How does Berberine work How to use Berberine. Berberine has multiple actions but the primary one believed to have the greatest impact on human health is its ability to activate AMP-activated protein kinase (AMPK). AMPK is a metabolic sensor and is regarded as a master regulatory switch for the management of cellular energy balance, growth, survival functions and inflammation. AMPK regulates an array of biological activities that normalize lipid, glucose, and energy balance. AMPK Activation positively affects Berberine is a yellow coloured alkaloid usually found in the roots, rhizomes, stems and bark of various plants such as Barberry, Tree Turmeric, Goldenseal and Oregon grape. Its history of use dates as far back as 3000 years where it has been used in Chinese traditional and Ayurvedic medicine. Berberine has fast become one of the most researched phytochemicals, evident from the increased research each year and the 4500 published studies as of 2017. Berberine has been successfully used by millions of people around the world and their clinicians to restore and maintain health. Whilst Berberine has a series of benefits the major interest lies in its ability to treat and manage conditions related to metabolic syndrome. Berberine is available through various supplements as a standalone supplement or in combination with other materials. Clinical studies have demonstrated that in order to receive the therapeutic and health benefits of Berberine in cases of metabolic syndrome, a daily dose of 1000mg – 1500mg is recommended. This is to be taken in equal amounts either two or three times per day with meals. It is not recommended that more than 500mg be taken at a time. For those wanting to receive the health related benefits of Berberine related to AMPK activation which include antiaging and targeted fat loss, it is suggested to take 500mg once per day with the largest meal of the day and to do this for no longer than 8 weeks at a time with an intermission of 4 weeks. Berberine. Hyperglycemia Hyperlipidemia Hypertension Liver function Inflammation Bodyfat composition Advanced: 500mg x 3 per day with main meals. Minimum 3 months. Moderate: 500mg x 2 per day with breakfast and dinner or main meals. Minimum 3 months. AMPK inhibition is directly linked to metabolic syndrome. It is therefore a key target in the treatment of metabolic syndrome with the activation of AMPK being the principal action of the drug Metformin. Clinical studies have indicated that Berberine and Metformin share a similar potency for AMPK activation and are amongst a handful of substances known to have such an effect. AMPK is activated naturally and triggered through exercise and an energy deficit through diet. It is important to note that excess energy consumption inhibits AMPK, in particular excessive sugar and high fat. AMKP Activation: 500mg x 1 per day with main meal. Maximum 8 weeks.