Table V. Correlations between WHOQOL-HIV domains and general quality of Life facets. Physical Psychol. Level of Indep. Social Rel. Environ. Spirit. General QOL Physical 1.000 Psychological 0.708* 1.000 Level of Indep 0.704* 0.645* 1.000 Social Rel. 0.525* 0.735* 0.535* 1.000 Environment 0.532* 0.663* 0.491* 0.731* 1.000 Spirit. 0.576* 0.723* 0.458* 0.564* 0.533* 1.000 General QOL 0.619* 0.635* 0.528* 0.638* 0.692* 0.501* 1.000 Note: *pB0.01. Quality of life in HIV-positive Brazilians 929 Downloaded by [Tulane University] at 08:09 12 January 2015 Independence domains. It is feasible that increased presence of symptoms, which limits self-management, increases the quantity of necessary anti-retroviral drugs. Moreover, the need for an increased number of medications may create the feeling of dependency on drugs and have repercussions in self-esteem. Among the limitations of this study is the convenience sample. The sample is composed solely of people in treatment and complying to it, therefore hampering data generalization. Due to the crosssectional design, the findings point more towards an association rather than to cause and effect. Amid the researched clinical variables, CD4 was informed verbally by patients themselves, which decreases the trustworthiness of the information. An issue not investigated in this study is the one of sensibility to change in relation to treatment. The use of the WHOQOL-HIV module in studies that evaluate new treatment strategies for the infection would be a potential application of this new instrument not contemplated in the cross-sectional design of the present study. Nonetheless, due to its cross-cultural perspective and adequate psychometric characteristics, the WHOQOL-HIV seems an interesting alternative for future studies regarding quality of life in HIV patients. References Ciconelli, R.M. 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