2017 Cardiovascular Research Day Abstract Book
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3<br />
Improving Patient Care on Left Ventricular Assist Device Support: Novel Outcome Predictors<br />
& Preventative Therapies<br />
Tara Shrout 1 • Travis Sexton, PhD 2 • Susan Smyth, MD, PhD 3<br />
1College of Medicine, University of Kentucky • 2 Saha <strong>Cardiovascular</strong> <strong>Research</strong> Center, University of<br />
Kentucky • 3 Chief, Division of <strong>Cardiovascular</strong> Medicine, University of Kentucky<br />
Medical Student<br />
Background:<br />
Left ventricular assist device (LVAD) implantation is an increasingly common and important<br />
intervention for heart failure. Despite advancements, implantation introduces a foreign body across<br />
which blood experiences aberrant sheer stress. Clinical complications of bleeding and stroke<br />
develop secondary to an acquired coagulopathy, and patients’ quality of life is an important<br />
outcome to consider. This study uniquely correlates early platelet function and biomarkers<br />
alterations with clinical outcomes, as well as patient quality of life measures to help predict,<br />
address, and explore complications with LVAD support.<br />
Objectives:<br />
1. Evaluate correlations between predictive measures of platelet function, biomarkers, laboratory<br />
trends with clinical complications outcomes and LVAD types.<br />
2. Characterize the role of a novel hemostatic agent as a preventative therapy for bleeding.<br />
3. Understand patients’ quality of life on LVAD support.<br />
Design:<br />
March 2014-August 2016, 68 enrolled patients underwent implantation of Heartmate II (n= 48),<br />
Heartmate III (n=2), Heartware (n=18). Blood collections: 24-hours preoperatively and 1-, 24-, 72-,<br />
and 168-hours postoperatively. Follow-up collections: between 30-90-days postoperatively.<br />
Platelet function analyzed via impedance aggregometry, five agonists, and novel hemostatic agent.<br />
Biomarkers of coagulation, platelet activation, and inflammation analyzed. Daily clinical data<br />
collected.<br />
Participants:<br />
Consecutive-based sample. Sociodemographics: age, gender, ethnicity, co-existing conditions<br />
collected. Eligibility: First-time LVAD implant. Exclusion: Age