Views
4 months ago

2017 Cardiovascular Research Day Abstract Book

9 Cerebro-cardiac and

9 Cerebro-cardiac and Cerebro-respiratory Interactions while Listening to Songs Mohammad Javad Mollakazemi 1 • Dibyajyoti Biswal 1 • Sridevi Thyagarajan 1 • Joyce Evans 1 • Abhijit Patwardhan, PhD 1 1 Biomedical Engineering, University of Kentucky Graduate Student Introduction: Since ancient times listening to music has been thought to affect mental as well as physical wellbeing. Previous studies have shown that autonomic responses change while listening to songs, but the interactions between respiratory, cardiovascular and cerebral rhythms while listening to songs are not as well understood. In this study, we investigated relations between cerebral, cardiac and respiratory rhythms while subjects listened to a variety of songs. Materials and Methods: All study procedures were approved by the Institutional Review Board at the University of Kentucky. Data were collected from 8 adult subjects (4 males and 4 females). A pair of circumaural headphones was used to listen to songs. A short audio acuity test was administered to each subject to rule out overt hearing loss. The following signals were recorded during the study: 6 channels of EEG (F3, T3, P3, F4, T4, P4), ECG (lead II, Spacelabs), Respiration (abdominal and thoracic, AMI Inductotrace) and non-invasive continuous finger blood pressure (Finapres). Some results from cardio-respiratory variables are reported in a companion abstract. All signals were digitized online at a rate of 1000 samples/second. In order to determine the contribution of cognition and memory recall in the evoked responses, we scrambled local phase spectra for a song of the subject’s choosing while preserving the magnitude spectra. In addition, subjects listened to two songs, one with a slow and the other with a fast tempo. Data were collected during 10 minutes of control at the beginning of the study when the subjects sat quietly in the chair without listening to any music. To find interactions between cerebro-cardiac and cerebrorespiratory rhythms, frequency spectra, magnitude squared coherencies and transfer functions were computed for all possible combinations of EEGs and cardiovascular variable (RR intervals, computed from the ECG) and between EEGs and respiratory time series. Welch’s method with 100 sec segments, 50% overlap and a Hanning window were used for these computations. Results and Discussion: Coherence, integrated over dc-0.5 Hz (the Nyquist frequency used for cardiac and respiratory variables) between RR intervals and most channels of EEG increased during listening to songs relative to control. An increase was seen regardless of the type of song that was listened to. A similar increase in integrated coherence was also observed between respiratory oscillations and EEGs, again, regardless of type of the song. Comparing slow and fast tempo songs: the fast tempo song increased the coherence between RR intervals and EEGs and between respiratory oscillations and EEGs more than the slow tempo song. When subjects listened to the song of their choosing, the average coherence between cerebro-cardiac and cerebro-respiratory rhythms was higher than control, the phase randomized version of the same song had a somewhat lower coherence but was still higher than control. However, differences in integrated cerebro-cardiac and cerebro-respiratory coherencies between the song of choice and the phase randomized version of it were not consistent. The autospectra of the envelopes of all channels of the EEG showed an overall decrease in spectral power within the 0-5 Hz range while listening to songs. Conclusions: Although we had anticipated that the differences between the responses for the song of choice and its phase scrambled version would be small, our results do not show a consistent difference. Many subjects could identify the phase scrambled song as being the same or similar to the one of their choosing, which may explain this finding. The increase in integrated coherencies between respiration and EEGs is indicative of entrainment of respiration to the music. The increase in coherencies between EEGs and RR intervals, during listening to songs, also indicates entrainment of RR intervals with music; however, whether this entrainment happens in parallel with entrainment with respiration or it is sequential remains unknown. Collectively, these results show that listening to songs increases coherent entrainment between cerebro-cardio and cerebro -respiratory variables. Acknowledgement: Supported by a grant from the National Science Foundation (EPSCoR RII Track-2). 25

10 Evidence of Angiotensin II-dependent Obesity-induced Hypertension in Female Mice Exposed to Postnatal Neglect Joseph Herald 1 • Jacqueline Leachman 1 • Analia Loria, PhD 1 1Pharmacology and Nutritional Sciences, University of Kentucky Undergraduate Previously, we have shown that female mice subjected to maternal separation with early weaning (MSEW), a model of postnatal neglect, display exacerbated diet-induced obesity and high blood pressure (BP) compared with control mice. Female MSEW mice show activated renin-angiotensin system components, including increased plasma renin activity and adipose tissue-derived angiotensinogen secretion. The goal of this study was to test whether augmented obesity-induced hypertension in female MSEW mice is AngII-dependent. Mouse MSEW was achieved by repeated, daily separations from the dam and 4-day early weaning. Normally reared controls (C) were weaned at postnatal day 21. Each experimental group of female weanlings was comprised of 6 mice each and derived from 3 different litters, that were placed on high fat diet (HFD, 60% kcal from fat). After 18 weeks, mice were implanted with radiotelemetry devices for BP measurement. At week 20, average 24-hr systolic blood pressure (SBP) was 134±2 mmHg in MSEW mice and 126±2 in C (P

Abstract Book Research Day 2013.pdf - University of Minnesota ...
Research Day Book 2013 - College of Medicine - Florida Atlantic ...
Meeting Program and Abstracts
Assessment of Tobacco Smoke-Mediated Atherosclerosis in Mouse ...
Research Days 2013 Abstract Book - Office of the Vice President for ...
Book of Abstracts - Australian Centre for Economic Research on ...
2010 Abstracts - Radiation Research Society
Abstract Booklet - University of Ottawa Heart Institute
Abstract Book - Pathology and Laboratory Medicine - University of ...
book of abstracts 11th annual research half day may 12, 2010 ...
research day - University of Toronto Department of Obstetrics and ...
Abstracts - Society of Cardiovascular Anesthesiologists
Abstracts - Interactive CardioVascular and Thoracic Surgery
Abstracts for The European Society for Cardiovascular Surgery 53rd ...
CARDIOVASCULAR DISEASE IN WOMEN - Epib.nl
Time for primary review: 25 Days - Cardiovascular Research
Serum bilirubin distribution and its relation to cardiovascular risk in children and young adults
PATHOLOGY OF THE CARDIOVASCULAR SYSTEM Dr: Khitam Dr ...
Conditional Risk Factors for Atherosclerosis - Mayo Medical ...
Oral Presentations - Arteriosclerosis, Thrombosis, and Vascular ...
Reverse cholesterol transport and cholesterol efflux in atherosclerosis
Arterial endothelial cells - Cardiovascular Research
Technologist Abstracts - Society of Cardiovascular Magnetic ...
The interplay of inflammation and cardiovascular disease in ...
Cardiovascular Research. 80(2)
Book of Abstracts - Oxygen Club of California
ABSTRACTS
Book of Abstracts - Oxygen Club of California
Cardiovascular Lab Indicators - Anaturalhealingcenter.com
Research Days Abstract Book - Office of the Vice President for ...