <strong>Medical</strong> <strong>Center</strong>, and a practicing physician<br />

at <strong>the</strong> Elmwood Pediatric Group. In pediatric<br />

research, his focus is on <strong>the</strong> development <strong>of</strong><br />

future vaccines and next-generation treatments<br />

for infectious diseases. Angela Pichichero is<br />

chair <strong>of</strong> <strong>the</strong> board <strong>of</strong> Hillside Children’s <strong>Center</strong><br />

and an associate pr<strong>of</strong>essor <strong>of</strong> Human Services<br />

at Monroe Community College.


Student and Faculty Awards<br />

The following honors were announced at<br />

Opening Convocation, Sept. 19, at <strong>the</strong><br />

<strong>Medical</strong> <strong>Center</strong>.<br />

<strong>Medical</strong> Student Achievement Awards<br />

• The Edward F. Adolph Medal in Physiology:<br />

Anne Marie Mattingly ’05<br />

• The Adenia Andrews Community Service Award:<br />

Jamika Hallman ’05<br />

• The Association <strong>of</strong> Pathology Chairs Honor<br />

Society: Terina Chen ’04, Abigail Dennis ’04,<br />

Jane Snyder (dermatology fellow),<br />

Craig Widness ’03<br />

• The American Society <strong>of</strong> Clinical Pathologists<br />

Award for Excellence & Achievement:<br />

Thad Carlson (M.D./Ph.D. program)<br />

• The Victor Meyer Emmel Prize: Tara Mahar ’05<br />

• The Gilbert B. Forbes Prize:<br />

Christine Gorman ’05<br />

• The Walle J.H. Nauta Prize: Grace Chen ’04<br />

• Honorable Mention: Joshua Diamond ’04,<br />

Brooke Henninger ’04, Brigit Taylor ’04<br />

• The Dr. Edwin A. Robinson Award:<br />

Camelia Lawrence ’05<br />

• The Kenneth Woodward Scholarship:<br />

Lissette Lopez ’03<br />

• The Hrolfe and Dorothy Ziegler Prize:<br />

Mary Mulcahey ’05<br />

<strong>University</strong>-wide Graduate Fellowships<br />

• The Provost’s Fellowship: Darwin Operario<br />

• The Robert L. and Mary L. Sproull <strong>University</strong><br />

Fellowship: Erin Johnson, Brian Jones<br />

• Alumni Award for Excellence in Graduate<br />

Education: Stephen Dewhurst, Ph.D.<br />

Graduate Student<br />

Achievement/Fellowship Awards<br />

• The Melville A. Hare Awards for Distinction in<br />

Teaching: Christine Malboeuf<br />

Research: Roger Smith, Ph.D.;<br />

Richard Willis, Ph.D.<br />

• The Merritt and Marjorie Cleveland Fellowship:<br />

Shannon Bennett<br />

• The Graduate Alumni Fellowship Award:<br />

Darwin Operario<br />

• The Leon L. Miller Graduate Fellowship:<br />

Rahul Tyagi, Lea Vacca<br />

• The Irving Spar Fellowship Award:<br />

Rosemarie Marchan<br />

• The Elmer H. Stotz Fellowship in Biochemistry:<br />

Patrick Brandt, Daniel Gestaut<br />

Faculty Teaching and Mentoring Awards<br />

• Graduate Student Society Faculty Award:<br />

Robert Dirksen, Ph.D.<br />

• Commendations for First-Year Teaching: Nancy<br />

Shafer-Clark, M.D.; Camillo Peracchia, M.D.<br />

• The Manuel D. Goldman Prize for Excellence<br />

in First-Year Teaching: Chin-to Fong, M.D.<br />

• Commendations for Second Year Teaching:<br />

Ralph Jozefowicz, M.D.; Daniel Williford, M.D.<br />

• The Herbert W. Mapstone Prize for Excellence<br />

in Second Year Teaching: David Kaufman, M.D.<br />

• Commendations for Third-Year Teaching:<br />

Jules Cohen, M.D.; Fred Marshall, M.D.;<br />

Elizabeth McAnarney, M.D.<br />

• The Harry L. Segal Prize for Excellence in<br />

Third-Year Teaching: Jeffrey Lyness, M.D.<br />

• Women in Science, Dentistry and<br />

Medicine Mentoring Awards,<br />

Junior Faculty Mentoring:<br />

Yeates Conwell, M.D.<br />

Trainee Mentoring:<br />

Richard Phipps, Ph.D.<br />

school news<br />

Dean’s Teaching Fellows<br />

• DeWitt Brower Dean’s Teaching Fellow:<br />

Chin-to Fong, M.D.<br />

• Jules Cohen Dean’s Teaching Fellow:<br />

Linda Spillane, M.D.<br />

• George W. Corner Dean’s Teaching Fellow:<br />

Stephanie Brown-Clark, M.D., Ph.D.<br />

• Lowell A. Glasgow Dean’s Teaching Fellow:<br />

Jeffrey Rubenstein, M.D., M.B.A.<br />

• Marshal A. Lichtman Dean’s Teaching Fellow:<br />

Barbara Davis, Ph.D.<br />

• Lawrence E. Young Dean’s Teaching Fellow:<br />

Mary Anne Courtney, Ph.D.<br />

Named Pr<strong>of</strong>essorships<br />

• Barbara Asselin, M.D., George Washington Goler<br />

Associate Pr<strong>of</strong>essor <strong>of</strong> Pediatrics<br />

• Stephen Dewhurst, Ph.D., Dean’s Pr<strong>of</strong>essor <strong>of</strong><br />

Microbiology and Immunology<br />

• Richard Fisher, M.D., Samuel E. Durand<br />

Pr<strong>of</strong>essor <strong>of</strong> Medicine<br />

• Timothy Mosmann, Ph.D., Michael and Angela<br />

Pichichero Director in <strong>the</strong> David H. Smith<br />

<strong>Center</strong> for Vaccine Biology and Immunology<br />

• Webster Pilcher, M.D., Ph.D., Frank P. Smith<br />

Pr<strong>of</strong>essor <strong>of</strong> Neurosurgery<br />

• James Woods, M.D., Henry A. Thiede Pr<strong>of</strong>essor <strong>of</strong><br />

Obstetrics and Gynecology<br />

FALL / WINTER 2002 37


school news<br />

CONTINUING A ROCHESTER TRADITION — graduates pose <strong>with</strong> <strong>the</strong>ir alumni family members<br />

Jack Rowe, MD (M ’70), delivers <strong>the</strong><br />

commencement speech for <strong>the</strong> Class <strong>of</strong> 2002<br />

James Goldman (MD ’02) and his sister<br />

Gwenda Goldman (BA ’95, MD ’99)<br />

Pamela Polashenski (BA ’91, MPH ’98, MD ’02)<br />

and husband, Walter Polashenski (BA ’90, MD ’93)<br />

38<br />

ROCHESTER MEDICINE<br />

Donald Medd (MD ’02) and his dad,<br />

William Medd (MD ’68, R ’70)<br />

Jasmin Low (MD ’02) and her sister<br />

Cecilia Low Wang (MD ’95)<br />

Dr. Robert E. O’Mara (BA ’55) and his<br />

granddaughter Bridget O’Mara (MD ’02)<br />

Greg Lam (MD ’02) and his bro<strong>the</strong>r<br />

Garrett Lam (MD ’96)


D. A. Henderson<br />

receives Presidential<br />

Medal <strong>of</strong> Freedom<br />

D. A. Henderson, M.D. (M ’54), M.P.H., received <strong>the</strong><br />

nation’s highest civilian honor, <strong>the</strong> Presidential<br />

Medal <strong>of</strong> Freedom, from President George W.<br />

Bush in a ceremony at <strong>the</strong> White House in July.<br />

Henderson was joined by such luminaries<br />

as Nelson Mandela, Placido Domingo<br />

and Bill Cosby in receiving <strong>the</strong> award.<br />

“It was <strong>the</strong> most moving event in which<br />

I have ever participated but, basically, a salute<br />

to public health and preventive medicine,” said<br />

Henderson, a few days after receiving <strong>the</strong><br />

medal. “Most welcome!”<br />

Henderson was cited for his leadership <strong>of</strong><br />

<strong>the</strong> World Health Organization’s global<br />

smallpox eradication campaign and his recent<br />

work in preparing <strong>the</strong> country against a potential<br />

bioterrorism attack. He has served in <strong>the</strong><br />

government under several presidents (most<br />

recently in <strong>the</strong> new federal Office <strong>of</strong> Public<br />

Health Preparedness) and is <strong>the</strong> director <strong>of</strong> <strong>the</strong><br />

Johns Hopkins <strong>Center</strong> for Civilian Biodefense<br />

Studies.<br />

“D. A. Henderson is a great general in<br />

mankind’s war against disease,” said President<br />

Bush in <strong>the</strong> ceremony. “Our nation is fortunate<br />

to be able to draw on D. A. Henderson’s great<br />

store <strong>of</strong> wisdom and experience as we work to<br />

lift <strong>the</strong> dark threat <strong>of</strong> terrorism from <strong>the</strong> nation<br />

and our world.”<br />

The Presidential Medal <strong>of</strong> Freedom was<br />

established by President Truman in 1945 to<br />

recognize civilians for <strong>the</strong>ir service during<br />

World War II and was reinstated by President<br />

Kennedy in 1963 to honor people who have<br />

made “an especially meritorious contribution<br />

to <strong>the</strong> security or national interests <strong>of</strong> <strong>the</strong><br />

United States, or to world peace, or to cultural<br />

or o<strong>the</strong>r significant public or private<br />

endeavors.”<br />

alumni news<br />

President George W. Bush congratulates D. A. Henderson, M.D. (M ’54),<br />

M.P.H., after presenting Henderson <strong>with</strong> <strong>the</strong> Presidential Medal <strong>of</strong><br />

Freedom. The ceremony took place at <strong>the</strong> White House.<br />

Frazee helps separate<br />

twins in landmark<br />

operation<br />

It was clear this wasn’t a typical surgery.<br />

The NBC Dateline television crew was perched<br />

outside <strong>the</strong> operating room door. Ano<strong>the</strong>r film<br />

crew shot hours <strong>of</strong> footage inside. A steady<br />

stream <strong>of</strong> residents and specialists wandered<br />

in and out to catch a glimpse <strong>of</strong> <strong>the</strong> operation.<br />

And two operating tables sat at <strong>the</strong> center <strong>of</strong><br />

all <strong>the</strong> excitement, each holding one <strong>of</strong> <strong>the</strong><br />

Guatemalan twins conjoined at <strong>the</strong> head.<br />

On August 6, <strong>with</strong> <strong>the</strong> world watching,<br />

John Frazee, M.D. (M ’75), served as lead<br />

vascular neurosurgeon on <strong>the</strong> UCLA team that<br />

successfully separated <strong>the</strong> one-year-old twins.<br />

The procedure took more than 22 hours and<br />

40 health-care pr<strong>of</strong>essionals to complete.<br />

Frazee joined a select group that day.<br />

Surgeons worldwide have attempted to separate<br />

twins joined at <strong>the</strong> head only 30 times in <strong>the</strong><br />

past 70 years.<br />

Frazee downplayed <strong>the</strong> work when he<br />

spoke about it several days later, calling it<br />

“<br />

pretty standard vascular neurosurgery.”<br />

But a look at his part <strong>of</strong> <strong>the</strong> operation shows<br />

just how unusual this procedure really was.<br />

It began long before <strong>the</strong> operation, <strong>with</strong><br />

what Frazee called “a tremendous amount <strong>of</strong><br />

pre-planning.” He studied three-dimensional<br />

CT scans <strong>of</strong> <strong>the</strong> twins’ brains, spending many<br />

hours essentially mapping out <strong>the</strong>ir shared<br />

blood vessels. As director <strong>of</strong> <strong>the</strong> UCLA<br />

Neuroendoscopy Program and chief <strong>of</strong> <strong>the</strong><br />

Division <strong>of</strong> Neurosurgery at <strong>the</strong> West Los<br />

Angeles VA <strong>Medical</strong> <strong>Center</strong>, Frazee usually<br />

needs to spend only a few minutes studying<br />

a patient’s brain before procedures such as<br />

aneurysm surgery. But, like almost every o<strong>the</strong>r<br />

surgeon in <strong>the</strong> world, he had never before<br />

operated on conjoined twins.<br />

“The biggest issue wasn’t if we could<br />

separate <strong>the</strong> bones,” he explained. “The issue<br />

was, could we separate <strong>the</strong> blood vessels and<br />

not cause a stroke.”<br />

The surgeons expected to find six or<br />

eight shared blood vessels, but it turned out<br />

to be twice that many once <strong>the</strong>y began <strong>the</strong><br />

operation. The major drama for <strong>the</strong> neurosur-<br />

FALL / WINTER 2002<br />

39


alumni news<br />

geons came when Frazee had to put temporary<br />

clips on two major veins and <strong>the</strong>n monitor <strong>the</strong><br />

twins for complications in ei<strong>the</strong>r brain. Several<br />

problems were possible: The brains could have<br />

swelled dangerously, or <strong>the</strong>re could have been<br />

excessive hemorrhaging or outright stroke.<br />

If any <strong>of</strong> those things occurred, said Frazee,<br />

<strong>the</strong> surgeons “would have had to make some<br />

critical decisions.”<br />

In o<strong>the</strong>r words, <strong>the</strong>y might have had to<br />

quickly divert more blood flow to one brain to<br />

reduce swelling in <strong>the</strong> o<strong>the</strong>r. Both twins would<br />

have been at more risk, but <strong>the</strong>re might have<br />

been little choice.<br />

The surgeons paused and tested closely<br />

for problems. Thankfully, none arose. But later<br />

in <strong>the</strong> surgery, one <strong>of</strong> <strong>the</strong> twins began losing a<br />

great deal <strong>of</strong> blood. Throughout <strong>the</strong> operation,<br />

two teams <strong>of</strong> anes<strong>the</strong>siologists had to replace<br />

<strong>the</strong> total amount <strong>of</strong> blood in her body 12 times<br />

over — all while keeping <strong>the</strong> amount <strong>of</strong> blood<br />

coagulation factor steady enough to prevent<br />

uncontrolled bleeding. Because <strong>the</strong> twins<br />

shared <strong>the</strong>ir blood supply, this was an<br />

extremely complicated task. Frazee said if<br />

anyone deserves <strong>the</strong> “hero” label, it’s <strong>the</strong> anes<strong>the</strong>siologists.<br />

Judging from <strong>the</strong> worldwide media<br />

coverage <strong>of</strong> <strong>the</strong> surgery, people weren’t being<br />

stingy <strong>with</strong> <strong>the</strong> use <strong>of</strong> <strong>the</strong> word “hero.” That<br />

includes <strong>the</strong> citizens <strong>of</strong> <strong>the</strong> Guatemalan village<br />

where <strong>the</strong> twins are from, who held candlelight<br />

vigils while <strong>the</strong> surgery proceeded hundreds <strong>of</strong><br />

miles away.<br />

Days after <strong>the</strong> surgery, Frazee said it<br />

would take time before he and <strong>the</strong> rest <strong>of</strong><br />

<strong>the</strong> team could call <strong>the</strong> operation a success.<br />

As Frazee put it, “It was an interesting technical<br />

feat, but it’s <strong>of</strong> no interest to me or<br />

anyone on <strong>the</strong> team if <strong>the</strong> kids aren’t okay.”<br />

NOTE: As <strong>of</strong> press time for this magazine,<br />

<strong>the</strong> twins had made steady progress. In fact,<br />

<strong>the</strong> physicians were close to scheduling a time<br />

for <strong>the</strong> twins to fly home to Guatemala.<br />

40<br />

ROCHESTER MEDICINE<br />

Henderson and<br />

Gensheimer named<br />

to HHS Council<br />

In August, Health and Human Services<br />

Secretary Tommy G. Thompson named 21<br />

people to <strong>the</strong> Secretary’s Council on Public<br />

Health Preparedness. D. A. Henderson, M.D.<br />

(M ’54), M.P.H., was named chair <strong>of</strong> <strong>the</strong> Council,<br />

and Kathleen F. Gensheimer, M.D. (M ’77), M.P.H.,<br />

was named as one <strong>of</strong> its members. They will<br />

advise <strong>the</strong> department on appropriate actions to<br />

prepare for and respond to public health emergencies,<br />

including acts <strong>of</strong> bioterrorism.<br />

“This diverse group <strong>of</strong> very experienced<br />

pr<strong>of</strong>essionals will be an invaluable resource in<br />

<strong>the</strong> ongoing effort to streng<strong>the</strong>n our nation’s<br />

bioterrorism preparedness and response,”<br />

Secretary Thompson said when announcing <strong>the</strong><br />

new council. “As we continue to build our public<br />

health capabilities for emergencies, <strong>the</strong>ir input<br />

will be an important element in our planning.”<br />

Henderson is currently Secretary<br />

Thompson’s principal science advisor for<br />

Public Health Preparedness. Gensheimer is<br />

<strong>the</strong> state epidemiologist for Maine’s<br />

Department <strong>of</strong> Human Services. She has served<br />

on <strong>the</strong> CDC’s National Advisory Committee for<br />

<strong>the</strong> Elimination <strong>of</strong> Tuberculosis, has been an<br />

advisor to <strong>the</strong> World Health Organization and<br />

a committee member for <strong>the</strong> National Academy<br />

<strong>of</strong> Sciences Institute.<br />

Tim Mhyre (Ph.D.<br />

’00) is all smiles<br />

<strong>with</strong> game-show<br />

host Alex Trebek<br />

after winning<br />

on Jeopardy!<br />

Researcher asks<br />

<strong>the</strong> right questions<br />

on Jeopardy!<br />

Meet Tim Mhyre: research assistant pr<strong>of</strong>essor,<br />

<strong>Rochester</strong> alumnus and Jeopardy! champion.<br />

Mhyre (Ph.D. ’00) appeared on <strong>the</strong> trivia<br />

game show on September 27 and 30 <strong>of</strong> this year,<br />

after taping in Los Angeles in June.<br />

But really <strong>the</strong> story began more than<br />

a year before that, when Andrew Want<br />

(M.S.’94), a friend and fellow researcher at <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> <strong>Rochester</strong> <strong>Medical</strong> <strong>Center</strong>, heard<br />

about a contestant search going on in Buffalo.<br />

The two found <strong>the</strong>mselves <strong>with</strong> hundreds <strong>of</strong><br />

o<strong>the</strong>r Jeopardy! hopefuls, standing in long<br />

lines snaking through <strong>the</strong> Convention <strong>Center</strong>.<br />

First <strong>the</strong>y answered and passed a ten-question<br />

test, which pared <strong>the</strong> hundreds <strong>of</strong> hopefuls<br />

down to about 65. Then <strong>the</strong>y went to a pub,<br />

had a few beers, came back and passed<br />

a 50-question test.<br />

“The beer actually helped,” says Mhyre.<br />

After a round <strong>of</strong> mock Jeopardy!, <strong>the</strong> two<br />

were among a dozen who were told <strong>the</strong>y might<br />

be called over <strong>the</strong> next 16 months.<br />

For <strong>the</strong> first month <strong>of</strong> waiting, <strong>the</strong>y were<br />

thrilled. Six months later, <strong>the</strong>y wondered if<br />

<strong>the</strong>y’d ever be called. Fourteen months later,<br />

when he finally got <strong>the</strong> call, Mhyre couldn’t<br />

remember why some guy from Los Angeles<br />

would be calling him.


He bought some trivia books, but he<br />

knew <strong>the</strong>re was only so much studying he<br />

could do. Mostly, he hoped for some good categories<br />

— science, <strong>of</strong> course, or “Potent<br />

Potables”— and prayed he wouldn’t get stuck<br />

<strong>with</strong> opera.<br />

He arrived at Sony Pictures Studios in<br />

Los Angeles and immediately started feeling <strong>the</strong><br />

pressure. He had to spend hours <strong>with</strong> his soonto-be<br />

adversaries, sizing <strong>the</strong>m up, waiting to be<br />

called to play. No chance to duck out to a pub<br />

this time — Alex Trebek runs a tight ship.<br />

Mhyre even had to sit while someone came to<br />

get him into makeup.<br />

“I wasn’t too keen on that,” he says.<br />

Jeopardy! tapes five shows in a day, and<br />

Mhyre had to sit and watch four <strong>of</strong> <strong>the</strong>m.<br />

Finally, for <strong>the</strong> day’s last show, he was called<br />

onto stage. He had hardly eaten all day because<br />

<strong>of</strong> nerves. But, buzzer in hand, something<br />

clicked. After all, since he was a kid, people had<br />

been telling him he should be on Jeopardy!.<br />

“Once we started, I just kind <strong>of</strong> got in<br />

that zone,” he says. “It was almost autopilot.”<br />

And so it was that Mhyre became a<br />

Jeopardy! champion.<br />

Eric Anish, M.D. (R ’98), Donald Bordley, M.D. (R ’80, F ’81),<br />

and I. Donald Stuard, M.D. (M ’60), enjoy <strong>the</strong> festivities at<br />

<strong>the</strong> ACP-ASIM reception in Philadelphia on April 12. Dr. Stuard<br />

was host <strong>of</strong> <strong>the</strong> event.<br />

He came back <strong>the</strong> next day to defend,<br />

but he found himself up against an expert<br />

buzzer-clicker and, as fate would have it, opera<br />

as one <strong>of</strong> <strong>the</strong> categories. Still, he finished in<br />

second, which netted him $2,000 plus $8,999<br />

for winning <strong>the</strong> day before. Later, a friend gave<br />

him a dollar to round it out.<br />

Mhyre, whose research at <strong>Rochester</strong><br />

involves searching genomes to determine<br />

which regions make for susceptibility or resistance<br />

to Parkinson’s disease, says <strong>the</strong>re’s no<br />

question about which is harder, science or<br />

Jeopardy!.<br />

“Definitely Jeopardy!,” he says.<br />

There’s a lot less opera in science.<br />

From rags to <strong>Rochester</strong><br />

to riches<br />

As a child in Little Italy, he delivered ice to<br />

Babe Ruth. As a medical student in <strong>Rochester</strong>,<br />

he learned at <strong>the</strong> feet <strong>of</strong> Nobel laureate and<br />

<strong>dean</strong> George H. Whipple. As a renowned physician<br />

in New York City, he treated Herbert<br />

alumni news<br />

Hoover and Greta Garbo. And just before his<br />

death in 2000, Michael J. Lepore, M.D. (M ’34),<br />

finished writing his memoirs, which were<br />

published this year by <strong>the</strong> <strong>University</strong> <strong>of</strong><br />

<strong>Rochester</strong> Press.<br />

Life <strong>of</strong> <strong>the</strong> Clinician tells <strong>the</strong> tale <strong>of</strong> how<br />

Lepore journeyed from humble origins as a son<br />

<strong>of</strong> Italian immigrants to medical school (where<br />

he became <strong>the</strong> first graduate <strong>of</strong> <strong>the</strong> <strong>University</strong><br />

<strong>of</strong> <strong>Rochester</strong> School <strong>of</strong> Medicine and Dentistry<br />

to receive <strong>the</strong> degree <strong>of</strong> M.D. <strong>with</strong> Honors) and<br />

finally back<br />

to New York City,<br />

where he made<br />

his mark.<br />

“He was very<br />

proud to be a<br />

<strong>University</strong> <strong>of</strong><br />

<strong>Rochester</strong> graduate,”<br />

says Tim<br />

Madigan, Ph.D.,<br />

editorial director <strong>of</strong> <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong><br />

Press. Madigan gave a presentation on<br />

Lepore’s memoirs in spring as part <strong>of</strong> <strong>the</strong><br />

George Washington Corner Society lecture<br />

series for alumni.<br />

Robert McCann, M.D., associate pr<strong>of</strong>essor <strong>of</strong> medicine at <strong>the</strong> UR School<br />

<strong>of</strong> Medicine and Dentistry; William Hall, M.D., president <strong>of</strong> <strong>the</strong> American<br />

College <strong>of</strong> Physicians; Mrs. Rayna Goldfarb and Stanley Goldfarb, M.D.<br />

(M ’69), meet up at <strong>the</strong> ACP–ASIM Philadelphia reception.<br />

FALL / WINTER 2002<br />

41


alumni news<br />

In his talk, Madigan said that Lepore<br />

came to <strong>Rochester</strong> because he felt that <strong>the</strong><br />

New York City schools were too didactic. It was<br />

an unpopular decision among his family<br />

members, who wanted him to stay close to<br />

home, but Lepore had heard about a new<br />

medical school in <strong>Rochester</strong> <strong>with</strong> a different,<br />

more personal approach.<br />

Lepore writes that, at <strong>Rochester</strong>, he<br />

found a place where scientific spirit was more<br />

important than memorizing by rote (and, as<br />

ano<strong>the</strong>r feature he appreciated, attendance was<br />

never taken formally). Still, he believed <strong>the</strong><br />

approach was more demanding than a highly<br />

structured program.<br />

Lepore enrolled in 1929 and quickly<br />

embraced <strong>the</strong> idea at <strong>Rochester</strong> that everything<br />

in medicine began <strong>with</strong> <strong>the</strong> patient, continued<br />

<strong>with</strong> <strong>the</strong> patient and was pursued <strong>with</strong> <strong>the</strong><br />

patient in mind. According to his son, who<br />

helped finish <strong>the</strong> manuscript (and who also<br />

became a physician), Lepore never forgot that<br />

lesson during his long career as a gastroenterologist.<br />

That career included a stint as something<br />

<strong>of</strong> a TV doctor, long before <strong>the</strong> concept<br />

existed. In 1955, a network got <strong>the</strong> idea to televise<br />

a physician in action for o<strong>the</strong>r physicians.<br />

Lepore, who had become chief <strong>of</strong> gastroenterology<br />

at New York’s Roosevelt Hospital and<br />

a faculty member at New York <strong>University</strong>, was<br />

chosen. His grand rounds were broadcast to<br />

20,000 physicians in 50 cities.<br />

Ultimately, <strong>the</strong> memoirs are a fond look<br />

back by a man who loved medicine because it<br />

afforded him a personal, one-on-one way <strong>of</strong><br />

life — whe<strong>the</strong>r he was treating famous<br />

patients, serving in <strong>the</strong> South Pacific during<br />

World War II, or making his way through an<br />

innovative new medical school as part <strong>of</strong> its<br />

fifth graduating class.<br />

NOTE: If you’re interested in ordering<br />

Life <strong>of</strong> <strong>the</strong> Clinician, by Michael J. Lepore,<br />

call Tim Madigan at <strong>the</strong> <strong>University</strong> <strong>of</strong><br />

<strong>Rochester</strong> Press: 585–273–5778; or e-mail<br />

him at urpress@mail.rochester.edu.<br />

42<br />

ROCHESTER MEDICINE<br />

Ozols receives award &<br />

endowed chair position<br />

Robert F. Ozols, M.D. (B.A. ’66, Ph.D. ’71, M ’74),<br />

senior vice president for medical science at Fox<br />

Chase Cancer <strong>Center</strong> in Philadelphia, and his<br />

research colleague — Robert C. Young, M.D.,<br />

president <strong>of</strong> <strong>the</strong> <strong>Center</strong> — have received <strong>the</strong><br />

Bristol-Myers Squibb Award for Distinguished<br />

Achievement in Cancer Research. An independent<br />

committee <strong>of</strong> cancer researchers,<br />

chaired by Nobel<br />

laureate Leland H.<br />

Hartwell<br />

<strong>of</strong> <strong>the</strong> Fred<br />

Hutchinson Cancer<br />

<strong>Center</strong> in Seattle,<br />

made <strong>the</strong> award<br />

Robert Ozols, M.D.<br />

selection.<br />

Ozols and Young<br />

will share a $50,000 cash prize, which is given<br />

as part <strong>of</strong> a “no-strings-attached” funding<br />

program.<br />

The two researchers are internationally<br />

known for <strong>the</strong>ir work in treating and<br />

researching ovarian cancer. When <strong>the</strong>y began<br />

<strong>the</strong>ir collaboration while at <strong>the</strong> National<br />

Cancer Institute, <strong>the</strong> disease was poorly understood<br />

and usually at an advanced stage at <strong>the</strong><br />

time <strong>of</strong> diagnosis. They were <strong>the</strong> first<br />

researchers to show that combination <strong>the</strong>rapy<br />

for ovarian cancer is more effective than single<br />

alkylating agents. They also were among <strong>the</strong><br />

first to recognize <strong>the</strong> effectiveness <strong>of</strong> using platinum<br />

compounds in treatment. Subsequently,<br />

<strong>the</strong>y devised a chemo<strong>the</strong>rapy regimen now<br />

considered <strong>the</strong> standard for advanced ovarian<br />

cancer.<br />

The award was presented at a dinner<br />

held in <strong>the</strong>ir honor in New York City, where<br />

<strong>the</strong>y also received a commemorative silver<br />

medallion.<br />

In July, Ozols also was appointed to<br />

hold <strong>the</strong> Audrey Weg Schaus and Ge<strong>of</strong>frey Alan<br />

Weg Endowed Chair, a newly endowed chair at<br />

Fox Chase Cancer <strong>Center</strong>.<br />

Alumni live ’la dolce<br />

vita’ during first<br />

international trip<br />

By Christina Mancini, Associate Director <strong>of</strong><br />

<strong>Medical</strong> Alumni Relations<br />

Spectacular scenery. Wonderful friendships.<br />

History, art, culture galore. Amazing food and<br />

wine — all <strong>the</strong> ingredients for an enjoyable<br />

travel experience. The 19 alumni and friends<br />

who took <strong>the</strong> jaunt to Tuscany are likely to rave<br />

about this recipe for some time. It was <strong>the</strong> first<br />

international alumni trip sponsored by <strong>the</strong> URMC<br />

Alumni Programs Office <strong>of</strong> Alumni Relations,<br />

and our time in Italia was “magnificato.”<br />

For eight glorious days, we traversed <strong>the</strong><br />

Tuscan countryside, traveling to Siena, Assisi,<br />

Perugia, Montepulciano, Florence and o<strong>the</strong>r<br />

beautiful destinations. We were fortunate to<br />

call Pienza our home away from home. This<br />

charming, sleepy town has a population <strong>of</strong> 400<br />

and was named after former resident Pope Pius<br />

III. English is a language familiar to all but<br />

known to few here, so body language and<br />

smiles were <strong>the</strong> common denominator.<br />

Although such entrees as “Wild Boar<br />

Stew” raised a few eyebrows, <strong>the</strong>y were soon<br />

discovered to be a treat for <strong>the</strong> taste buds.<br />

Enticing entrees, delectable desserts, and wine,<br />

wine, wine were in order at every meal.<br />

Culinary delights were but one<br />

wonderful aspect <strong>of</strong> this trip. Seymour<br />

Schwartz, M.D. (R ’57), participated as <strong>the</strong><br />

faculty enrichment lecturer. He gave several<br />

interesting lectures on map-making and on<br />

<strong>the</strong> history <strong>of</strong> surgery in Italy and <strong>the</strong> United<br />

States. While in Florence, our group had <strong>the</strong><br />

opportunity to learn from his expert insight<br />

on Galileo’s globes.<br />

We also visited a vineyard, ca<strong>the</strong>drals<br />

and basilicas, including <strong>the</strong> basilica in Siena,<br />

where we saw Ca<strong>the</strong>rine <strong>of</strong> Siena’s actual<br />

preserved head, skin and all. About half <strong>the</strong><br />

group also took advantage <strong>of</strong> <strong>the</strong> optional side<br />

trip to Rome.


Alumni were from all three <strong>of</strong> <strong>the</strong> URMC’s<br />

schools — medicine, dentistry and nursing.<br />

Friendships grew throughout <strong>the</strong> week, and<br />

a post-trip party was planned for mid-July<br />

before we even left Italy!<br />

Future trips include <strong>the</strong> French Riviera<br />

(Dec. 27–Jan. 4, 2003), Ireland (May 21–29,<br />

2003) and Scandinavia (Aug. 3–10, 2003).<br />

For more information on <strong>the</strong> travel program<br />

or to register for a trip, contact Christina<br />

Mancini, associate director <strong>of</strong> medical alumni<br />

relations, at 800–333–4428.<br />

Christina’s travelogue<br />

•<br />

Heshy Tabechian, M.D. (M ’61), searched for<br />

meatballs at every restaurant, to no avail.<br />

The post-trip party has been scheduled at an<br />

Italian restaurant, which he has already visited<br />

to ensure <strong>the</strong>re are meatballs on <strong>the</strong> menu.<br />

• Bette Smith from <strong>the</strong> School <strong>of</strong> Nursing and<br />

Don Vair have been dating for about six years.<br />

A coppersmith in Montepulciano was very<br />

taken by <strong>the</strong> couple. He created a “good luck in<br />

love” piece for <strong>the</strong>m and said <strong>the</strong> couple would<br />

cause an earthquake. Later, <strong>the</strong> paper reported<br />

alumni news<br />

(Clockwise from left) A charming street in Pienza. The Pienza landscape. The vineyard that produces<br />

<strong>the</strong> award-winning “Altesino Brunello di Montalcino.” The gang: Don Vair, Mary Kremer, Christina<br />

Mancini, Andrea Marshall, Marge Tabechian, Lee Caldwell, Bob Caldwell, Bette Smith, Maureen<br />

Kieman, Lynn McLellan, Judy Reemstma, Bill Bowen, Lynn Rosen, Carole Bowen, Mac McLellan,<br />

Heshy Tabechian, Sy Schwartz, Lynn Kaiser, Dionne Grant.<br />

•<br />

•<br />

that an earthquake did occur that day.<br />

Bob Caldwell, M.D. (M ’61), and Lee Caldwell,<br />

M.D. (R ’69), spent 90 percent <strong>of</strong> <strong>the</strong> afternoon<br />

in Florence trying to get to <strong>the</strong> statue <strong>of</strong> David<br />

and 10 percent looking at it.<br />

Maureen Kiernan and Andrea Marshall <strong>of</strong> <strong>the</strong><br />

School <strong>of</strong> Nursing spent <strong>the</strong> day in Florence<br />

shopping for lea<strong>the</strong>r coats. I spent <strong>the</strong> day<br />

looking for lea<strong>the</strong>r boots. We all found <strong>the</strong>m ten<br />

minutes before <strong>the</strong> bus was scheduled to leave.<br />

We sprinted a mile through a hailstorm and<br />

got to <strong>the</strong> bus just in time. We’ve been asked<br />

to wear our new garb to <strong>the</strong> post-trip dinner.<br />

FALL / WINTER 2002 43


alumni news<br />

<strong>University</strong> <strong>of</strong> <strong>Rochester</strong> School <strong>of</strong> Medicine & Dentistry<br />

44<br />

Fall & Reunion<br />

Weekend 2002<br />

October 3 – 5<br />

Trailblazing: Frontiers in Medicine<br />

ROCHESTER MEDICINE<br />

Alumni get into <strong>the</strong> spirit …<br />

Robert L. Berg, M.D., pr<strong>of</strong>essor in Community and Preventive Medicine at<br />

<strong>Rochester</strong>, accepts <strong>the</strong> 51st annual Gold Medal Award from Bob Caldwell,<br />

M.D. (M ’61, R ’69), and Hechmat Tabechian, M.D., Ph.D. (M ’61).<br />

<strong>Medical</strong> student Trinitia Ash, her husband Cory Cannon and her son<br />

Dela-Shown enjoy <strong>the</strong> all-alumni event.


Members <strong>of</strong> <strong>the</strong> Class <strong>of</strong> ’62 celebrate <strong>the</strong><br />

dedication <strong>of</strong> <strong>the</strong> auditorium that bears <strong>the</strong>ir<br />

class name.<br />

Donald Su<strong>the</strong>rland, M.D. (M ’47), chats at<br />

<strong>the</strong> Alumni Association luncheon.<br />

Alumni and friends ga<strong>the</strong>r for <strong>the</strong><br />

<strong>Medical</strong> Alumni Association Luncheon.<br />

Mildred Donlon (Ph.D ’72) and Jerome Donlon, M.D. (Ph.D. ’68, M.D. ’72, R ’73), enjoy lunch<br />

<strong>with</strong> <strong>the</strong>ir daughter, Margaret, a first-year medical student at <strong>Rochester</strong>.<br />

alumni news<br />

Fritz Parker, M.D. (M ’62), and Dean Guzick cut<br />

<strong>the</strong> ribbon to dedicate <strong>the</strong> Class <strong>of</strong> ’62 <strong>Medical</strong><br />

Education Auditorium.<br />

Chloe Alexson, M.D. (M ’54, R ’57, F ’59), was <strong>the</strong><br />

inaugural recipient <strong>of</strong> <strong>the</strong> Alumni Service Award,<br />

which recognizes volunteerism and support <strong>of</strong><br />

<strong>the</strong> school.<br />

FALL / WINTER 2002 45


alumni news<br />

Marlene Ma<strong>the</strong>ws ‘05 and Sarah Buhay ‘05 set a musical mood as<br />

guests arrive at <strong>the</strong> 31st Annual Whipple Dinner.<br />

Robert Greenlaw, M.D. (M ’52, F ’57, R ’58), Charles Lobeck, Jr., M.D.<br />

(M ’52) and Robert Dole, M.D. (M ’52), get into <strong>the</strong> "Trailblazing: Frontiers<br />

<strong>of</strong> Medicine" <strong>the</strong>me <strong>of</strong> Reunion Weekend at <strong>the</strong> all-alumni event.<br />

Frederic Stone (M ’52) and his wife, Nella, enjoy <strong>the</strong> Colonial Belle<br />

boat tour.<br />

46<br />

ROCHESTER MEDICINE<br />

Class <strong>of</strong> 1954 Members pose <strong>with</strong> <strong>the</strong> 2002 Class <strong>of</strong> 1954 scholarship<br />

winners. Joseph Flatley, M.D. (’54), Mary Flatley, Thomas Walters ’03,<br />

Meghan Nicholson ’03, David Kluge, M.D. (’54), and Beverly Kluge.<br />

Second-year medical student Natalie Bello chats <strong>with</strong> John Seidlin, M.D.<br />

(M ’52), and Barbara Hulfish, M.D. (M ’52).<br />

Ruth Lawrence, M.D. (M ’49), and Don Stuard, M.D.<br />

(M ’60), compare notes during <strong>the</strong> festivities.


Julliard-trained Eugene Toy, M.D. (R ’99),<br />

showed what good can come from practicing<br />

<strong>the</strong> piano as well as medicine.<br />

Alumni and friends <strong>of</strong> all ages enjoyed<br />

<strong>the</strong> “Trailblazing” <strong>the</strong>me <strong>of</strong> <strong>the</strong> weekend.<br />

If you’re considering a charitable bequest in<br />

your will to <strong>the</strong> <strong>University</strong>, it might be advantageous<br />

from a tax perspective to make a<br />

charitable gift from an IRA or o<strong>the</strong>r qualified<br />

retirement plan ra<strong>the</strong>r than from o<strong>the</strong>r estate<br />

assets. Many people have more assets in<br />

<strong>the</strong>ir IRAs or qualified retirement plans than<br />

<strong>the</strong>y will need during <strong>the</strong>ir lifetimes, which<br />

represents a very attractive gifting opportunity<br />

that will preserve more <strong>of</strong> an estate’s value.<br />

For example: Robert plans to leave<br />

a $100,000 bequest in his will to <strong>the</strong> School <strong>of</strong><br />

Medicine and Dentistry. Among his o<strong>the</strong>r<br />

estate assets is an IRA, which is estimated to<br />

maintain a similar $100,000 value at his death<br />

and which is beneficiary designated to his<br />

daughter. Because <strong>the</strong> IRA has not previously<br />

been taxed to Robert, <strong>the</strong> daughter will have<br />

to pay income taxes on her distribution from<br />

<strong>the</strong> IRA when she receives it at Robert’s<br />

death. Her distribution may also be reduced<br />

by estate tax. Dependent on applicable tax<br />

rates, this combined tax can total as much as<br />

60–70% <strong>of</strong> <strong>the</strong> retirement plan accumulations.<br />

There is a better way for Robert to<br />

accomplish his generous philanthropic<br />

purpose, while avoiding a potential double<br />

taxation on his daughter’s inheritance. The<br />

solution is simply to reverse <strong>the</strong> process,<br />

leaving his daughter her $100,000 as a<br />

bequest from <strong>the</strong> general estate and designating<br />

<strong>the</strong> School <strong>of</strong> Medicine and Dentistry<br />

to receive its $100,000 from <strong>the</strong> IRA. Because<br />

alumni news<br />

Tax-wise giving<br />

Using retirement funds for charitable giving can reduce tax load<br />

<strong>the</strong> School <strong>of</strong> Medicine and Dentistry is taxexempt,<br />

it escapes <strong>the</strong> usual income and<br />

estate tax on <strong>the</strong> IRA distribution. And, as<br />

estate bequests are generally not subject to<br />

income tax, <strong>the</strong> daughter receives a far larger<br />

inheritance than would o<strong>the</strong>rwise be <strong>the</strong><br />

case. Through this tax-wise approach, both<br />

gifting purposes are achieved and a<br />

significant amount <strong>of</strong> tax is avoided.<br />

Prior to recent tax law changes, donors<br />

were <strong>of</strong>ten advised by counsel to segregate<br />

in a separate account that portion <strong>of</strong> IRA or<br />

o<strong>the</strong>r retirement plan assets earmarked for<br />

charity. This is no longer necessary. Also, <strong>the</strong><br />

charity’s portion can be designated ei<strong>the</strong>r as<br />

a dollar amount or as a fraction <strong>of</strong> <strong>the</strong> total on<br />

<strong>the</strong> death beneficiary designation form (available<br />

from <strong>the</strong> IRA custodian or retirement plan<br />

administrator). It is <strong>the</strong>se beneficiary designation<br />

forms, and not your will, that control <strong>the</strong><br />

distribution <strong>of</strong> retirement plan assets.<br />

Gifts from retirement funds can be<br />

designated to support a variety <strong>of</strong> critical<br />

needs <strong>with</strong>in <strong>the</strong> School <strong>of</strong> Medicine and<br />

Dentistry. We would be pleased to discuss<br />

<strong>the</strong>se needs and tax-wise methods <strong>of</strong> giving.<br />

Before making decisions on how to accomplish<br />

philanthropic goals, it is best to consult<br />

<strong>with</strong> personal legal and financial advisors.<br />

For more information, contact Jack<br />

Kreckel in <strong>the</strong> Office <strong>of</strong> Trusts and Estates<br />

at 585–273–5930, 800–635–4672, or at<br />

kreckel@alumni.rochester.edu.<br />

FALL / WINTER 2002 47


class notes<br />

If you want to contact alumni, you can get<br />

address information in <strong>the</strong> On-line Directory<br />

at www.alumniconnections.com/urmc.<br />

You’ll need to register if you haven’t already.<br />

Your security ID code is listed on <strong>the</strong> back<br />

cover <strong>of</strong> this magazine, over your name on<br />

<strong>the</strong> address label (it consists <strong>of</strong> a letter and<br />

a series <strong>of</strong> eight numbers).<br />

The names <strong>of</strong> Class Agents appear next to<br />

some <strong>of</strong> <strong>the</strong> years in <strong>the</strong> Class Notes section.<br />

Class Agents stay in touch <strong>with</strong> classmates<br />

and act as focal points for getting news into<br />

<strong>the</strong> magazine.<br />

If you’re interested in becoming a<br />

Class Agent, call Don Stuard, M.D. (M ’60),<br />

at 610–429–4362 or <strong>the</strong> School <strong>of</strong> Medicine and<br />

Dentistry Development Office at 800–333–4428.<br />

CLASS OF 1939<br />

Class Agent: John Frazer, 329 Orchard Park<br />

Blvd., <strong>Rochester</strong>, NY 14609, 585–288–4002<br />

CLASS OF 1942<br />

Class Agent: Arthur Redmond, 210 Hollywood<br />

Ave., <strong>Rochester</strong>, NY 14618, 585–271–2339<br />

CLASS OF 1944<br />

Class Agent: Stuart Finch, 20 Avondale Ave.,<br />

Haddonfield, NJ 08033, 856–427–0772,<br />

finch@umdnj.edu<br />

48<br />

C. McCollister Evarts, M.D. (M ’75, R ’64), shakes hands <strong>with</strong> Ele<strong>the</strong>a<br />

Caldwell, M.D. (R ’69), after delivering <strong>the</strong> AOA lecture on March 26.<br />

Evarts’ lecture was titled “The 21st Century Physician: Courage<br />

Under Fire.” Caldwell is <strong>the</strong> councilor <strong>of</strong> <strong>the</strong> AOA.<br />

ROCHESTER MEDICINE<br />

CLASS OF 1949<br />

Class Agent: Ruth Lawrence, 1836 Clover St.,<br />

<strong>Rochester</strong>, NY 14618, 585–461–0018,<br />

ruth_lawrence@urmc.rochester.edu<br />

Clifford C. Roosa, M.D., has written a book<br />

titled Charlie Ain’t Been By. It recalls personal<br />

experiences, including his medical practice in<br />

<strong>the</strong> Marshall Islands. You can obtain a copy<br />

by sending e-mail to roosa@southshore.com.<br />

CLASS OF 1950<br />

Class Agent: Theodore Vanzandt,<br />

79 Stuyvesant Rd., Pittsford, NY 14534,<br />

585–385–1183, Joannevz@aol.com<br />

Maurice S. Reizen, M.D. (M ’50, M.P.H.),<br />

received <strong>the</strong> Distinguished Service Award<br />

from <strong>the</strong> Michigan Public Health Association<br />

for “a lifetime <strong>of</strong> distinguished service in<br />

protecting and preserving <strong>the</strong> health <strong>of</strong><br />

Michigan’s citizens” in May.<br />

CLASS OF 1951<br />

Class Agent: George D’Angelo, 3232<br />

Westwood Estates Dr., Erie, PA 16506,<br />

814–833–9065, gjdmd@adelphia.net<br />

Robert V. Silicano, M.D. (M ’51, R ’56), and<br />

his wife, Ann, moved to Claremont, CA, last<br />

January. They find it to be a great place to<br />

retire, <strong>with</strong> a warm climate, mountains and<br />

an inland valley.<br />

Hugh Upton, M.D., has created a yearbook<br />

<strong>of</strong> <strong>the</strong> medical students in <strong>the</strong> Class <strong>of</strong> 1951,<br />

including pictures and signatures. For more<br />

information or to obtain a copy, contact <strong>the</strong><br />

Office <strong>of</strong> <strong>Medical</strong> Alumni Relations at<br />

800–333–4428.<br />

Alvin L. Ureles, M.D., has written a novel,<br />

The Mizar Project, about “a top-secret drug<br />

ploy that misfires into a surprise weapon <strong>of</strong><br />

mass destruction.” The book was published<br />

as an e-book by The 1st Books Library. For<br />

information on obtaining a copy, go to <strong>the</strong><br />

Web site at www.1stbooks.com.<br />

CLASS OF 1952<br />

Class Agent: Dr. Charles Lobeck, Jr.<br />

3420 Valley Creek Cir., Middleton, WI 53562<br />

608–831–2047, cclobeck@aol.com<br />

Gertrude A. Bales, M.D., Gerald L. Glaser,<br />

M.D., and L. Holland Taylor, M.D. (FLW ’54),<br />

were honored by <strong>the</strong> Monroe County <strong>Medical</strong><br />

Society in <strong>Rochester</strong> for having served 50<br />

years in <strong>the</strong> medical field. <strong>Rochester</strong><br />

Distinguished Pr<strong>of</strong>essor Robert J. Joynt, M.D.,<br />

was also honored.<br />

Kenneth G. Goss, M.D., is an emeritus<br />

pr<strong>of</strong>essor <strong>of</strong> family practice at <strong>the</strong> <strong>University</strong><br />

<strong>of</strong> Arkansas. He spent 20 years as a general<br />

practitioner and 20 years in academic family<br />

practice and has been retired for 10 years.<br />

He enjoys travel, and has been a visiting<br />

pr<strong>of</strong>essor and tourist in Scandinavia, Russia,<br />

Greece, Taiwan and South Africa. He is very<br />

involved in church, civic and family activities.<br />

CLASS OF 1954<br />

Class Agent: Chloe Alexson, 57 Inglewood Dr.,<br />

<strong>Rochester</strong>, NY 14619, 585-328-4193,<br />

drcgamd@aol.com<br />

Irwin Frank, M.D., received <strong>the</strong> Award <strong>of</strong><br />

Merit from <strong>the</strong> <strong>Rochester</strong> Academy <strong>of</strong><br />

Medicine last spring.<br />

A note from <strong>the</strong> Class <strong>of</strong> ’54: Members <strong>of</strong> <strong>the</strong><br />

Class <strong>of</strong> ’54 have seen more <strong>of</strong> each o<strong>the</strong>r<br />

recently than usual. On May 9, a good-sized


group met <strong>with</strong> D. A. Henderson (M ’54) and<br />

his wife, Nana, as he dedicated <strong>the</strong> second<br />

<strong>Medical</strong> Research Building in <strong>Rochester</strong>. The<br />

usual <strong>Rochester</strong> classmates (Chloe Alexson,<br />

Joe and Mary Flatley, Irwin Frank, Helene<br />

Friedman, Dave and Beverly Kluge, Jim and<br />

Nancy MacWhinney, Neal McNabb, Sue<br />

Meyerowitz, Jack and Sue Peachey, and Jose<br />

Skakey <strong>with</strong> a friend) were <strong>the</strong>re but we also<br />

had Bud and Roxanne Coleman from<br />

California, Jim and Ronnie Gregg from<br />

Massachusetts, Lanse and Pat Hoskins from<br />

Cleveland, Ted and Melva Max from Holland<br />

Patent, NY. We were very pleased that one <strong>of</strong><br />

our scholarship recipients, Pete Le Tourneau,<br />

M.D. (’02), was able to join us. The o<strong>the</strong>r<br />

recipient, Sara Tamarin, M.D. (’02), was<br />

unable to come.<br />

In mid-August, a group <strong>of</strong> ’54 classmates<br />

and wives met in Seattle for a<br />

three-day meeting, which we called our<br />

“48th-and-a-half reunion.” Dean David Guzick<br />

spoke at our dinner and somehow managed to<br />

wear a ’54 waterpro<strong>of</strong> windbreaker and a ’54<br />

hat in a non-air conditioned room — not only<br />

as he spoke but also during <strong>the</strong> dinner. He<br />

endeared himself to us forever by getting up<br />

halfway through our class meeting and<br />

saying, in a little boy voice, “I’m tired. I’m<br />

going to bed.”<br />

His talk covered <strong>the</strong> current state <strong>of</strong> <strong>the</strong><br />

school, and more importantly, his vision for<br />

Members <strong>of</strong> <strong>the</strong> class <strong>of</strong> 1954 cruised<br />

to Alaska recently. See below for<br />

details <strong>of</strong> <strong>the</strong> trip.<br />

<strong>the</strong> future. He was accompanied by Cameron<br />

Gardner, a fourth-year med student, who<br />

added his thoughts.<br />

The following morning, as <strong>the</strong> <strong>dean</strong><br />

took an early flight back to <strong>Rochester</strong>, we<br />

toured Mt. Rainier on a gloriously clear day,<br />

seeing all <strong>the</strong>re was to see. Wandering<br />

through <strong>the</strong> beautiful Bloedel Conservatory<br />

and having a huge picnic at Bob and Anne<br />

Wright’s house and an equally huge breakfast<br />

at Bob and Marge Willkens’ house <strong>the</strong> next<br />

morning completed our Seattle trip.<br />

But we weren’t through yet! We<br />

hopped on a bus to Vancouver and boarded<br />

<strong>the</strong> Star Princess (as 19 <strong>of</strong> 2700 passengers)<br />

for a week-long cruise to Alaska. We were<br />

shameless tourists, seeing whales, sea lions,<br />

eagles, seals, sea otters, puffins and goldmining<br />

sites. We also took a narrow-gauge<br />

railroad trip (following in <strong>the</strong> steps <strong>of</strong> <strong>the</strong><br />

Klondike gold miners) and a trip through <strong>the</strong><br />

rainforest, stopping for tours <strong>of</strong> <strong>the</strong> towns<br />

along <strong>the</strong> way and a visit to a Native Alaskan<br />

Heritage <strong>Center</strong>. We did, <strong>of</strong> course, eat too<br />

much, including salmon in more ways than<br />

imaginable.<br />

We sent postcards to our classmates<br />

who had been unable to join us, mostly because<br />

<strong>the</strong> dates coincided <strong>with</strong> “grandparent time”<br />

and long-standing family vacations; some,<br />

unfortunately, because <strong>of</strong> illness.<br />

There wasn’t a single problem on <strong>the</strong><br />

class notes<br />

trip and our way was smoo<strong>the</strong>d throughout by<br />

Karen Gaffney from <strong>the</strong> Alumni Office. Our<br />

thanks to her for a wonderful job well done.<br />

CLASS OF 1955<br />

Class Agent: Saul Milles, 304 Hotchkiss Rd.,<br />

Orange, CT 06477, 203–795–4019,<br />

docsaul@aol.com<br />

CLASS OF 1956<br />

Class Agent: William Kern, 109 Breeze Haven<br />

Ter., Huddleston, VA 24104, 405–579–4765<br />

CLASS OF 1957<br />

Richard F. Bakemeier, M.D. (B.A. ’52, M ’57),<br />

is serving his second term as chair <strong>of</strong> <strong>the</strong><br />

<strong>University</strong> Faculty Council <strong>of</strong> <strong>the</strong> <strong>University</strong> <strong>of</strong><br />

Colorado, which represents <strong>the</strong> entire faculty<br />

<strong>of</strong> all four campuses <strong>of</strong> <strong>the</strong> university. He<br />

previously served as chair <strong>of</strong> <strong>the</strong> Faculty<br />

Assembly <strong>of</strong> <strong>the</strong> <strong>University</strong> <strong>of</strong> Colorado Health<br />

Sciences <strong>Center</strong>, where he is pr<strong>of</strong>essor <strong>of</strong><br />

medicine, associate <strong>dean</strong> for continuing<br />

medical education, and associate director <strong>of</strong><br />

<strong>the</strong> <strong>University</strong> <strong>of</strong> Colorado Comprehensive<br />

Cancer <strong>Center</strong>.<br />

Bakemeier, <strong>the</strong> first medical oncologist<br />

in <strong>Rochester</strong>, was pr<strong>of</strong>essor <strong>of</strong> medicine at<br />

<strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> School <strong>of</strong><br />

Medicine and Dentistry and associate director<br />

<strong>of</strong> <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> Cancer <strong>Center</strong><br />

until 1986.<br />

CLASS OF 1958<br />

Edward S. Irwin, M.D. (R ’58), is an emeritus<br />

clinical pr<strong>of</strong>essor <strong>of</strong> ophthalmology at <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> Vermont College <strong>of</strong> Medicine.<br />

CLASS OF 1960<br />

Class Agent: I. Donald Stuard, 1507 Greenhill<br />

Rd., West Chester, PA 19380, 610–429–4362,<br />

idstuard@alumni.urmc.rochester.edu<br />

Mal Gorin, M.D., is still living in Haddam,<br />

Conn. He retired two years ago but recently<br />

has been drawn back to <strong>the</strong> <strong>of</strong>fice one day a<br />

week. His practice <strong>of</strong> ophthalmology, which<br />

started solo in 1966, has grown to five<br />

ophthalmologists <strong>with</strong> an <strong>of</strong>fice staff <strong>of</strong><br />

around 30 — a track record that can give one<br />

pleasure. As Mal moved into retirement<br />

he decided to run for <strong>the</strong> town board for<br />

FALL / WINTER 2002 49


class notes<br />

planning, zoning and development. It was a<br />

fierce battle. Haddam residents were not<br />

aware Mal was a candidate until <strong>the</strong>y saw his<br />

name on <strong>the</strong> ballot.<br />

He won handily and enjoys his<br />

comrades on <strong>the</strong> board, as well as his service<br />

to <strong>the</strong> community. Mal and wife Linda have<br />

two sons, a daughter and six grandchildren,<br />

who live close enough so baby-sitting is part<br />

<strong>of</strong> <strong>the</strong> Gorins’ lifestyle. If anyone is looking for<br />

a Vermont house and 200 acres, call Mal:<br />

He has one on <strong>the</strong> market. The Gorins are<br />

world travelers. This fall <strong>the</strong>y are <strong>of</strong>f to Machu<br />

Picchu, Peru and o<strong>the</strong>r interesting destinations.<br />

Ken Draper, M.D., lives in Conshohocken, Pa.<br />

He had four years <strong>of</strong> surgical residency at<br />

Duke, only to decide it was not his cup <strong>of</strong> tea.<br />

He switched to psychiatry, taking training<br />

at North Carolina, <strong>Rochester</strong> and Temple.<br />

Routine psychiatry was not to be his bag.<br />

He became interested in emergency room<br />

psychiatry (at <strong>the</strong> time not part <strong>of</strong> <strong>the</strong><br />

curriculum, but now a required rotation at<br />

Penn, Temple and Jefferson). Ken has made<br />

an impact. The Kenneth Draper award for<br />

outstanding performance in emergency room<br />

psychiatry at Temple is eight years old. In<br />

his spare time, Ken has become an American<br />

history buff <strong>with</strong> a strong interest in <strong>the</strong><br />

Civil War.<br />

Don and Sue Stuard enjoyed more than<br />

three months on Squaw Island on <strong>the</strong><br />

Canadian side <strong>of</strong> <strong>the</strong> Thousand Islands this<br />

summer. Not content <strong>with</strong> a summer <strong>of</strong><br />

Canada, “we traveled a week in <strong>the</strong> Canadian<br />

Maritime provinces, seeing <strong>the</strong> St. Lawrence<br />

River become 30 miles wide, visiting <strong>the</strong> Bay<br />

<strong>of</strong> Fundy and enjoying <strong>the</strong> rugged scenery <strong>of</strong><br />

sparsely populated eastern Canada. On our<br />

last evening we had a splendid dinner at <strong>the</strong><br />

Culinary Institute in Charlottetown, Prince<br />

Edward Island, overlooking <strong>the</strong> harbor.<br />

We watched 18 sailboats conduct <strong>the</strong>ir<br />

weekly race in <strong>the</strong> face <strong>of</strong> oncoming hurricane<br />

Gustaf.”<br />

Note from Don : Fellow classmates, please<br />

e-mail me your news, stories and pictures.<br />

C. Arthur Pearson, M.D., hosted a symposium<br />

on “Genetic Engineering and <strong>Medical</strong> Ethics<br />

50<br />

ROCHESTER MEDICINE<br />

in Congenital Conditions” in Naples, FL, in<br />

November 2001. The symposium was sponsored<br />

by Retired Physicians <strong>of</strong> Collier County,<br />

<strong>of</strong> which he is <strong>the</strong> founder and first president.<br />

CLASS OF 1961<br />

Class Agent: Hechmat Tabechian, 3901 East<br />

Ave., <strong>Rochester</strong>, NY 14618, 585–385–2413,<br />

htab@rochester.rr.com<br />

Paul H. Fine, M.D. (B.A. ’57, R ’65), received<br />

<strong>the</strong> 2001–2002 James M. Stewart Award from<br />

<strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong> School <strong>of</strong><br />

Medicine and Dentistry in recognition <strong>of</strong><br />

“distinguished clinical teaching.” The award<br />

is given each year by <strong>the</strong> Department <strong>of</strong><br />

Medicine.<br />

Carol Cooperman Nadelson, M.D., received<br />

<strong>the</strong> Alexandra Symonds Award Lecture at<br />

<strong>the</strong> American Psychiatric Association 2002<br />

Annual Meeting in Philadelphia. This award<br />

is given to recognize and honor outstanding<br />

contributions and leadership <strong>of</strong> women<br />

psychiatrists in promoting women’s health and<br />

<strong>the</strong> advancement <strong>of</strong> women.<br />

Hechmat Tabechian, M.D., has been named<br />

<strong>the</strong> executive director <strong>of</strong> <strong>the</strong> <strong>Rochester</strong><br />

Academy <strong>of</strong> Medicine. He is an active<br />

member <strong>of</strong> <strong>the</strong> School <strong>of</strong> Medicine and<br />

Dentistry’s <strong>Medical</strong> Alumni Council and is on<br />

<strong>the</strong> admissions committee for <strong>the</strong> school.<br />

CLASS OF 1962<br />

Class Agent: Frederick Parker,<br />

310 Dewittshire Rd. S., De Witt, NY 13214,<br />

315–446–8495, parkerf@upstate.edu<br />

CLASS OF 1963<br />

Robert C. Scaer, M.D. (B.S. ’59), is semiretired.<br />

He has authored several books.<br />

CLASS OF 1964<br />

Mary Dohrmann (M.S. ’64) was ordained<br />

as a minister in 1983 and got her M.S.W. from<br />

Kansas <strong>University</strong> in 1985. She is in private<br />

practice <strong>with</strong> her husband, and <strong>the</strong>y focus on<br />

integration <strong>of</strong> body, mind and spirit.<br />

Mark A. Hardy, M.D. (R ’64), is <strong>the</strong> vice<br />

chairman and program director <strong>of</strong> surgery at<br />

Columbia <strong>University</strong> and <strong>the</strong> director <strong>of</strong> renal<br />

and islet transplantation. He writes, “Fa<strong>the</strong>r<br />

<strong>of</strong> three and grandfa<strong>the</strong>r <strong>of</strong> two. What else do<br />

I need?”<br />

Raymond B. Otero, Ph.D. (M.S. ’64), writes:<br />

I am now enjoying retirement. I still do a little<br />

consulting on <strong>the</strong> side to keep my mind sharp,<br />

but I have been playing a lot <strong>of</strong> golf. I’ve been<br />

in Kentucky for 34 years and am loving it. I do<br />

enjoy your magazine. Keep up <strong>the</strong> good work.<br />

Robert Tatelbaum, M.D. (R ’69), is <strong>the</strong> associate<br />

chairman <strong>of</strong> <strong>the</strong> Department <strong>of</strong> OB/GYN<br />

at <strong>Rochester</strong> General Hospital, <strong>the</strong> program<br />

director for <strong>the</strong> OB/GYN residency program at<br />

<strong>Rochester</strong> General and an associate<br />

pr<strong>of</strong>essor <strong>of</strong> OB/GYN at <strong>the</strong> <strong>University</strong> <strong>of</strong><br />

<strong>Rochester</strong> School <strong>of</strong> Medicine and Dentistry.<br />

CLASS OF 1966<br />

Class Agent: Donald A. Grover, 21 Countryside<br />

Rd., Fairport, NY 14450, 585–385–3639,<br />

dkgrover@frontiernet.net<br />

CLASS OF 1967<br />

Robert M. Blumenberg, M.D. (R ’67), is a staff<br />

member <strong>of</strong> <strong>the</strong> Institute for Vascular Disease<br />

at Albany <strong>Medical</strong> College. He has retired<br />

from operative vascular surgery but does<br />

diagnosis, consultations, <strong>of</strong>fice evaluations<br />

and vascular lab diagnosis part time.<br />

Anthony M. Foti, M.D. (R ’67), is an associate<br />

pr<strong>of</strong>essor emeritus <strong>with</strong> <strong>the</strong> medical school at<br />

<strong>the</strong> <strong>University</strong> <strong>of</strong> Buffalo. He also continues in<br />

private practice.<br />

Carleton C. Stewart (M.S. ’64, Ph.D. ’67)<br />

received <strong>the</strong> Thomas B. Tomasi Achievement<br />

Award in March for his pioneering work in<br />

flow cytometry. The award was presented by<br />

<strong>the</strong> Roswell Park Alliance. Stewart is a<br />

pr<strong>of</strong>essor <strong>of</strong> immunology at Roswell Park<br />

Cancer Institute and <strong>the</strong> director <strong>of</strong> its Flow<br />

Cytometry Resource.<br />

CLASS OF 1968<br />

Marvin Goldstein, M.D. (R ’68), received <strong>the</strong><br />

Award <strong>of</strong> Merit from <strong>the</strong> <strong>Rochester</strong> Academy<br />

<strong>of</strong> Medicine this spring.<br />

Cyril “Kim” Hetsko, M.D., became treasurer<br />

<strong>of</strong> <strong>the</strong> American College <strong>of</strong> Physicians–


American Society <strong>of</strong> Internal Medicine in<br />

April. Hetsko is chief medical <strong>of</strong>ficer <strong>with</strong><br />

COLA (formerly <strong>the</strong> Commission on Office and<br />

Laboratory Accrediation) and a clinical<br />

pr<strong>of</strong>essor <strong>of</strong> medicine at <strong>the</strong> <strong>University</strong> <strong>of</strong><br />

Wisconsin-Madison.<br />

CLASS OF 1969<br />

Norman Spack, M.D., was awarded an<br />

honorary degree from Hebrew College for<br />

“his dedication to Hebrew College, Jewish<br />

learning and <strong>the</strong> Boston Jewish community”<br />

in June.<br />

CLASS OF 1970<br />

Dr. Philip A. Pizzo, Stanford <strong>University</strong> School<br />

<strong>of</strong> Medicine, 300 Pasteur Dr., Suite M–121,<br />

Stanford, CA 94305, philip.pizzo@stanford.edu<br />

Richard M. Green, M.D. (R ’76), pr<strong>of</strong>essor and<br />

chair <strong>of</strong> <strong>the</strong> Division <strong>of</strong> Vascular Surgery at<br />

Strong Memorial Hospital, was named president-elect<br />

<strong>of</strong> <strong>the</strong> Society for Vascular Surgery<br />

in June. Green specializes in surgery for<br />

carotid artery disease, aortic aneurysms and<br />

thoracic outlet syndrome. Also, he has been<br />

named one <strong>of</strong> <strong>the</strong> “Best Doctors in America.”<br />

Charles B. Rodning, M.D., received <strong>the</strong><br />

Howard L. Holley Award from <strong>the</strong> <strong>Medical</strong><br />

Association <strong>of</strong> <strong>the</strong> State <strong>of</strong> Alabama for his<br />

More than 250<br />

Whipple Society<br />

members ga<strong>the</strong>red<br />

for this year's<br />

event at Oak Hill<br />

Country Club.<br />

“faithful and meritorious service to <strong>the</strong> pr<strong>of</strong>ession<br />

<strong>of</strong> medicine.” The award was presented<br />

on June 7. He also received <strong>the</strong> Humanism<br />

in Medicine Award this year, in recognition <strong>of</strong><br />

“compassion, enthusiasm and leadership”<br />

demonstrated by a teaching physician.<br />

Carole W. Samuelson, M.D. (R ’70), recently<br />

retired after 17 years as <strong>the</strong> health <strong>of</strong>ficer for<br />

Jefferson County, AL. She continues to be<br />

very involved in community activities and is<br />

teaching a class at <strong>the</strong> <strong>University</strong> <strong>of</strong> Alabama<br />

at Birmingham School <strong>of</strong> Public Health. She<br />

enjoys traveling and being a grandmo<strong>the</strong>r.<br />

CLASS OF 1971<br />

Class Agent: Thomas McMeekin, 300 White<br />

Spruce Blvd., <strong>Rochester</strong>, NY 14623,<br />

585–385–1500, 041745@msn.com<br />

CLASS OF 1975<br />

F. M. Baker, M.D., is in her second year as<br />

medical director <strong>of</strong> <strong>the</strong> Lower Shore Clinic in<br />

Salisbury, Md. She is also an adjunct<br />

pr<strong>of</strong>essor <strong>of</strong> psychiatry at <strong>the</strong> <strong>University</strong> <strong>of</strong><br />

Maryland School <strong>of</strong> Medicine.<br />

Carol W. Nichols (B.A. ’72, M.S. ’75) was<br />

elected to <strong>the</strong> Quincy Public School District<br />

172 Board <strong>of</strong> Education in 2001. Her daughter,<br />

Aja Marie, graduated from Northwestern<br />

class notes<br />

<strong>University</strong> in 2002 <strong>with</strong> a degree in computing<br />

systems.<br />

CLASS OF 1976<br />

Beverly Love, M.D., is quite a busy guy. Aside<br />

from running <strong>the</strong> Women’s Wellness <strong>Center</strong> in<br />

Montgomery, Ala., <strong>with</strong> a fellow physician, he<br />

has a weekly radio talk show called “Doctor’s<br />

House Calls.” He is running for Alabama state<br />

senate as well.<br />

CLASS OF 1977<br />

Dr. Kathleen Gensheimer, 130 <strong>Center</strong> St., Bath,<br />

Maine 04530, 207–846–1053,<br />

kathleen.f.gensheimer@state.me.us<br />

Dr. James Powers, 714 Darrow Dr., Pleasant<br />

View, TN 37146, 615–746–8917,<br />

james.powers@vanderbilt.edu<br />

CLASS OF 1978<br />

Robert W. Loss, Jr., M.D. (R ’81), is <strong>the</strong><br />

managing partner <strong>of</strong> Dermatology Associates<br />

<strong>of</strong> <strong>Rochester</strong>, which was recently selected to<br />

be a National Training <strong>Center</strong> for Botox.<br />

CLASS OF 1979<br />

Robert T. Brodell, M.D., has been elected to<br />

serve as a director <strong>of</strong> <strong>the</strong> American Board <strong>of</strong><br />

Dermatology, effective in January 2003.<br />

David A. Martin, M.D. (R ’79), is a clinical<br />

pr<strong>of</strong>essor <strong>of</strong> medicine at Nor<strong>the</strong>astern Ohio<br />

<strong>University</strong> College <strong>of</strong> Medicine.<br />

Howard Sohnen, M.D., is <strong>the</strong> residency<br />

program director and vice chairman <strong>of</strong> <strong>the</strong><br />

Department <strong>of</strong> OB/GYN at Mercer <strong>University</strong><br />

School <strong>of</strong> Medicine in Georgia.<br />

CLASS OF 1980<br />

Class Agent: G. Allen Power, 150 Highland<br />

Ave., <strong>Rochester</strong>, NY 14628, 585–271–1680,<br />

apower@stjohnshome.com<br />

Mason Gross (M.S. ’80) resides in Houston,<br />

TX, <strong>with</strong> his wife, Carol, and three children,<br />

Sarah, Alex, and Daniel. He is a patent attorney<br />

at Akin, Gump, Strauss, Hauer & Feld, L.L.P.,<br />

in Houston and has a Ph.D. in electrical engineering<br />

from Georgia Institute <strong>of</strong> Technology.<br />

In addition to his M.S. degree in biophysics<br />

FALL / WINTER 2002 51


class notes<br />

from <strong>the</strong> School <strong>of</strong> Medicine and Dentistry,<br />

he earned an M.S. degree in optical engineering<br />

from <strong>the</strong> Institute <strong>of</strong> Optics at <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> <strong>Rochester</strong>.<br />

Lee Deakins Hieb, M.D. (M ’80, R ’90), was<br />

recently elected to <strong>the</strong> executive committee<br />

<strong>of</strong> <strong>the</strong> Arizona <strong>Medical</strong> Association. She<br />

currently lives in Yuma, AZ.<br />

CLASS OF 1983<br />

Jeanne L. DelSignore, M.D. (R ’88), has been<br />

appointed Chair <strong>of</strong> <strong>the</strong> American Academy <strong>of</strong><br />

Orthopaedic Surgeons Committee on Ethics.<br />

The committee’s mission is to review and<br />

revise <strong>the</strong> Academy’s Guide to <strong>the</strong> Ethical<br />

Practice <strong>of</strong> Orthopaedic Surgery, address<br />

concerns <strong>of</strong> members regarding ethical<br />

issues, and provide guidelines for <strong>the</strong> entire<br />

Academy fellowship. DelSignore is a practicing<br />

hand surgeon and <strong>the</strong> owner <strong>of</strong> Hand<br />

Surgery Associates, L.L.P., in <strong>Rochester</strong>.<br />

Melinda Saran (B.S. ’82, M.S. ’83) received<br />

<strong>the</strong> “Friend <strong>of</strong> Gateway-Longview” award in<br />

Buffalo, NY, for her work assisting administrators<br />

and staff to advocate for <strong>the</strong> educational<br />

needs <strong>of</strong> <strong>the</strong>ir residents. In 2001–02, she was<br />

<strong>the</strong> president <strong>of</strong> <strong>the</strong> Western New York<br />

chapter <strong>of</strong> <strong>the</strong> Women’s Bar Association <strong>of</strong><br />

<strong>the</strong> State <strong>of</strong> New York.<br />

52<br />

The “Ten-Year Club” (alumni who graduated between 1992 and 2002)<br />

joined members <strong>of</strong> <strong>the</strong> <strong>Medical</strong> Alumni Council in New York City for an<br />

event at John’s Pizzeria on May 10. From left are: Raissa Bennett, Deb<br />

Mulford, M.D. ’99, Joshua Schwimmer, M.D. ’98; Bob Thompson, M.D. ’99;<br />

Bill Tew, M.D. ’99; and Garrett Bennett, M.D. ’99.<br />

ROCHESTER MEDICINE<br />

Sidney Sobel, M.D. (FLW ’73), received <strong>the</strong><br />

Award <strong>of</strong> Merit from <strong>the</strong> <strong>Rochester</strong> Academy<br />

<strong>of</strong> Medicine this spring.<br />

CLASS OF 1985<br />

Margaret Gaines, M.D. (FLW ’85), has a geriatric/long-term<br />

care practice and very much<br />

enjoys teaching nursing-home medicine and<br />

assisted-living clinic practice to medical<br />

students and family practice residents. She<br />

has a 4 1/2-year-old son, adopted from<br />

Guatemala.<br />

CLASS OF 1986<br />

Dolores J. Bacon, M.D., is <strong>the</strong> director <strong>of</strong><br />

medicine for <strong>the</strong> Brown Scholars Program in<br />

Primary Care for medical students at <strong>the</strong><br />

Columbia <strong>University</strong> College <strong>of</strong> Physicians and<br />

Surgeons in New York City.<br />

CLASS OF 1988<br />

Amy E. Evans, M.D. (M ’88, R ’91), is a<br />

pr<strong>of</strong>essor <strong>of</strong> pediatrics at UCSF–Fresno.<br />

CLASS OF 1989<br />

Claire E. Gavin (M.S. ’89, Ph.D. ’91) is a senior<br />

research investigator in <strong>the</strong> Department <strong>of</strong><br />

Toxological Sciences at Pfizer, Inc.<br />

Steven D. Hanks, M.D., was awarded <strong>the</strong><br />

Master <strong>of</strong> <strong>Medical</strong> Management (MMM)<br />

degree from Carnegie Mellon <strong>University</strong> in<br />

May. He joins an exclusive group <strong>of</strong> physicians,<br />

numbering fewer than 300 nationwide,<br />

who hold <strong>the</strong> degree. Hanks is <strong>the</strong> vice president<br />

<strong>of</strong> medical affairs and chief medical<br />

<strong>of</strong>ficer at Finger Lakes Health in Geneva, NY.<br />

He also is a diplomate <strong>of</strong> <strong>the</strong> American<br />

College <strong>of</strong> Physicians/American Society <strong>of</strong><br />

Internal Medicine, an <strong>of</strong>ficer <strong>of</strong> <strong>the</strong> <strong>Medical</strong><br />

Society <strong>of</strong> <strong>the</strong> State <strong>of</strong> New York and a past<br />

president <strong>of</strong> <strong>the</strong> Monroe County <strong>Medical</strong><br />

Society.<br />

Mark Vossler, M.D. (B.S. ’85, M ’89), writes:<br />

“I recently moved from Portland, OR, to <strong>the</strong><br />

Seattle area <strong>with</strong> my wife, Susan, and my<br />

daughters, Lydia and Ellen. I left my faculty<br />

position at Oregon Health Sciences <strong>University</strong><br />

to join Eastside Cardiology Associates in<br />

Kirkland, WA. I’m working to set up a community-based<br />

heart failure treatment program at<br />

Evergreen Community Hospital.”<br />

Barry J. Wu, M.D., received <strong>the</strong> National<br />

Association <strong>of</strong> Inpatient Physicians’ (NAIP)<br />

fifth annual Award for Excellence in Teaching<br />

in April. Wu was recognized for his “exemplary<br />

role as a teacher, academician, mentor<br />

and role model in hospital medicine.” NAIP is<br />

<strong>the</strong> premier U.S. medical society representing<br />

“hospitalists”— physicians whose primary<br />

pr<strong>of</strong>essional focus is <strong>the</strong> general medical care<br />

<strong>of</strong> hospitalized patients. Wu is an associate<br />

clinical pr<strong>of</strong>essor at Yale <strong>University</strong>.<br />

CLASS OF 1990<br />

Class Agent: Peter S. Reichard,<br />

25 Melrose Rd., Mountain Lakes, NJ 07046,<br />

973-394-7995, epreichard@msn.com<br />

CLASS OF 1991<br />

Irene Rupp Hodge, M.D. (B.S. ’87, M ’91),<br />

and her husband, Michael, are pleased<br />

to announce <strong>the</strong> birth <strong>of</strong> <strong>the</strong>ir son, Mark<br />

Patterson Hodge. Their first son, Andrew,<br />

is two.<br />

Darrell S. Pardi, M.D., was recently appointed<br />

as director <strong>of</strong> GI and Hepatology Training<br />

Programs at <strong>the</strong> Mayo Clinic. He also serves<br />

as director <strong>of</strong> <strong>the</strong> Emergency Endoscopy<br />

Service and wrote that he is “Dad” to three<br />

children: Ryan, 4 1/2, Amanda, 3, Lauren,<br />

6 weeks.


CLASS OF 1993<br />

Michael S. Albert, M.D. (R ’93), is <strong>the</strong><br />

chairman <strong>of</strong> <strong>the</strong> Department <strong>of</strong> Pathology at<br />

Buffalo Mercy Hospital. He is also <strong>the</strong> director<br />

<strong>of</strong> Transfusion Services for Catholic Health<br />

System in Buffalo and <strong>the</strong> president and board<br />

chair <strong>of</strong> X-Cell Laboratories <strong>of</strong> western New<br />

York. He is <strong>the</strong> 3rd District Councilman for <strong>the</strong><br />

New York State Society <strong>of</strong> Pathologists.<br />

Fabio Benedetti, M.D. (R ’93), recently joined<br />

Millennium Pharmaceuticals as <strong>the</strong> vice president<br />

<strong>of</strong> Global <strong>Medical</strong> Affairs.<br />

CLASS OF 1994<br />

Joe Bliss: See note under “CLASS <strong>of</strong> 1998”<br />

about <strong>the</strong> birth <strong>of</strong> his son.<br />

Anne Olinger, M.D. (M ’94, R ’02), married<br />

Patrick J. Billone on October 12, 2002. Anne<br />

began a fellowship in July 2002 at <strong>Rochester</strong>,<br />

specializing in geriatric medicine. Patrick is a<br />

broadcast meteorologist at WOKR-TV Channel<br />

13 in <strong>Rochester</strong>.<br />

CLASS OF 1995<br />

Hannah Borisute, M.D., recently accepted a<br />

position <strong>with</strong> Merck & Co., Inc., as associate<br />

medical director in <strong>the</strong>ir Clinical Development<br />

Division.<br />

Dwight Heron, M.D., a radiologist at Magee<br />

Women’s Hospital in Pittsburgh, is part <strong>of</strong> a<br />

team developing a new procedure to deliver<br />

radiation to some women who undergo a<br />

lumpectomy for breast cancer. The procedure<br />

implants a balloon device at <strong>the</strong> tumor site,<br />

<strong>with</strong> a ca<strong>the</strong>ter left partially outside <strong>the</strong> body.<br />

In later sessions, radioactive seeds are<br />

implanted temporarily through <strong>the</strong> ca<strong>the</strong>ter<br />

opening to deliver radiation treatments.<br />

David V. Mungo, M.D. (B.S. ’91, M ’95),<br />

is enjoying country life in Alliance, OH.<br />

He and his wife, Michelle, have two children<br />

(Savanna, 4, and James, 2 1/2). Their third<br />

child is due in December.<br />

CLASS OF 1996<br />

Alexander Judkins, M.D., has been appointed<br />

an assistant pr<strong>of</strong>essor in <strong>the</strong> Department <strong>of</strong><br />

Pathology and Laboratory Medicine at <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> Pennsylvania School <strong>of</strong><br />

Medicine. He has recently completed a<br />

fellowship in forensic pathology at <strong>the</strong> Office<br />

<strong>of</strong> <strong>the</strong> <strong>Medical</strong> Examiner for <strong>the</strong> city <strong>of</strong><br />

Philadelphia. Judkins is also an assistant<br />

neuropathologist at Children’s Hospital in<br />

Philadelphia, where he wants to establish a<br />

tissue microarray core lab for basic and clinical<br />

research. He does ongoing research on<br />

cortical dysplasias and <strong>the</strong>ir role in <strong>the</strong> development<br />

<strong>of</strong> pediatric epilepsy.<br />

Robert M. Raphael (M.S. ’92, Ph.D. ’96) just<br />

started a faculty position as <strong>the</strong> T.N. Law<br />

Pr<strong>of</strong>essor <strong>of</strong> Bioengineering at Rice<br />

<strong>University</strong>. He welcomes any alumni in <strong>the</strong><br />

Houston area to contact him.<br />

Fenton (Drew) A. Smith (M.S. ’96) was<br />

appointed technical director for Monroe<br />

County’s Environmental Lab in December 2001.<br />

Drew, who received his M.S. degree in industrial<br />

hygiene, has been <strong>with</strong> <strong>the</strong> county for ten<br />

years and will head up <strong>the</strong> labs that have<br />

been consolidated from Pure Waters and <strong>the</strong><br />

Health Department.<br />

CLASS OF 1997<br />

Laureen Ann Burke, M.D. (B.A. ’93, M ’97),<br />

was recently featured in an Associated Press<br />

story titled, “Boomers leave jobs at <strong>the</strong> height<br />

<strong>of</strong> <strong>the</strong>ir careers to study law or medicine.”<br />

Burke, who left a successful marketing career<br />

to attend medical school at <strong>the</strong> age <strong>of</strong> 35, is<br />

now an obstetrician and gynecologist in<br />

<strong>Rochester</strong>.<br />

Brent Williams, M.D., and Dr. Alice Wei were<br />

married on May 26, 2002, in Brooklyn. Both<br />

Brent and Alice are fellows specializing in<br />

kidney diseases at St. Vincent’s Manhattan<br />

Hospital.<br />

CLASS OF 1998<br />

Joe Bliss, M.D. (M.S. ’94, Ph.D. ’98, M ’98),<br />

and his wife, Cindy, are proud to announce<br />

<strong>the</strong> birth <strong>of</strong> <strong>the</strong>ir son, Daniel Joseph Bliss.<br />

He was born on March 25, 2002, weighing in<br />

at 8 pounds, 2 ounces.<br />

CLASS OF 1999<br />

Class Agent: Hans Stohrer, 41–41 76th St. #5E,<br />

Elmhurst, NY 11373, 718–458–1111,<br />

haifanhans@msn.com<br />

class notes<br />

CLASS OF 2000<br />

Timothy R. Harrison, M.D., and his wife,<br />

Susan, are pleased to announce <strong>the</strong> birth<br />

<strong>of</strong> <strong>the</strong>ir son, Joseph. He was born on January<br />

10, 2002.<br />

Sunmi Kim, M.D., and Dr. Richard Lin were<br />

married on June 15, 2002, in Roslyn Harbor,<br />

NY. Sunmi is currently an intern at New York<br />

Hospital Queens.<br />

Denise (Armstrong) Ray (M.S. ’00) and Steven<br />

Ray were married on September 29, 2001.<br />

Both are pursuing <strong>the</strong>ir doctoral degrees<br />

in microbiology and immunology at <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> <strong>Rochester</strong>.<br />

CLASS OF 2001<br />

Megan D. Grace, M.D. (B.S. ’97, M ’01),<br />

and Jason J. Lyons, M.D. (B.A. ’94), were<br />

married on May 11, 2002. Both are first-year<br />

residents in internal medicine at <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> <strong>Rochester</strong> <strong>Medical</strong> <strong>Center</strong>.<br />

CLASS OF 2002<br />

Class Agent: Pam Polashenski, 1190<br />

Canandaigua Rd., Macedon, NY 14502,<br />

315–986–4380, ppolashe@mc.rochester.edu<br />

Richard Chang, M.D. (FLW ’02), recently joined<br />

Donald J. Digby and Associates<br />

in Greensboro, NC. Chang specializes<br />

in diseases <strong>of</strong> <strong>the</strong> cornea, in addition<br />

to general ophthalmology.<br />

FALL / WINTER 2002 53


class notes<br />

Author Author!<br />

The third edition <strong>of</strong> Handbook <strong>of</strong> Symptom-<br />

Oriented Neurology, co-written by Roger A.<br />

Brumback, M.D. (R ’86), was published this<br />

year. Brumback, pr<strong>of</strong>essor and chairman <strong>of</strong><br />

<strong>the</strong> Pathology Department at <strong>the</strong> Creighton<br />

<strong>University</strong> School <strong>of</strong> Medicine, St. Joseph<br />

Hospital, in Omaha, Neb., originally wrote<br />

<strong>the</strong> book <strong>with</strong> three o<strong>the</strong>r authors.<br />

The handbook is dubbed an “on-<strong>the</strong>spot<br />

guide to diagnosis and treatment <strong>of</strong><br />

common neurologic complaints.”<br />

In 1986, while still a resident in<br />

pathology at <strong>Rochester</strong>, Brumback started <strong>the</strong><br />

Journal <strong>of</strong> Child Neurology and served as its<br />

first editor-in-chief — a position he still holds<br />

at <strong>the</strong> prestigious and now monthly journal.<br />

Laurence A. Savett, M.D. (M ’61), has written<br />

The Human Side <strong>of</strong> Medicine: Learning<br />

What It’s Like to Be a Patient and What It’s<br />

Like to Be a Physician.<br />

Savett was inspired to write <strong>the</strong> book<br />

because <strong>of</strong> his belief that it’s as important for<br />

a physician to master <strong>the</strong> human side <strong>of</strong> medicine<br />

as it is biology and technology.<br />

“Unless one understands what it’s like<br />

to be a patient, one can’t be a good physician,”<br />

says Savett.<br />

Savett teaches a seminar class at<br />

Macalester College in Minnesota on <strong>the</strong> importance<br />

<strong>of</strong> <strong>the</strong> doctor-patient relationship. He<br />

learned about illness as <strong>the</strong> child <strong>of</strong> seriously<br />

ill parents, as an internist, and as a patient<br />

when he underwent bypass surgery and later<br />

dealt <strong>with</strong> a life-threatening illness.<br />

The book is about what Savett feels is<br />

stimulating about <strong>the</strong> practice <strong>of</strong> medicine:<br />

not fascinating cases but fascinating people<br />

and relations. It’s what Savett considers <strong>the</strong><br />

best reason to enter medicine.<br />

Savett is a clinical pr<strong>of</strong>essor <strong>of</strong> medicine<br />

54<br />

ROCHESTER MEDICINE<br />

at Macalester College and <strong>the</strong> <strong>University</strong> <strong>of</strong><br />

St. Thomas. He also teaches about <strong>the</strong> psychological<br />

and social dimensions <strong>of</strong> medicine and<br />

<strong>the</strong> doctor-patient relationship at <strong>the</strong> <strong>University</strong><br />

<strong>of</strong> Minnesota <strong>Medical</strong> School.<br />

Thomas A. Pearson, M.D., M.P.H., Ph.D., <strong>the</strong><br />

recently appointed senior associate <strong>dean</strong> for<br />

clinical research at <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong><br />

<strong>Medical</strong> <strong>Center</strong>, has put toge<strong>the</strong>r <strong>the</strong> Risk<br />

Assessment Guide to help determine a patient’s<br />

risk for myocardial infarction and also to<br />

detect, evaluate and manage high blood<br />

cholesterol.<br />

The complimentary guide is <strong>of</strong>fered by<br />

KOS Pharmaceuticals, which has printed 165,000<br />

copies. The guide came out <strong>of</strong> Pearson’s work<br />

in <strong>the</strong> Strong Preventive Cardiology Program<br />

at Strong Memorial Hospital.


Adele H<strong>of</strong>mann, M.D. (M ’52)<br />

Adele D. H<strong>of</strong>mann, a pioneer in adolescent<br />

medicine, died June 15, 2001, at <strong>the</strong> age <strong>of</strong> 74.<br />

H<strong>of</strong>mann spent nearly 50 years in pediatrics,<br />

leading a movement that redefined how<br />

<strong>the</strong> medical community viewed and served<br />

adolescents. She combined excellence in<br />

endocrinology, psychology and medicine <strong>with</strong> a<br />

passion for helping teenagers. Due in large part<br />

to her vision and work, adolescent medicine is<br />

now seen as a vital specialty <strong>with</strong>in pediatrics.<br />

After graduating from Smith College,<br />

H<strong>of</strong>mann earned her medical degree from<br />

<strong>Rochester</strong>. She did a pediatric residency at<br />

Babies’ Hospital in New York and was a National<br />

Foundation Fellow in endocrinology at<br />

Presbyterian Hospital. She was affiliated <strong>with</strong><br />

programs at Beth Israel Hospital, NYU <strong>Medical</strong><br />

<strong>Center</strong>, Bellevue Hospital <strong>Center</strong>, Children’s<br />

Hospital <strong>of</strong> Orange County and UC-Irvine.<br />

In <strong>the</strong> ’60s and ’70s, when most physicians<br />

still treated teenagers <strong>the</strong> same as<br />

younger children, H<strong>of</strong>mann was tirelessly<br />

giving a voice to adolescents, empowering<br />

<strong>the</strong>m to be active participants in <strong>the</strong>ir treatment.<br />

Deborah Stewart, associate <strong>dean</strong> <strong>of</strong><br />

medical education at <strong>the</strong> UC-San Francisco<br />

facility in Fresno, calls H<strong>of</strong>mann “<strong>the</strong> grandmo<strong>the</strong>r<br />

<strong>of</strong> adolescent medicine. She was one <strong>of</strong><br />

<strong>the</strong> first doctors to focus a practice on teenage<br />

patients. She championed <strong>the</strong> legal rights <strong>of</strong><br />

adolescents … and she spoke out for granting<br />

teenagers rights to give consent for desperately<br />

needed health care in <strong>the</strong> areas <strong>of</strong> sexuality,<br />

pregnancy, mental health and STDs.” H<strong>of</strong>mann<br />

also was <strong>the</strong> driving force behind guidelines for<br />

<strong>the</strong> confidential treatment <strong>of</strong> adolescents.<br />

She was a charter member and president<br />

<strong>of</strong> <strong>the</strong> Society for Adolescent Medicine. In 1978<br />

she founded <strong>the</strong> Section on Adolescent Health,<br />

a special group <strong>with</strong>in <strong>the</strong> American Academy<br />

<strong>of</strong> Pediatrics.<br />

H<strong>of</strong>mann published many articles on<br />

<strong>the</strong> rights <strong>of</strong> minors, teenage sexuality, adolescent<br />

behavior and treating high-risk youth. In<br />

1982, H<strong>of</strong>mann co-wrote Adolescent Medicine,<br />

a premier textbook now in its third edition.<br />

In 1988, <strong>the</strong> Outstanding Achievement<br />

Award in Adolescent Health <strong>of</strong> <strong>the</strong> American<br />

Academy <strong>of</strong> Pediatrics, which H<strong>of</strong>mann<br />

received in 1984, was renamed The Adele<br />

Dellenbaugh H<strong>of</strong>mann Award in Adolescent<br />

Health. She trained numerous Fellows who<br />

went on to be national leaders in <strong>the</strong> field.<br />

Upon retiring, she served as a consultant<br />

and mentored residents. She volunteered at<br />

a youth shelter, sailed, fished, and spent much<br />

<strong>of</strong> her later years traveling <strong>the</strong> world and<br />

photographing people. In her final trip, she<br />

sailed around Tierra Del Fuego. She died<br />

shortly <strong>the</strong>reafter <strong>of</strong> congestive heart failure.<br />

Adele H<strong>of</strong>mann lived in Laguna Beach,<br />

Calif., and is survived by a daughter, Annie<br />

Gardiner, and son, Peter H<strong>of</strong>mann.<br />

Oksana M. Korzeniowski, M.D. (M ’71)<br />

By Melanie Burney, Philadelphia Inquirer<br />

Oksana M. Korzeniowski, M.D., ’57, <strong>of</strong> Glenside,<br />

a physician and pr<strong>of</strong>essor at <strong>the</strong> <strong>Medical</strong><br />

College <strong>of</strong> Pennsylvania-Hahnemann<br />

<strong>University</strong> School <strong>of</strong> Medicine, died <strong>of</strong> peritoneal<br />

cancer on March 29, 2002.<br />

Korzeniowski, who specialized in diagnosing<br />

and treating infectious diseases, was an<br />

avid researcher, teacher, and advocate for her<br />

patients, colleagues said. She was elected to<br />

four terms as chief <strong>of</strong> <strong>the</strong> medical/dental staff<br />

in memoriam<br />

at <strong>the</strong> medical college. She was a fellow <strong>of</strong> <strong>the</strong><br />

American College <strong>of</strong> Physicians and secretary<br />

<strong>of</strong> <strong>the</strong> American Board <strong>of</strong> Internal Medicine.<br />

She relinquished those responsibilities last year<br />

because <strong>of</strong> her illness. Korzeniowski received<br />

numerous teaching awards, including <strong>the</strong><br />

Golden Apple award in 1987 and 1994.<br />

Her colleagues and former students from<br />

around <strong>the</strong> world recently began compiling<br />

a scrapbook to pay tribute to Korzeniowski.<br />

Known for her sense <strong>of</strong> humor, Korzeniowski<br />

would <strong>of</strong>ten tell patients that <strong>the</strong>y would be<br />

discharged when <strong>the</strong>y could spell her name.<br />

Korzeniowski was born in Ukraine<br />

in 1945 and spent <strong>the</strong> first seven years <strong>of</strong> her life<br />

in displaced-persons camps in Eastern Europe<br />

after her family fled <strong>the</strong>ir war-torn country.<br />

Korzeniowski and her family arrived in <strong>the</strong><br />

U.S. in 1952. She graduated from Philadelphia<br />

High School for Girls.<br />

Korzeniowski earned an undergraduate<br />

degree from <strong>the</strong> <strong>University</strong> <strong>of</strong> Pennsylvania.<br />

She earned her medical degree from <strong>Rochester</strong><br />

in 1971 and undertook post-graduate training<br />

at <strong>the</strong> <strong>University</strong> <strong>of</strong> Virginia School <strong>of</strong> Medicine<br />

in Charlottesville. She joined <strong>the</strong> medical<br />

college staff in 1979 as an assistant pr<strong>of</strong>essor.<br />

She is survived by her husband <strong>of</strong> 20<br />

years, Lee Rudakewych; a daughter, Alexis;<br />

her mo<strong>the</strong>r, Irena Korzeniowski; a sister, Daria<br />

Blackwell; and a bro<strong>the</strong>r, Walter Korzeniowski.<br />

James H. Lockhart Jr., M.D. (R ’44)<br />

James H. Lockhart Jr., M.D., died on Feb. 26 at<br />

<strong>the</strong> age <strong>of</strong> 90 in Rotonda West, Fla. Lockhart,<br />

who lived in Geneseo, N.Y., 45 minutes from<br />

<strong>Rochester</strong>, was extremely active in <strong>the</strong> community,<br />

working <strong>with</strong> numerous committees and<br />

organizations.<br />

“He was very helpful on all <strong>of</strong> <strong>the</strong><br />

committees and was looked up to,” says Arthur<br />

Redmond, M.D. (M ’42) <strong>of</strong> <strong>Rochester</strong>. “He was a<br />

gentleman, but he was also just one <strong>of</strong> <strong>the</strong> boys.”<br />

Lockhart was also a major benefactor<br />

<strong>of</strong> <strong>the</strong> arts. State <strong>University</strong> <strong>of</strong> New York at<br />

FALL / WINTER 2002 55


in memoriam<br />

Geneseo’s new Lockhart Gallery, named after<br />

him, featured his original artwork in its inaugural<br />

exhibit.<br />

Lockhart was predeceased by his wife,<br />

Julia Sc<strong>of</strong>ield Lockhart, in 1980. He is survived<br />

by his daughter, Susan Lockhart, and sons<br />

John M. Lockhart II and James H. Lockhart III,<br />

all <strong>of</strong> Geneseo, and several grandchildren and<br />

great-grandchildren.<br />

Harvey Preisler, M.D. (M ’65)<br />

By Annie Sweeney, Reporter, Chicago Sun-Times<br />

Harvey D. Preisler, a renowned leukemia<br />

researcher and director <strong>of</strong> <strong>the</strong> Rush Cancer<br />

Institute, died May 19, 2002, <strong>of</strong> lymphoma.<br />

He was 61.<br />

From <strong>the</strong> butterfly collection at <strong>the</strong><br />

Notebaert Nature Museum to his own collection<br />

<strong>of</strong> 10,000 books, Preisler spent his days satisfying<br />

his intense curiosity about life and<br />

people, said his wife and colleague, Azra Raza.<br />

He typically slept two hours a night so<br />

he could find time to read, and <strong>the</strong> only pictures<br />

he hung in his <strong>of</strong>fice were <strong>of</strong> his three heroes:<br />

Sigmund Freud, Albert Einstein and Moses.<br />

Preisler believed that Freud had <strong>the</strong><br />

biggest impact in this century on how humans<br />

interact, that Einstein had <strong>the</strong> biggest impact<br />

in science and technology, and that Moses was<br />

<strong>the</strong> greatest leader <strong>of</strong> men, she said.<br />

“He was <strong>the</strong> single most intellectually<br />

curious person,” Raza said. “His mind is just<br />

incredible, his desire to learn more and more<br />

about all sorts <strong>of</strong> things.”<br />

Preisler dedicated his life to finding a<br />

cure for leukemia, Raza said. She said her<br />

husband’s favorite quote was borrowed from a<br />

56<br />

ROCHESTER MEDICINE<br />

colleague: “If I had a choice between a walk on<br />

<strong>the</strong> moon and curing one person <strong>with</strong> leukemia,<br />

I would never look at <strong>the</strong> moon again.”<br />

Preisler was named director <strong>of</strong> <strong>the</strong><br />

Cancer Institute at Rush in 1992 and later was<br />

named <strong>the</strong> Samuel G. Taylor Pr<strong>of</strong>essor <strong>of</strong><br />

Medicine at Rush-Presbyterian-St. Luke’s<br />

<strong>Medical</strong> <strong>Center</strong>. He was a leader in “bench-tobedside”<br />

research in acute myeloid leukemias.<br />

He conducted molecular research on leukemia<br />

cells and <strong>the</strong>n turned <strong>the</strong>m into <strong>the</strong>rapies that<br />

improved <strong>the</strong> outcome for his patients.<br />

And that, Raza said, was his greatest joy.<br />

“<br />

Such a beautiful smile would come on his face”<br />

when he spoke <strong>of</strong> past patients, Raza said.<br />

Preisler earned his undergraduate degree<br />

from Brooklyn College. He earned his medical<br />

degree from <strong>Rochester</strong> and trained at New York<br />

Hospital-Cornell <strong>Medical</strong> <strong>Center</strong>, and specialized<br />

in medical oncology at <strong>the</strong> National Cancer<br />

Institute in Washington, D.C., and at Columbia<br />

Presbyterian Hospital in New York City.<br />

Preisler worked at Mount Sinai Hospital<br />

in New York City, at Roswell Park Cancer<br />

Institute in Buffalo, N.Y., directing <strong>the</strong> leukemia<br />

service, and at <strong>the</strong> Barrett Cancer <strong>Center</strong> at <strong>the</strong><br />

<strong>University</strong> <strong>of</strong> Cincinnati. In addition to his wife,<br />

Preisler is survived by his daughters Sarah,<br />

Vanessa and Sheherzad; his son, Mark, his<br />

parents and his bro<strong>the</strong>r.<br />

Paul Stark, Ph.D., J.D. (Ph.D. ’64)<br />

Courtesy <strong>of</strong> The Indianapolis Star<br />

Paul Stark, Ph.D., J.D., 73, <strong>of</strong> Sanibel Island, FL<br />

and <strong>of</strong> Indianapolis, IN, passed away in Ft.<br />

Myers, FL, on February 22, 2002.<br />

During <strong>the</strong> 1950s Stark was a pharma-<br />

cologist, and from 1965 to 1984 he was clinical<br />

assistant pr<strong>of</strong>essor <strong>of</strong> pharmacology at <strong>the</strong><br />

Indiana <strong>University</strong> School <strong>of</strong> Medicine. From<br />

1963 to 1984 he served as medical director for<br />

Eli Lilly & Company, where he played an essential<br />

role in <strong>the</strong> development <strong>of</strong> Prozac.<br />

Stark earned his B.S. in Biochemistry<br />

from McGill <strong>University</strong> in Montreal, Canada<br />

1945–1949, attended Western Reserve<br />

<strong>University</strong>’s Department <strong>of</strong> Pharmacology in<br />

Cleveland, OH 1950–1952, received his Ph.D. in<br />

Pharmacology from <strong>Rochester</strong> in 1960–1963<br />

and received his J.D. <strong>with</strong> honors from <strong>the</strong><br />

IU School <strong>of</strong> Law-Indianapolis 1973–1977 He<br />

was admitted into <strong>the</strong> Indiana Bar in 1977.<br />

He was president and CEO <strong>of</strong> International<br />

Clinical Research Corporation, a company he<br />

founded in San Diego, Calif., until 1995.<br />

He and his wife, Carole Stark, endowed<br />

<strong>the</strong> Paul Stark Chair in Pharmacology at <strong>the</strong><br />

Indiana <strong>University</strong> School <strong>of</strong> Medicine in 1993.<br />

The chair was endowed to provide lasting<br />

support for pharmacological research <strong>of</strong> <strong>the</strong><br />

central nervous system. A chair was also<br />

endowed at <strong>the</strong> <strong>University</strong> <strong>of</strong> <strong>Rochester</strong>. The<br />

Starks also established <strong>the</strong> Stark Neurosciences<br />

Research Institute, <strong>the</strong> Stark Neurosciences<br />

Scholarship Fund and <strong>the</strong> Stark Foundation,<br />

which provides scholarships to colleges. The<br />

Stark Neurosciences Research Institute will<br />

house researchers from many disciplines.<br />

Stark was preceded in death by his first<br />

wife, Rita Smalline Stark. Survivors include his<br />

wife, Carole Lucas Stark; daughters, Mona L<strong>of</strong>t,<br />

Barbar Stark and Toby Stark; stepdaughters,<br />

Lynn Lapin and Susan Fuldauer; bro<strong>the</strong>r,<br />

Norman Stark; and one grandchild.<br />

In Memoriam<br />

Raymond Gramiak, M.D. (M ’49, R ’51)<br />

Frank W. McKee, M.D. (M ’43)<br />

Raymond A. Russell (M.S. ’41, Ph.D. ’51)<br />

Henry F. Stoltmann, M.D. (R ’62)<br />

W. George Swalbach, M.D. (B.S. ’36, M ’43)


<strong>Appointment</strong> <strong>with</strong> <strong>the</strong> <strong>dean</strong><br />

from page 11<br />

So, Guzick has one more ball to toss in<br />

<strong>the</strong> air. Yet through it all, <strong>the</strong>re’s one area he<br />

has vowed not to slight: time <strong>with</strong> family. His<br />

ideal morning is to get up by 5:30, hit <strong>the</strong> gym<br />

and return home in time to wake up his two<br />

sons and feed <strong>the</strong>m breakfast before school.<br />

Ask him about hobbies, and he answers<br />

“<br />

Benjamin and Andrew,” ages 10 and 12.<br />

“I don’t know if you call that a hobby,<br />

but that’s what I do,” he explains. “If <strong>the</strong>y’re<br />

awake and <strong>the</strong>y’re here, <strong>the</strong>n I don’t do any<br />

work. I spend time <strong>with</strong> <strong>the</strong>m.”<br />

Sure he plays golf whenever he can,<br />

but mostly when <strong>the</strong> course is empty so he can<br />

walk nine holes quickly, preferably <strong>with</strong> one<br />

<strong>of</strong> his sons. Or, he’ll get some work done while<br />

he plays. Jim Woods recalls a working weekend<br />

<strong>with</strong> Guzick in Vermont two years ago<br />

consisting <strong>of</strong> nonstop golf while <strong>the</strong>y<br />

hammered out strategic plans — <strong>the</strong> very<br />

plans Woods is implementing as <strong>the</strong> new<br />

department chair.<br />

Guzick saves his work-at-home time for<br />

late at night, after <strong>the</strong> kids are in bed. So when<br />

does he sleep? Hoeger says, “I’m not sure he<br />

does, to be honest.”<br />

Guzick smiles when <strong>the</strong> subject comes up.<br />

“I’m not one <strong>of</strong> those who only needs<br />

three or four hours <strong>of</strong> sleep, but sometimes<br />

that’s all I get,” he admits.<br />

How appropriate that his wife, Donna<br />

Giles, Ph.D., a pr<strong>of</strong>essor in <strong>the</strong> Department <strong>of</strong><br />

Psychiatry, works as a sleep researcher. People<br />

have joked that he could probably serve as a<br />

subject in one <strong>of</strong> her studies.<br />

Hmmm, a clinical research study?<br />

No one would be surprised if he tried to fit it in.<br />

Not all play<br />

from page 32<br />

Just three months after <strong>the</strong> injury, Adam<br />

took his first step.<br />

“It was a real miracle, to be honest <strong>with</strong><br />

you,” Sebastianelli says.<br />

Sebastianelli continued to help Adam’s<br />

family <strong>with</strong> things like preparing <strong>the</strong>ir house<br />

for <strong>the</strong>ir son, who needed rails in <strong>the</strong> bathroom<br />

and a lift system to get up stairs. Now, two years<br />

later, Adam can throw a ball, write, use a<br />

computer — all <strong>with</strong> reduced strength and<br />

speed, but effectively. And he’s back <strong>with</strong> <strong>the</strong><br />

team, analyzing game film and, more important,<br />

inspiring everyone around him.<br />

Even now, Sebastianelli says he still gets<br />

upset when he thinks about <strong>the</strong> injury. But he<br />

tries to look for a larger meaning.<br />

“All I know is this kid has touched more<br />

lives working through this injury than he ever<br />

would have playing football,” he says. “He has<br />

been placed on a pedestal <strong>of</strong> admiration, and<br />

he’s helping people who are less fortunate.”<br />

Adam has done work <strong>with</strong> <strong>the</strong> Special<br />

Olympics and troubled youth and is an ambassador<br />

for people who have suffered similar<br />

injuries. “He’s been given a different stage,”<br />

is how Sebastianelli puts it.<br />

Being part <strong>of</strong> a miraculous recovery like<br />

that is why Sebastianelli says he wouldn’t trade<br />

his job for anything. Likewise, Lintner says that<br />

<strong>the</strong> satisfaction from his work makes all <strong>the</strong><br />

extra hours worthwhile. He talks <strong>of</strong> <strong>the</strong> pride in<br />

operating on someone’s torn-up knee and <strong>the</strong>n<br />

watching <strong>the</strong> player stretch a single into a<br />

double, or repairing a pitcher’s shoulder and<br />

seeing him regain his form and throw a fastball<br />

in <strong>the</strong> mid-90s again. Plus, <strong>the</strong>re is a bit<br />

<strong>of</strong> glamour after all.<br />

“How many people get to stand on <strong>the</strong><br />

sidelines at <strong>the</strong> start <strong>of</strong> a pro football game?”<br />

Lintner says. “Just <strong>the</strong> excitement <strong>of</strong> competition<br />

at that level is exhilarating.”<br />

It’s exhilarating for his sons, too,<br />

who at age 5 and 10 are big sports fans. They<br />

only have one complaint. As Lintner explains<br />

it, “They don’t like that I can’t sit <strong>with</strong> <strong>the</strong>m<br />

in <strong>the</strong> stands.”<br />

Pioneers in <strong>the</strong> field<br />

from page 33<br />

Jennifer Capriati, Martina Hingis and Arantxa<br />

Sanchez Vicario, and she was team physician<br />

for <strong>the</strong> U.S. Olympic tennis team in <strong>the</strong> last two<br />

Olympic Games.<br />

As female residents in <strong>the</strong> physically<br />

demanding field <strong>of</strong> orthopaedics, both women<br />

faced doubters. But DeHaven recalls that it<br />

didn’t discourage <strong>the</strong>m. Arendt credits <strong>the</strong><br />

people at <strong>Rochester</strong> for not limiting her<br />

because she was a woman. “I was so grateful<br />

for that,” she says. “My mentors encouraged<br />

me. I wasn’t treated any differently than my<br />

male cohorts.” It was only after leaving<br />

<strong>Rochester</strong>, she says, that she met people who<br />

thought she was crazy for wanting to enter<br />

sports medicine. But by <strong>the</strong>n, she had crossed<br />

enough barriers to know how to persevere.<br />

These days, <strong>the</strong> sports Arendt plays are a<br />

little easier on <strong>the</strong> joints than in <strong>the</strong> past: golf,<br />

biking, cross-country skiing. She leaves <strong>the</strong><br />

rougher stuff to her 13-year-old daughter (who,<br />

like her mo<strong>the</strong>r, samples numerous sports<br />

nonstop, including soccer, volleyball and swimming)<br />

and her 16-year-old son, who plays<br />

hockey and football. In o<strong>the</strong>r words, it’s not<br />

easy for Arendt to leave those sideline worries<br />

behind, even when she’s <strong>of</strong>f duty.<br />

“There are fears both <strong>of</strong>ficially and<br />

un<strong>of</strong>ficially,” she says. “But I’m far more<br />

anxious watching my son playing hockey.”<br />

FALL / WINTER 2002 57


<strong>University</strong> <strong>of</strong> <strong>Rochester</strong><br />

School <strong>of</strong> Medicine and Dentistry<br />

601 Elmwood Avenue, Box 643<br />

<strong>Rochester</strong>, NY 14642<br />

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