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final_thp_3rdedition

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De Novo<br />

by Loranna Grigoryan and Jon Lee<br />

development, and the<br />

biochemical machinery<br />

responsible for this<br />

coordination. Dr. Segil told<br />

us this: “We are engaged in<br />

identifying and manipulating<br />

sensory progenitors/stem<br />

cells as potential targets<br />

for therapeutic approaches<br />

to hearing loss through<br />

regeneration. We have<br />

developed tools, in the form of<br />

cell-type specific markers and<br />

purification techniques, as well<br />

as cell culture methods<br />

for studying the behavior of<br />

sensory cell progenitors. We<br />

are currently using these tools<br />

to characterize the lineage<br />

and regenerative potential of<br />

specific cell populations within<br />

the postnatal inner ear.”<br />

Based on this, we decided<br />

to create a piece that reflects<br />

all of the above. Hence, we<br />

have the base/structure look<br />

like the DNA double helix,<br />

which holds the ears that are<br />

arranged like inner ear hair<br />

cells.<br />

We spoke with Dr. Segil from<br />

the Broad/CIRM Center<br />

for Regenerative Medicine<br />

and Stem Cell Research. Dr.<br />

Segil explained to us that<br />

their research is on embryonic<br />

development of the inner ear.<br />

The researchers are exploring<br />

the proliferation of cells, their<br />

growth and<br />

USC Roski + Stem Cell<br />

Stem cell research through the lens of art<br />

PAGE | 33 PAGE | 34

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