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Review of Pharmacology - 9E (2015)

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(c) Erythropoietin<br />

(d) Filgrastim (G-CSF)<br />

14. The difference between iron sorbitol-citric acid and<br />

iron dextran is that the former<br />

(a) Cannot be injected i.v.<br />

(b) Is not bound to transferrin in plasma<br />

(c) Is not excreted in urine<br />

(d) Produces fewer side effects<br />

15. Which <strong>of</strong> the following metabolic reactions require<br />

vitamin B 12<br />

but not folate?<br />

(a) Conversion <strong>of</strong> malonic acid to succinic acid<br />

(b) Conversion <strong>of</strong> homocysteine to methionine<br />

(c) Conversion <strong>of</strong> serine to glycine<br />

(d) Thymidylate synthesis<br />

16. Which <strong>of</strong> the following is an indication for the use <strong>of</strong><br />

folinic acid?<br />

(a) Prophylaxis <strong>of</strong> neural tube defects in the <strong>of</strong>fspring <strong>of</strong><br />

women receiving anticonvulsant medications<br />

(b) Counteracting toxicity <strong>of</strong> high dose methotrexate<br />

therapy<br />

(c) Pernicious anemia<br />

(d) Anemia associated with renal failure<br />

17. An old woman is required to receive 4 cycles <strong>of</strong> cancer<br />

chemotherapy. After her first cycle, she developed<br />

chemotherapy induced thrombo-cytopenia. Then in the<br />

next cycle, it would be appropriate to give this patient:<br />

(a) Darbopoietin alpha<br />

(b) Filgrastim (G-CSF)<br />

(c) Iron dextran<br />

(d) Oprelvekin (IL-11)<br />

18. A 40 year old man has megaloblastic anemia and early<br />

signs <strong>of</strong> neurological abnormality. The drug most<br />

probably required is:<br />

(a) Folic acid<br />

(b) Iron sulphate<br />

(c) Erythropoietin<br />

(d) Vitamin B 12<br />

19. A patient Seeta is diagnosed to be having iron deficiency<br />

anemia. The agent that can be used to improve<br />

the absorption <strong>of</strong> iron is:<br />

(a) Antacids<br />

(b) Tetracyclines<br />

(c) Phosphates<br />

(d) Ascorbic acid<br />

20. Dr Nitin decided to give oral iron therapy to a patient <strong>of</strong><br />

iron deficiency anemia. Which <strong>of</strong> the following adverse<br />

effects leads to poor compliance <strong>of</strong> medicine by the<br />

patient?<br />

(a) Epigastric pain and bowel upset<br />

(b) Black stools<br />

(c) Staining <strong>of</strong> teeth<br />

(d) Metallic taste<br />

Hematology<br />

21. An old man, Om prakash presented with anorexia,<br />

weak ness and paraesthesia. On further investigation<br />

his hemoglobin came out to be 5.8 g% and the<br />

peripheral smear showed the presence <strong>of</strong> macrocytes<br />

and neutrophils having hypersegmented nuclei. His<br />

tendon reflexes also were sluggish. Endoscopy revealed<br />

atrophic gastritis. Deficiency <strong>of</strong> which <strong>of</strong> the following<br />

factors can lead to such a clinical situation?<br />

(a) Folic acid<br />

(b) Vitamin B 12<br />

(c) Pyridoxine<br />

(d) Rib<strong>of</strong>lavin<br />

22. Megaloblastic anaemia may be caused by all <strong>of</strong> the<br />

following, except: (MPPG 2007)<br />

(a) Dilantin toxicity<br />

(b) Vitamin B 12<br />

deficiency<br />

(c) Folic acid deficiency<br />

(d) Long term aspirin intake<br />

23. Megaloblastic anemia is caused by all EXCEPT:<br />

(a) Aspirin (MPPG 2004)<br />

(b) Primidone<br />

(c) Methotrexate<br />

(d) N 2<br />

O<br />

24. Folic acid: (TN 2006)<br />

(a) Is also called as pteroyl glutamic acid<br />

(b) Is useful in carriage <strong>of</strong> one carbon atom moiety<br />

(c) Tetrahydr<strong>of</strong>olate is the active form<br />

(d) All <strong>of</strong> the above<br />

25. Filgrastim is a: (TN 2008)<br />

(a) T-cell stimulating factor<br />

(b) GnRH analogue<br />

(c) G-CSF<br />

(d) GM-CSF<br />

26. Erythropoietin is mainly produced in: (RJ 2006)<br />

(a) Liver<br />

(b) Kidney<br />

(c) Intestine<br />

(d) Bone<br />

27. Indication for intramuscular iron therapy is:<br />

(a) Pregnancy (MH 2000)<br />

(b) Postpartum period<br />

(c) Emergency surgery<br />

(d) Oral iron intolerance<br />

28. Methotrexate should be given with which <strong>of</strong> the<br />

following to decrease its side effects? (MH 2002)<br />

(a) Folic acid<br />

(b) Cyanocobalamin<br />

(c) Thiamine<br />

(d) Folinic acid<br />

29. Macrocytic anemia is noted with all <strong>of</strong> the following<br />

except: (Jharkhand 2006)<br />

(a) Phenytoin<br />

(b) Methotrexate<br />

(c) Pyrimethamine<br />

(d) Cipr<strong>of</strong>loxacin<br />

451<br />

General Hematology <strong>Pharmacology</strong><br />

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