Man's physical universe

xanabras

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CHEMISTRY AND THE CONTROL OF DISEASE 773

H—

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H—C—C=0

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C—

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mandelic acid

It was found that maggots hatched from eggs laid in wounds by

blowflies, while repulsive to contemplate, caused suppurating wounds

to heal. A great deal of research led to the discovery that it is the urea

produced by these maggots that is the active agent. Later it was

shown that the still simpler substance, ammonium bicarbonate, is

equally effective. Ammonium bicarbonate has been used with success

for such infections as chronic osteomyelitis, varicose ulcers, middle-ear

infections, and suture abscesses.

Some compounds of silver are effective disinfectants.

Water may be

sterilized by the use of silver ions in the ratio of one part to 20,000,000

parts of water at a cost of only a few dollars per million gallons of

water. Silver nitrate is corrosive to the tissues unless used in very

dilute concentrations.

born from mothers infected with gonorrhea.

It has saved the eyesight of thousands of babies

Colloidal silver (argyrol) and colloidal silver bromide (argental)

are used in the treatment of infections of the mucous membranes.

Sulfanilamide and Its

Derivatives Introduced a New Era in Chemotherapy.

Within the five-year period, 1935-1940, the unbelievable achievements

of sulfanilamide in the treatment of formerly unconquerable

diseases were quickly followed by the preparation of several derivatives

of sulfanilamide which proved to be even better than the parent substance

in some diseases. The discovery of these new wonder drugs is one

of the greatest events since the preparation of arsphenamine by Ehrlich.

Truly it represents the beginning of a new era in chemotherapy.

Prontosil and similar dyes containing the NH2C6H4-SO2NH2

group were found by the German, Domagk, and his co-workers, Klarer

and Mietzsch, to be effective in the treatment of streptococcic infections.

Later in 1935 the Trefonels and their associates showed that all

of these prontosil dyes owed their chemotherapeutic properties to a

simpler substance contained in their molecules; this was sulfanilamide.

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