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A publication for alumni, friends and donors of the University of Washington Division of Gastroenterology


READ MORE DR. ALEXANDER ENDE: SYMPTOMATIC PANCREATIC DUCT STONES IN THE DISCONNECTED BILE DUCT. PUBLISHED IN PANCREATOLOGY. Pancreaticobiliary maljunction refers to the union of the pancreatic and biliary ducts outside of the duodenal wall. Patients are at increased risk of bile duct and gallbladder cancer, likely secondary to pancreatic juice refluxing into the biliary tree, and it is recommended that they undergo biliary diversion. DR. FENG SU (FELLOW) AND DR. GEORGE IOANNOU: ASSOCIATION BETWEEN RACE/ETHNICITYAND THE EFFECTIVENESS OF DIRECT ANTIVIRAL AGENTS FOR HEPATITIS C VIRUS INFECTION. PUBLISHED IN HEPATOLOGY. New direct-acting antiviral agents (DAAs) have substantially changed the hepatitis C virus (HCV) treatment landscape. Different racial and ethnic groups in the United States are known to have different responses to traditional, interferon-based HCV regimens. It is not yet clear whether the effectiveness of DAAs varies between racial and ethnic groups. READ MORE READ MORE DR. GEORGE IOANNOU: TRANSPLANT-RELATED SURVIVAL BENEFIT SHOULD INFLUENCE PRIORITIZATION FOR LIVER TRANSPLANTATION. PUBLISHED IN LIVER TRANSPLANTATION. Transplant-related survival benefit is calculated as the difference between life expectancy with transplantation and life expectancy without transplantation. Determining eligibility and prioritization for liver transplantation based on the highest survival benefit is a superior strategy to prioritization based on the highest urgency or the highest utility, because prioritization based on the highest survival benefit maximizes the overall life expectancy of all patients in need of liver transplantation. FACULTY IN THE NEWS DR. JOHN INADOMI: SCREENING FOR COLORECTAL NEOPLASIA. PUBLISHED IN THE NEW ENGLAND JOURNAL OF MEDICINE. Colorectal cancer is the third most commonly diagnosed cancer and cause of death from cancer in the United States; however, it can be detected in asymptomatic patients at a curable stage. Multiple strategies are available to screen patients who are at average risk for the development of colorectal cancer. Each strategy has differing characteristics with respect to accuracy, invasiveness, interval, costs, and quality of evidence supporting its use. READ MORE READ MORE DR. NINA SAXENA (FELLOW) AND DR. JOHN INADOMI: EFFECTIVENESS AND COST-EFFECTIVENESS OF ENDOSCOPIC SCREENING AND SURVEILLANCE. PUBLISHED IN GASTROINTESTINAL ENDOSCOPY CLINICS OF NORTH AMERICA. Guidelines for the screening and surveillance of Barrett’s esophagus continue to evolve as the incidence of esophageal adenocarcinoma increases, identification of individuals at highest risk for cancer improves, and management of dysplasia evolves. Advances in diagnosis offer promising strategies to help focus screening efforts on those individuals who are most likely to develop esophageal adenocarcinoma. DR. LISA STRATE: ARE MAJOR DIETARY PATTERNS ASSOCIATED WITH RISK OF INCIDENT DIVERTICULITIS? PUBLISHED IN GASTROENTEROLOGY. Dietary fiber is implicated as a risk factor for diverticulitis. Analyses of dietary patterns may provide information on risk beyond those of individual foods or nutrients. The increasing incidence of diverticulitis has been attributed to changes in diet and lifestyle, predominantly a decrease in dietary fiber consumption. READ MORE

DR. STEPHEN VINDIGNI (FELLOW) AND DR. CHRISTINA SURAWICZ: FECAL MICROBIOTA TRANSPLANTATION. PUBLISHED IN GASTROENTEROLOGY CLINICS OF NORTH AMERICA. Fecal microbiota transplantation (FMT) is the transfer of stool from a healthy donor into the colon of a patient whose disease is a result of an altered microbiome, with the goal of restoring the normal microbiota and thus curing the disease. The most effective and well-studied indication for FMT is recurrent Clostridium difficile infection. The field is rapidly emerging and has become a focus in both the public media and peer-reviewed literature. READ MORE READ MORE DR. JOSEPH ROBERTS (FELLOW) AND DR. ANDREW KAZ: ANAL INTRAEPITHELIAL NEOPLASIA. PUBLISHED IN THE WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY. AIN is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. Although anal cancer is relatively uncommon, rates of this malignancy are steadily rising in the United States, and among certain high risk populations the incidence of anal cancer may exceed that of colon cancer. DR. BRIAN REID: GENOMICS, ENDOSCOPY AND CONTROL OF GASTROESOPHAGEAL CANCERS: A PERSPECTIVE. PUBLISHED IN CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY. Esophageal adenocarcinoma (EA) is remarkably similar to gastric adenocarcinoma CIN subtype. Current enthusiasm for endoscopic control of EA has little impact on mortality. Current strategies need to be revisited given emerging evidence that many cancers develop rapidly by punctuated and catastrophic genome evolution. READ MORE READ MORE DR. WILLIAM DEPAOLO STUDIES BACTERIA, BUT HIS SCIENCE GOES VIRAL. PUBLISHED BY THE WHOLE U: FACULTY FRIDAY SERIES. The associate professor of medicine’s videos exploring the bacterial science behind everyday objects have amassed millions of hits on BuzzFeed and led to appearances on The Today Show, but DePaolo, the director of the University of Washington’s new Center for Microbiome Sciences and Therapeutics (CMiST), says he sees his sliver of cyber celebrity as a means to an end. DR. GEORGE MCDONALD: PREDICTIVE VALUE OF CLINICAL FINDINGS AND PLASMA BIOMARKERS AFTER 14 DAYS OF PREDNISONE TREATMENT FOR ACUTE GVHD. PUBLISHED IN BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION. The frequency of acute graft-versus-host-disease (GVHD) after allogeneic hematopoietic cell transplantation is in the 50% to 70% range, with gastrointestinal symptoms the most common presentation. A recent study examines the hypothesis that plasma biomarkers and concomitant clinical findings after initial glucocorticoid therapy can accurately predict failure of GVHD treatment and mortality. READ MORE READ MORE DR. TATIANA KHOKHLOVA: BOILING HISTOTRIPSY OF DEEP ABDOMINAL TISSUE TARGETS. PUBLISHED IN ULTRASOUND IN MEDICINE AND BIOLOGY. Boiling histotripsy (BH) is a high-intensity focused ultrasound (HIFU)–based method of mechanical tissue fractionation that utilizes millisecond-long bursts of HIFU shock waves to cause boiling at the focus in milliseconds. Multiple clinical applications for BH have been suggested, primarily in oncology, to mechanically ablate unwanted soft tissues. The most relevant applications, in which traditional HIFU is faced with substantial problems, are deep abdominal organ malignancies, including the liver, pancreas and kidney.