Review of Pharmacology - 9E (2015)

33. Post dural (Spinal) puncture headache is due to:
(a) Seepage of CSF (UP 2007)
(b) Fine needle
(c) Toxic effects of the drugs
(d) Traumatic damage to nerve roots
34. True statement regarding Bupivacaine is:
(a) Used intravenously along with lignocaine (UP 2005)
(b) More cardiotoxic than lignocaine
(c) Contraindicated in pregnancy
(d) All of the above
35. Percentage of lignocaine used in spinal anesthesia is:
(a) 0.5% (RJ 2001)
(b) 1%
(c) 2%
(d) 5%
36. The mechanism of action of local anesthetics is that
they act on Na + channels in their:
(a) Activated state (Kolkata 2008)
(b) Inactivated state
(c) Resting state
(d) Any state
37. The most potent and longest acting anaesthetic agent
is: (Karnataka 2008)
(a) Dibucaine
(b) Tetracaine
(c) Bupivacaine
(d) Lignocaine
38. Adrenaline is added to lignocaine to prolong its effect
and decrease its absorption into blood stream in a ratio of:
(a) 1:50,000 (Karnataka 2006)
(b) 1:100,000
(c) 1:200,000
(d) 1:500,000
Skeletal Muscle Relaxants
39. Which of the following skeletal muscles is relaxed first
by tubocurarine? (AIIMS Nov, 2013)
(a) Respiratory
(b) Fingers
(c) Limbs
(d) Head and neck
40. Central muscle relaxants act by: (PGI June, 2002)
(a) Decreasing nerve conduction
(b) Inhibiting spinal polysynaptic reflexes
(c) Blocking conduction across NM junction
(d) Causing CNS depression
(e) Decreasing muscle excitation
41. Which of the following drugs has spasmolytic activity
and could also be used in the management of seizure
caused by overdose of a local anesthetic?
(a) Baclofen (AIIMS May 2012)
(b) Dantrolene
(c) Diazepam
(d) Tizanidine
Anaesthesia
42. Which one of the following skeletal muscle relaxants
causes pain on injection? (AIIMS Nov 2011) (AI 2012)
(a) Succinyl choline
(b) Vecuronium
(c) Rocuronium
(d) Pancuronium
43. Cis-atracurium is preferred over atracurium, because:
(a) It has rapid onset of action (AIIMS May 2011)
(b) It causes less release of histamine
(c) It has short duration of action
(d) It has less depressant action on heart
44. Laudanosine is a metabolite of:
(a) Atracurium (AIIMS May 2011)
(b) Cis-atracurium
(c) Pancuronium
(d) Vecuronium
45. Muscular rigidity caused by opioids is due to the
agonistic effect on which receptor?
(a) Mu (AIIMS May 2011)
(b) Kappa
(c) Delta
(d) Sigma
46. A 70 kg young athlete was planned for surgery. During
anaesthesia, vecuronium was not available, so repeated
doses of succinylcholine was given intermittently up
to 640 mg. During recovery, patient was not able to
spontaneously respire and move limbs. What is the
cause?
(a) Pseudocholinesterase deficiency (AIIMS Nov 2010)
(b) Phase II blockade
(c) Muscle weakness due to repeated fasciculations
(d) Undiagnosed muscular dystrophy
47. The administration of succinylcholine to a paraplegic
patient led to appearance of dysarrythmias, conduction
abnormalities and finally cardiac arrest. The most likely
cause is: (DPG 2011)
(a) Hypercalcemia
(b) Hyperkalemia
(c) Anaphylaxis
(d) Hypermagnesemia
48. Muscle relaxant of choice in liver disease is?
(a) Atracurium (AI 2010)
(b) Pipecuronium
(c) Rocuronium
(d) Vecuronium
49. Which of the following is a metabolite of carisoprodol?
(AIIMS Nov 2009)
(a) Doxylamine
(b) Meprobromate
(c) Dimethadione
(d) Amphetamine
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General Anaesthesia Pharmacology
https://kat.cr/user/Blink99/