Views
1 week ago

2017 Cardiovascular Research Day Abstract Book

99 Dynamic hepatic

99 Dynamic hepatic oxidized phospholipid composition promotes non-alcoholic fatty liver disease progression Clint Upchurch 1 • Vlad Serbulea 1 • Norbert Leitinger, PhD 1 1Pharmacology, University of Virginia Graduate Student Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome, affects 25% of individuals within the United States. NAFLD is a progressive pathology initiating with accumulation of fat within the liver (hepatic steatosis) followed by inflammation (steatohepatitis) and liver fibrosis. Currently, drivers of NAFLD progression are poorly understood. We propose that oxidized phospholipids (OxPLs) within the liver promote NAFLD pathophysiology. We developed a liquid chromatography-mass spectrometry method to quantify oxidation products of 1-palmitoyl-2- arachidonoyl-sn-glycero-3-phosphatidylcholine (PAPC) in liver tissue and observed an increase in full-length PAPC oxidation products (OxPAPC) in mice fed a high fat diet (HFD). HFD-fed mice exhibit extensive hepatic steatosis, the first stage of NAFLD. Separately, using immunohistochemistry we observed an increase in liver OxPLs in mice treated with carbon tetrachloride, a model of liver damage. Furthermore, hepatic stellate cells, the major contributor to fibrosis, show an increase in fibrotic gene expression in response to treatment with OxPAPC. Taken together, OxPLs play a role in stellate cell over-activation in response to liver damage and subsequent fibrosis. 115

100 Short-Term Exercise Training Differently Modifies Aspects of HDL Function in Lean, Obese and Diabetic Subjects Lin Zhu, PhD 1 • Nicolas Musi, MD 2 • John Stafford, MD, PhD 1 1Diabetes, Vanderbilt University Medical Center • 2 Diabetes, University of Texas Health Science Center Faculty The triglyceride (TG)-lowering effects of exercise have been well documented. In contrast, mechanisms for the cardiovascular protective effects of exercise are not well established. We previously showed that short-term exercise training improves insulin sensitivity but does not inhibit inflammatory pathways in immune cells from insulin-resistant subject. The purpose of this study is to evaluate metabolic changes of lipoproteins after short-term exercise training in lean, obese and type 2 diabetic (T2D) subjects. Lean, obese nondiabetic, and obese T2D individuals (n=6 per group) underwent a high intensity aerobic exercise program for 15 days. Blood lipid parameters and HDL functions were analyzed before and after exercise. Blood cholesterol levels were higher in obese and T2D than in lean subjects. Exercise training primarily reduced LDL- and HDL-cholesterol (17%-21%, P

Abstract Book Research Day 2013.pdf - University of Minnesota ...
Research Day Book 2013 - College of Medicine - Florida Atlantic ...
Book of Abstracts - Australian Centre for Economic Research on ...
Research Days 2013 Abstract Book - Office of the Vice President for ...
Assessment of Tobacco Smoke-Mediated Atherosclerosis in Mouse ...
Abstract Book - Pathology and Laboratory Medicine - University of ...
book of abstracts 11th annual research half day may 12, 2010 ...
2010 Abstracts - Radiation Research Society
Abstract Booklet - University of Ottawa Heart Institute
research day - University of Toronto Department of Obstetrics and ...
Abstracts - Society of Cardiovascular Anesthesiologists
Abstracts - Interactive CardioVascular and Thoracic Surgery
Abstracts for The European Society for Cardiovascular Surgery 53rd ...
CARDIOVASCULAR DISEASE IN WOMEN - Epib.nl
PATHOLOGY OF THE CARDIOVASCULAR SYSTEM Dr: Khitam Dr ...
Conditional Risk Factors for Atherosclerosis - Mayo Medical ...
Reverse cholesterol transport and cholesterol efflux in atherosclerosis
Oral Presentations - Arteriosclerosis, Thrombosis, and Vascular ...
Technologist Abstracts - Society of Cardiovascular Magnetic ...
The interplay of inflammation and cardiovascular disease in ...
Book of Abstracts - Oxygen Club of California
Book of Abstracts - Oxygen Club of California
Research Days Abstract Book - Office of the Vice President for ...
Cardiovascular Lab Indicators - Anaturalhealingcenter.com