Views
1 week ago

2017 Cardiovascular Research Day Abstract Book

103 Alternating heights

103 Alternating heights of the R wave in ECG: possible link with depolarization alternans Sahar Varnoosfaderani 1 , David Wasemiller 1 , Siqi Wang 1 , Paul Anaya 2 , and Abhijit Patwardhan 1 . 1 Department of Biomedical Engineering and 2 Division of Cardiovascular Medicine. University of Kentucky. Alternans of the T wave in the ECG (TWA) is widely investigated as a potential predictor of ventricular arrhythmia, however, clinical trials show that TWA has high negative predictive value but poor positive predictive value. A possible reason that TWA has a large number of false positives is that a pattern of alternans, concordant alternans, may not be as arrhythmogenic as discordant alternans. Currently, it is not possible to discern the pattern of alternans using clinical ECGs. However, our research using tissue and cellular level electrophysiological measurements suggest that depolarization alternans which affects the pattern of alternans may manifest itself in the amplitude of the R wave of the ECGs. In order to investigate the link between depolarization alternans and changes in ECGs, we used a mathematical model which simulated ECGs from the cellular level changes observed in our experimental studies. These results suggest that the changes in ECGs should appear as alternating pattern of the heights of the R wave. However, there are a variety of factors which may also cause the R wave heights to change. We use signal analysis and statistical modeling to determine the link between the observed changes in R wave heights and depolarization alternans. Results from ECGs recorded from patients show that heights of the R wave can change as predicted by our experimental results and mathematical models. These results support further exploration of the link between depolarization and repolarization alternans as it has the potential to improve the positive predictive value of TWA. Supported by grants from the Kentucky Science and Engineering Foundation (KSEF RDE18) and NSF EPSCoR RII Track-2. 119

NOTES 120

Abstract Book Research Day 2013.pdf - University of Minnesota ...
Research Day Book 2013 - College of Medicine - Florida Atlantic ...
Book of Abstracts - Australian Centre for Economic Research on ...
Assessment of Tobacco Smoke-Mediated Atherosclerosis in Mouse ...
Research Days 2013 Abstract Book - Office of the Vice President for ...
Abstract Book - Pathology and Laboratory Medicine - University of ...
2010 Abstracts - Radiation Research Society
Abstract Booklet - University of Ottawa Heart Institute
research day - University of Toronto Department of Obstetrics and ...
book of abstracts 11th annual research half day may 12, 2010 ...
Abstracts - Society of Cardiovascular Anesthesiologists
Abstracts - Interactive CardioVascular and Thoracic Surgery
Abstracts for The European Society for Cardiovascular Surgery 53rd ...
CARDIOVASCULAR DISEASE IN WOMEN - Epib.nl
PATHOLOGY OF THE CARDIOVASCULAR SYSTEM Dr: Khitam Dr ...
Conditional Risk Factors for Atherosclerosis - Mayo Medical ...
Oral Presentations - Arteriosclerosis, Thrombosis, and Vascular ...
Reverse cholesterol transport and cholesterol efflux in atherosclerosis
The interplay of inflammation and cardiovascular disease in ...
Technologist Abstracts - Society of Cardiovascular Magnetic ...
Book of Abstracts - Oxygen Club of California
Book of Abstracts - Oxygen Club of California
Research Days Abstract Book - Office of the Vice President for ...
Cardiovascular Lab Indicators - Anaturalhealingcenter.com