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1 year ago

Charlot Biosciences - Customer Brochure

Charlot Biosciences is commercializing innovative physics to study life. We are introducing a novel live cell analysis platform to the world of cell sorting and analysis. The technology is called cellPhoresis™. The Technology: Our platform has the unique ability to rapidly fractionate and sort cells based on biophysical properties.allowing researchers to study important differences between living cells only identifiable with genetic sequencing or protein sequencing. Being an agnostic approach to cell separation, we can support wide range of applications ranging from CRISPR gene editing verification, drug discovery for diseases like cancer and Alzheimer’s, and diagnostic assay development.

The technology is backed by exclusive IP from ASU, Cal-Tech, and Charlot Biosciences. The platform separates cells based on inherent biophysical properties (external properties as well as internal structure and content). This approach enables the identification of important differences between live cells without labeling or destructive alteration. This benefit saves labs both time and money. The technology has already been validated in rapid pathogen identification and used for tracking human embryonic stem cell differentiation into various neural populations. Our interested partners have cited the value our cellPhoresis™ platform provides to develop new classes of molecular assays that help researchers and pharmaceutical companies screen for unintended side effects of gene therapy. Our affordable technology also enables enrichment of cells based on functional differences prior to nucleic acid purification and NGS. This approach enables faster discover of new biomarkers associated with complex disease.

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cellPhoresis High resolution separation of cells based on their inherent biophysical properties. cellPhoresis combines the power of cytometry and electrophoresis within a micro channel. The technology exploits high resolution insulating gradient dielectrophoresis to provide researchers the ability to perform gel-free electrophoretic separation of cells. This approach is akin to gradient gel electrophoresis for cells and other biomolecules without the fuss. cellPhoresis is gel-free electrophoretic cytometry powered by electricity. Amazing what a little charge can do! Vision A multifunciontal platform for every lab. Charlot Biosciences' Vision platform brings solid-state optics with outstanding sensitivity, maximum resolution, and zero pixel shift to all researchers. The system streamlines filtration, refinement, and quantification of biomolecules directly from physiological samples. Rapid Detection of Pathogens Characterization of Stem Cells Isolation of Exosomes Sorting of Nanoparticles Antibiotic Resistance and Lyme Disease ImmunoTherapy and Drug Discovery Diabetes, Inflammatory Disease, Oncology NGS, Drug Delivery Research, Basic Science

How It Works CRISPR Verification cellPhoresis 8-Channel Launching Q3 2018 We will save companies time and recurring costs to validate gene editing. We verify all of the edited cells. A New Form of Biophysical Analysis Life Science (Dynamically track live cell activity) Verifiable predictive power Identify and track side effects V2 - The verification cohort of cells can be used for therapy or additional testing. Cells are alive, viable, and useful for therapy