Views
6 months ago

2017 Cardiovascular Research Day Abstract Book

1 Extracorporeal

1 Extracorporeal Membrane Oxygenation as a Rescue Measure in Patients Experiencing Respiratory Distress After Non-cardiac Thoracic Surgery Dwight Harris 1 • Sibu Saha, MD 2 1College of Medicine, University of Kentucky • 2 Cardiothoracic Surgery, University of Kentucky Medical Student Extracorporeal Membrane Oxygenation (ECMO) is a rescue measure used to treat patients in every age group from neonates to adults. ECMO is used to treat many different conditions including respiratory distress, cardiogenic shock, and trauma. In these patient groups ECMO has been extensively studied. Recently, physicians have begun using ECMO as a rescue measure in patients experiencing acute respiratory distress syndrome (ARDS) after non-cardiac thoracic surgery. Studies on the use of ECMO after non-cardiac thoracic surgery are lacking with only a hand full of reports published. The goal of this report is to present our experience with patients experiencing ARDS after non-cardiac thoracic surgery. We conducted a retrospective review of all patients that had received ECMO after thoracic surgery at the University of Kentucky from January 9, 2012 to January 9, 2017. We identified 8 patients. The average time on ECMO was 9.125 days, and the average hospital stay was 65.125 days. Of the eight patients placed on ECMO three of them survived to discharge. Of the 3 that survived to discharge one died within six months and two are less than four months out to follow up. The average charge per patient was calculated to be 1,053,551 dollars, and the average charge per day for ECMO was 16,177 dollars. The contribution margin per case was $109,200. ECMO is a tool that saves lives, but ECMO does not appear to have the same yield in patients experiencing ARDS after Thoracic surgery compared to other patient groups. ECMO after non-cardiac thoracic surgery is low yield and costly compared to other patient populations. 17

2 Inhibition of Megalin Reduces Atherosclerosis and Improves Hypercholesterolemia-induced Lysosomal Dysfunction in Kidney Feiming Ye 1 • Chia-Hua Wu 1 • Deborah Howatt 1 • Adam Mullick 2 • Mark Graham 2 • Anju Balakrishnan 1 • Craig Vander Kooi 3 • Jan Danser 4 • Jian-An Wang 5 • Alan Daugherty 1 • Hong Lu 1 1Saha Cardiovascular Research Center, University of Kentucky • 2 Ionis Pharmaceuticals • 3Molecular and Cellular Biochemistry, University of Kentucky • 4 Erasmus MC • 5 Department of Cardiology, Zhejiang University Graduate Student Objective: Our previous study has demonstrated that hepatocyte-specific deficiency of angiotensinogen (hepAGT-/-) reduces atherosclerosis. Megalin interacts with AGT and determines its presence in proximal convoluted tubules of kidney. In this study, we investigated effects of megalin inhibition on hypercholesterolemia-induced atherosclerosis and kidney pathologies. Methods and Results: Male LDL receptor -/- mice at the age of 8 - 10 weeks were injected subcutaneously with PBS, control antisense oligonucleotides (ASO), or megalin ASO for 13 weeks. One week after the initial injection, mice were fed a Western diet enriched with saturated fat for 12 weeks. Inhibition of megalin profoundly reduced atherosclerotic lesion area, compared to the two control groups (Percent lesion area in PBS, control ASO and megalin ASO groups: 23 ± 2, 20 ± 2, 12 ± 1 %, respectively; P < 0.001). Histological analysis of kidney sections exhibited extensive vacuolar formation in proximal convoluted tubules of kidney in mice injected with PBS or control ASO, which were absent in mice injected with megalin ASO. Immunostaining of lysosomal-associated membrane protein 1 demonstrated that these vacuoles were derived from enlarged lysosomes. Same kidney pathology was also found in hepAGT+/+ mice in an LDL receptor -/- background fed the Western diet, but not observed in hepAGT-/- mice fed this diet. Conclusions: Megalin in proximal convoluted tubules of kidney and AGT derived from hepatocytes may interact to promote hypercholesterolemia-induced atherosclerosis and renal lysosomal dysfunction. 18

Assessment of Tobacco Smoke-Mediated Atherosclerosis in Mouse ...
2010 Abstracts - Radiation Research Society
Abstract Booklet - University of Ottawa Heart Institute
Abstract Book Research Day 2013.pdf - University of Minnesota ...
Research Day Book 2013 - College of Medicine - Florida Atlantic ...
Book of Abstracts - Australian Centre for Economic Research on ...
Research Days 2013 Abstract Book - Office of the Vice President for ...
Abstract Book - Pathology and Laboratory Medicine - University of ...
book of abstracts 11th annual research half day may 12, 2010 ...
research day - University of Toronto Department of Obstetrics and ...
Abstracts - Interactive CardioVascular and Thoracic Surgery
Abstracts - Society of Cardiovascular Anesthesiologists
Abstracts for The European Society for Cardiovascular Surgery 53rd ...
CARDIOVASCULAR DISEASE IN WOMEN - Epib.nl
PATHOLOGY OF THE CARDIOVASCULAR SYSTEM Dr: Khitam Dr ...
Conditional Risk Factors for Atherosclerosis - Mayo Medical ...
Reverse cholesterol transport and cholesterol efflux in atherosclerosis
Oral Presentations - Arteriosclerosis, Thrombosis, and Vascular ...
The interplay of inflammation and cardiovascular disease in ...
Technologist Abstracts - Society of Cardiovascular Magnetic ...
Cardiovascular Lab Indicators - Anaturalhealingcenter.com
Research Days Abstract Book - Office of the Vice President for ...
Book of Abstracts - Oxygen Club of California
Cardiovascular Disease: C-Reactive Protein - Thorne Research