Review of Pharmacology - 9E (2015)

120. Regarding ritonavir use in AIDS patient, which of the
following is/are true? (PGI Dec. 2004)
(a) Interacts with terfenadine
(b) G.I. symptoms are seen
(c) Contraindicated in renal failure
(d) It is NNRTI
(e) Should not be used in AIDS patient with bleeding
disorder
121. Bone marrow depressive drugs in the treatment of
AIDS patient are: (PGI June, 2003)
(a) Didanosine
(b) Zalcitabine
(c) Zidovudine
(d) Cotrimoxazole
(e) Ganciclovir
122. Drugs used for treatment of chorioretinitis in AIDS
patients are: (PGI June, 2003)
(a) Valacyclovir
(b) Ganciclovir
(c) Rivabirin
(d) Amantadine
(e) Cidofovir
123. Protease inhibitors are: (PGI Dec. 2002)
(a) Saquinavir
(b) Nevirapine
(c) Nelfinavir
(d) Abacavir
(e) Efavirenz
124. Which of the following statements about stavudine is
accurate?
(a) Bone marrow suppression is dose limiting
(b) It causes marked neurotoxicity
(c) It inhibits HIV protease
(d) It is a non-nucleoside reverse transcriptase inhibitor
125. Select the drug that is active against both HIV and
hepatitis B virus:
(a) Lamivudine
(b) Indinavir
(c) Didanosine
(d) Efavirenz
126. Efavirenz limits HIV infection by:
(a) Binding to active site of HIV reverse transcriptase
(b) Impairing the binding of HIV virion to CD4 receptors
on T- cells
(c) Inhibiting the HIV protease
(d) Serving as an allosteric inhibitor of HIV reverse
transcriptase
127. Which of the following drugs inhibits post translational
modification of viral proteins?
(a) Indinavir
(b) Enfuvirtide
(c) Lamivudine
(d) Zalcitabine
Chemotherapy B: Antimicrobials for Specific Conditions
128. Which of the following binds to viral envelope glycoprotein
preventing the conformational changes required
for the fusion of viral and cellular membranes?
(a) Abacavir
(b) Indinavir
(c) Enfuvirtide
(d) Oseltamivir
129. A patient with AIDS and a CD4 cell count of 100/µl,
has a persistent fever and a weight loss associated with
invasive pulmonary disease due to M avium complex.
Optimal management of this case requires:
(a) Select an antibiotic regimen based on drug
susceptibility of the cultured organism
(b) Start treatment with isoniazid and rifampicin
(c) Treat the patient with clarithromycin, ethambutol
and rifabutin
(d) Treat with trimethoprim sulfamethoxazole
130. In an accidental needle stick, an unknown quantity of
blood from an AIDS patient is injected into a nurse.
The most recent laboratory report on the AIDS patient
shows a CD4 count of 20/µL and a viral RNA load of
greater than 10 7 copies/ml. The most appropriate course
of action regarding treatment of the nurse is to:
(a) Monitor the nurse’s blood to determine whether HIV
transmission has occurred
(b) Treat with full doses of zidovudine for 2 weeks
(c) Add acyclovir to the 4-weeks zidovudine regimen
(d) Administer zidovudine with lamivudine for 4 weeks
131. Which of the following drugs is most likely to cause
additive anemia and neutropenia if administered to an
AIDS patient taking zidovudine?
(a) Acyclovir
(b) Amantadine
(c) Ganciclovir
(d) Stavudine
132. Zidovudine and didanosine used in HAART act by:
(a) Inhibitory effects on viral DNA (UP 2008)
(b) Nucleoside reverse transcriptase inhibition
(c) Inhibit the synthesis of gp41
(d) Protease inhibition
133. Zidovudine causes: (UP 2005)
(a) Neurotoxicity
(b) Nephrotoxicity
(c) Neutropenia
(d) Ototoxicity
134. Antiviral drug having dual antiviral activity against
HIV and HBV is: (RJ 2008)
(a) Enfuvirtide
(b) Emtricitabine
(c) Abacavir
(d) Entecavir
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Chemotherapy B: General Antimicrobials Pharmacology for Specific Conditions
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