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2017 Cardiovascular Research Day Abstract Book

2017

2017 DISTINGUISHED ALUMNI SPEAKER John Charles, Ph.D. Chief Scientist, NASA Human Research Program at Johnson Space Center John B. Charles, Ph.D., is the Chief Scientist of NASA’s Human Research Program (HRP), responsible for the scientific direction of human research and technology development enabling astronauts to go beyond low Earth orbit and eventually to Mars. Previously he was HRP’s Associate Manager for International Science and led NASA’s space life sciences planning for the joint US/Russian oneyear mission on ISS and the Twins Study. Dr. Charles earned his B.S. in biophysics at The Ohio State University and his doctorate in physiology and biophysics at the University of Kentucky. He came to the Johnson Space Center in 1983 a postdoctoral fellow and became a civil servant in 1985. He is co-developer of the Shuttle-era fluid-loading countermeasure, and investigated the cardiovascular effects of space flight using ultrasound, re-entry data recording and in-flight lower body negative pressure on Space Shuttle astronauts and on crewmembers of the Russian space station Mir. He coordinated all of the NASA-sponsored biomedical, biological and microgravity science investigations as Mission Scientist for American astronaut missions on Mir, on STS-95, John Glenn’s Shuttle flight, and on STS- 107, Columbia’s last mission in January 2003. He is a Fellow of the Aerospace Medical Association and has been a member since 1983. He is also a Full Member of the International Academy of Astronautics (IAA) and co-chaired the 18 th IAA “Humans in Space Symposium” in Houston in 2011. He has published 75 scientific papers and space history articles and has received several professional awards, including National Space Club and Foundation Eagle Manned Mission Award (2017), the NASA Exceptional Achievement Medal (2014), the ASMA “Joe Kerwin Award” (2011), the “Hubertus Strughold Award” of the Space Medicine Association (2001) and the NASA Exceptional Service Medal (2000). 7

FEATURED SPEAKER Calum MacRae, M.D., Ph.D. Chief, Cardiovascular Medicine, Brigham and Women’s Hospital Associate Professor of Medicine, Harvard Medical School Calum MacRae is a cardiologist, geneticist and developmental biologist who trained in Edinburgh, London and Boston. He is Chief of Cardiovascular Medicine at Brigham and Women’s Hospital and Associate Professor of Medicine at Harvard Medical School. He is also an Associate Member at the Broad Institute and a Principal Faculty Member at the Harvard Stem Cell Institute. His research is focused on understanding the fundamental mechanisms of disease using human studies and complementary efforts combining systems level modeling with empiric high-throughput biology in the zebrafish. His lab uses automated screens in fish to define the genetic architecture of disease and to explore gene-drug (or environment) interactions through the interrogation of large-scale chemical libraries. His interests include heart failure, arrhythmias and coronary disease, genomic medicine, innovation in phenotyping and the redesign of clinical care. 8

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